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Caspase-3 is a caspase protein that interacts with caspase-8 and caspase-9. It is encoded by the CASP3 gene. CASP3 orthologs have been identified in numerous mammals for which complete genome data are available. Unique orthologs are also present in birds, lizards, lissamphibians, and teleosts.
Overview, Enzymatic activity & Function
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caspase-3 caspase protein caspases activation cell activity casp3 apoptosis acid apoptotic active aspartic caspase-9 gene orthologs role site cys-163 cleavage
| Subject | Predicate | Object | Confidence | Src |
|---|---|---|---|---|
| Caspase 3 | 3.4.22.56 | ↗ | 1.00 | infobox |
| Caspase 3 | Aliases | CASP3, CPP32, CPP32B, SCA-1, caspase 3 | 1.00 | infobox |
| Caspase 3 | Available structures | Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1CP3, 1GFW, 1I3O, 1NME, 1NMQ, 1NMS, 1PAU, 1QX3, 1RE1, 1RHJ, 1RHK, 1RHM, 1RHQ, 1RHR, 1RHU, 2C1E, 2C2K, 2C2M,… | 1.00 | infobox |
| Caspase 3 | Band | 8 B1.1|8 26.39 cM | 1.00 | infobox |
| Caspase 3 | Bgee | medial ganglionic eminence | 1.00 | infobox |
| Caspase 3 | Bgee | barrel cortex | 1.00 | infobox |
| Caspase 3 | Bgee | Rostral migratory stream | 1.00 | infobox |
| Caspase 3 | Bgee | neural tube | 1.00 | infobox |
| Caspase 3 | Bgee | trigeminal ganglion | 1.00 | infobox |
| Caspase 3 | Bgee | renal corpuscle | 1.00 | infobox |
| Caspase 3 | Bgee | granulocyte | 1.00 | infobox |
| Caspase 3 | Bgee | tail of embryo | 1.00 | infobox |
| Caspase 3 | Bgee | epiblast | 1.00 | infobox |
| Caspase 3 | Bgee | superior cervical ganglion | 1.00 | infobox |
| Caspase 3 | BioGPS | More reference expression data | 1.00 | infobox |
| Caspase 3 | Chr. | Chromosome 8 (mouse) | 1.00 | infobox |
| Caspase 3 | Databases | NCBI: entry; OMA: entry | 1.00 | infobox |
| Caspase 3 | End | 47,092,724 bp | 1.00 | infobox |
| Caspase 3 | Ensembl | ENSG00000164305 | 1.00 | infobox |
| Caspase 3 | Entrez | 836 | 1.00 | infobox |
| Caspase 3 | Enzyme activity | Enzyme activityEC #BRENDAExPASyKEGGMetaCyc3.4.22.56↗↗↗↗ | 1.00 | infobox |
| Caspase 3 | External IDs | OMIM: 600636; MGI: 107739; GeneCards: CASP3 | 1.00 | infobox |
| Caspase 3 | Gene location (Mouse) | Gene location (Mouse)Chr.Chromosome 8 (mouse)Band8 B1.1|8 26.39 cMStart47,070,326 bpEnd47,092,724 bp | 1.00 | infobox |
| Caspase 3 | Gene ontology | cysteine-type peptidase activity | 1.00 | infobox |
| Caspase 3 | Gene ontology | peptidase activity | 1.00 | infobox |
| Caspase 3 | Gene ontology | protein binding | 1.00 | infobox |
| Caspase 3 | Gene ontology | phospholipase A2 activator activity | 1.00 | infobox |
| Caspase 3 | Gene ontology | cyclin-dependent protein serine/threonine kinase inhibitor activity | 1.00 | infobox |
| Caspase 3 | Gene ontology | cysteine-type endopeptidase activity involved in apoptotic process | 1.00 | infobox |
| Caspase 3 | Gene ontology | cysteine-type endopeptidase activity involved in execution phase of apoptosis | 1.00 | infobox |
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