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Promethazine

Promethazine, sold under the brand name Phenergan among others, is a first-generation antihistamine, sedative, and antiemetic used to treat allergies, nausea, and vomiting. It may also help with some symptoms associated with the common cold and may also be used for sedating people who are agitated or anxious, an effect that has led to some recreational…

History, Community, Culture & Applications

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Key facts & relationships

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3D model (JSmol)
Interactive image
Addiction liability
None-Very low
AHFS/Drugs.com
Monograph
ATC code
D04AA10 (WHO) R06AD02 (WHO)
Bioavailability
88% absorbed but after first-pass metabolism reduced to 25% absolute bioavailability
CAS Number
60-87-7 Y 58-33-3 (HCl)

Topics to explore

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Overview

Medical uses

Side effects

Overdose

Pharmacology

Chemistry

History

Society and culture

Advanced semantic analysis

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Map overview Semantic statistics

Promethazine

Nodes126
Edges125
Triples99
Avg. degree1.98
Density0.015873
Components1

How this topic connects Entity context

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Promethazine

Top relations

related to Pharmacology · 14
Promethazine → AMPA, Another, Both, D2, Despite, EC50, H1, However, HT2A, HT2C, It, Ki, New, NMDA
related to Product liability lawsuit · 13
Promethazine → Diana Levine, Drug Administration, FDA, In, IV, IV-push, Supreme Court, The, The Supreme Court, US Food, US Supreme Court, Wyeth, Wyeth's Phenergan
related to Tissue necrosis risks specific to the injectable form · 8
Promethazine → Injectable, Institute, One, Safe Medication Practices, Severe, Supreme Court, United States, When
related to Medical uses · 7
Promethazine → For, In, It, Second-choice, SedationIn Germany, The, UK
Legal status · 6
Promethazine → AU: S3 (Pharmacist only), CA: OTC, NZ: OTC -Pharmacist only, South Africa: S5 IV, S2 oral; Sweden: Rx-only, UK: P (Pharmacy medicines) (POM when injection), US: ℞-only
related to Overdose · 5
Promethazine → Anticholinergic, Atypically, CNS, Other, Treatment
related to history · 4
Promethazine → Paul Charpentier, Rhone-Poulenc, Sanofi, The
is a · 3
Promethazine → chiral compound, drug of first choice, vesicant and is capable of damaging blood vessel intima
related to Chemistry · 3
Promethazine → Its, Slow, Solid
related to Recreational use · 2
Promethazine → Sprite, The

Important terminology Word statistics

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Important terminology

use effects drug used also symptoms due injection anticholinergic may side including medical phenergan mouth names pregnancy include many brand

Entity relationships Subject–Predicate–Object triples

SubjectPredicateObjectConfidenceSrc
Promethazine3D model (JSmol)Interactive image1.00infobox
PromethazineAddiction liabilityNone-Very low1.00infobox
PromethazineAHFS/Drugs.comMonograph1.00infobox
PromethazineATC codeD04AA10 (WHO) R06AD02 (WHO)1.00infobox
PromethazineBioavailability88% absorbed but after first-pass metabolism reduced to 25% absolute bioavailability1.00infobox
PromethazineCAS Number60-87-7 Y 58-33-3 (HCl)1.00infobox
PromethazineChEBICHEBI:8461 Y1.00infobox
PromethazineChEMBLChEMBL643 Y1.00infobox
PromethazineChemSpider4758 Y1.00infobox
PromethazineChiralityRacemic mixture1.00infobox
PromethazineCompTox Dashboard (EPA)DTXSID70235181.00infobox
PromethazineDependence liabilityLow1.00infobox
PromethazineDrugBankDB01069 Y1.00infobox
PromethazineDuration of action4–6 hours (sometimes up to 12 hours)1.00infobox
PromethazineECHA InfoCard100.000.4451.00infobox
PromethazineElimination half-life10–19 hours1.00infobox
PromethazineExcretionKidney and Bile duct1.00infobox
PromethazineFormulaC17H20N2S1.00infobox
PromethazineIUPHAR/BPS72821.00infobox
PromethazineKEGGD00494 Y1.00infobox
PromethazineLegal statusAU: S3 (Pharmacist only)1.00infobox
PromethazineLegal statusCA: OTC1.00infobox
PromethazineLegal statusNZ: OTC -Pharmacist only1.00infobox
PromethazineLegal statusUK: P (Pharmacy medicines) (POM when injection)1.00infobox
PromethazineLegal statusUS: ℞-only1.00infobox
PromethazineLegal statusSouth Africa: S5 IV, S2 oral; Sweden: Rx-only1.00infobox
PromethazineLicense dataUS DailyMed: Promethazine1.00infobox
PromethazineMedlinePlusa6822841.00infobox
PromethazineMetabolismLiver glucuronidation and sulfoxidation1.00infobox
PromethazineMetabolitesPromethazine Sulphoxide, Desmethylpromethazine, Promethazine Hydroxy1.00infobox

Related concept clusters Concept neighborhoods

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