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CCL2

The chemokine (C-C motif) ligand 2 (CCL2) is also referred to as monocyte chemoattractant protein 1 (MCP1) and small inducible cytokine A2. CCL2 is a small cytokine that belongs to the CC chemokine family. CCL2 tightly regulates cellular mechanics and thereby recruits monocytes, memory T cells, and dendritic cells to the sites of inflammation produced by…

Clinical importance, Molecular biology & Genomics

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Aliases
CCL2, GDCF-2, HC11, HSMCR30, MCAF, MCP-1, MCP1, SCYA2, SMC-CF, C-C motif chemokine ligand 2
Available structures
Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1DOK, 1DOL, 1DOM, 1DON, 1ML0, 2BDN, 2NZ1, 4DN4, 3IFD, 4R8I, 4ZK9
Band
17q12 · 11 C|11 49.9 cM
Bgee
vena cava · gallbladder · islet of Langerhans · gastric mucosa · beta cell
BioGPS
More reference expression data
Chr.
Chromosome 17 (human) · Chromosome 11 (mouse)

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Genomics

Molecular biology

Clinical importance

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Map overview Semantic statistics

CCL2

Nodes62
Edges61
Triples140
Avg. degree1.97
Density0.032258
Components1

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CCL2

Top relations

Gene ontology · 63
CCL2 → angiogenesis, animal organ morphogenesis, astrocyte cell migration, CCR chemokine receptor binding, CCR2 chemokine receptor binding, cell adhesion, cell surface receptor signaling pathway, cellular homeostasis, cellular response to fibroblast growth factor stimulus, cellular response to interferon-gamma, cellular response to interleukin-1, cellular response to lipopolysaccharide, cellular response to organic cyclic compound, cellular response to tumor necrosis factor, chemokine activity, chemokine-mediated signaling pathway, chemotaxis, cytokine activity, cytokine-mediated signaling pathway, cytoskeleton organization
Bgee · 20
CCL2 → aortic valve, beta cell, cervix, dermis, efferent ductule, embryo, epithelium of colon, gallbladder, gastric mucosa, islet of Langerhans, left uterine tube, rectum, right kidney, saphenous vein, smooth muscle tissue, stroma of bone marrow, subcutaneous adipose tissue, thymus, vena cava, white adipose tissue
RNA expression pattern · 20
CCL2 → aortic valve, beta cell, cervix, dermis, efferent ductule, embryo, epithelium of colon, gallbladder, gastric mucosa, islet of Langerhans, left uterine tube, rectum, right kidney, saphenous vein, smooth muscle tissue, stroma of bone marrow, subcutaneous adipose tissue, thymus, vena cava, white adipose tissue
related to Genomics · 5
CCL2 → CC, In, The, The CCL2, Watson
related to Molecular biology · 3
CCL2 → CCR2, CCR4, Platelet
Band · 2
CCL2 → 11 C|11 49.9 cM, 17q12
Chr. · 2
CCL2 → Chromosome 11 (mouse), Chromosome 17 (human)
End · 2
CCL2 → 34,257,208 bp, 81,994,226 bp
related to External links · 2
CCL2 → Human CCL2, UCSC Genome Browser
related to Population genetics · 2
CCL2 → European, In

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Important terminology

human cells bp expression gene chemokine chr band chromosome 17 protein monocytes cytokine tissue location ccr2 inflammation molecular also muscle

Entity relationships Subject–Predicate–Object triples

SubjectPredicateObjectConfidenceSrc
CCL2AliasesCCL2, GDCF-2, HC11, HSMCR30, MCAF, MCP-1, MCP1, SCYA2, SMC-CF, C-C motif chemokine ligand 21.00infobox
CCL2Available structuresAvailable structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1DOK, 1DOL, 1DOM, 1DON, 1ML0, 2BDN, 2NZ1, 4DN4, 3IFD, 4R8I, 4ZK91.00infobox
CCL2Band17q121.00infobox
CCL2Band11 C|11 49.9 cM1.00infobox
CCL2Bgeevena cava1.00infobox
CCL2Bgeegallbladder1.00infobox
CCL2Bgeeislet of Langerhans1.00infobox
CCL2Bgeegastric mucosa1.00infobox
CCL2Bgeebeta cell1.00infobox
CCL2Bgeerectum1.00infobox
CCL2Bgeeleft uterine tube1.00infobox
CCL2Bgeesmooth muscle tissue1.00infobox
CCL2Bgeesaphenous vein1.00infobox
CCL2Bgeeepithelium of colon1.00infobox
CCL2Bgeecervix1.00infobox
CCL2Bgeeright kidney1.00infobox
CCL2Bgeeembryo1.00infobox
CCL2Bgeethymus1.00infobox
CCL2Bgeesubcutaneous adipose tissue1.00infobox
CCL2Bgeeaortic valve1.00infobox
CCL2Bgeestroma of bone marrow1.00infobox
CCL2Bgeedermis1.00infobox
CCL2Bgeeefferent ductule1.00infobox
CCL2Bgeewhite adipose tissue1.00infobox
CCL2BioGPSMore reference expression data1.00infobox
CCL2Chr.Chromosome 17 (human)1.00infobox
CCL2Chr.Chromosome 11 (mouse)1.00infobox
CCL2DatabasesNCBI: entry; OMA: entry1.00infobox
CCL2End34,257,208 bp1.00infobox
CCL2End81,994,226 bp1.00infobox

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