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Stimulator of interferon genes: Function, STING signaling mechanisms & Expression

Stimulator of interferon genes (STING), also known as transmembrane protein 173 (TMEM173) and MPYS/MITA/ERIS is a regulator protein that in humans is encoded by the STING1 gene.

Language: English [EN]
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Stimulator of interferon genes topic overview

The analysis highlights Function, STING signaling mechanisms and Expression as prominent areas in the source structure around Stimulator of interferon genes.

Related topics
75
Source areas
6
Connected nodes
81
Extracted relationships
106
Concept neighborhoods
24
Bridge connections
81

What this topic covers Research coverage

Source areas are shown by the number of related topics found in each part of the analysis. Use smaller areas too: they can reveal specialized angles and content gaps.

Function · 26 topics
Overview · 16 topics
STING signaling mechanisms · 12 topics
Expression · 10 topics
Localization · 7 topics
Structure · 4 topics

Smaller areas are not necessarily less important. They contain fewer connections in this analysis and can be useful for finding specialized angles or coverage gaps.

Key facts & relationships

High-confidence facts extracted from structured source data. Use them as anchors for further research.

Aliases
STING1, ERIS, MITA, MPYS, NET23, SAVI, STING, hMITA, hSTING, Stimulator of interferon genes, transmembrane protein 173, STING-beta, TMEM173, stimulator of interferon response cG…
Available structures
Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes4EF4, 4EF5, 4EMT, 4EMU, 4F5D, 4F5E, 4F5W, 4F5Y, 4F9E, 4F9G, 4KSY, 4LOH, 4LOI, 4QXO, 4QXP, 4QXQ, 4QXR, 5BQX,…
Band
5q31.2 · 18 B2|18
Bgee
right uterine tube · olfactory zone of nasal mucosa · granulocyte · gastric mucosa · right coronary artery
BioGPS
n/a
Chr.
Chromosome 5 (human) · Chromosome 18 (mouse)

Suggested research paths

A focused starting point derived from the topic graph, ranked independently of the source article order.

Start with these areas

Explore all related topics Closing gaps

Browse the complete topic structure, not only the most central items. Less prominent entities and concepts can reveal missing angles, specialized context and useful research gaps. Each item opens a new analysis centered on that subject.

Overview

Structure

Expression

Localization

Function

STING signaling mechanisms

Advanced semantic analysis

Deeper signals for content research, entity SEO and topical coverage. The plain-language headings explain what each technical view is useful for.

How Stimulator of interferon genes connects Entity context

The extracted context around Stimulator of interferon genes shows recurring relationship patterns in the source. For example, Stimulator of interferon genes → 2',3'-cyclic GMP-AMP binding, activation of innate immune response, apoptotic process, cellular response to exogenous dsRNA, cellular response to interferon-beta, cellular response to organic cyclic compound, cyclic-di-GMP binding, cytoplasm, cytoplasmic pattern recognition receptor signaling pathway in response to virus, cytoplasmic vesicle membrane, defense response to virus, endoplasmic reticulum, endoplasmic reticulum membrane, Golgi apparatus, identical protein binding, immune system process, innate immune response, integral component of membrane, interferon-beta production, membrane Another extracted example is Stimulator of interferon genes → apex of heart, ascending aorta, blood, cervix, Descending thoracic aorta, endothelial cell of lymphatic vessel, gastric mucosa, granulocyte, internal carotid artery, interventricular septum, left uterine tube, lumbar spinal ganglion, mesenteric lymph nodes, olfactory zone of nasal mucosa, right coronary artery, right uterine tube, spleen, tail of embryo, thymus, upper lobe of left lung. Use these groups to spot repeated connection types before inspecting the individual relationships.

Stimulator of interferon genes

Top relations

Gene ontology · 43
Stimulator of interferon genes → 2',3'-cyclic GMP-AMP binding, activation of innate immune response, apoptotic process, cellular response to exogenous dsRNA, cellular response to interferon-beta, cellular response to organic cyclic compound, cyclic-di-GMP binding, cytoplasm, cytoplasmic pattern recognition receptor signaling pathway in response to virus, cytoplasmic vesicle membrane, defense response to virus, endoplasmic reticulum, endoplasmic reticulum membrane, Golgi apparatus, identical protein binding, immune system process, innate immune response, integral component of membrane, interferon-beta production, membrane
Bgee · 20
Stimulator of interferon genes → apex of heart, ascending aorta, blood, cervix, Descending thoracic aorta, endothelial cell of lymphatic vessel, gastric mucosa, granulocyte, internal carotid artery, interventricular septum, left uterine tube, lumbar spinal ganglion, mesenteric lymph nodes, olfactory zone of nasal mucosa, right coronary artery, right uterine tube, spleen, tail of embryo, thymus, upper lobe of left lung
RNA expression pattern · 20
Stimulator of interferon genes → apex of heart, ascending aorta, blood, cervix, Descending thoracic aorta, endothelial cell of lymphatic vessel, gastric mucosa, granulocyte, internal carotid artery, interventricular septum, left uterine tube, lumbar spinal ganglion, mesenteric lymph nodes, olfactory zone of nasal mucosa, right coronary artery, right uterine tube, spleen, tail of embryo, thymus, upper lobe of left lung
Band · 2
Stimulator of interferon genes → 18 B2|18, 5q31.2
Chr. · 2
Stimulator of interferon genes → Chromosome 18 (mouse), Chromosome 5 (human)
End · 2
Stimulator of interferon genes → 139,482,935 bp, 35,873,607 bp
Aliases · 1
Stimulator of interferon genes → STING1, ERIS, MITA, MPYS, NET23, SAVI, STING, hMITA, hSTING, Stimulator of interferon genes, transmembrane protein 173, STING-beta, TMEM173, stimulator of interferon response cG…
Available structures · 1
Stimulator of interferon genes → Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes4EF4, 4EF5, 4EMT, 4EMU, 4F5D, 4F5E, 4F5W, 4F5Y, 4F9E, 4F9G, 4KSY, 4LOH, 4LOI, 4QXO, 4QXP, 4QXQ, 4QXR, 5BQX,…
BioGPS · 1
Stimulator of interferon genes → n/a
Databases · 1
Stimulator of interferon genes → NCBI: entry; OMA: entry

Important terminology

Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.

Important terminology

sting interferon type response dna intracellular infection protein immune signaling shown cells production innate human bp role host infected also

Stimulator of interferon genes relationships Subject–Predicate–Object triples

TTTA extracted 106 structured relationships around Stimulator of interferon genes. Examples in this analysis include Stimulator of interferon genes → Aliases → STING1, ERIS, MITA, MPYS, NET23, SAVI, STING, hMITA, hSTING, Stimulator of interferon genes, transmembrane protein 173, STING-beta, TMEM173, stimulator of interferon response cG… and Stimulator of interferon genes → Available structures → Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes4EF4, 4EF5, 4EMT, 4EMU, 4F5D, 4F5E, 4F5W, 4F5Y, 4F9E, 4F9G, 4KSY, 4LOH, 4LOI, 4QXO, 4QXP, 4QXQ, 4QXR, 5BQX,…. The table shows each extracted connection, where it came from and its confidence.

SubjectPredicateObjectConfidenceSrc
Stimulator of interferon genesAliasesSTING1, ERIS, MITA, MPYS, NET23, SAVI, STING, hMITA, hSTING, Stimulator of interferon genes, transmembrane protein 173, STING-beta, TMEM173, stimulator of interferon response cG…1.00infobox
Stimulator of interferon genesAvailable structuresAvailable structuresPDBOrtholog search: PDBe RCSB List of PDB id codes4EF4, 4EF5, 4EMT, 4EMU, 4F5D, 4F5E, 4F5W, 4F5Y, 4F9E, 4F9G, 4KSY, 4LOH, 4LOI, 4QXO, 4QXP, 4QXQ, 4QXR, 5BQX,…1.00infobox
Stimulator of interferon genesBand5q31.21.00infobox
Stimulator of interferon genesBand18 B2|181.00infobox
Stimulator of interferon genesBgeeright uterine tube1.00infobox
Stimulator of interferon genesBgeeolfactory zone of nasal mucosa1.00infobox
Stimulator of interferon genesBgeegranulocyte1.00infobox
Stimulator of interferon genesBgeegastric mucosa1.00infobox
Stimulator of interferon genesBgeeright coronary artery1.00infobox
Stimulator of interferon genesBgeeupper lobe of left lung1.00infobox
Stimulator of interferon genesBgeeDescending thoracic aorta1.00infobox
Stimulator of interferon genesBgeeleft uterine tube1.00infobox
Stimulator of interferon genesBgeeapex of heart1.00infobox
Stimulator of interferon genesBgeeascending aorta1.00infobox
Stimulator of interferon genesBgeelumbar spinal ganglion1.00infobox
Stimulator of interferon genesBgeemesenteric lymph nodes1.00infobox
Stimulator of interferon genesBgeeendothelial cell of lymphatic vessel1.00infobox
Stimulator of interferon genesBgeeinterventricular septum1.00infobox
Stimulator of interferon genesBgeespleen1.00infobox
Stimulator of interferon genesBgeetail of embryo1.00infobox
Stimulator of interferon genesBgeeblood1.00infobox
Stimulator of interferon genesBgeethymus1.00infobox
Stimulator of interferon genesBgeecervix1.00infobox
Stimulator of interferon genesBgeeinternal carotid artery1.00infobox
Stimulator of interferon genesBioGPSn/a1.00infobox
Stimulator of interferon genesChr.Chromosome 5 (human)1.00infobox
Stimulator of interferon genesChr.Chromosome 18 (mouse)1.00infobox
Stimulator of interferon genesDatabasesNCBI: entry; OMA: entry1.00infobox
Stimulator of interferon genesEnd139,482,935 bp1.00infobox
Stimulator of interferon genesEnd35,873,607 bp1.00infobox

Related concept clusters Concept neighborhoods

The concept neighborhoods around Stimulator of interferon genes bring nearby vocabulary together. In this analysis, examples include Type, Response and Sting. Use the clusters to find adjacent concepts and terminology that may deserve separate research.

  • Stimulator of interferon genes
    • Type
    • Response
    • Sting
    • Signaling
    • Production
    • Dna
    • Infection
    • Cyclic
    • Infected
    • Protein
    • Cells
    • Intracellular
  • stimulator of interferon genes
    • Type
    • Response
    • Sting
    • Signaling
    • Production
    • Dna
    • Infection
    • Cyclic
    • Infected
    • Protein
    • Cells
    • Intracellular
  • protein
    • Sting1
    • Signaling
    • Dna
    • Chromosome
    • Direct
    • Bp
    • Chr
    • Cytosolic
    • Human
    • Sting
    • Host
    • Immune
  • gene
    • Sting1
    • Chromosome
    • Bp
    • Chr
    • Human
    • Protein
    • Band
    • Host
    • Signaling
    • Acids
    • Bacteria
    • Cytosolic
  • innate immunity
    • Immune
    • Role
    • Activate
    • Important
    • Shown
    • Host
    • Response
    • Plays
    • Sting1
    • Viruses
    • Chromosome
    • Intracellular
  • type i interferon
    • Type
    • Response
    • Sting
    • Signaling
    • Production
    • Dna
    • Infection
    • Cyclic
    • Infected
    • Mediated
    • Protein
    • Cells
  • intracellular parasites
    • Bacteria
    • Response
    • Production
    • Sting
    • Immune
    • Viruses
    • Downstream
    • Infection
    • Dna
    • Activation
    • Cyclic
    • Mediated
  • cytosolic dna sensor
    • Dna
    • Interferon
    • Bacteria
    • Protein
    • Response
    • Signaling
    • Shown
    • Sting
    • Activate
    • Host
    • Type
    • Intracellular

Connections between topic areas Semantic bridges

For Stimulator of interferon genes, one of the stronger structural bridges in this analysis connects Stimulator of interferon genes with Function. Bridges highlight paths between different parts of the map and can reveal research angles that are easy to miss in a flat list.

Min side: 3
Stimulator of interferon genesFunction · splits 55 ⟂ 27
Stimulator of interferon genesOverview · splits 65 ⟂ 17
Stimulator of interferon genesSTING signaling mechanisms · splits 69 ⟂ 13
Stimulator of interferon genesExpression · splits 71 ⟂ 11
Stimulator of interferon genesLocalization · splits 74 ⟂ 8
Stimulator of interferon genesStructure · splits 77 ⟂ 5

Map overview Semantic statistics

Stimulator of interferon genes

Nodes82
Edges81
Triples106
Avg. degree1.98
Density0.02439
Components1

Source & methodology

TTTA analyzes the structure around Stimulator of interferon genes to surface related topics, entities, relationships, concept neighborhoods and bridge connections. Use the map to explore areas such as Function, STING signaling mechanisms & Expression, including less central topics that may reveal useful research gaps. Automatically extracted connections are research leads rather than rewritten encyclopedia content.

Source: Wikipedia — Stimulator of interferon genes · EN edition · Analysis: TopicsToTalkAbout

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