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SGK1

Serine/threonine-protein kinase Sgk1 also known as serum and glucocorticoid-regulated kinase 1 is an enzyme that in humans is encoded by the SGK1 gene.

Function, Clinical significance & Overview

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Function

36 related topics

Clinical significance

13 related topics

Overview

42 related topics

Interactions

5 related topics

Key facts & relationships

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2.7.11.1
Aliases
SGK1, SGK, serum/glucocorticoid regulated kinase 1
Available structures
Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes2R5T, 3HDM, 3HDN
Band
6q23.2 · 10|10 A3
Bgee
palpebral conjunctiva · right lung · Epithelium of choroid plexus · gingival epithelium · parietal pleura
BioGPS
More reference expression data

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Overview

Function

Clinical significance

Interactions

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Map overview Semantic statistics

SGK1

Nodes101
Edges100
Triples217
Avg. degree1.98
Density0.019802
Components1

How this topic connects Entity context

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SGK1

Top relations

Gene ontology · 41
SGK1 → apoptotic process, ATP binding, calcium channel regulator activity, cellular response to DNA damage stimulus, chloride channel regulator activity, cytoplasm, cytosol, endoplasmic reticulum, endoplasmic reticulum membrane, intracellular signal transduction, ion transmembrane transport, kinase activity, long-term memory, membrane, mitochondrion, neuron projection morphogenesis, nuclear speck, nucleotide binding, nucleus, peptidyl-serine phosphorylation
Bgee · 18
SGK1 → ciliary body, decidua, endothelial cell of lymphatic vessel, Epithelium of choroid plexus, gallbladder, gastrula, gingival epithelium, iris, lower lobe of lung, mucosa of urinary bladder, nasal epithelium, palpebral conjunctiva, parietal pleura, retinal pigment epithelium, right lung, seminal vesicula, stria vascularis, triceps brachii muscle
RNA expression pattern · 18
SGK1 → ciliary body, decidua, endothelial cell of lymphatic vessel, Epithelium of choroid plexus, gallbladder, gastrula, gingival epithelium, iris, lower lobe of lung, mucosa of urinary bladder, nasal epithelium, palpebral conjunctiva, parietal pleura, retinal pigment epithelium, right lung, seminal vesicula, stria vascularis, triceps brachii muscle
related to Ion channel and transporter regulation · 16
SGK1 → Ca2, Cardiac, ClC2, CLCN2, ENaCRenal, Epithelial Na, KCNE1/KCNQ1Voltage-gated, KCNJ1, Kv1, Kv4, Na, Receptors, Renal, ROMK1, SCN5ACardiac, TRPV5Ubiquitous Cl
related to Clinical significance · 12
SGK1 → By, KCNE1, KvLQT1, KvLQT1/KCNE1, KvLQT1/KCNE1-containing, Long QT Syndrome, P2, PI, PIKfyve, QT, RAB11-dependent, Stress-induced
related to Regulation of cell volume · 11
SGK1 → Cl, ClC2, However, It, KCl, Moreover, Na, NaCl, SGK1-dependent, The, This
related to Kidney · 10
SGK1 → ADH, ADH/insulin, By, ENaC, IGF-I, It, Na, NaCl, One, Renal ENaC
related to Role in neuronal disease · 10
SGK1 → ALS, AMPA, Amyotrophic, GluR2, Kainate, SGK, SGK1-dependent, Studies, Two, Where
related to Cardiovascular · 9
SGK1 → Activated SGK1, As, As SGK1, In, Na, Q-T, QT, SGK1-induced, The
related to Memory formation · 8
SGK1 → AMPA, It, On, SGK, Synaptic, The, This, Wild-type SGK1

Important terminology Word statistics

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Important terminology

cell regulation expression kinase shown glucocorticoids function activity channel may also gene renal transcription na serum volume role sgk channels

Entity relationships Subject–Predicate–Object triples

SubjectPredicateObjectConfidenceSrc
SGK12.7.11.11.00infobox
SGK1AliasesSGK1, SGK, serum/glucocorticoid regulated kinase 11.00infobox
SGK1Available structuresAvailable structuresPDBOrtholog search: PDBe RCSB List of PDB id codes2R5T, 3HDM, 3HDN1.00infobox
SGK1Band6q23.21.00infobox
SGK1Band10|10 A31.00infobox
SGK1Bgeepalpebral conjunctiva1.00infobox
SGK1Bgeeright lung1.00infobox
SGK1BgeeEpithelium of choroid plexus1.00infobox
SGK1Bgeegingival epithelium1.00infobox
SGK1Bgeeparietal pleura1.00infobox
SGK1Bgeemucosa of urinary bladder1.00infobox
SGK1Bgeenasal epithelium1.00infobox
SGK1Bgeelower lobe of lung1.00infobox
SGK1Bgeegallbladder1.00infobox
SGK1Bgeeretinal pigment epithelium1.00infobox
SGK1Bgeeseminal vesicula1.00infobox
SGK1Bgeedecidua1.00infobox
SGK1Bgeegastrula1.00infobox
SGK1Bgeeiris1.00infobox
SGK1Bgeeendothelial cell of lymphatic vessel1.00infobox
SGK1Bgeeciliary body1.00infobox
SGK1Bgeestria vascularis1.00infobox
SGK1Bgeetriceps brachii muscle1.00infobox
SGK1BioGPSMore reference expression data1.00infobox
SGK1Chr.Chromosome 6 (human)1.00infobox
SGK1Chr.Chromosome 10 (mouse)1.00infobox
SGK1DatabasesNCBI: entry; OMA: entry1.00infobox
SGK1End134,318,112 bp1.00infobox
SGK1End21,875,802 bp1.00infobox
SGK1EnsemblENSG000001185151.00infobox

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