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Protective index

The protective index (PI) is a comparison of the amount of a therapeutic agent that causes the therapeutic effect to the amount that causes toxicity. Quantitatively, it is the ratio given by the toxic dose divided by the therapeutic dose. A protective index is the toxic dose of a drug for 50% of the population (TD50) divided by the minimum effective dose…

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Protective index

Nodes7
Edges6
Triples3
Avg. degree1.71
Density0.285714
Components1

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Protective index

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is a · 3
Protective index → more accurate measure of the benefit-to-risk ratio than the therapeutic index, smaller ratio, toxic dose of a drug for 50

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protective index therapeutic toxicity presence ld50 dose higher cyanide effect ratio given toxic drug 50 alone potassium mg kg nitrite

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SubjectPredicateObjectConfidenceSrc
Protective indexis atoxic dose of a drug for 500.90text
Protective indexis asmaller ratio0.90text
Protective indexis amore accurate measure of the benefit-to-risk ratio than the therapeutic index0.90text

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