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SMAD9

SMAD9 (also known as SMAD8, MADH6, and Mothers against decapentaplegic homolog 9) is a homolog protein encoded by the SMAD9 gene. SMADs are a protein family that transduce receptors of the transforming growth factor beta (TGF-B) superfamily and are significant in regulating cell development. The name derives from two homologies: the "small" worm…

Function, Structure & Nomenclature and Classification

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Function

Holo-complexKinaseNuclear Pore ComplexesImportinBeta-hairpin
14 related topics

Structure

Amino acidsN-terminusC-terminusDNA motifsHeterotrimers
13 related topics

Nomenclature and Classification

I-SmadsR-SmadsBMPDrosophilaDecapentaplegic
8 related topics

Clinical Significance

Pulmonary Arterial Hypertension (PAH
1 related topics

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Overview

Nomenclature and Classification

Structure

Function

Clinical Significance

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Map overview Semantic statistics

SMAD9

Nodes47
Edges46
Triples89
Avg. degree1.96
Density0.042553
Components1

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SMAD9

Top relations

related to Nomenclature and Classification · 29
SMAD9 → Before, BMP, Co-SMADs, Drosophila, During Drosophila, I-Smads, MAD, MADD, MADH6, MADH9, Mothers, Mothers Against Decapentaplegic, Mothers Against Drunk Driving, PPH2, R-Smads, SMAD, Smad1, Smad2, Smad3, Smad5
related to Structure · 20
SMAD9 → C-terminus, CAGAC, CAGCC, CDK, CDK8, DNA, GSK3, MH1, MH2, N-terminus, Once, R-Smad, R-Smads, Receptor-phosphorylated R-Smads, SMAD, SMADs, TGF-B, The, This, To
related to Clinical Significance · 17
SMAD9 → BMP, BMPR2, BMPs, Furthermore, II, In, PAH, Pulmonary Arterial Hypertension, R-SMADs, SMAD, Smad1, Smad5, SMADs, The, There, This, While PAH
related to Function · 13
SMAD9 → Although SMAD9, BMPs, DNA, Essentially, Once, R-SMADs, Smad, Smad4, SMADs, TGF-B, The, The R-Smads, This
is a · 3
SMAD9 → critical, key player in BMPs, transcriptional modulator activated by bone morphogenetic proteins

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Important terminology

r-smads protein tgf-b smad gene domain signaling cell smads binding dna transcription genes decapentaplegic receptor nucleus smad8 mothers family growth

Entity relationships Subject–Predicate–Object triples

SubjectPredicateObjectConfidenceSrc
SMAD9is acritical0.90text
SMAD9is atranscriptional modulator activated by bone morphogenetic proteins0.90text
SMAD9is akey player in BMPs0.90text
ALK2 or ALK3instance ofThey form heterodimers which bind to Type I receptors0.80text
to activate intracellular SMAD signalinginstance ofThey form heterodimers which bind to Type I receptors0.80text
Smad2instance ofOther members of the SMAD family0.80text
Smad3 have similar binding sites but with differing amino acids at important sequence positionsinstance ofOther members of the SMAD family0.80text
mRNAsinstance ofto precursor miRNAs that yield various RNA products0.80text
tRNAsinstance ofto precursor miRNAs that yield various RNA products0.80text
and rRNAsinstance ofto precursor miRNAs that yield various RNA products0.80text
SMAD9related to Clinical SignificanceThere0.60section
SMAD9related to Clinical SignificanceSMAD0.60section

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