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Gamma-interferon-inducible protein Ifi-16 (Ifi-16) also known as interferon-inducible myeloid differentiation transcriptional activator is a protein that in humans is encoded by the IFI16 gene.
The analysis highlights Function and Overview as prominent areas in the source structure around IFI16.
Source areas are shown by the number of related topics found in each part of the analysis. Use smaller areas too: they can reveal specialized angles and content gaps.
Smaller areas are not necessarily less important. They contain fewer connections in this analysis and can be useful for finding specialized angles or coverage gaps.
High-confidence facts extracted from structured source data. Use them as anchors for further research.
Browse the complete topic structure, not only the most central items. Less prominent entities and concepts can reveal missing angles, specialized context and useful research gaps. Each item opens a new analysis centered on that subject.
Deeper signals for content research, entity SEO and topical coverage. The plain-language headings explain what each technical view is useful for.
The extracted context around IFI16 shows recurring relationship patterns in the source. For example, IFI16 → activation of cysteine-type endopeptidase activity, activation of innate immune response, apoptotic process, autophagy, cell population proliferation, cellular response to glucose starvation, cellular response to interferon-beta, cellular response to ionizing radiation, cytoplasm, cytosol, defense response to virus, DNA binding, DNA-binding transcription repressor activity, RNA polymerase II-specific, double-stranded DNA binding, hemopoiesis, identical protein binding, immune system process, inflammatory response, innate immune response, intrinsic apoptotic signaling pathway by p53 class mediator Another extracted example is IFI16 → Achilles tendon, blood, bone marrow, germinal epithelium, granulocyte, human penis, lumbar spinal ganglion, lymph node, mesenteric lymph nodes, mucosa of nose, palpebral conjunctiva, pericardium, spleen, stroma of bone marrow, subcutaneous adipose tissue, superficial temporal artery, thymus, vena cava, white adipose tissue. Use these groups to spot repeated connection types before inspecting the individual relationships.
Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.
bp protein human gene chr band chromosome location function dna p53 uniprot mouse binding cell myeloid differentiation external nucleoplasm also
TTTA extracted 124 structured relationships around IFI16. Examples in this analysis include IFI16 → Aliases → IFI16, IFNGIP1, PYHIN2, interferon gamma inducible protein 16 and IFI16 → Available structures → Available structuresPDBHuman UniProt search: PDBe RCSB List of PDB id codes2OQ0, 3B6Y, 3RLN, 3RLO, 3RNU, 4QGU. The table shows each extracted connection, where it came from and its confidence.
| Subject | Predicate | Object | Confidence | Src |
|---|---|---|---|---|
| IFI16 | Aliases | IFI16, IFNGIP1, PYHIN2, interferon gamma inducible protein 16 | 1.00 | infobox |
| IFI16 | Available structures | Available structuresPDBHuman UniProt search: PDBe RCSB List of PDB id codes2OQ0, 3B6Y, 3RLN, 3RLO, 3RNU, 4QGU | 1.00 | infobox |
| IFI16 | Band | 1q23.1 | 1.00 | infobox |
| IFI16 | Band | 1|1 H3 | 1.00 | infobox |
| IFI16 | Bgee | germinal epithelium | 1.00 | infobox |
| IFI16 | Bgee | pericardium | 1.00 | infobox |
| IFI16 | Bgee | palpebral conjunctiva | 1.00 | infobox |
| IFI16 | Bgee | Achilles tendon | 1.00 | infobox |
| IFI16 | Bgee | lymph node | 1.00 | infobox |
| IFI16 | Bgee | superficial temporal artery | 1.00 | infobox |
| IFI16 | Bgee | vena cava | 1.00 | infobox |
| IFI16 | Bgee | mucosa of nose | 1.00 | infobox |
| IFI16 | Bgee | spleen | 1.00 | infobox |
| IFI16 | Bgee | human penis | 1.00 | infobox |
| IFI16 | Bgee | mesenteric lymph nodes | 1.00 | infobox |
| IFI16 | Bgee | subcutaneous adipose tissue | 1.00 | infobox |
| IFI16 | Bgee | thymus | 1.00 | infobox |
| IFI16 | Bgee | bone marrow | 1.00 | infobox |
| IFI16 | Bgee | white adipose tissue | 1.00 | infobox |
| IFI16 | Bgee | blood | 1.00 | infobox |
| IFI16 | Bgee | granulocyte | 1.00 | infobox |
| IFI16 | Bgee | lumbar spinal ganglion | 1.00 | infobox |
| IFI16 | Bgee | stroma of bone marrow | 1.00 | infobox |
| IFI16 | BioGPS | More reference expression data | 1.00 | infobox |
| IFI16 | Chr. | Chromosome 1 (human) | 1.00 | infobox |
| IFI16 | Chr. | Chromosome 1 (mouse) | 1.00 | infobox |
| IFI16 | Databases | NCBI: entry; OMA: entry | 1.00 | infobox |
| IFI16 | End | 159,055,155 bp | 1.00 | infobox |
| IFI16 | End | 173,426,840 bp | 1.00 | infobox |
| IFI16 | Ensembl | ENSG00000163565 | 1.00 | infobox |
The concept neighborhoods around IFI16 bring nearby vocabulary together. In this analysis, examples include Protein, Gene and Human. Use the clusters to find adjacent concepts and terminology that may deserve separate research.
For IFI16, one of the stronger structural bridges in this analysis connects IFI16 with Function. Bridges highlight paths between different parts of the map and can reveal research angles that are easy to miss in a flat list.
TTTA analyzes the structure around IFI16 to surface related topics, entities, relationships, concept neighborhoods and bridge connections. Use the map to explore areas such as Function & Overview, including less central topics that may reveal useful research gaps. Automatically extracted connections are research leads rather than rewritten encyclopedia content.
Source: Wikipedia — IFI16 · EN edition · Analysis: TopicsToTalkAbout