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CCL7: Regions, Clinical importance & Genomics

Chemokine (C-C motif) ligand 7 (CCL7) is a small cytokine that was previously called monocyte-chemotactic protein 3 (MCP3). CCL7 is a small protein that belongs to the CC chemokine family and is most closely related to CCL2 (previously called MCP1).

Language: English [EN]
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CCL7 topic overview

The analysis highlights Regions, Clinical importance and Genomics as prominent areas in the source structure around CCL7.

Related topics
20
Source areas
5
Connected nodes
25
Extracted relationships
110
Concept neighborhoods
10
Bridge connections
25

What this topic covers Research coverage

Source areas are shown by the number of related topics found in each part of the analysis. Use smaller areas too: they can reveal specialized angles and content gaps.

Clinical importance · 6 topics
Genomics · 5 topics
Function · 4 topics
Overview · 4 topics
Molecular biology · 1 topics

Smaller areas are not necessarily less important. They contain fewer connections in this analysis and can be useful for finding specialized angles or coverage gaps.

Key facts & relationships

High-confidence facts extracted from structured source data. Use them as anchors for further research.

Aliases
CCL7, FIC, MARC, MCP-3, MCP3, NC28, SCYA6, SCYA7, C-C motif chemokine ligand 7
Available structures
Available structuresPDBHuman UniProt search: PDBe RCSB List of PDB id codes1BO0, 1NCV, 4ZKC
Band
17q12
Bgee
islet of Langerhans · mucosa of urinary bladder · stromal cell of endometrium · amniotic fluid · cartilage tissue
BioGPS
More reference expression data
Chr.
Chromosome 17 (human)

Explore all related topics Closing gaps

Browse the complete topic structure, not only the most central items. Less prominent entities and concepts can reveal missing angles, specialized context and useful research gaps. Each item opens a new analysis centered on that subject.

Overview

Genomics

Molecular biology

Function

Clinical importance

Advanced semantic analysis

Deeper signals for content research, entity SEO and topical coverage. The plain-language headings explain what each technical view is useful for.

How CCL7 connects Entity context

The extracted context around CCL7 shows recurring relationship patterns in the source. For example, CCL7 → CCR chemokine receptor binding, CCR1 chemokine receptor binding, CCR2 chemokine receptor binding, cell-cell signaling, cellular calcium ion homeostasis, cellular response to ethanol, cellular response to interferon-gamma, cellular response to interleukin-1, cellular response to tumor necrosis factor, chemokine activity, chemokine-mediated signaling pathway, chemotaxis, cytokine activity, cytoskeleton organization, eosinophil chemotaxis, extracellular region, extracellular space, G protein-coupled receptor signaling pathway, heparin binding, immune response Another extracted example is CCL7 → CCL7-mediated, CCR2, Diseases, Early, For, Furthermore, HIV, Listeria, Next, The, TipDCs, TLR9, TNF/iNOS-producing, West Nile Virus. Use these groups to spot repeated connection types before inspecting the individual relationships.

CCL7

Top relations

Gene ontology · 33
CCL7 → CCR chemokine receptor binding, CCR1 chemokine receptor binding, CCR2 chemokine receptor binding, cell-cell signaling, cellular calcium ion homeostasis, cellular response to ethanol, cellular response to interferon-gamma, cellular response to interleukin-1, cellular response to tumor necrosis factor, chemokine activity, chemokine-mediated signaling pathway, chemotaxis, cytokine activity, cytoskeleton organization, eosinophil chemotaxis, extracellular region, extracellular space, G protein-coupled receptor signaling pathway, heparin binding, immune response
related to Clinical importance · 14
CCL7 → CCL7-mediated, CCR2, Diseases, Early, For, Furthermore, HIV, Listeria, Next, The, TipDCs, TLR9, TNF/iNOS-producing, West Nile Virus
Bgee · 10
CCL7 → amniotic fluid, appendix, cartilage tissue, islet of Langerhans, lower lobe of lung, mucosa of urinary bladder, parietal pleura, rectum, smooth muscle tissue, stromal cell of endometrium
RNA expression pattern · 10
CCL7 → amniotic fluid, appendix, cartilage tissue, islet of Langerhans, lower lobe of lung, mucosa of urinary bladder, parietal pleura, rectum, smooth muscle tissue, stromal cell of endometrium
related to Genomics · 10
CCL7 → AU-rich, C-terminal, CC, In, MCP, SCYA7, The, The CCL7, This, UTR
related to Function · 8
CCL7 → Ca2, CXC, DCs, Furthermore, It, NK, The, Thus
related to Molecular biology · 3
CCL7 → COS, In, The
related to External links · 2
CCL7 → Human CCL7, UCSC Genome Browser
Aliases · 1
CCL7 → CCL7, FIC, MARC, MCP-3, MCP3, NC28, SCYA6, SCYA7, C-C motif chemokine ligand 7
Available structures · 1
CCL7 → Available structuresPDBHuman UniProt search: PDBe RCSB List of PDB id codes1BO0, 1NCV, 4ZKC

Important terminology

Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.

Important terminology

chemokine gene protein human immune cells chromosome signal 17 bp leukocytes also ccr2 region response chr molecular amino acids monocytes

CCL7 relationships Subject–Predicate–Object triples

TTTA extracted 110 structured relationships around CCL7. Examples in this analysis include CCL7 → Aliases → CCL7, FIC, MARC, MCP-3, MCP3, NC28, SCYA6, SCYA7, C-C motif chemokine ligand 7 and CCL7 → Available structures → Available structuresPDBHuman UniProt search: PDBe RCSB List of PDB id codes1BO0, 1NCV, 4ZKC. The table shows each extracted connection, where it came from and its confidence.

SubjectPredicateObjectConfidenceSrc
CCL7AliasesCCL7, FIC, MARC, MCP-3, MCP3, NC28, SCYA6, SCYA7, C-C motif chemokine ligand 71.00infobox
CCL7Available structuresAvailable structuresPDBHuman UniProt search: PDBe RCSB List of PDB id codes1BO0, 1NCV, 4ZKC1.00infobox
CCL7Band17q121.00infobox
CCL7Bgeeislet of Langerhans1.00infobox
CCL7Bgeemucosa of urinary bladder1.00infobox
CCL7Bgeestromal cell of endometrium1.00infobox
CCL7Bgeeamniotic fluid1.00infobox
CCL7Bgeecartilage tissue1.00infobox
CCL7Bgeeappendix1.00infobox
CCL7Bgeerectum1.00infobox
CCL7Bgeesmooth muscle tissue1.00infobox
CCL7Bgeelower lobe of lung1.00infobox
CCL7Bgeeparietal pleura1.00infobox
CCL7BioGPSMore reference expression data1.00infobox
CCL7Chr.Chromosome 17 (human)1.00infobox
CCL7DatabasesNCBI: entry; OMA: entry1.00infobox
CCL7End34,272,242 bp1.00infobox
CCL7EnsemblENSG000001086881.00infobox
CCL7Entrez63541.00infobox
CCL7External IDsOMIM: 158106; GeneCards: CCL71.00infobox
CCL7Gene location (Human)Gene location (Human)Chr.Chromosome 17 (human)Band17q12Start34,270,221 bpEnd34,272,242 bp1.00infobox
CCL7Gene ontologycytokine activity1.00infobox
CCL7Gene ontologyheparin binding1.00infobox
CCL7Gene ontologychemokine activity1.00infobox
CCL7Gene ontologyCCR1 chemokine receptor binding1.00infobox
CCL7Gene ontologyprotein binding1.00infobox
CCL7Gene ontologyCCR2 chemokine receptor binding1.00infobox
CCL7Gene ontologyCCR chemokine receptor binding1.00infobox
CCL7Gene ontologyextracellular region1.00infobox
CCL7Gene ontologyextracellular space1.00infobox

Related concept clusters Concept neighborhoods

The concept neighborhoods around CCL7 bring nearby vocabulary together. In this analysis, examples include Chemokine, Also and Immune. Use the clusters to find adjacent concepts and terminology that may deserve separate research.

  • CCL7
    • Chemokine
    • Also
    • Immune
    • Leukocytes
    • Gene
    • Binding
    • Cell
    • Expression
    • Location
    • Molecular
    • Ccr2
    • Human
  • ccl7
    • Chemokine
    • Also
    • Immune
    • Leukocytes
    • Gene
    • Binding
    • Cell
    • Expression
    • Location
    • Molecular
    • Ccr2
    • Human
  • cytokine
    • Protein
    • Band
    • Function
    • Ligand
    • Mcp3
    • Motif
    • Previously
    • Small
    • Uniprot
    • Binding
    • Bp
    • Cell
  • cc chemokine
    • Protein
    • Called
    • Cytokine
    • Function
    • Ligand
    • Mcp3
    • Motif
    • Previously
    • Small
    • Uniprot
    • Bp
    • Chr
  • protein
    • Signal
    • Small
    • Region
    • Band
    • Function
    • Uniprot
    • Binding
    • Bp
    • Cell
    • Chr
    • Chromosome
    • Exon
  • chromosome
    • Bp
    • Human
    • Band
    • Function
    • Uniprot
    • Location
    • Molecular
    • External
    • Gene
    • Cytokine
    • Ligand
    • Mcp3
  • function
    • Uniprot
    • Bp
    • Chr
    • Chromosome
    • Location
    • Molecular
    • External
    • Human
    • Band
    • Gene
    • Ligand
    • Mcp3
  • gene
    • Location
    • Human
    • Uniprot
    • Bp
    • Chr
    • Chromosome
    • Molecular
    • Region
    • Band
    • Ligand
    • Mcp3
    • Motif

Connections between topic areas Semantic bridges

For CCL7, one of the stronger structural bridges in this analysis connects CCL7 with Clinical importance. Bridges highlight paths between different parts of the map and can reveal research angles that are easy to miss in a flat list.

Min side: 3
CCL7Clinical importance · splits 19 ⟂ 7
CCL7Genomics · splits 20 ⟂ 6
CCL7Overview · splits 21 ⟂ 5
CCL7Function · splits 21 ⟂ 5

Map overview Semantic statistics

CCL7

Nodes26
Edges25
Triples110
Avg. degree1.92
Density0.076923
Components1

Source & methodology

TTTA analyzes the structure around CCL7 to surface related topics, entities, relationships, concept neighborhoods and bridge connections. Use the map to explore areas such as Regions, Clinical importance & Genomics, including less central topics that may reveal useful research gaps. Automatically extracted connections are research leads rather than rewritten encyclopedia content.

Source: Wikipedia — CCL7 · EN edition · Analysis: TopicsToTalkAbout

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