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DISC1: Geography & Art

Disrupted in schizophrenia 1 is a protein that in humans is encoded by the DISC1 gene. In coordination with a wide array of interacting partners, DISC1 has been shown to participate in the regulation of cell proliferation, differentiation, migration, neuronal axon and dendrite outgrowth, mitochondrial transport, fission and/or fusion, and cell-to-cell…

Language: English [EN]
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DISC1 topic overview

The analysis highlights Geography and Art as prominent areas in the source structure around DISC1.

Related topics
95
Source areas
7
Connected nodes
102
Extracted relationships
249
Related term clusters
19
Bridge connections
102

What this topic covers Research coverage

Source areas are shown by the number of related topics found in each part of the analysis. Use smaller areas too: they can reveal specialized angles and content gaps.

Protein interactions · 29 topics
Function · 18 topics
Gene location and transcription · 14 topics
Protein structure and subcellular distribution · 14 topics
Overview · 10 topics
Discovery · 6 topics
Clinical implications · 4 topics

Smaller areas are not necessarily less important. They contain fewer connections in this analysis and can be useful for finding specialized angles or coverage gaps.

Key facts & relationships

High-confidence facts extracted from structured source data. Use them as anchors for further research.

Aliases
DISC1, C1orf136, SCZD9, disrupted in schizophrenia 1, DISC1 scaffold protein
Band
1q42.2 · 8 E2|8 73.26 cM
Bgee
buccal mucosa cell · sural nerve · decidua · monocyte · Achilles tendon
BioGPS
More reference expression data
Chr.
Chromosome 1 (human) · Chromosome 8 (mouse)
Databases
NCBI: entry; OMA: entry

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Explore all related topics Closing gaps

Browse the complete topic structure, not only the most central items. Less prominent entities and concepts can reveal missing angles, specialized context and useful research gaps. Each item opens a new analysis centered on that subject.

Overview

Discovery

Gene location and transcription

Protein structure and subcellular distribution

Function

Protein interactions

Clinical implications

For the semantics nerds

You can skip this section if you’re here for content ideas and keyword inspiration.

Advanced semantic analysis

How DISC1 connects Entity context

The extracted context around DISC1 shows recurring relationship patterns in the source. For example, DISC1 → axon, canonical Wnt signaling pathway, cell body, cell junction, cell proliferation in forebrain, central region of growth cone, centrosome, cerebral cortex radially oriented cell migration, ciliary basal body, ciliary base, cilium assembly, cytoplasm, cytoskeleton, cytosol, dynein complex, endoplasmic reticulum, intermediate filament cytoskeleton, kinesin binding, kinesin complex, membrane Another extracted example is DISC1 → Aberdeen, ACTN2, Amongst, Another, BBS4, CALM1, CEP63, CNS, Disrupted-In-Schizophrenia, DNA, EIF3A, Five, Given, Kamiya, London, Markers, PCM1, Pericentriolar Material, RANBP9, Resequencing. Use these groups to spot repeated connection types before inspecting the individual relationships.

DISC1

Top relations

Gene ontology · 56
DISC1 → axon, canonical Wnt signaling pathway, cell body, cell junction, cell proliferation in forebrain, central region of growth cone, centrosome, cerebral cortex radially oriented cell migration, ciliary basal body, ciliary base, cilium assembly, cytoplasm, cytoskeleton, cytosol, dynein complex, endoplasmic reticulum, intermediate filament cytoskeleton, kinesin binding, kinesin complex, membrane
related to PCM1/Pericentriolar material · 21
DISC1 → Aberdeen, ACTN2, Amongst, Another, BBS4, CALM1, CEP63, CNS, Disrupted-In-Schizophrenia, DNA, EIF3A, Five, Given, Kamiya, London, Markers, PCM1, Pericentriolar Material, RANBP9, Resequencing
Bgee · 20
DISC1 → Achilles tendon, blood, buccal mucosa cell, CA3 field, decidua, germinal epithelium, gonad, granular layer, granular layer of dentate gyrus, granulocyte, monocyte, morula, primary oocyte, Region I of hippocampus proper, Region II of hippocampus proper, secondary oocyte, Subplate, sural nerve, testicle, zygote
RNA expression pattern · 20
DISC1 → Achilles tendon, blood, buccal mucosa cell, CA3 field, decidua, germinal epithelium, gonad, granular layer, granular layer of dentate gyrus, granulocyte, monocyte, morula, primary oocyte, Region I of hippocampus proper, Region II of hippocampus proper, secondary oocyte, Subplate, sural nerve, testicle, zygote
related to Gene location and transcription · 13
DISC1 → Alternate, C-terminus, DISC2, Es, Especially, Human DISC1, Long, Lv, Multiple DISC1, RNA, Small, The DISC1, TSNAX-DISC1
related to Discovery · 10
DISC1 → According, Diagnostic, DSM-IV, Edinburgh, Fourth Edition, Mental Disorders, Scotland, Scottish, Statistical Manual, University
related to Function · 10
DISC1 → Among, Controlling, DISC1 GSK3/β-catenin, DISC1-GSK3, GSK3/β-catenin, LIS1, Many, Much, NUDEL, PDE4B
related to Autism and Asperger's syndrome · 9
DISC1 → Asperger's, Belgians, DNA, Finnish, Furthermore, Many, Mice, Studies, Transgenic
related to Kalirin-7 · 7
DISC1 → Activation, GDP/GTP, Kal-7, Kal-7-dependent, NMDA, Rac1, The DISC1
related to ATF4/ATF5 · 6
DISC1 → ATF4, ATF4/ATF5, ATF5, C-terminal, CREB, GABAB

Important terminology

Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.

Important terminology

protein schizophrenia gene function also studies family may found translocation disorder expression development interaction genetic psychiatric shown chromosome research nudel

DISC1 relationships Subject–Predicate–Object triples

TTTA extracted 249 structured relationships around DISC1. Examples in this analysis include DISC1 → Aliases → DISC1, C1orf136, SCZD9, disrupted in schizophrenia 1, DISC1 scaffold protein and DISC1 → Band → 1q42.2. The table shows each extracted connection, where it came from and its confidence.

SubjectPredicateObjectConfidenceSrc
DISC1AliasesDISC1, C1orf136, SCZD9, disrupted in schizophrenia 1, DISC1 scaffold protein1.00infobox
DISC1Band1q42.21.00infobox
DISC1Band8 E2|8 73.26 cM1.00infobox
DISC1Bgeebuccal mucosa cell1.00infobox
DISC1Bgeesural nerve1.00infobox
DISC1Bgeedecidua1.00infobox
DISC1Bgeemonocyte1.00infobox
DISC1BgeeAchilles tendon1.00infobox
DISC1Bgeeblood1.00infobox
DISC1Bgeetesticle1.00infobox
DISC1Bgeegerminal epithelium1.00infobox
DISC1Bgeegonad1.00infobox
DISC1Bgeegranulocyte1.00infobox
DISC1BgeeRegion II of hippocampus proper1.00infobox
DISC1BgeeCA3 field1.00infobox
DISC1Bgeegranular layer of dentate gyrus1.00infobox
DISC1BgeeRegion I of hippocampus proper1.00infobox
DISC1Bgeeprimary oocyte1.00infobox
DISC1Bgeezygote1.00infobox
DISC1Bgeesecondary oocyte1.00infobox
DISC1Bgeegranular layer1.00infobox
DISC1BgeeSubplate1.00infobox
DISC1Bgeemorula1.00infobox
DISC1BioGPSMore reference expression data1.00infobox
DISC1Chr.Chromosome 1 (human)1.00infobox
DISC1Chr.Chromosome 8 (mouse)1.00infobox
DISC1DatabasesNCBI: entry; OMA: entry1.00infobox
DISC1End232,041,272 bp1.00infobox
DISC1End125,988,597 bp1.00infobox
DISC1EnsemblENSG000001629461.00infobox

Related concept clusters Related term clusters

The concept neighborhoods around DISC1 bring nearby vocabulary together. In this analysis, examples include Protein, Function and Gene. Use the clusters to find adjacent concepts and terminology that may deserve separate research.

  • DISC1
    • Protein
    • Function
    • Gene
    • Interaction
    • Also
    • May
    • Expression
    • Studies
    • Schizophrenia
    • Development
    • Nudel
    • Role
  • disc1
    • Protein
    • Function
    • Gene
    • Interaction
    • Also
    • May
    • Expression
    • Studies
    • Schizophrenia
    • Development
    • Nudel
    • Role
  • protein
    • Function
    • Gene
    • Also
    • Development
    • Expression
    • Interaction
    • Schizophrenia
    • Location
    • Fez1
    • Human
    • Interactions
    • Nudel
  • gene
    • Chromosome
    • Genetic
    • Schizophrenia
    • Location
    • Bp
    • Chr
    • Protein
    • Studies
    • Human
    • Family
    • Associated
    • Pcm1
  • schizophrenia
    • Disorder
    • Found
    • Bipolar
    • Pcm1
    • Genetic
    • Studies
    • Associated
    • Mutation
    • Research
    • Major
    • Psychiatric
    • Translocation
  • bipolar disorder
    • Disorder
    • Major
    • Found
    • Schizophrenia
    • Translocation
    • Research
    • Studies
    • Location
    • Bp
    • Chr
    • Autism
    • Genetic
  • conduct disorder
    • Major
    • Found
    • Schizophrenia
    • Translocation
    • Research
    • Location
    • Bp
    • Chr
    • Studies
    • Autism
    • Human
    • Family
  • chromosome 1q
    • Bp
    • Human
    • Band
    • Location
    • Gene
    • Research
    • Translocation
    • Disorder
    • Found
    • Family
    • Disrupted
    • Function

Connections between topic areas Semantic bridges

For DISC1, one of the stronger structural bridges in this analysis connects DISC1 with Protein interactions. Bridges highlight paths between different parts of the map and can reveal research angles that are easy to miss in a flat list.

Min side: 3
DISC1 — Protein interactions · splits 73 ⟂ 30
DISC1 — Function · splits 84 ⟂ 19
DISC1 — Gene location and transcription · splits 88 ⟂ 15
DISC1 — Protein structure and subcellular distribution · splits 88 ⟂ 15
DISC1 — Overview · splits 92 ⟂ 11
DISC1 — Discovery · splits 96 ⟂ 7
DISC1 — Clinical implications · splits 98 ⟂ 5

Map overview Semantic statistics

DISC1

Nodes103
Edges102
Triples249
Avg. degree1.98
Density0.019417
Components1

Source & methodology

TTTA analyzes the structure around DISC1 to surface related topics, entities, relationships, concept neighborhoods and bridge connections. Use the map to explore areas such as Geography & Art, including less central topics that may reveal useful research gaps. Automatically extracted connections are research leads rather than rewritten encyclopedia content.

Source: Wikipedia — DISC1 · EN edition · Analysis: TopicsToTalkAbout

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