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Mothers against decapentaplegic homolog 5 also known as SMAD5 is a protein that in humans is encoded by the SMAD5 gene.
The analysis highlights Overview and Clinical Significance as prominent areas in the source structure around SMAD5.
Source areas are shown by the number of related topics found in each part of the analysis. Use smaller areas too: they can reveal specialized angles and content gaps.
Smaller areas are not necessarily less important. They contain fewer connections in this analysis and can be useful for finding specialized angles or coverage gaps.
High-confidence facts extracted from structured source data. Use them as anchors for further research.
Browse the complete topic structure, not only the most central items. Less prominent entities and concepts can reveal missing angles, specialized context and useful research gaps. Each item opens a new analysis centered on that subject.
Deeper signals for content research, entity SEO and topical coverage. The plain-language headings explain what each technical view is useful for.
The extracted context around SMAD5 shows recurring relationship patterns in the source. For example, SMAD5 → BMP signaling pathway, bone development, cardiac muscle contraction, cartilage development, cellular response to BMP stimulus, cellular response to organic cyclic compound, cytoplasm, cytosol, DEAD/H-box RNA helicase binding, DNA binding, DNA-binding transcription factor activity, DNA-binding transcription factor activity, RNA polymerase II-specific, embryonic pattern specification, erythrocyte differentiation, germ cell development, intracellular anatomical structure, metal ion binding, Mullerian duct regression, negative regulation of transcription by RNA polymerase II, nucleoplasm Another extracted example is SMAD5 → Achilles tendon, caput epididymis, corpus epididymis, genital tubercle, germinal epithelium, hair follicle, lactiferous duct, mandibular prominence, maxillary prominence, medial ganglionic eminence, mucosa of paranasal sinus, nipple, Paneth cell, skin of hip, stroma of kidney, superficial temporal artery, tail of embryo, tail of epididymis, ureter, ventricular zone. Use these groups to spot repeated connection types before inspecting the individual relationships.
Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.
gene bp protein smad chr human band tgfβ chromosome family bone location mothers decapentaplegic homolog proteins morphogenetic phosphorylation mouse involved
TTTA extracted 105 structured relationships around SMAD5. Examples in this analysis include SMAD5 → Aliases → SMAD5, DWFC, JV5-1, MADH5, SMAD family member 5 and SMAD5 → Band → 5q31.1. The table shows each extracted connection, where it came from and its confidence.
| Subject | Predicate | Object | Confidence | Src |
|---|---|---|---|---|
| SMAD5 | Aliases | SMAD5, DWFC, JV5-1, MADH5, SMAD family member 5 | 1.00 | infobox |
| SMAD5 | Band | 5q31.1 | 1.00 | infobox |
| SMAD5 | Band | 13 B1|13 30.12 cM | 1.00 | infobox |
| SMAD5 | Bgee | mucosa of paranasal sinus | 1.00 | infobox |
| SMAD5 | Bgee | caput epididymis | 1.00 | infobox |
| SMAD5 | Bgee | tail of epididymis | 1.00 | infobox |
| SMAD5 | Bgee | lactiferous duct | 1.00 | infobox |
| SMAD5 | Bgee | corpus epididymis | 1.00 | infobox |
| SMAD5 | Bgee | nipple | 1.00 | infobox |
| SMAD5 | Bgee | germinal epithelium | 1.00 | infobox |
| SMAD5 | Bgee | superficial temporal artery | 1.00 | infobox |
| SMAD5 | Bgee | Achilles tendon | 1.00 | infobox |
| SMAD5 | Bgee | skin of hip | 1.00 | infobox |
| SMAD5 | Bgee | genital tubercle | 1.00 | infobox |
| SMAD5 | Bgee | ventricular zone | 1.00 | infobox |
| SMAD5 | Bgee | tail of embryo | 1.00 | infobox |
| SMAD5 | Bgee | mandibular prominence | 1.00 | infobox |
| SMAD5 | Bgee | maxillary prominence | 1.00 | infobox |
| SMAD5 | Bgee | Paneth cell | 1.00 | infobox |
| SMAD5 | Bgee | stroma of kidney | 1.00 | infobox |
| SMAD5 | Bgee | ureter | 1.00 | infobox |
| SMAD5 | Bgee | medial ganglionic eminence | 1.00 | infobox |
| SMAD5 | Bgee | hair follicle | 1.00 | infobox |
| SMAD5 | BioGPS | n/a | 1.00 | infobox |
| SMAD5 | Chr. | Chromosome 5 (human) | 1.00 | infobox |
| SMAD5 | Chr. | Chromosome 13 (mouse) | 1.00 | infobox |
| SMAD5 | Databases | NCBI: entry; OMA: entry | 1.00 | infobox |
| SMAD5 | End | 136,188,747 bp | 1.00 | infobox |
| SMAD5 | End | 56,890,190 bp | 1.00 | infobox |
| SMAD5 | Ensembl | ENSG00000113658 | 1.00 | infobox |
The concept neighborhoods around SMAD5 bring nearby vocabulary together. In this analysis, examples include Bone, Binding and Cell. Use the clusters to find adjacent concepts and terminology that may deserve separate research.
For SMAD5, one of the stronger structural bridges in this analysis connects SMAD5 with Overview. Bridges highlight paths between different parts of the map and can reveal research angles that are easy to miss in a flat list.
TTTA analyzes the structure around SMAD5 to surface related topics, entities, relationships, concept neighborhoods and bridge connections. Use the map to explore areas such as Overview & Clinical Significance, including less central topics that may reveal useful research gaps. Automatically extracted connections are research leads rather than rewritten encyclopedia content.
Source: Wikipedia — SMAD5 · EN edition · Analysis: TopicsToTalkAbout