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DOT1-like (Disruptor of telomeric silencing 1-like), histone H3K79 methyltransferase (S. cerevisiae), also known as DOT1L, is a protein found in humans, as well as other eukaryotes.
The analysis highlights Overview, Related Topics and Entities as prominent areas in the source structure around DOT1L.
Source areas are shown by the number of related topics found in each part of the analysis. Use smaller areas too: they can reveal specialized angles and content gaps.
Smaller areas are not necessarily less important. They contain fewer connections in this analysis and can be useful for finding specialized angles or coverage gaps.
High-confidence facts extracted from structured source data. Use them as anchors for further research.
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The extracted context around DOT1L shows recurring relationship patterns in the source. For example, DOT1L → chromatin organization, DNA binding, DNA damage checkpoint signaling, DNA repair, histone H3-K79 methylation, histone methyltransferase activity, histone methyltransferase activity (H3-K79 specific), histone-lysine N-methyltransferase activity, intracellular membrane-bounded organelle, methylation, methyltransferase activity, nucleoplasm, nucleus, positive regulation of cell population proliferation, positive regulation of transcription by RNA polymerase II, protein binding, protein-containing complex, regulation of cell cycle, regulation of receptor signaling pathway via JAK-STAT, regulation of transcription regulatory region DNA binding Another extracted example is DOT1L → cerebellar cortex, cerebellar vermis, ganglionic eminence, genital tubercle, hand, left testis, lobe of cerebellum, mucosa of ileum, mucosa of transverse colon, muscle of thigh, primary visual cortex, right hemisphere of cerebellum, right lobe of thyroid gland, right testis, sperm, spermatid, superior frontal gyrus, sural nerve, ventricular zone, zygote. Use these groups to spot repeated connection types before inspecting the individual relationships.
Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.
bp chr human band chromosome 19 h3k79 methylation histone methyltransferase activity uniprot gene location also role protein mouse dot1 dna
TTTA extracted 89 structured relationships around DOT1L. Examples in this analysis include DOT1L → 2.1.1.360 → ↗ and DOT1L → Aliases → DOT1L, DOT1, KMT4, DOT1 like histone lysine methyltransferase. The table shows each extracted connection, where it came from and its confidence.
| Subject | Predicate | Object | Confidence | Src |
|---|---|---|---|---|
| DOT1L | 2.1.1.360 | ↗ | 1.00 | infobox |
| DOT1L | Aliases | DOT1L, DOT1, KMT4, DOT1 like histone lysine methyltransferase | 1.00 | infobox |
| DOT1L | Available structures | Available structuresPDBHuman UniProt search: PDBe RCSB List of PDB id codes1NW3, 2MV7, 3QOW, 3QOX, 3SR4, 3SX0, 3UWP, 4EK9, 4EKG, 4EKI, 4EQZ, 4ER0, 4ER3, 4ER5, 4ER6, 4ER7, 4HRA,… | 1.00 | infobox |
| DOT1L | Band | 19p13.3 | 1.00 | infobox |
| DOT1L | Band | 10|10 C1 | 1.00 | infobox |
| DOT1L | Bgee | right testis | 1.00 | infobox |
| DOT1L | Bgee | left testis | 1.00 | infobox |
| DOT1L | Bgee | mucosa of ileum | 1.00 | infobox |
| DOT1L | Bgee | ventricular zone | 1.00 | infobox |
| DOT1L | Bgee | sural nerve | 1.00 | infobox |
| DOT1L | Bgee | ganglionic eminence | 1.00 | infobox |
| DOT1L | Bgee | sperm | 1.00 | infobox |
| DOT1L | Bgee | right hemisphere of cerebellum | 1.00 | infobox |
| DOT1L | Bgee | right lobe of thyroid gland | 1.00 | infobox |
| DOT1L | Bgee | mucosa of transverse colon | 1.00 | infobox |
| DOT1L | Bgee | cerebellar cortex | 1.00 | infobox |
| DOT1L | Bgee | zygote | 1.00 | infobox |
| DOT1L | Bgee | hand | 1.00 | infobox |
| DOT1L | Bgee | superior frontal gyrus | 1.00 | infobox |
| DOT1L | Bgee | lobe of cerebellum | 1.00 | infobox |
| DOT1L | Bgee | primary visual cortex | 1.00 | infobox |
| DOT1L | Bgee | cerebellar vermis | 1.00 | infobox |
| DOT1L | Bgee | muscle of thigh | 1.00 | infobox |
| DOT1L | Bgee | genital tubercle | 1.00 | infobox |
| DOT1L | Bgee | spermatid | 1.00 | infobox |
| DOT1L | BioGPS | More reference expression data | 1.00 | infobox |
| DOT1L | Chr. | Chromosome 19 (human) | 1.00 | infobox |
| DOT1L | Chr. | Chromosome 10 (mouse) | 1.00 | infobox |
| DOT1L | Databases | NCBI: entry; OMA: entry | 1.00 | infobox |
| DOT1L | End | 2,232,578 bp | 1.00 | infobox |
The concept neighborhoods around DOT1L bring nearby vocabulary together. In this analysis, examples include Activity, Histone and Methyltransferase. Use the clusters to find adjacent concepts and terminology that may deserve separate research.
Bridges highlight paths between different parts of the DOT1L map and can reveal research angles that are easy to miss in a flat list.
TTTA analyzes the structure around DOT1L to surface related topics, entities, relationships, concept neighborhoods and bridge connections. Use the map to explore areas such as Overview, Related Topics & Entities, including less central topics that may reveal useful research gaps. Automatically extracted connections are research leads rather than rewritten encyclopedia content.
Source: Wikipedia — DOT1L · EN edition · Analysis: TopicsToTalkAbout
