Research any topic before you write.

Find related topics. | Discover entities. | See connections. | Build a topical map.

NMDA receptor

The N-methyl-D-aspartate receptor (also known as the NMDA receptor or NMDAR) is a glutamate receptor and a predominantly Ca2+ ion channel found in neurons. The NMDA receptor is one of three types of ionotropic glutamate receptors, the other two being AMPA and kainate receptors. Depending on its subunit composition, its ligands are glutamate and glycine…

History, Art & Measurement

Use the mouse wheel or two fingers (on touchscreens) to zoom in and out of the map.

Research this topic

Explore the main themes, entities and connections around NMDA receptor. Start with the topic map, then use the sections below for research and deeper semantic analysis.

Explore this topic

Start with a few of the strongest sections from the source topic. These are research directions, not a list of keywords you must use.

Topics to explore

Browse the full topic structure. Each item opens a new analysis centered on that subject.

Overview

History

Structure

Gating

Mechanism of action

Variants

Role in excitotoxicity

Ligands

Receptor modulation

Clinical significance

Advanced semantic analysis

Deeper signals for content research, entity SEO and topical coverage. The plain-language headings explain what each technical view is useful for.

Map overview Semantic statistics

NMDA receptor

Nodes313
Edges312
Triples292
Avg. degree1.99
Density0.00639
Components1

How this topic connects Entity context

See the strongest relationship patterns around the current topic before diving into the raw triples.

NMDA receptor

Top relations

related to Gating · 24
NMDA receptor → A-D, Activation, All, Allosteric, AMPA, C-terminus, Ca2, D-serine, Figure, GluN1, GluN1-linked, GluN1/GluN2, GluN2, GluN3, GRIN1, Mg2, N-terminus, Na, NMDA, On
related to Clinical significance · 21
NMDA receptor → Aberrant NMDAR, AGN-241751, AMPA, AV-101, BDNFTooltip, CERC-301, For, GLYX-13, Grin, In, JNJ-54135419, MK-0657, Mutations, NMDA, NMDAR, NMDAR-targeting, NMDARs, NRX-1074, Research, These
related to Structure · 21
NMDA receptor → A-B, A-D, All NMDARs, Functional NMDA, GluN1, GluN1-2A-1-2A, GluN1-2A-1-2B, GluN1-2A-3A-2A, GluN2, GluN3, Grin1-Grin3, GRIN1GluN2GluN2A, GRIN2AGluN2B, GRIN2BGluN2C, GRIN2CGluN2D, GRIN2DGluN3GluN3A, GRIN3AGluN3B, GRIN3B, NMDARs, There
related to history · 19
NMDA receptor → Alzheimer's, CNS, Extrasynaptic NMDA, From, Hilmar Bading, Huntington's, In, Jeff Watkins, N-methyl-D-aspartic, NMDA, NMDAR/TRPM4, NR2B, Parkinson's, Receptor, Synaptic NMDA, The, These, This, TRPM4
related to GluN2 · 18
NMDA receptor → C-terminal, GluN2, GluN2A, GluN2B, GluN2D, GRIN2A, GRIN2B, GRIN2C, GRIN2D, However, In, More, NMDA, Strong, They, This, Unlike GluN1, While
related to Receptor modulation · 14
NMDA receptor → Ca2, EPSP, However, Its, LTP, Magnesium, Mg2, Na, NMDA, The, The Ca2, The NMDA, Therefore, This
related to Role of differing subunits · 14
NMDA receptor → Although, Another, Despite, GluN1, GluN2A, GluN2B, In, NMDA, NMDAR, NMDARs, Some, The, This, Two
related to Differing cascade pathways · 13
NMDA receptor → ERK1/2, Experiments, Extrasynaptic, For, In, Jacob, Many, NMDA, NMDARs, Phosphorylation, These, This, Two
related to External links · 13
NMDA receptor → But Not, Combined Gene Disruption, Discoordination Results, Media, NMDA, NMDA Receptor NR2A, NR2A, NR2C SubunitDrosophila NMDA, NR2C Subunits, Single Disruption, The Interactive Fly, Wikimedia CommonsNMDA, Wiktionary-logo-en-v2
related to Excitotoxicity in a clinical setting · 12
NMDA receptor → Alzheimer's, D-serine, Excitotoxicity, GRIN1, GRIN2B, Huntington's, Most, NMDA, One, These, Treating, Treatment

Important terminology Word statistics

Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.

Important terminology

nmda receptor receptors memantine channel subunit glutamate synaptic also glun2b glun1 activity antagonists subunits site antagonist binding cell glycine two

Entity relationships Subject–Predicate–Object triples

SubjectPredicateObjectConfidenceSrc
NMDA receptoris aglutamate and ion channel protein receptor that is activated when glycine and glutamate bind to it0.90text
NMDA receptoris anon-specific cation channel that can allow the passage of Ca20.90text
phencyclidineinstance ofions.Activity of the NMDA receptor is blocked by many psychoactive drugs0.80text
epilepsyinstance ofFrom this it was considered that NMDA receptors were associated with a variety of neurological disorders0.80text
Parkinson'sinstance ofFrom this it was considered that NMDA receptors were associated with a variety of neurological disorders0.80text
Alzheimer'sinstance ofFrom this it was considered that NMDA receptors were associated with a variety of neurological disorders0.80text
Huntington'sinstance ofFrom this it was considered that NMDA receptors were associated with a variety of neurological disorders0.80text
other CNS disorders.In 2002instance ofFrom this it was considered that NMDA receptors were associated with a variety of neurological disorders0.80text
it was discovered by Hilmar Badinginstance ofFrom this it was considered that NMDA receptors were associated with a variety of neurological disorders0.80text
co-workers that the cellular consequences of NMDA receptor stimulation depend on the receptor's location on the neuronal cell surfaceinstance ofFrom this it was considered that NMDA receptors were associated with a variety of neurological disorders0.80text
learninginstance ofproteins and the polyamines spermidine and spermine are also modulators for the NMDA receptor channels.The GluN2B subunit has been involved in modulating activity0.80text
memoryinstance ofproteins and the polyamines spermidine and spermine are also modulators for the NMDA receptor channels.The GluN2B subunit has been involved in modulating activity0.80text

Related concept clusters Concept neighborhoods

These clusters group vocabulary that occurs around closely connected concepts in the source material.

    Connections between topic areas Semantic bridges

    Bridges can reveal useful research angles that are easy to miss in a flat list of related terms.

    Min side: 3
    For writers, content strategists, SEOs, marketers and creators — from quick topic research to advanced semantic analysis.