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The chemokine (C-C motif) ligand 2 (CCL2) is also referred to as monocyte chemoattractant protein 1 (MCP1) and small inducible cytokine A2. CCL2 is a small cytokine that belongs to the CC chemokine family. CCL2 tightly regulates cellular mechanics and thereby recruits monocytes, memory T cells, and dendritic cells to the sites of inflammation produced by…
The analysis highlights Clinical importance, Molecular biology and Genomics as prominent areas in the source structure around CCL2.
Source areas are shown by the number of related topics found in each part of the analysis. Use smaller areas too: they can reveal specialized angles and content gaps.
Smaller areas are not necessarily less important. They contain fewer connections in this analysis and can be useful for finding specialized angles or coverage gaps.
High-confidence facts extracted from structured source data. Use them as anchors for further research.
Browse the complete topic structure, not only the most central items. Less prominent entities and concepts can reveal missing angles, specialized context and useful research gaps. Each item opens a new analysis centered on that subject.
Deeper signals for content research, entity SEO and topical coverage. The plain-language headings explain what each technical view is useful for.
The extracted context around CCL2 shows recurring relationship patterns in the source. For example, CCL2 → angiogenesis, animal organ morphogenesis, astrocyte cell migration, CCR chemokine receptor binding, CCR2 chemokine receptor binding, cell adhesion, cell surface receptor signaling pathway, cellular homeostasis, cellular response to fibroblast growth factor stimulus, cellular response to interferon-gamma, cellular response to interleukin-1, cellular response to lipopolysaccharide, cellular response to organic cyclic compound, cellular response to tumor necrosis factor, chemokine activity, chemokine-mediated signaling pathway, chemotaxis, cytokine activity, cytokine-mediated signaling pathway, cytoskeleton organization Another extracted example is CCL2 → aortic valve, beta cell, cervix, dermis, efferent ductule, embryo, epithelium of colon, gallbladder, gastric mucosa, islet of Langerhans, left uterine tube, rectum, right kidney, saphenous vein, smooth muscle tissue, stroma of bone marrow, subcutaneous adipose tissue, thymus, vena cava, white adipose tissue. Use these groups to spot repeated connection types before inspecting the individual relationships.
Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.
human cells bp expression gene chemokine chr band chromosome 17 protein monocytes cytokine tissue location ccr2 inflammation molecular also muscle
TTTA extracted 140 structured relationships around CCL2. Examples in this analysis include CCL2 → Aliases → CCL2, GDCF-2, HC11, HSMCR30, MCAF, MCP-1, MCP1, SCYA2, SMC-CF, C-C motif chemokine ligand 2 and CCL2 → Available structures → Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1DOK, 1DOL, 1DOM, 1DON, 1ML0, 2BDN, 2NZ1, 4DN4, 3IFD, 4R8I, 4ZK9. The table shows each extracted connection, where it came from and its confidence.
| Subject | Predicate | Object | Confidence | Src |
|---|---|---|---|---|
| CCL2 | Aliases | CCL2, GDCF-2, HC11, HSMCR30, MCAF, MCP-1, MCP1, SCYA2, SMC-CF, C-C motif chemokine ligand 2 | 1.00 | infobox |
| CCL2 | Available structures | Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1DOK, 1DOL, 1DOM, 1DON, 1ML0, 2BDN, 2NZ1, 4DN4, 3IFD, 4R8I, 4ZK9 | 1.00 | infobox |
| CCL2 | Band | 17q12 | 1.00 | infobox |
| CCL2 | Band | 11 C|11 49.9 cM | 1.00 | infobox |
| CCL2 | Bgee | vena cava | 1.00 | infobox |
| CCL2 | Bgee | gallbladder | 1.00 | infobox |
| CCL2 | Bgee | islet of Langerhans | 1.00 | infobox |
| CCL2 | Bgee | gastric mucosa | 1.00 | infobox |
| CCL2 | Bgee | beta cell | 1.00 | infobox |
| CCL2 | Bgee | rectum | 1.00 | infobox |
| CCL2 | Bgee | left uterine tube | 1.00 | infobox |
| CCL2 | Bgee | smooth muscle tissue | 1.00 | infobox |
| CCL2 | Bgee | saphenous vein | 1.00 | infobox |
| CCL2 | Bgee | epithelium of colon | 1.00 | infobox |
| CCL2 | Bgee | cervix | 1.00 | infobox |
| CCL2 | Bgee | right kidney | 1.00 | infobox |
| CCL2 | Bgee | embryo | 1.00 | infobox |
| CCL2 | Bgee | thymus | 1.00 | infobox |
| CCL2 | Bgee | subcutaneous adipose tissue | 1.00 | infobox |
| CCL2 | Bgee | aortic valve | 1.00 | infobox |
| CCL2 | Bgee | stroma of bone marrow | 1.00 | infobox |
| CCL2 | Bgee | dermis | 1.00 | infobox |
| CCL2 | Bgee | efferent ductule | 1.00 | infobox |
| CCL2 | Bgee | white adipose tissue | 1.00 | infobox |
| CCL2 | BioGPS | More reference expression data | 1.00 | infobox |
| CCL2 | Chr. | Chromosome 17 (human) | 1.00 | infobox |
| CCL2 | Chr. | Chromosome 11 (mouse) | 1.00 | infobox |
| CCL2 | Databases | NCBI: entry; OMA: entry | 1.00 | infobox |
| CCL2 | End | 34,257,208 bp | 1.00 | infobox |
| CCL2 | End | 81,994,226 bp | 1.00 | infobox |
The concept neighborhoods around CCL2 bring nearby vocabulary together. In this analysis, examples include Cells, Gene and Expression. Use the clusters to find adjacent concepts and terminology that may deserve separate research.
For CCL2, one of the stronger structural bridges in this analysis connects CCL2 with Clinical importance. Bridges highlight paths between different parts of the map and can reveal research angles that are easy to miss in a flat list.
TTTA analyzes the structure around CCL2 to surface related topics, entities, relationships, concept neighborhoods and bridge connections. Use the map to explore areas such as Clinical importance, Molecular biology & Genomics, including less central topics that may reveal useful research gaps. Automatically extracted connections are research leads rather than rewritten encyclopedia content.
Source: Wikipedia — CCL2 · EN edition · Analysis: TopicsToTalkAbout