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DISC1

Disrupted in schizophrenia 1 is a protein that in humans is encoded by the DISC1 gene. In coordination with a wide array of interacting partners, DISC1 has been shown to participate in the regulation of cell proliferation, differentiation, migration, neuronal axon and dendrite outgrowth, mitochondrial transport, fission and/or fusion, and cell-to-cell…

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Protein interactions

DimersMultimersOligomersAlzheimer's diseaseParkinson's disease
29 related topics

Function

Neural developmentCAMPModel organismsGSK3Β-catenin
18 related topics

Gene location and transcription

Chromosome 1qDISC2Open reading frameIsoformsRNA
14 related topics

Protein structure and subcellular distribution

Coiled coilMotifC-terminalN-terminalLeucine zippers
14 related topics

Key facts & relationships

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Aliases
DISC1, C1orf136, SCZD9, disrupted in schizophrenia 1, DISC1 scaffold protein
Band
1q42.2 · 8 E2|8 73.26 cM
Bgee
buccal mucosa cell · sural nerve · decidua · monocyte · Achilles tendon
BioGPS
More reference expression data
Chr.
Chromosome 1 (human) · Chromosome 8 (mouse)
Databases
NCBI: entry; OMA: entry

Topics to explore

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Overview

Discovery

Gene location and transcription

Protein structure and subcellular distribution

Function

Protein interactions

Clinical implications

Advanced semantic analysis

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Map overview Semantic statistics

DISC1

Nodes103
Edges102
Triples281
Avg. degree1.98
Density0.019417
Components1

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DISC1

Top relations

Gene ontology · 56
DISC1 → axon, canonical Wnt signaling pathway, cell body, cell junction, cell proliferation in forebrain, central region of growth cone, centrosome, cerebral cortex radially oriented cell migration, ciliary basal body, ciliary base, cilium assembly, cytoplasm, cytoskeleton, cytosol, dynein complex, endoplasmic reticulum, intermediate filament cytoskeleton, kinesin binding, kinesin complex, membrane
related to PCM1/Pericentriolar material · 24
DISC1 → Aberdeen, ACTN2, Amongst, Another, BBS4, CALM1, CEP63, CNS, Disrupted-In-Schizophrenia, DNA, EIF3A, Five, Given, Kamiya, London, Markers, Other, PCM1, Pericentriolar Material, RANBP9
Bgee · 20
DISC1 → Achilles tendon, blood, buccal mucosa cell, CA3 field, decidua, germinal epithelium, gonad, granular layer, granular layer of dentate gyrus, granulocyte, monocyte, morula, primary oocyte, Region I of hippocampus proper, Region II of hippocampus proper, secondary oocyte, Subplate, sural nerve, testicle, zygote
RNA expression pattern · 20
DISC1 → Achilles tendon, blood, buccal mucosa cell, CA3 field, decidua, germinal epithelium, gonad, granular layer, granular layer of dentate gyrus, granulocyte, monocyte, morula, primary oocyte, Region I of hippocampus proper, Region II of hippocampus proper, secondary oocyte, Subplate, sural nerve, testicle, zygote
related to Gene location and transcription · 15
DISC1 → Alternate, C-terminus, DISC2, Es, Especially, Human DISC1, Long, Lv, Multiple DISC1, Of, RNA, Small, The, The DISC1, TSNAX-DISC1
related to Discovery · 13
DISC1 → According, After, Diagnostic, DSM-IV, Edinburgh, Fourth Edition, In, Mental Disorders, Scotland, Scottish, Statistical Manual, The, University
related to Function · 13
DISC1 → Among, Controlling, DISC1 GSK3/β-catenin, DISC1-GSK3, GSK3/β-catenin, In, LIS1, Many, Much, NUDEL, PDE4B, The, This
related to Autism and Asperger's syndrome · 11
DISC1 → Asperger's, Belgians, DNA, Finnish, Furthermore, In, Many, Mice, Studies, These, Transgenic
related to ATF4/ATF5 · 8
DISC1 → ATF4, ATF4/ATF5, ATF5, Both, C-terminal, CREB, GABAB, They
related to Importance of genetic studies · 8
DISC1 → Besides, In, LOD, Scottish, Such, The, The LOD, This

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Important terminology

protein schizophrenia gene function also studies family may found translocation disorder expression development interaction genetic psychiatric shown chromosome research nudel

Entity relationships Subject–Predicate–Object triples

SubjectPredicateObjectConfidenceSrc
DISC1AliasesDISC1, C1orf136, SCZD9, disrupted in schizophrenia 1, DISC1 scaffold protein1.00infobox
DISC1Band1q42.21.00infobox
DISC1Band8 E2|8 73.26 cM1.00infobox
DISC1Bgeebuccal mucosa cell1.00infobox
DISC1Bgeesural nerve1.00infobox
DISC1Bgeedecidua1.00infobox
DISC1Bgeemonocyte1.00infobox
DISC1BgeeAchilles tendon1.00infobox
DISC1Bgeeblood1.00infobox
DISC1Bgeetesticle1.00infobox
DISC1Bgeegerminal epithelium1.00infobox
DISC1Bgeegonad1.00infobox
DISC1Bgeegranulocyte1.00infobox
DISC1BgeeRegion II of hippocampus proper1.00infobox
DISC1BgeeCA3 field1.00infobox
DISC1Bgeegranular layer of dentate gyrus1.00infobox
DISC1BgeeRegion I of hippocampus proper1.00infobox
DISC1Bgeeprimary oocyte1.00infobox
DISC1Bgeezygote1.00infobox
DISC1Bgeesecondary oocyte1.00infobox
DISC1Bgeegranular layer1.00infobox
DISC1BgeeSubplate1.00infobox
DISC1Bgeemorula1.00infobox
DISC1BioGPSMore reference expression data1.00infobox
DISC1Chr.Chromosome 1 (human)1.00infobox
DISC1Chr.Chromosome 8 (mouse)1.00infobox
DISC1DatabasesNCBI: entry; OMA: entry1.00infobox
DISC1End232,041,272 bp1.00infobox
DISC1End125,988,597 bp1.00infobox
DISC1EnsemblENSG000001629461.00infobox

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