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DOT1L

DOT1-like (Disruptor of telomeric silencing 1-like), histone H3K79 methyltransferase (S. cerevisiae), also known as DOT1L, is a protein found in humans, as well as other eukaryotes.

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2.1.1.360
Aliases
DOT1L, DOT1, KMT4, DOT1 like histone lysine methyltransferase
Available structures
Available structuresPDBHuman UniProt search: PDBe RCSB List of PDB id codes1NW3, 2MV7, 3QOW, 3QOX, 3SR4, 3SX0, 3UWP, 4EK9, 4EKG, 4EKI, 4EQZ, 4ER0, 4ER3, 4ER5, 4ER6, 4ER7, 4HRA,…
Band
19p13.3 · 10|10 C1
Bgee
right testis · left testis · mucosa of ileum · ventricular zone · sural nerve
BioGPS
More reference expression data

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Map overview Semantic statistics

DOT1L

Nodes8
Edges7
Triples89
Avg. degree1.75
Density0.25
Components1

How this topic connects Entity context

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DOT1L

Top relations

Gene ontology · 24
DOT1L → chromatin organization, DNA binding, DNA damage checkpoint signaling, DNA repair, histone H3-K79 methylation, histone methyltransferase activity, histone methyltransferase activity (H3-K79 specific), histone-lysine N-methyltransferase activity, intracellular membrane-bounded organelle, methylation, methyltransferase activity, nucleoplasm, nucleus, positive regulation of cell population proliferation, positive regulation of transcription by RNA polymerase II, protein binding, protein-containing complex, regulation of cell cycle, regulation of receptor signaling pathway via JAK-STAT, regulation of transcription regulatory region DNA binding
Bgee · 20
DOT1L → cerebellar cortex, cerebellar vermis, ganglionic eminence, genital tubercle, hand, left testis, lobe of cerebellum, mucosa of ileum, mucosa of transverse colon, muscle of thigh, primary visual cortex, right hemisphere of cerebellum, right lobe of thyroid gland, right testis, sperm, spermatid, superior frontal gyrus, sural nerve, ventricular zone, zygote
RNA expression pattern · 20
DOT1L → cerebellar cortex, cerebellar vermis, ganglionic eminence, genital tubercle, hand, left testis, lobe of cerebellum, mucosa of ileum, mucosa of transverse colon, muscle of thigh, primary visual cortex, right hemisphere of cerebellum, right lobe of thyroid gland, right testis, sperm, spermatid, superior frontal gyrus, sural nerve, ventricular zone, zygote
Band · 2
DOT1L → 10|10 C1, 19p13.3
Chr. · 2
DOT1L → Chromosome 10 (mouse), Chromosome 19 (human)
End · 2
DOT1L → 2,232,578 bp, 80,631,295 bp
2.1.1.360 · 1
DOT1L → ↗
Aliases · 1
DOT1L → DOT1L, DOT1, KMT4, DOT1 like histone lysine methyltransferase
Available structures · 1
DOT1L → Available structuresPDBHuman UniProt search: PDBe RCSB List of PDB id codes1NW3, 2MV7, 3QOW, 3QOX, 3SR4, 3SX0, 3UWP, 4EK9, 4EKG, 4EKI, 4EQZ, 4ER0, 4ER3, 4ER5, 4ER6, 4ER7, 4HRA,…
BioGPS · 1
DOT1L → More reference expression data

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Important terminology

bp chr human band chromosome 19 h3k79 methylation histone methyltransferase activity uniprot gene location also role protein mouse dot1 dna

Entity relationships Subject–Predicate–Object triples

SubjectPredicateObjectConfidenceSrc
DOT1L2.1.1.3601.00infobox
DOT1LAliasesDOT1L, DOT1, KMT4, DOT1 like histone lysine methyltransferase1.00infobox
DOT1LAvailable structuresAvailable structuresPDBHuman UniProt search: PDBe RCSB List of PDB id codes1NW3, 2MV7, 3QOW, 3QOX, 3SR4, 3SX0, 3UWP, 4EK9, 4EKG, 4EKI, 4EQZ, 4ER0, 4ER3, 4ER5, 4ER6, 4ER7, 4HRA,…1.00infobox
DOT1LBand19p13.31.00infobox
DOT1LBand10|10 C11.00infobox
DOT1LBgeeright testis1.00infobox
DOT1LBgeeleft testis1.00infobox
DOT1LBgeemucosa of ileum1.00infobox
DOT1LBgeeventricular zone1.00infobox
DOT1LBgeesural nerve1.00infobox
DOT1LBgeeganglionic eminence1.00infobox
DOT1LBgeesperm1.00infobox
DOT1LBgeeright hemisphere of cerebellum1.00infobox
DOT1LBgeeright lobe of thyroid gland1.00infobox
DOT1LBgeemucosa of transverse colon1.00infobox
DOT1LBgeecerebellar cortex1.00infobox
DOT1LBgeezygote1.00infobox
DOT1LBgeehand1.00infobox
DOT1LBgeesuperior frontal gyrus1.00infobox
DOT1LBgeelobe of cerebellum1.00infobox
DOT1LBgeeprimary visual cortex1.00infobox
DOT1LBgeecerebellar vermis1.00infobox
DOT1LBgeemuscle of thigh1.00infobox
DOT1LBgeegenital tubercle1.00infobox
DOT1LBgeespermatid1.00infobox
DOT1LBioGPSMore reference expression data1.00infobox
DOT1LChr.Chromosome 19 (human)1.00infobox
DOT1LChr.Chromosome 10 (mouse)1.00infobox
DOT1LDatabasesNCBI: entry; OMA: entry1.00infobox
DOT1LEnd2,232,578 bp1.00infobox

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