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Glial cell line-derived neurotrophic factor

Glial cell line-derived neurotrophic factor (GDNF) is a protein that, in humans, is encoded by the GDNF gene. GDNF is a small protein that potently promotes the survival of many types of neurons. It signals through GFRα receptors, particularly GFRα1. It is also responsible for the determination of spermatogonia into primary spermatocytes, i.e. it is…

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Aliases
GDNF, ATF1, ATF2, HFB1-HSCR3, glial cell derived neurotrophic factor, ATF
Available structures
Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes2V5E, 3FUB, 4UX8
Band
5p13.2 · 15|15 A1
Bgee
muscle of thigh · tibialis anterior muscle · deltoid muscle · Skeletal muscle tissue of biceps brachii · muscle layer of sigmoid colon
BioGPS
More reference expression data
Chr.
Chromosome 5 (human) · Chromosome 15 (mouse)

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Glial cell line-derived neurotrophic factor

Nodes62
Edges61
Triples125
Avg. degree1.97
Density0.032258
Components1

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Glial cell line-derived neurotrophic factor

Top relations

Gene ontology · 49
Glial cell line-derived neurotrophic factor → adult locomotory behavior, axon guidance, branching involved in ureteric bud morphogenesis, chemoattractant activity involved in axon guidance, chemoattraction of axon, commissural neuron axon guidance, dorsal spinal cord development, embryonic organ development, enteric nervous system development, extracellular region, extracellular space, growth factor activity, intracellular anatomical structure, MAPK cascade, mesenchymal to epithelial transition involved in metanephros morphogenesis, metanephros development, mRNA stabilization, negative regulation of apoptotic process, negative regulation of extrinsic apoptotic signaling pathway in absence of ligand, negative regulation of neuron apoptotic process
Bgee · 20
Glial cell line-derived neurotrophic factor → Bowman's capsule, deltoid muscle, epithelium of small intestine, gastric mucosa, gastrocnemius muscle, genitourinary system, Gonadal ridge, Hindgut, inner muscle layer, medullary collecting duct, migratory enteric neural crest cell, mucosa of ileum, muscle layer of sigmoid colon, muscle of thigh, muscularis mucosae, quadriceps femoris muscle, renal corpuscle, Skeletal muscle tissue of biceps brachii, Skeletal muscle tissue of rectus abdominis, tibialis anterior muscle
RNA expression pattern · 20
Glial cell line-derived neurotrophic factor → Bowman's capsule, deltoid muscle, epithelium of small intestine, gastric mucosa, gastrocnemius muscle, genitourinary system, Gonadal ridge, Hindgut, inner muscle layer, medullary collecting duct, migratory enteric neural crest cell, mucosa of ileum, muscle layer of sigmoid colon, muscle of thigh, muscularis mucosae, quadriceps femoris muscle, renal corpuscle, Skeletal muscle tissue of biceps brachii, Skeletal muscle tissue of rectus abdominis, tibialis anterior muscle
related to Interactions · 13
Glial cell line-derived neurotrophic factor → FAK, Fyn, GDNF, GFLs, GFRA1, GFRα1, GFRα1 GPI-anchor, Glial, GPI-anchor, In, NCAM, RET, The
Band · 2
Glial cell line-derived neurotrophic factor → 15|15 A1, 5p13.2
Chr. · 2
Glial cell line-derived neurotrophic factor → Chromosome 15 (mouse), Chromosome 5 (human)
End · 2
Glial cell line-derived neurotrophic factor → 37,840,041 bp, 7,867,056 bp
Aliases · 1
Glial cell line-derived neurotrophic factor → GDNF, ATF1, ATF2, HFB1-HSCR3, glial cell derived neurotrophic factor, ATF
Available structures · 1
Glial cell line-derived neurotrophic factor → Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes2V5E, 3FUB, 4UX8
BioGPS · 1
Glial cell line-derived neurotrophic factor → More reference expression data

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Important terminology

gdnf protein gene gfrα1 receptor also cell bp ret parkinson's cells factor chr human band disease neurotrophic neurons chromosome spermatogonia

Entity relationships Subject–Predicate–Object triples

SubjectPredicateObjectConfidenceSrc
Glial cell line-derived neurotrophic factorAliasesGDNF, ATF1, ATF2, HFB1-HSCR3, glial cell derived neurotrophic factor, ATF1.00infobox
Glial cell line-derived neurotrophic factorAvailable structuresAvailable structuresPDBOrtholog search: PDBe RCSB List of PDB id codes2V5E, 3FUB, 4UX81.00infobox
Glial cell line-derived neurotrophic factorBand5p13.21.00infobox
Glial cell line-derived neurotrophic factorBand15|15 A11.00infobox
Glial cell line-derived neurotrophic factorBgeemuscle of thigh1.00infobox
Glial cell line-derived neurotrophic factorBgeetibialis anterior muscle1.00infobox
Glial cell line-derived neurotrophic factorBgeedeltoid muscle1.00infobox
Glial cell line-derived neurotrophic factorBgeeSkeletal muscle tissue of biceps brachii1.00infobox
Glial cell line-derived neurotrophic factorBgeemuscle layer of sigmoid colon1.00infobox
Glial cell line-derived neurotrophic factorBgeegastrocnemius muscle1.00infobox
Glial cell line-derived neurotrophic factorBgeeSkeletal muscle tissue of rectus abdominis1.00infobox
Glial cell line-derived neurotrophic factorBgeequadriceps femoris muscle1.00infobox
Glial cell line-derived neurotrophic factorBgeegastric mucosa1.00infobox
Glial cell line-derived neurotrophic factorBgeemucosa of ileum1.00infobox
Glial cell line-derived neurotrophic factorBgeemedullary collecting duct1.00infobox
Glial cell line-derived neurotrophic factorBgeeinner muscle layer1.00infobox
Glial cell line-derived neurotrophic factorBgeemuscularis mucosae1.00infobox
Glial cell line-derived neurotrophic factorBgeerenal corpuscle1.00infobox
Glial cell line-derived neurotrophic factorBgeeHindgut1.00infobox
Glial cell line-derived neurotrophic factorBgeeBowman's capsule1.00infobox
Glial cell line-derived neurotrophic factorBgeeepithelium of small intestine1.00infobox
Glial cell line-derived neurotrophic factorBgeemigratory enteric neural crest cell1.00infobox
Glial cell line-derived neurotrophic factorBgeegenitourinary system1.00infobox
Glial cell line-derived neurotrophic factorBgeeGonadal ridge1.00infobox
Glial cell line-derived neurotrophic factorBioGPSMore reference expression data1.00infobox
Glial cell line-derived neurotrophic factorChr.Chromosome 5 (human)1.00infobox
Glial cell line-derived neurotrophic factorChr.Chromosome 15 (mouse)1.00infobox
Glial cell line-derived neurotrophic factorDatabasesNCBI: entry; OMA: entry1.00infobox
Glial cell line-derived neurotrophic factorEnd37,840,041 bp1.00infobox
Glial cell line-derived neurotrophic factorEnd7,867,056 bp1.00infobox

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