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Therapeutic index

The therapeutic index (TI; also referred to as therapeutic ratio) is a quantitative measurement of the relative safety of a drug with regard to risk of overdose. It is a comparison of the amount of a therapeutic agent that causes toxicity to the amount that causes the therapeutic effect. The related terms therapeutic window or safety window refer to a…

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Overview

Types

Drug development

Range of therapeutic indices

Safety ratio

Synergistic effect

Maximum tolerated dose

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Therapeutic index

Nodes97
Edges96
Triples35
Avg. degree1.98
Density0.020619
Components1

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Therapeutic index

Top relations

related to Range of therapeutic indices · 8
Therapeutic index → Diazepam, For, However, In, LD50, Morphine, Some, The
related to Types · 6
Therapeutic index → Based, ED50, In, It, LD50, TIsafety
related to Drug development · 5
Therapeutic index → At, Depending, However, Recognizing, TI
related to Synergistic effect · 3
Therapeutic index → For, Therapeutic, This

Important terminology Word statistics

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Important terminology

therapeutic drug dose index ti safety efficacy effect toxicity cells effects toxic radiation dna window range ld50 ed50 50 also

Entity relationships Subject–Predicate–Object triples

SubjectPredicateObjectConfidenceSrc
morphineinstance ofopioids0.80text
fentanylinstance ofopioids0.80text
and remifentanil are generally considered to have a narrow therapeutic window due to dose-dependent respiratory depressioninstance ofopioids0.80text
the need for careful titrationinstance ofopioids0.80text
monitoring.Less safe are cocaineinstance ofopioids0.80text
digoxininstance ofalso has a therapeutic index of 10.Even less safe are drugs0.80text
a cardiac glycosideinstance ofalso has a therapeutic index of 10.Even less safe are drugs0.80text
micronucleationinstance of75 cell diameters distant from irradiated cells exhibit a phenotype of enhanced genetic instability0.80text
paracrineinstance ofThis suggests an effect on cell-to-cell communication0.80text
juxtacrine signalinginstance ofThis suggests an effect on cell-to-cell communication0.80text
EGFRinstance ofIndirect inhibitors target protein tumor cell signaling proteins0.80text
insulin growth factor.The effective therapeutic index can be affected by targetinginstance ofIndirect inhibitors target protein tumor cell signaling proteins0.80text

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