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Caspase 3

Caspase-3 is a caspase protein that interacts with caspase-8 and caspase-9. It is encoded by the CASP3 gene. CASP3 orthologs have been identified in numerous mammals for which complete genome data are available. Unique orthologs are also present in birds, lizards, lissamphibians, and teleosts.

Overview, Enzymatic activity & Function

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Overview

23 related topics

Enzymatic activity

10 related topics

Function

9 related topics

Interactions

9 related topics

Key facts & relationships

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3.4.22.56
Aliases
CASP3, CPP32, CPP32B, SCA-1, caspase 3
Available structures
Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1CP3, 1GFW, 1I3O, 1NME, 1NMQ, 1NMS, 1PAU, 1QX3, 1RE1, 1RHJ, 1RHK, 1RHM, 1RHQ, 1RHR, 1RHU, 2C1E, 2C2K, 2C2M,…
Band
8 B1.1|8 26.39 cM
Bgee
medial ganglionic eminence · barrel cortex · Rostral migratory stream · neural tube · trigeminal ganglion
BioGPS
More reference expression data

Topics to explore

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Overview

Structure

Function

Enzymatic activity

Regulation

Interactions

Advanced semantic analysis

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Map overview Semantic statistics

Caspase 3

Nodes68
Edges67
Triples151
Avg. degree1.97
Density0.029412
Components1

How this topic connects Entity context

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Caspase 3

Top relations

Gene ontology · 86
Caspase 3 → activation of cysteine-type endopeptidase activity involved in apoptotic process, anterior neural tube closure, apoptotic DNA fragmentation, apoptotic process, apoptotic signaling pathway, aspartic-type endopeptidase activity, axonal fasciculation, B cell homeostasis, cell fate commitment, cellular response to DNA damage stimulus, cellular response to organic cyclic compound, cellular response to organic substance, cellular response to staurosporine, cyclin-dependent protein serine/threonine kinase inhibitor activity, cysteine-type endopeptidase activator activity involved in apoptotic process, cysteine-type endopeptidase activity, cysteine-type endopeptidase activity involved in apoptotic process, cysteine-type endopeptidase activity involved in apoptotic signaling pathway, cysteine-type endopeptidase activity involved in execution phase of apoptosis, cysteine-type peptidase activity
related to Activation · 12
Caspase 3 → Apaf-1, As, ATP, B-amyloid, Caspase-3, Garcinia, In, Mangosteen, One, The, These, This
Bgee · 10
Caspase 3 → barrel cortex, epiblast, granulocyte, medial ganglionic eminence, neural tube, renal corpuscle, Rostral migratory stream, superior cervical ganglion, tail of embryo, trigeminal ganglion
RNA expression pattern · 10
Caspase 3 → barrel cortex, epiblast, granulocyte, medial ganglionic eminence, neural tube, renal corpuscle, Rostral migratory stream, superior cervical ganglion, tail of embryo, trigeminal ganglion
related to External links · 6
Caspase 3 → Archived, C14, Caspase, The MEROPS, The Proteolysis Map-animation, Wayback MachineApoptosis
related to Substrate specificity · 4
Caspase 3 → Asp-x-x-Asp, Caspase, The C-terminal Asp, Under
related to Interactions · 2
Caspase 3 → CASP8NMT2CFLARDCCGroELHCLS1SurvivinTRAF3XIAPNFE2L2, Caspase
3.4.22.56 · 1
Caspase 3 → ↗
Aliases · 1
Caspase 3 → CASP3, CPP32, CPP32B, SCA-1, caspase 3
Available structures · 1
Caspase 3 → Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1CP3, 1GFW, 1I3O, 1NME, 1NMQ, 1NMS, 1PAU, 1QX3, 1RE1, 1RHJ, 1RHK, 1RHM, 1RHQ, 1RHR, 1RHU, 2C1E, 2C2K, 2C2M,…

Important terminology Word statistics

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Important terminology

caspase-3 caspase protein caspases activation cell activity casp3 apoptosis acid apoptotic active aspartic caspase-9 gene orthologs role site cys-163 cleavage

Entity relationships Subject–Predicate–Object triples

SubjectPredicateObjectConfidenceSrc
Caspase 33.4.22.561.00infobox
Caspase 3AliasesCASP3, CPP32, CPP32B, SCA-1, caspase 31.00infobox
Caspase 3Available structuresAvailable structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1CP3, 1GFW, 1I3O, 1NME, 1NMQ, 1NMS, 1PAU, 1QX3, 1RE1, 1RHJ, 1RHK, 1RHM, 1RHQ, 1RHR, 1RHU, 2C1E, 2C2K, 2C2M,…1.00infobox
Caspase 3Band8 B1.1|8 26.39 cM1.00infobox
Caspase 3Bgeemedial ganglionic eminence1.00infobox
Caspase 3Bgeebarrel cortex1.00infobox
Caspase 3BgeeRostral migratory stream1.00infobox
Caspase 3Bgeeneural tube1.00infobox
Caspase 3Bgeetrigeminal ganglion1.00infobox
Caspase 3Bgeerenal corpuscle1.00infobox
Caspase 3Bgeegranulocyte1.00infobox
Caspase 3Bgeetail of embryo1.00infobox
Caspase 3Bgeeepiblast1.00infobox
Caspase 3Bgeesuperior cervical ganglion1.00infobox
Caspase 3BioGPSMore reference expression data1.00infobox
Caspase 3Chr.Chromosome 8 (mouse)1.00infobox
Caspase 3DatabasesNCBI: entry; OMA: entry1.00infobox
Caspase 3End47,092,724 bp1.00infobox
Caspase 3EnsemblENSG000001643051.00infobox
Caspase 3Entrez8361.00infobox
Caspase 3Enzyme activityEnzyme activityEC #BRENDAExPASyKEGGMetaCyc3.4.22.56↗↗↗↗1.00infobox
Caspase 3External IDsOMIM: 600636; MGI: 107739; GeneCards: CASP31.00infobox
Caspase 3Gene location (Mouse)Gene location (Mouse)Chr.Chromosome 8 (mouse)Band8 B1.1|8 26.39 cMStart47,070,326 bpEnd47,092,724 bp1.00infobox
Caspase 3Gene ontologycysteine-type peptidase activity1.00infobox
Caspase 3Gene ontologypeptidase activity1.00infobox
Caspase 3Gene ontologyprotein binding1.00infobox
Caspase 3Gene ontologyphospholipase A2 activator activity1.00infobox
Caspase 3Gene ontologycyclin-dependent protein serine/threonine kinase inhibitor activity1.00infobox
Caspase 3Gene ontologycysteine-type endopeptidase activity involved in apoptotic process1.00infobox
Caspase 3Gene ontologycysteine-type endopeptidase activity involved in execution phase of apoptosis1.00infobox

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