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SND1

Staphylococcal nuclease domain-containing protein 1 also known as 100 kDa coactivator or Tudor domain-containing protein 11 (TDRD11) is a protein that in humans is encoded by the SND1 gene. SND1 is a main component of RISC complex and plays an important role in miRNA function. SND1 is Tudor domain containing protein and Tudor Proteins are highly…

Interactions, Clinical significance & Overview

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Interactions

InteractMYBPIM1POLR2ARBPJ
8 related topics

Clinical significance

OncogeneHepatocellular carcinomaNF-kappaBMiR-221Mir-184
6 related topics

Overview

ProteinGeneRISC complexMiRNATudor domain
5 related topics

Key facts & relationships

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3.1.31.1
↗
Aliases
SND1, TDRD11, p100, staphylococcal nuclease and tudor domain containing 1, Tudor-SN
Available structures
Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes2E6N, 2HQE, 2HQX, 2O4X, 3BDL, 3OMC, 3OMG, 4QMG
Band
7q32.1 · 6|6 A3.3
Bgee
body of pancreas · stromal cell of endometrium · islet of Langerhans · parotid gland · epithelium of colon
BioGPS
n/a

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Overview

Clinical significance

Interactions

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Map overview Semantic statistics

SND1

Nodes23
Edges22
Triples103
Avg. degree1.91
Density0.086957
Components1

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SND1

Top relations

Gene ontology · 30
SND1 → cadherin binding, cytoplasm, cytosol, dense body, endonuclease activity, endoribonuclease activity, extracellular exosome, gene silencing, hydrolase activity, melanosome, membrane, miRNA catabolic process, mitochondrion, nuclease activity, nucleic acid binding, nucleic acid phosphodiester bond hydrolysis, nucleus, osteoblast differentiation, protein binding, regulation of cell cycle process
Bgee · 19
SND1 → anterior pituitary, body of pancreas, canal of the cervix, dentate gyrus of hippocampal formation granule cell, epiblast, epithelium of colon, islet of Langerhans, lacrimal gland, left ovary, lip, molar, parotid gland, placenta, right ovary, smooth muscle tissue, stroma of bone marrow, stromal cell of endometrium, ventricular zone, yolk sac
RNA expression pattern · 19
SND1 → anterior pituitary, body of pancreas, canal of the cervix, dentate gyrus of hippocampal formation granule cell, epiblast, epithelium of colon, islet of Langerhans, lacrimal gland, left ovary, lip, molar, parotid gland, placenta, right ovary, smooth muscle tissue, stroma of bone marrow, stromal cell of endometrium, ventricular zone, yolk sac
related to Interactions · 5
SND1 → MYB, PIM1, POLR2A, RBPJ, STAT6
related to Clinical significance · 4
SND1 → II, Mir-184, NF-kappaB, TGFβ
Band · 2
SND1 → 6|6 A3.3, 7q32.1
Chr. · 2
SND1 → Chromosome 6 (mouse), Chromosome 7 (human)
End · 2
SND1 → 128,092,609 bp, 28,935,161 bp
3.1.31.1 · 1
SND1 → ↗
Aliases · 1
SND1 → SND1, TDRD11, p100, staphylococcal nuclease and tudor domain containing 1, Tudor-SN

Important terminology Word statistics

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Important terminology

bp human chr band protein gene chromosome tudor nuclease also location mirna mouse staphylococcal tdrd11 component risc complex function domain

Entity relationships Subject–Predicate–Object triples

SubjectPredicateObjectConfidenceSrc
SND13.1.31.1↗1.00infobox
SND1AliasesSND1, TDRD11, p100, staphylococcal nuclease and tudor domain containing 1, Tudor-SN1.00infobox
SND1Available structuresAvailable structuresPDBOrtholog search: PDBe RCSB List of PDB id codes2E6N, 2HQE, 2HQX, 2O4X, 3BDL, 3OMC, 3OMG, 4QMG1.00infobox
SND1Band7q32.11.00infobox
SND1Band6|6 A3.31.00infobox
SND1Bgeebody of pancreas1.00infobox
SND1Bgeestromal cell of endometrium1.00infobox
SND1Bgeeislet of Langerhans1.00infobox
SND1Bgeeparotid gland1.00infobox
SND1Bgeeepithelium of colon1.00infobox
SND1Bgeecanal of the cervix1.00infobox
SND1Bgeeleft ovary1.00infobox
SND1Bgeesmooth muscle tissue1.00infobox
SND1Bgeeanterior pituitary1.00infobox
SND1Bgeeright ovary1.00infobox
SND1Bgeelacrimal gland1.00infobox
SND1Bgeedentate gyrus of hippocampal formation granule cell1.00infobox
SND1Bgeeyolk sac1.00infobox
SND1Bgeelip1.00infobox
SND1Bgeeepiblast1.00infobox
SND1Bgeeventricular zone1.00infobox
SND1Bgeemolar1.00infobox
SND1Bgeestroma of bone marrow1.00infobox
SND1Bgeeplacenta1.00infobox
SND1BioGPSn/a1.00infobox
SND1Chr.Chromosome 7 (human)1.00infobox
SND1Chr.Chromosome 6 (mouse)1.00infobox
SND1DatabasesNCBI: entry; OMA: entry1.00infobox
SND1End128,092,609 bp1.00infobox
SND1End28,935,161 bp1.00infobox

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