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Lissencephaly

Lissencephaly (/ˌlɪs.ɛnˈsɛf.əl.i/, meaning 'smooth brain') is a set of rare brain disorders whereby the whole or parts of the surface of the brain are smooth. It is caused by defective neuronal migration during the 12th to 24th weeks of gestation, resulting in a lack of development of brain folds (gyri) and grooves (sulci). It is a form of cephalic…

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Causes
Absence of gyrification
Prognosis
Usually die young; see below for details
Specialty
Medical genetics, neurology
Treatment
See below

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Causes

Diagnosis

Treatment

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Lissencephaly

Nodes57
Edges56
Triples71
Avg. degree1.96
Density0.035088
Components1

How this topic connects Entity context

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Lissencephaly

Top relations

has treatment · 14
Lissencephaly → Arc, Dimes, If, In, March, National Organization, Rare Disorders, Seizures, Supportive, Therapies, There, They, Treatment, United States
related to Diagnosis · 8
Lissencephaly → Before, CT, However, If, MRI, NMR, The, Up
related to Prognosis · 8
Lissencephaly → Aspiration, However, In, Life, Many, Some, The, With
related to Classification · 6
Lissencephaly → Different, II, One, Other, The, There
related to Neuronal migration · 6
Lissencephaly → Folding, It, Neuronal, The, This, Three
related to Signs and symptoms · 5
Lissencephaly → Affected, It, MRI, Other, Symptoms
related to Viral infection · 5
Lissencephaly → CMV, Cytomegalovirus, It, The, This
related to External links · 4
Lissencephaly → DCX-Related DisordersGeneReview/NIH/UW, DCX-Related DisordersOMIM, LIS1 Lissencephaly, NINDSGeneReviews/NCBI/NIH/UW
has cause · 3
Lissencephaly → Causes, Genetic, There
see also · 2
Lissencephaly → CEP85L, Gene

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Important terminology

brain lis1 migration causes neuronal surface mutation development symptoms gyri cerebral children dcx gestation cortex chromosome reln arx may genetic

Entity relationships Subject–Predicate–Object triples

SubjectPredicateObjectConfidenceSrc
LissencephalyCausesAbsence of gyrification1.00infobox
LissencephalyPrognosisUsually die young; see below for details1.00infobox
LissencephalySpecialtyMedical genetics, neurology1.00infobox
LissencephalyTreatmentSee below1.00infobox
agyriainstance ofTerms0.80text
absence of portions of the braininstance ofARX is an X chromosome linked gene and is linked with other symptoms0.80text
abnormal genitaliainstance ofARX is an X chromosome linked gene and is linked with other symptoms0.80text
severe epilepsy.RELNReelininstance ofARX is an X chromosome linked gene and is linked with other symptoms0.80text
severe epilepsyinstance ofARX is an X chromosome linked gene and is linked with other symptoms0.80text
lissencephalyinstance ofa gastrostomy tube may be considered.There are a number of organisations that raise awareness and funding for rare disabilities0.80text
Lissencephalyhas causeCauses0.60section
Lissencephalyhas causeThere0.60section

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    Min side: 3
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