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CCL2: Clinical importance, Molecular biology & Genomics

The chemokine (C-C motif) ligand 2 (CCL2) is also referred to as monocyte chemoattractant protein 1 (MCP1) and small inducible cytokine A2. CCL2 is a small cytokine that belongs to the CC chemokine family. CCL2 tightly regulates cellular mechanics and thereby recruits monocytes, memory T cells, and dendritic cells to the sites of inflammation produced by…

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CCL2 topic overview

The analysis highlights Clinical importance, Molecular biology and Genomics as prominent areas in the source structure around CCL2.

Related topics
57
Source areas
4
Connected nodes
61
Extracted relationships
140
Concept neighborhoods
19
Bridge connections
61

What this topic covers Research coverage

Source areas are shown by the number of related topics found in each part of the analysis. Use smaller areas too: they can reveal specialized angles and content gaps.

Clinical importance · 27 topics
Molecular biology · 16 topics
Genomics · 7 topics
Overview · 7 topics

Smaller areas are not necessarily less important. They contain fewer connections in this analysis and can be useful for finding specialized angles or coverage gaps.

Key facts & relationships

High-confidence facts extracted from structured source data. Use them as anchors for further research.

Aliases
CCL2, GDCF-2, HC11, HSMCR30, MCAF, MCP-1, MCP1, SCYA2, SMC-CF, C-C motif chemokine ligand 2
Available structures
Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1DOK, 1DOL, 1DOM, 1DON, 1ML0, 2BDN, 2NZ1, 4DN4, 3IFD, 4R8I, 4ZK9
Band
17q12 · 11 C|11 49.9 cM
Bgee
vena cava · gallbladder · islet of Langerhans · gastric mucosa · beta cell
BioGPS
More reference expression data
Chr.
Chromosome 17 (human) · Chromosome 11 (mouse)

Explore all related topics Closing gaps

Browse the complete topic structure, not only the most central items. Less prominent entities and concepts can reveal missing angles, specialized context and useful research gaps. Each item opens a new analysis centered on that subject.

Overview

Genomics

Molecular biology

Clinical importance

Advanced semantic analysis

Deeper signals for content research, entity SEO and topical coverage. The plain-language headings explain what each technical view is useful for.

How CCL2 connects Entity context

The extracted context around CCL2 shows recurring relationship patterns in the source. For example, CCL2 → angiogenesis, animal organ morphogenesis, astrocyte cell migration, CCR chemokine receptor binding, CCR2 chemokine receptor binding, cell adhesion, cell surface receptor signaling pathway, cellular homeostasis, cellular response to fibroblast growth factor stimulus, cellular response to interferon-gamma, cellular response to interleukin-1, cellular response to lipopolysaccharide, cellular response to organic cyclic compound, cellular response to tumor necrosis factor, chemokine activity, chemokine-mediated signaling pathway, chemotaxis, cytokine activity, cytokine-mediated signaling pathway, cytoskeleton organization Another extracted example is CCL2 → aortic valve, beta cell, cervix, dermis, efferent ductule, embryo, epithelium of colon, gallbladder, gastric mucosa, islet of Langerhans, left uterine tube, rectum, right kidney, saphenous vein, smooth muscle tissue, stroma of bone marrow, subcutaneous adipose tissue, thymus, vena cava, white adipose tissue. Use these groups to spot repeated connection types before inspecting the individual relationships.

CCL2

Top relations

Gene ontology · 63
CCL2 → angiogenesis, animal organ morphogenesis, astrocyte cell migration, CCR chemokine receptor binding, CCR2 chemokine receptor binding, cell adhesion, cell surface receptor signaling pathway, cellular homeostasis, cellular response to fibroblast growth factor stimulus, cellular response to interferon-gamma, cellular response to interleukin-1, cellular response to lipopolysaccharide, cellular response to organic cyclic compound, cellular response to tumor necrosis factor, chemokine activity, chemokine-mediated signaling pathway, chemotaxis, cytokine activity, cytokine-mediated signaling pathway, cytoskeleton organization
Bgee · 20
CCL2 → aortic valve, beta cell, cervix, dermis, efferent ductule, embryo, epithelium of colon, gallbladder, gastric mucosa, islet of Langerhans, left uterine tube, rectum, right kidney, saphenous vein, smooth muscle tissue, stroma of bone marrow, subcutaneous adipose tissue, thymus, vena cava, white adipose tissue
RNA expression pattern · 20
CCL2 → aortic valve, beta cell, cervix, dermis, efferent ductule, embryo, epithelium of colon, gallbladder, gastric mucosa, islet of Langerhans, left uterine tube, rectum, right kidney, saphenous vein, smooth muscle tissue, stroma of bone marrow, subcutaneous adipose tissue, thymus, vena cava, white adipose tissue
related to Genomics · 5
CCL2 → CC, In, The, The CCL2, Watson
related to Molecular biology · 3
CCL2 → CCR2, CCR4, Platelet
Band · 2
CCL2 → 11 C|11 49.9 cM, 17q12
Chr. · 2
CCL2 → Chromosome 11 (mouse), Chromosome 17 (human)
End · 2
CCL2 → 34,257,208 bp, 81,994,226 bp
related to External links · 2
CCL2 → Human CCL2, UCSC Genome Browser
related to Population genetics · 2
CCL2 → European, In

Important terminology

Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.

Important terminology

human cells bp expression gene chemokine chr band chromosome 17 protein monocytes cytokine tissue location ccr2 inflammation molecular also muscle

CCL2 relationships Subject–Predicate–Object triples

TTTA extracted 140 structured relationships around CCL2. Examples in this analysis include CCL2 → Aliases → CCL2, GDCF-2, HC11, HSMCR30, MCAF, MCP-1, MCP1, SCYA2, SMC-CF, C-C motif chemokine ligand 2 and CCL2 → Available structures → Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1DOK, 1DOL, 1DOM, 1DON, 1ML0, 2BDN, 2NZ1, 4DN4, 3IFD, 4R8I, 4ZK9. The table shows each extracted connection, where it came from and its confidence.

SubjectPredicateObjectConfidenceSrc
CCL2AliasesCCL2, GDCF-2, HC11, HSMCR30, MCAF, MCP-1, MCP1, SCYA2, SMC-CF, C-C motif chemokine ligand 21.00infobox
CCL2Available structuresAvailable structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1DOK, 1DOL, 1DOM, 1DON, 1ML0, 2BDN, 2NZ1, 4DN4, 3IFD, 4R8I, 4ZK91.00infobox
CCL2Band17q121.00infobox
CCL2Band11 C|11 49.9 cM1.00infobox
CCL2Bgeevena cava1.00infobox
CCL2Bgeegallbladder1.00infobox
CCL2Bgeeislet of Langerhans1.00infobox
CCL2Bgeegastric mucosa1.00infobox
CCL2Bgeebeta cell1.00infobox
CCL2Bgeerectum1.00infobox
CCL2Bgeeleft uterine tube1.00infobox
CCL2Bgeesmooth muscle tissue1.00infobox
CCL2Bgeesaphenous vein1.00infobox
CCL2Bgeeepithelium of colon1.00infobox
CCL2Bgeecervix1.00infobox
CCL2Bgeeright kidney1.00infobox
CCL2Bgeeembryo1.00infobox
CCL2Bgeethymus1.00infobox
CCL2Bgeesubcutaneous adipose tissue1.00infobox
CCL2Bgeeaortic valve1.00infobox
CCL2Bgeestroma of bone marrow1.00infobox
CCL2Bgeedermis1.00infobox
CCL2Bgeeefferent ductule1.00infobox
CCL2Bgeewhite adipose tissue1.00infobox
CCL2BioGPSMore reference expression data1.00infobox
CCL2Chr.Chromosome 17 (human)1.00infobox
CCL2Chr.Chromosome 11 (mouse)1.00infobox
CCL2DatabasesNCBI: entry; OMA: entry1.00infobox
CCL2End34,257,208 bp1.00infobox
CCL2End81,994,226 bp1.00infobox

Related concept clusters Concept neighborhoods

The concept neighborhoods around CCL2 bring nearby vocabulary together. In this analysis, examples include Cells, Gene and Expression. Use the clusters to find adjacent concepts and terminology that may deserve separate research.

  • CCL2
    • Cells
    • Gene
    • Expression
    • Human
    • Chemokine
    • Ccr2
    • Expressed
    • Molecular
    • Plasma
    • Protein
    • Activity
    • Bone
  • ccl2
    • Cells
    • Gene
    • Expression
    • Human
    • Chemokine
    • Ccr2
    • Expressed
    • Molecular
    • Plasma
    • Protein
    • Activity
    • Bone
  • cytokine
    • Small
    • Monocyte
    • Protein
    • Genome
    • Mouse
    • Activity
    • Adipose
    • Bone
    • Cell
    • Erk1
    • Factor
    • Negative
  • cc chemokine
    • Cytokine
    • Small
    • Monocyte
    • Chromosome
    • Expressed
    • Location
    • Molecular
    • Bp
    • Chr
    • Protein
    • Gene
    • Human
  • human genome
    • Chromosome
    • Location
    • Bp
    • Chr
    • Band
    • Mouse
    • Erk1
    • Factor
    • Genome
    • Human
    • Monocyte
    • Negative
  • chromosome 17
    • Bp
    • Band
    • Location
    • Human
    • Mouse
    • Gene
    • Molecular
    • Genome
    • Activity
    • Adipose
    • Bone
    • Cell
  • protein precursor
    • Ccr2
    • Expression
    • Genome
    • Mouse
    • Small
    • Activity
    • Adipose
    • Bone
    • Cell
    • Erk1
    • Factor
    • Melatonin
  • ccr2
    • Cell
    • Erk1
    • Signaling
    • Protein
    • Expression
    • Genome
    • Mouse
    • Cytokine
    • Factor
    • Monocyte
    • Negative
    • Chromosome

Connections between topic areas Semantic bridges

For CCL2, one of the stronger structural bridges in this analysis connects CCL2 with Clinical importance. Bridges highlight paths between different parts of the map and can reveal research angles that are easy to miss in a flat list.

Min side: 3
CCL2Clinical importance · splits 34 ⟂ 28
CCL2Molecular biology · splits 45 ⟂ 17
CCL2Overview · splits 54 ⟂ 8
CCL2Genomics · splits 54 ⟂ 8

Map overview Semantic statistics

CCL2

Nodes62
Edges61
Triples140
Avg. degree1.97
Density0.032258
Components1

Source & methodology

TTTA analyzes the structure around CCL2 to surface related topics, entities, relationships, concept neighborhoods and bridge connections. Use the map to explore areas such as Clinical importance, Molecular biology & Genomics, including less central topics that may reveal useful research gaps. Automatically extracted connections are research leads rather than rewritten encyclopedia content.

Source: Wikipedia — CCL2 · EN edition · Analysis: TopicsToTalkAbout

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