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Mothers against decapentaplegic homolog 1 also known as SMAD family member 1 or SMAD1 is a protein that in humans is encoded by the SMAD1 gene.
The analysis highlights Function, Nomenclature and Clinical Significance as prominent areas in the source structure around SMAD1.
Source areas are shown by the number of related topics found in each part of the analysis. Use smaller areas too: they can reveal specialized angles and content gaps.
Smaller areas are not necessarily less important. They contain fewer connections in this analysis and can be useful for finding specialized angles or coverage gaps.
High-confidence facts extracted from structured source data. Use them as anchors for further research.
Browse the complete topic structure, not only the most central items. Less prominent entities and concepts can reveal missing angles, specialized context and useful research gaps. Each item opens a new analysis centered on that subject.
Deeper signals for content research, entity SEO and topical coverage. The plain-language headings explain what each technical view is useful for.
The extracted context around SMAD1 shows recurring relationship patterns in the source. For example, SMAD1 → BMP signaling pathway, bone development, cardiac muscle cell proliferation, cartilage development, cellular response to BMP stimulus, cellular response to organic cyclic compound, co-SMAD binding, cytoplasm, cytosol, DEAD/H-box RNA helicase binding, DNA binding, DNA-binding transcription activator activity, RNA polymerase II-specific, DNA-binding transcription factor activity, DNA-binding transcription factor activity, RNA polymerase II-specific, embryonic pattern specification, gamete generation, hindbrain development, homeostatic process, I-SMAD binding, identical protein binding Another extracted example is SMAD1 → Alternatively, BMP, BMPs, In, R-SMAD, SMAD, SMAD-specific E3, SMAD4, SMURF1, SMURF2, The, This. Use these groups to spot repeated connection types before inspecting the individual relationships.
Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.
protein smad gene bp family chr function mothers mouse band decapentaplegic kinase bone receptor member external proteins mad search location
TTTA extracted 132 structured relationships around SMAD1. Examples in this analysis include SMAD1 → Aliases → SMAD1, BSP-1, BSP1, JV4-1, JV41, MADH1, MADR1, SMAD family member 1 and SMAD1 → Available structures → Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1KHU, 2LAW, 2LAX, 2LAY, 2LAZ, 2LB0, 2LB1, 3Q47, 3Q4A. The table shows each extracted connection, where it came from and its confidence.
| Subject | Predicate | Object | Confidence | Src |
|---|---|---|---|---|
| SMAD1 | Aliases | SMAD1, BSP-1, BSP1, JV4-1, JV41, MADH1, MADR1, SMAD family member 1 | 1.00 | infobox |
| SMAD1 | Available structures | Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1KHU, 2LAW, 2LAX, 2LAY, 2LAZ, 2LB0, 2LB1, 3Q47, 3Q4A | 1.00 | infobox |
| SMAD1 | Band | 8|8 C1 | 1.00 | infobox |
| SMAD1 | Bgee | Ileal epithelium | 1.00 | infobox |
| SMAD1 | Bgee | Paneth cell | 1.00 | infobox |
| SMAD1 | Bgee | ureter | 1.00 | infobox |
| SMAD1 | Bgee | conjunctival fornix | 1.00 | infobox |
| SMAD1 | Bgee | fossa | 1.00 | infobox |
| SMAD1 | Bgee | endothelial cell of lymphatic vessel | 1.00 | infobox |
| SMAD1 | Bgee | medullary collecting duct | 1.00 | infobox |
| SMAD1 | Bgee | internal carotid artery | 1.00 | infobox |
| SMAD1 | Bgee | lacrimal gland | 1.00 | infobox |
| SMAD1 | Bgee | hair follicle | 1.00 | infobox |
| SMAD1 | BioGPS | More reference expression data | 1.00 | infobox |
| SMAD1 | Chr. | Chromosome 8 (mouse) | 1.00 | infobox |
| SMAD1 | Databases | NCBI: entry; OMA: entry | 1.00 | infobox |
| SMAD1 | End | 80,126,147 bp | 1.00 | infobox |
| SMAD1 | Ensembl | ENSG00000170365 | 1.00 | infobox |
| SMAD1 | Entrez | 4086 | 1.00 | infobox |
| SMAD1 | External IDs | OMIM: 601595; MGI: 109452; GeneCards: SMAD1 | 1.00 | infobox |
| SMAD1 | Gene location (Mouse) | Gene location (Mouse)Chr.Chromosome 8 (mouse)Band8|8 C1Start80,065,024 bpEnd80,126,147 bp | 1.00 | infobox |
| SMAD1 | Gene ontology | DNA binding | 1.00 | infobox |
| SMAD1 | Gene ontology | co-SMAD binding | 1.00 | infobox |
| SMAD1 | Gene ontology | protein homodimerization activity | 1.00 | infobox |
| SMAD1 | Gene ontology | I-SMAD binding | 1.00 | infobox |
| SMAD1 | Gene ontology | DNA-binding transcription factor activity | 1.00 | infobox |
| SMAD1 | Gene ontology | DNA-binding transcription activator activity, RNA polymerase II-specific | 1.00 | infobox |
| SMAD1 | Gene ontology | metal ion binding | 1.00 | infobox |
| SMAD1 | Gene ontology | protein binding | 1.00 | infobox |
| SMAD1 | Gene ontology | identical protein binding | 1.00 | infobox |
The concept neighborhoods around SMAD1 bring nearby vocabulary together. In this analysis, examples include Transcription, Proteins and Smad1. Use the clusters to find adjacent concepts and terminology that may deserve separate research.
For SMAD1, one of the stronger structural bridges in this analysis connects SMAD1 with Function. Bridges highlight paths between different parts of the map and can reveal research angles that are easy to miss in a flat list.
TTTA analyzes the structure around SMAD1 to surface related topics, entities, relationships, concept neighborhoods and bridge connections. Use the map to explore areas such as Function, Nomenclature & Clinical Significance, including less central topics that may reveal useful research gaps. Automatically extracted connections are research leads rather than rewritten encyclopedia content.
Source: Wikipedia — SMAD1 · EN edition · Analysis: TopicsToTalkAbout