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Histone deacetylase

Histone deacetylases (EC 3.5.1.98, HDAC) are a class of enzymes that remove acetyl groups (O=C-CH3) from an ε-N-acetyl lysine amino acid on both histone and non-histone proteins. HDACs allow histones to wrap the DNA more tightly. This is important because DNA is wrapped around histones, and DNA expression is regulated by acetylation and de-acetylation.…

Function, HDAC inhibitors & Classes of HDACs in higher eukaryotes

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Function

AmineArgininePhosphate groupsAcetylationAmides
38 related topics

HDAC inhibitors

Valproic acidNeurodegenerative diseasesVorinostat (SAHA)FDACutaneous T cell lymphoma
24 related topics

Classes of HDACs in higher eukaryotes

SirtuinsRossmann architectureNAD+
3 related topics

Subcellular distribution

TubulinHsp90Cortactin
3 related topics

Key facts & relationships

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BRENDA
enzyme data
CAS no.
9076-57-7
EC no.
3.5.1.98
ExPASy
NiceZyme view
Gene Ontology
AmiGO / QuickGO
KEGG
enzyme entry

Topics to explore

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Overview

HDAC super family

Classes of HDACs in higher eukaryotes

Subtypes

Evolution

Subcellular distribution

Function

HDAC inhibitors

Advanced semantic analysis

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Map overview Semantic statistics

Histone deacetylase

Nodes91
Edges90
Triples94
Avg. degree1.98
Density0.021978
Components1

How this topic connects Entity context

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Histone deacetylase

Top relations

related to HDAC inhibitors · 37
Histone deacetylase → ACTR, Also, CTCL, DNA, E2F1, EKLF, FDA, FEN, For, Function, GATA, HDAC, HDACs, HDI, HDIs, Histone, HIV, HNF-4, HSP90, In
related to Subtypes · 17
Histone deacetylase → Class, Class II, Class III, Class IV, DNA, HDAC, HDAC11, HDACs, Homologues, II, IV, NAD, Rpd3, Sir2, The Class III, TSA, Zn2
related to Histone modification · 11
Histone deacetylase → According, Acetylation, DNA, Genes, Genomes, Histone, KEGG, Kyoto Encyclopedia, The, These, This
related to Classes of HDACs in higher eukaryotes · 7
Histone deacetylase → HDAC, HDACs, III, NAD, Rossmann, They, Zn2
see also · 4
Histone deacetylase → HAT, Histone, Histone-modifying, HMT
BRENDA · 1
Histone deacetylase → enzyme data
CAS no. · 1
Histone deacetylase → 9076-57-7
EC no. · 1
Histone deacetylase → 3.5.1.98
ExPASy · 1
Histone deacetylase → NiceZyme view
Gene Ontology · 1
Histone deacetylase → AmiGO / QuickGO

Important terminology Word statistics

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Important terminology

histone hdacs proteins acetylation hdac class deacetylase dna non-histone function transcription hdis deacetylases gene enzymes lysine found activity histones expression

Entity relationships Subject–Predicate–Object triples

SubjectPredicateObjectConfidenceSrc
Histone deacetylaseBRENDAenzyme data1.00infobox
Histone deacetylaseCAS no.9076-57-71.00infobox
Histone deacetylaseEC no.3.5.1.981.00infobox
Histone deacetylaseExPASyNiceZyme view1.00infobox
Histone deacetylaseGene OntologyAmiGO / QuickGO1.00infobox
Histone deacetylaseKEGGenzyme entry1.00infobox
Histone deacetylaseMetaCycmetabolic pathway1.00infobox
Histone deacetylaseNCBIproteins1.00infobox
Histone deacetylasePDB structuresRCSB PDB PDBe PDBsum1.00infobox
Histone deacetylasePMCarticles1.00infobox
Histone deacetylasePubMedarticles1.00infobox
Histone deacetylaseRheareactions1.00infobox
Histone deacetylaseSearchSearchPMCarticlesPubMedarticlesNCBIproteins1.00infobox

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