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Conserved sequence

In evolutionary biology, conserved sequences are identical or similar sequences in nucleic acids (DNA and RNA) or proteins across species (orthologous sequences), or within a genome (paralogous sequences), or between donor and receptor taxa (xenologous sequences). Conservation indicates that a sequence has been maintained by natural selection.

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Overview

History

Mechanisms

Identification

Extreme conservation

Applications

Advanced semantic analysis

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Map overview Semantic statistics

Conserved sequence

Nodes129
Edges128
Triples76
Avg. degree1.98
Density0.015504
Components1

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Conserved sequence

Top relations

related to Homology search · 15
Conserved sequence → Acceptable, BLAST, BLOSUM, Conserved, Highly, HMMER, HMMs, Homology, Infernal, Input, OrthologR, PAM, RNA, Statistical, The
related to Mechanisms · 8
Conserved sequence → Conservation, Conserved, DNA, Highly, Many, Over, Sequences, The
related to Medical research · 7
Conserved sequence → Alzehimer's, As, Genetic, Genome-wide, Lysosomal, Many, More
related to Phylogenetics and taxonomy · 6
Conserved sequence → For, ITS, RNA, Sequences, Sets, The
related to Scoring systems · 6
Conserved sequence → Genomic Evolutionary Rate Profiling, GERP, Other, The GERP, These, This
related to Functional annotation · 5
Conserved sequence → Conserved, Conserved Domain Database, Databases, Identifying, Pfam
related to Identification · 3
Conserved sequence → Advances, Conserved, DNA
related to Multiple sequence alignment · 3
Conserved sequence → Multiple, Sequence, The CLUSTAL

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Important terminology

conserved sequences sequence may conservation used highly also genes protein species multiple alignment rna genome acid nucleic evolutionary proteins coding

Entity relationships Subject–Predicate–Object triples

SubjectPredicateObjectConfidenceSrc
BLASTinstance ofusing tools0.80text
HMMERinstance ofusing tools0.80text
OrthologRinstance ofusing tools0.80text
and Infernalinstance ofusing tools0.80text
profile-HMMsinstance ofStatistical models0.80text
and RNA covariance models which also incorporate structural informationinstance ofStatistical models0.80text
can be helpful when searching for more distantly related sequencesinstance ofStatistical models0.80text
PAMinstance ofAcceptable conservative substitutions may be identified using substitution matrices0.80text
BLOSUMinstance ofAcceptable conservative substitutions may be identified using substitution matrices0.80text
PhyloPinstance ofwhich are segments that are subject to purifying selection and are typically critical for normal protein function.Other approaches0.80text
PhyloHMM incorporate statistical phylogenetics methods to compare probability distributions of substitution ratesinstance ofwhich are segments that are subject to purifying selection and are typically critical for normal protein function.Other approaches0.80text
which allows the detection of both conservationinstance ofwhich are segments that are subject to purifying selection and are typically critical for normal protein function.Other approaches0.80text

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