SMAD1

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Explore the main themes, entities and connections around SMAD1. Start with the topic map, then use the sections below for research and deeper semantic analysis.

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Function

Bone morphogenetic proteins Apoptosis Morphogenesis Development Phosphorylated

11 related topics

Nomenclature

SMAD Drosophila Mothers against decapentaplegic C. elegans Decapentaplegic

5 related topics

Clinical Significance

Loss-of-function mutation Congenital heart disease Autosomal dominant

3 related topics

Overview

Protein Gene

2 related topics

Key facts & relationships

High-confidence facts extracted from structured source data. Use them as anchors for further research.

Aliases: SMAD1, BSP-1, BSP1, JV4-1, JV41, MADH1, MADR1, SMAD family member 1
Available structures: Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1KHU, 2LAW, 2LAX, 2LAY, 2LAZ, 2LB0, 2LB1, 3Q47, 3Q4A
Band: 8|8 C1
Bgee: Ileal epithelium · Paneth cell · ureter · conjunctival fornix · fossa
BioGPS: More reference expression data
Chr.: Chromosome 8 (mouse)

Topics to explore

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Overview

Nomenclature

Function

Bone morphogenetic proteins Bone morphogenetic protein
Apoptosis
Morphogenesis
Development Development (biology)
Phosphorylated Phosphorylation
SMAD4
E3 ubiquitin ligases E3 ubiquitin ligase
SMURF1
SMURF2
Proteasome-mediated degradation
R-SMAD

Clinical Significance

Advanced semantic analysis

Deeper signals for content research, entity SEO and topical coverage. The plain-language headings explain what each technical view is useful for.

Map overview Semantic statistics

Nodes26

Edges25

Triples132

Avg. degree1.92

Density0.076923

Components1

How this topic connects Entity context

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SMAD1

Top relations

Gene ontology · 61

SMAD1 → BMP signaling pathway, bone development, cardiac muscle cell proliferation, cartilage development, cellular response to BMP stimulus, cellular response to organic cyclic compound, co-SMAD binding, cytoplasm, cytosol, DEAD/H-box RNA helicase binding, DNA binding, DNA-binding transcription activator activity, RNA polymerase II-specific, DNA-binding transcription factor activity, DNA-binding transcription factor activity, RNA polymerase II-specific, embryonic pattern specification, gamete generation, hindbrain development, homeostatic process, I-SMAD binding, identical protein binding

related to Function · 12

SMAD1 → Alternatively, BMP, BMPs, In, R-SMAD, SMAD, SMAD-specific E3, SMAD4, SMURF1, SMURF2, The, This

Bgee · 10

SMAD1 → conjunctival fornix, endothelial cell of lymphatic vessel, fossa, hair follicle, Ileal epithelium, internal carotid artery, lacrimal gland, medullary collecting duct, Paneth cell, ureter

RNA expression pattern · 10

SMAD1 → conjunctival fornix, endothelial cell of lymphatic vessel, fossa, hair follicle, Ileal epithelium, internal carotid artery, lacrimal gland, medullary collecting duct, Paneth cell, ureter

related to External links · 9

SMAD1 → Drosophila Mothers, Medicine, Medicine Medical Subject Headings, MeSH, National Library, Protein, The Interactive FlySmad1, This, United States National Library

related to Nomenclature · 7

SMAD1 → Drosophila, It, Mad, Mothers, Sma, SMAD, The

is a · 2

SMAD1 → protein that in humans is encoded by the SMAD1 gene, receptor regulated SMAD

related to Clinical Significance · 2

SMAD1 → It, Loss-of-function

Aliases · 1

SMAD1 → SMAD1, BSP-1, BSP1, JV4-1, JV41, MADH1, MADR1, SMAD family member 1

Available structures · 1

SMAD1 → Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1KHU, 2LAW, 2LAX, 2LAY, 2LAZ, 2LB0, 2LB1, 3Q47, 3Q4A

Important terminology Word statistics

Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.

Important terminology

protein smad gene bp family chr function mothers mouse band decapentaplegic kinase bone receptor member external proteins mad search location

Entity relationships Subject–Predicate–Object triples

Subject	Predicate	Object	Confidence	Src
SMAD1	Aliases	SMAD1, BSP-1, BSP1, JV4-1, JV41, MADH1, MADR1, SMAD family member 1	1.00	infobox
SMAD1	Available structures	Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1KHU, 2LAW, 2LAX, 2LAY, 2LAZ, 2LB0, 2LB1, 3Q47, 3Q4A	1.00	infobox
SMAD1	Band	8\|8 C1	1.00	infobox
SMAD1	Bgee	Ileal epithelium	1.00	infobox
SMAD1	Bgee	Paneth cell	1.00	infobox
SMAD1	Bgee	ureter	1.00	infobox
SMAD1	Bgee	conjunctival fornix	1.00	infobox
SMAD1	Bgee	fossa	1.00	infobox
SMAD1	Bgee	endothelial cell of lymphatic vessel	1.00	infobox
SMAD1	Bgee	medullary collecting duct	1.00	infobox
SMAD1	Bgee	internal carotid artery	1.00	infobox
SMAD1	Bgee	lacrimal gland	1.00	infobox
SMAD1	Bgee	hair follicle	1.00	infobox
SMAD1	BioGPS	More reference expression data	1.00	infobox
SMAD1	Chr.	Chromosome 8 (mouse)	1.00	infobox
SMAD1	Databases	NCBI: entry; OMA: entry	1.00	infobox
SMAD1	End	80,126,147 bp	1.00	infobox
SMAD1	Ensembl	ENSG00000170365	1.00	infobox
SMAD1	Entrez	4086	1.00	infobox
SMAD1	External IDs	OMIM: 601595; MGI: 109452; GeneCards: SMAD1	1.00	infobox
SMAD1	Gene location (Mouse)	Gene location (Mouse)Chr.Chromosome 8 (mouse)Band8\|8 C1Start80,065,024 bpEnd80,126,147 bp	1.00	infobox
SMAD1	Gene ontology	DNA binding	1.00	infobox
SMAD1	Gene ontology	co-SMAD binding	1.00	infobox
SMAD1	Gene ontology	protein homodimerization activity	1.00	infobox
SMAD1	Gene ontology	I-SMAD binding	1.00	infobox
SMAD1	Gene ontology	DNA-binding transcription factor activity	1.00	infobox
SMAD1	Gene ontology	DNA-binding transcription activator activity, RNA polymerase II-specific	1.00	infobox
SMAD1	Gene ontology	metal ion binding	1.00	infobox
SMAD1	Gene ontology	protein binding	1.00	infobox
SMAD1	Gene ontology	identical protein binding	1.00	infobox

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