DISC1

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DISC1 topic overview

The analysis highlights Geography and Art as prominent areas in the source structure around DISC1.

Related topics: 95
Source areas: 7
Connected nodes: 102
Extracted relationships: 281
Concept neighborhoods: 19
Bridge connections: 102

What this topic covers Research coverage

Source areas are shown by the number of related topics found in each part of the analysis. Use smaller areas too: they can reveal specialized angles and content gaps.

Protein interactions · 29 topics

Function · 18 topics

Gene location and transcription · 14 topics

Protein structure and subcellular distribution · 14 topics

Overview · 10 topics

Discovery · 6 topics

Clinical implications · 4 topics

Smaller areas are not necessarily less important. They contain fewer connections in this analysis and can be useful for finding specialized angles or coverage gaps.

Key facts & relationships

High-confidence facts extracted from structured source data. Use them as anchors for further research.

Aliases: DISC1, C1orf136, SCZD9, disrupted in schizophrenia 1, DISC1 scaffold protein
Band: 1q42.2 · 8 E2|8 73.26 cM
Bgee: buccal mucosa cell · sural nerve · decidua · monocyte · Achilles tendon
BioGPS: More reference expression data
Chr.: Chromosome 1 (human) · Chromosome 8 (mouse)
Databases: NCBI: entry; OMA: entry

Explore all related topics Closing gaps

Browse the complete topic structure, not only the most central items. Less prominent entities and concepts can reveal missing angles, specialized context and useful research gaps. Each item opens a new analysis centered on that subject.

Overview

Protein
Gene
Proliferation Cell growth
Differentiation Cellular differentiation
Migration Cell migration
Fission Mitochondrial fission
Fusion Mitochondrial fusion
Schizophrenia
Clinical depression
Bipolar disorder

Discovery

University of Edinburgh
Cytogenetic Cytogenetics
Translocation Chromosomal translocation
DSM-IV Diagnostic and Statistical Manual of Mental Disorders
Conduct disorder
LOD Genetic linkage

Gene location and transcription

Chromosome 1q Chromosome 1
DISC2
Open reading frame
Isoforms Protein isoform
RNA
TSNAX
Common chimpanzee Pan troglodytes
Rhesus monkey Macaca mulatta
House mouse Mus musculus
Brown rat Rattus norvegicus
Zebrafish Danio rerio
Pufferfish Takifugu rubripes
Cattle Bos taurus
Dogs Canis familiaris

Clinical implications

Advanced semantic analysis

Deeper signals for content research, entity SEO and topical coverage. The plain-language headings explain what each technical view is useful for.

How DISC1 connects Entity context

The extracted context around DISC1 shows recurring relationship patterns in the source. For example, DISC1 → axon, canonical Wnt signaling pathway, cell body, cell junction, cell proliferation in forebrain, central region of growth cone, centrosome, cerebral cortex radially oriented cell migration, ciliary basal body, ciliary base, cilium assembly, cytoplasm, cytoskeleton, cytosol, dynein complex, endoplasmic reticulum, intermediate filament cytoskeleton, kinesin binding, kinesin complex, membrane Another extracted example is DISC1 → Aberdeen, ACTN2, Amongst, Another, BBS4, CALM1, CEP63, CNS, Disrupted-In-Schizophrenia, DNA, EIF3A, Five, Given, Kamiya, London, Markers, Other, PCM1, Pericentriolar Material, RANBP9. Use these groups to spot repeated connection types before inspecting the individual relationships.

Top relations

Gene ontology · 56

DISC1 → axon, canonical Wnt signaling pathway, cell body, cell junction, cell proliferation in forebrain, central region of growth cone, centrosome, cerebral cortex radially oriented cell migration, ciliary basal body, ciliary base, cilium assembly, cytoplasm, cytoskeleton, cytosol, dynein complex, endoplasmic reticulum, intermediate filament cytoskeleton, kinesin binding, kinesin complex, membrane

related to PCM1/Pericentriolar material · 24

DISC1 → Aberdeen, ACTN2, Amongst, Another, BBS4, CALM1, CEP63, CNS, Disrupted-In-Schizophrenia, DNA, EIF3A, Five, Given, Kamiya, London, Markers, Other, PCM1, Pericentriolar Material, RANBP9

Bgee · 20

DISC1 → Achilles tendon, blood, buccal mucosa cell, CA3 field, decidua, germinal epithelium, gonad, granular layer, granular layer of dentate gyrus, granulocyte, monocyte, morula, primary oocyte, Region I of hippocampus proper, Region II of hippocampus proper, secondary oocyte, Subplate, sural nerve, testicle, zygote

RNA expression pattern · 20

related to Gene location and transcription · 15

DISC1 → Alternate, C-terminus, DISC2, Es, Especially, Human DISC1, Long, Lv, Multiple DISC1, Of, RNA, Small, The, The DISC1, TSNAX-DISC1

related to Discovery · 13

DISC1 → According, After, Diagnostic, DSM-IV, Edinburgh, Fourth Edition, In, Mental Disorders, Scotland, Scottish, Statistical Manual, The, University

related to Function · 13

DISC1 → Among, Controlling, DISC1 GSK3/β-catenin, DISC1-GSK3, GSK3/β-catenin, In, LIS1, Many, Much, NUDEL, PDE4B, The, This

related to Autism and Asperger's syndrome · 11

DISC1 → Asperger's, Belgians, DNA, Finnish, Furthermore, In, Many, Mice, Studies, These, Transgenic

related to ATF4/ATF5 · 8

DISC1 → ATF4, ATF4/ATF5, ATF5, Both, C-terminal, CREB, GABAB, They

related to Importance of genetic studies · 8

DISC1 → Besides, In, LOD, Scottish, Such, The, The LOD, This

Important terminology

Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.

Important terminology

protein schizophrenia gene function also studies family may found translocation disorder expression development interaction genetic psychiatric shown chromosome research nudel

DISC1 relationships Subject–Predicate–Object triples

TTTA extracted 281 structured relationships around DISC1. Examples in this analysis include DISC1 → Aliases → DISC1, C1orf136, SCZD9, disrupted in schizophrenia 1, DISC1 scaffold protein and DISC1 → Band → 1q42.2. The table shows each extracted connection, where it came from and its confidence.

Subject	Predicate	Object	Confidence	Src
DISC1	Aliases	DISC1, C1orf136, SCZD9, disrupted in schizophrenia 1, DISC1 scaffold protein	1.00	infobox
DISC1	Band	1q42.2	1.00	infobox
DISC1	Band	8 E2\|8 73.26 cM	1.00	infobox
DISC1	Bgee	buccal mucosa cell	1.00	infobox
DISC1	Bgee	sural nerve	1.00	infobox
DISC1	Bgee	decidua	1.00	infobox
DISC1	Bgee	monocyte	1.00	infobox
DISC1	Bgee	Achilles tendon	1.00	infobox
DISC1	Bgee	blood	1.00	infobox
DISC1	Bgee	testicle	1.00	infobox
DISC1	Bgee	germinal epithelium	1.00	infobox
DISC1	Bgee	gonad	1.00	infobox
DISC1	Bgee	granulocyte	1.00	infobox
DISC1	Bgee	Region II of hippocampus proper	1.00	infobox
DISC1	Bgee	CA3 field	1.00	infobox
DISC1	Bgee	granular layer of dentate gyrus	1.00	infobox
DISC1	Bgee	Region I of hippocampus proper	1.00	infobox
DISC1	Bgee	primary oocyte	1.00	infobox
DISC1	Bgee	zygote	1.00	infobox
DISC1	Bgee	secondary oocyte	1.00	infobox
DISC1	Bgee	granular layer	1.00	infobox
DISC1	Bgee	Subplate	1.00	infobox
DISC1	Bgee	morula	1.00	infobox
DISC1	BioGPS	More reference expression data	1.00	infobox
DISC1	Chr.	Chromosome 1 (human)	1.00	infobox
DISC1	Chr.	Chromosome 8 (mouse)	1.00	infobox
DISC1	Databases	NCBI: entry; OMA: entry	1.00	infobox
DISC1	End	232,041,272 bp	1.00	infobox
DISC1	End	125,988,597 bp	1.00	infobox
DISC1	Ensembl	ENSG00000162946	1.00	infobox

Related concept clusters Concept neighborhoods

The concept neighborhoods around DISC1 bring nearby vocabulary together. In this analysis, examples include Protein, Function and Gene. Use the clusters to find adjacent concepts and terminology that may deserve separate research.

DISC1
- Protein
- Function
- Gene
- Interaction
- Also
- May
- Expression
- Studies
- Schizophrenia
- Development
- Nudel
- Role
disc1
- Protein
- Function
- Gene
- Interaction
- Also
- May
- Expression
- Studies
- Schizophrenia
- Development
- Nudel
- Role
protein
- Function
- Gene
- Also
- Development
- Expression
- Interaction
- Schizophrenia
- Location
- Fez1
- Human
- Interactions
- Nudel
gene
- Chromosome
- Genetic
- Schizophrenia
- Location
- Bp
- Chr
- Protein
- Studies
- Human
- Family
- Associated
- Pcm1
schizophrenia
- Disorder
- Found
- Bipolar
- Pcm1
- Genetic
- Studies
- Associated
- Mutation
- Research
- Major
- Psychiatric
- Translocation
bipolar disorder
- Disorder
- Major
- Found
- Schizophrenia
- Translocation
- Research
- Studies
- Location
- Bp
- Chr
- Autism
- Genetic
conduct disorder
- Major
- Found
- Schizophrenia
- Translocation
- Research
- Location
- Bp
- Chr
- Studies
- Autism
- Human
- Family
chromosome 1q
- Bp
- Human
- Band
- Location
- Gene
- Research
- Translocation
- Disorder
- Found
- Family
- Disrupted
- Function

Connections between topic areas Semantic bridges

For DISC1, one of the stronger structural bridges in this analysis connects DISC1 with Protein interactions. Bridges highlight paths between different parts of the map and can reveal research angles that are easy to miss in a flat list.

Min side: 3

DISC1 — Protein interactions · splits 73 ⟂ 30

DISC1 — Function · splits 84 ⟂ 19

DISC1 — Gene location and transcription · splits 88 ⟂ 15

DISC1 — Protein structure and subcellular distribution · splits 88 ⟂ 15

DISC1 — Overview · splits 92 ⟂ 11

DISC1 — Discovery · splits 96 ⟂ 7

DISC1 — Clinical implications · splits 98 ⟂ 5

Map overview Semantic statistics

DISC1

Nodes103

Edges102

Triples281

Avg. degree1.98

Density0.019417

Components1

Source & methodology

TTTA analyzes the structure around DISC1 to surface related topics, entities, relationships, concept neighborhoods and bridge connections. Use the map to explore areas such as Geography & Art, including less central topics that may reveal useful research gaps. Automatically extracted connections are research leads rather than rewritten encyclopedia content.

Source: Wikipedia — DISC1 · EN edition · Analysis: TopicsToTalkAbout