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Folinic acid: History, Community, Culture & Applications

Folinic acid, also known as leucovorin, is a medication used to decrease the toxic effects of methotrexate and pyrimethamine. It is also used in combination with 5-fluorouracil to treat colorectal cancer and pancreatic cancer, and may be used to treat folate deficiency, anemia, and methanol poisoning. It is taken by mouth, injection into a muscle, or…

Language: English [EN]
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Folinic acid topic overview

The analysis highlights History, Community, Culture and Applications as prominent areas in the source structure around Folinic acid.

Related topics
67
Source areas
8
Connected nodes
75
Extracted relationships
101
Concept neighborhoods
23
Bridge connections
75

What this topic covers Research coverage

Source areas are shown by the number of related topics found in each part of the analysis. Use smaller areas too: they can reveal specialized angles and content gaps.

Overview · 22 topics
Medical uses · 17 topics
Mechanism of action · 8 topics
Biochemistry · 7 topics
Drug interactions · 4 topics
History · 3 topics
Side effects · 3 topics
Society and culture · 3 topics

Smaller areas are not necessarily less important. They contain fewer connections in this analysis and can be useful for finding specialized angles or coverage gaps.

Key facts & relationships

High-confidence facts extracted from structured source data. Use them as anchors for further research.

3D model (JSmol)
Interactive image
AHFS/Drugs.com
Monograph
ATC code
V03AF03 (WHO)
Bioavailability
Dose dependent
CAS Number
1492-18-8
ChEMBL
ChEMBL1679

Explore all related topics Closing gaps

Browse the complete topic structure, not only the most central items. Less prominent entities and concepts can reveal missing angles, specialized context and useful research gaps. Each item opens a new analysis centered on that subject.

Overview

Medical uses

Side effects

Drug interactions

Biochemistry

Mechanism of action

History

Society and culture

Advanced semantic analysis

Deeper signals for content research, entity SEO and topical coverage. The plain-language headings explain what each technical view is useful for.

How Folinic acid connects Entity context

The extracted context around Folinic acid shows recurring relationship patterns in the source. For example, Folinic acid → Baumann, Drug Administration, FDA, FDA's, Folinic, From, In September, It, Leuconostoc, Sauberlich, The, This, US Food Another extracted example is Folinic acid → According, AICARFT, In, It, MTHF, MTHFR, MTHFS, SHMT, THF. Use these groups to spot repeated connection types before inspecting the individual relationships.

Folinic acid

Top relations

related to history · 13
Folinic acid → Baumann, Drug Administration, FDA, FDA's, Folinic, From, In September, It, Leuconostoc, Sauberlich, The, This, US Food
related to Biochemistry · 9
Folinic acid → According, AICARFT, In, It, MTHF, MTHFR, MTHFS, SHMT, THF
related to Cerebral folate deficiency · 9
Folinic acid → As, CFD, CSF, Drug Administration, FDA, Folinic, MTHF, This, US Food
related to Mechanism of action · 8
Folinic acid → Although, DNA, Folinic, In, It, One, Since, This
has effect · 7
Folinic acid → Different, Folinic, However, In, Severe, This, While
related to Names · 7
Folinic acid → B9, Folinic, However, INN, It, Levofolinic, They
related to Drug interactions · 6
Folinic acid → AIDS, Fluorouracil, Folinic, Pneumocystis, Some, Sulfamethoxazole-trimethoprim
related to Autism spectrum disorder · 5
Folinic acid → All, ASD, December, Folinic, In January
related to Other uses or indications · 4
Folinic acid → Folinic, In, It, Its
is a · 2
Folinic acid → form of folic acid that does not require activation by dihydrofolate reductase to be useful to the body.Folinic acid was first made in 1945, vitamer of folic acid and has the full vitamin activity of this vitamin

Important terminology

Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.

Important terminology

acid folinic folate methotrexate used leucovorin also deficiency treatment may effects folic calcium dihydrofolate reductase known drug cerebral citrovorum factor

Folinic acid relationships Subject–Predicate–Object triples

TTTA extracted 101 structured relationships around Folinic acid. Examples in this analysis include Folinic acid → 3D model (JSmol) → Interactive image and Folinic acid → AHFS/Drugs.com → Monograph. The table shows each extracted connection, where it came from and its confidence.

SubjectPredicateObjectConfidenceSrc
Folinic acid3D model (JSmol)Interactive image1.00infobox
Folinic acidAHFS/Drugs.comMonograph1.00infobox
Folinic acidATC codeV03AF03 (WHO)1.00infobox
Folinic acidBioavailabilityDose dependent1.00infobox
Folinic acidCAS Number1492-18-81.00infobox
Folinic acidChEMBLChEMBL16791.00infobox
Folinic acidChemSpider57841.00infobox
Folinic acidCompTox Dashboard (EPA)DTXSID00482161.00infobox
Folinic acidDrugBankDB006501.00infobox
Folinic acidECHA InfoCard100.000.3281.00infobox
Folinic acidElimination half-life6.2 hours1.00infobox
Folinic acidExcretionKidney1.00infobox
Folinic acidFormulaC20H23N7O71.00infobox
Folinic acidIUPHAR/BPS48161.00infobox
Folinic acidLegal statusUS: ℞-only1.00infobox
Folinic acidLicense dataUS DailyMed: Leucovorin calcium1.00infobox
Folinic acidMedlinePlusa6080381.00infobox
Folinic acidMelting point245 °C (473 °F) decomp1.00infobox
Folinic acidMolar mass473.446 g·mol−11.00infobox
Folinic acidOther namesLeucovorin, citrovorum factor, 5-formyltetrahydrofolate1.00infobox
Folinic acidPregnancy categoryAU: A1.00infobox
Folinic acidPronunciationLeucovorin /ˌljuːkoʊˈvɔːrɪn/1.00infobox
Folinic acidProtein binding~15%1.00infobox
Folinic acidPubChem CID1354036481.00infobox
Folinic acidRoutes of administrationBy mouth, intramuscular, intravenous1.00infobox
Folinic acidSolubility in water~0.3 mg/mL (20 °C)1.00infobox
Folinic acidUNIIRPR1R4C0P41.00infobox
Folinic acidis aform of folic acid that does not require activation by dihydrofolate reductase to be useful to the body.Folinic acid was first made in 19450.90text
Folinic acidis avitamer of folic acid and has the full vitamin activity of this vitamin0.90text

Related concept clusters Concept neighborhoods

The concept neighborhoods around Folinic acid bring nearby vocabulary together. In this analysis, examples include Folinic, Methotrexate and Used. Use the clusters to find adjacent concepts and terminology that may deserve separate research.

  • Folinic acid
    • Folinic
    • Methotrexate
    • Used
    • Dihydrofolate
    • Reductase
    • Effects
    • Treatment
    • Patients
    • Also
    • Folic
    • Factor
    • Administered
  • folinic acid
    • Folinic
    • Methotrexate
    • Used
    • Folic
    • Dihydrofolate
    • Reductase
    • Effects
    • Treatment
    • Patients
    • Also
    • Factor
    • May
  • folate deficiency
    • Cerebral
    • Deficiency
    • Folate
    • Administration
    • Tablets
    • Calcium
    • Drug
    • Leucovorin
    • Fda
    • Clear
    • Form
    • Citrovorum
  • folate
    • Deficiency
    • Cerebral
    • Administration
    • Tablets
    • Leucovorin
    • Calcium
    • Drug
    • Clear
    • Form
    • Fda
    • Citrovorum
    • May
  • folic acid
    • Folinic
    • Vitamin
    • Activity
    • Methotrexate
    • Used
    • Dihydrofolate
    • Reductase
    • Folic
    • Treatment
    • Effects
    • Also
    • Form
  • cerebral folate deficiency
    • Cerebral
    • Deficiency
    • Folate
    • Tablets
    • Drug
    • Leucovorin
    • Administration
    • Calcium
    • Fda
    • Clear
    • Form
    • Treatment
  • tetrahydrofolic acid
    • Folinic
    • Methotrexate
    • Used
    • Folic
    • Treatment
    • Dihydrofolate
    • Reductase
    • Effects
    • Also
    • Patients
    • Factor
    • May
  • methotrexate
    • Dihydrofolate
    • Reductase
    • Side
    • Used
    • Treatment
    • Clear
    • First
    • Function
    • Mouth
    • Pyrimethamine
    • Administered
    • Administration

Connections between topic areas Semantic bridges

For Folinic acid, one of the stronger structural bridges in this analysis connects Folinic acid with Overview. Bridges highlight paths between different parts of the map and can reveal research angles that are easy to miss in a flat list.

Min side: 3
Folinic acid — Overview · splits 53 ⟂ 23
Folinic acid — Medical uses · splits 58 ⟂ 18
Folinic acid — Mechanism of action · splits 67 ⟂ 9
Folinic acid — Biochemistry · splits 68 ⟂ 8
Folinic acid — Drug interactions · splits 71 ⟂ 5
Folinic acid — Side effects · splits 72 ⟂ 4
Folinic acid — History · splits 72 ⟂ 4
Folinic acid — Society and culture · splits 72 ⟂ 4

Map overview Semantic statistics

Folinic acid

Nodes76
Edges75
Triples101
Avg. degree1.97
Density0.026316
Components1

Source & methodology

TTTA analyzes the structure around Folinic acid to surface related topics, entities, relationships, concept neighborhoods and bridge connections. Use the map to explore areas such as History, Community, Culture & Applications, including less central topics that may reveal useful research gaps. Automatically extracted connections are research leads rather than rewritten encyclopedia content.

Source: Wikipedia — Folinic acid · EN edition · Analysis: TopicsToTalkAbout

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