Folinic acid

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Folinic acid topic overview

The analysis highlights History, Community, Culture and Applications as prominent areas in the source structure around Folinic acid.

Related topics: 66
Source areas: 8
Connected nodes: 74
Extracted relationships: 78
Related term clusters: 23
Bridge connections: 74

What this topic covers Research coverage

Source areas are shown by the number of related topics found in each part of the analysis. Use smaller areas too: they can reveal specialized angles and content gaps.

Overview · 22 topics

Medical uses · 17 topics

Mechanism of action · 8 topics

Biochemistry · 6 topics

Drug interactions · 4 topics

History · 3 topics

Side effects · 3 topics

Society and culture · 3 topics

Smaller areas are not necessarily less important. They contain fewer connections in this analysis and can be useful for finding specialized angles or coverage gaps.

Key facts & relationships

High-confidence facts extracted from structured source data. Use them as anchors for further research.

3D model (JSmol): Interactive image
AHFS/Drugs.com: Monograph
ATC code: V03AF03 (WHO)
Bioavailability: Dose dependent
CAS Number: 1492-18-8
ChEMBL: ChEMBL1679

Start with your topic. Discover where to go next.

Explore different angles and find fresh ideas to shape your next piece of content.

Folinic acid

12Methotrexate · Pyrimethamine · 5-fluorouracil

3Folic acid · Food and Drug Administration · Calcium

6Allergic reactions · Fever · Pregnancy

14Cerebral folate deficiency · WHO Model List of Essential Medicines · Bone marrow suppression

Explore all related topics Closing gaps

Browse the complete topic structure, not only the most central items. Less prominent entities and concepts can reveal missing angles, specialized context and useful research gaps. Each item opens a new analysis centered on that subject.

Medical uses

Side effects

Drug interactions

Biochemistry

Mechanism of action

History

Society and culture

For the semantics nerds

You can skip this section if you’re here for content ideas and keyword inspiration.

Advanced semantic analysis

How Folinic acid connects Entity context

The extracted context around Folinic acid shows recurring relationship patterns in the source. For example, Folinic acid → Baumann, Drug Administration, FDA, FDA's, Folinic, In September, Leuconostoc, Sauberlich, US Food Another extracted example is Folinic acid → According, AICARFT, MTHF, MTHFR, MTHFS, SHMT, THF. Use these groups to spot repeated connection types before inspecting the individual relationships.

Top relations

related to history · 9

Folinic acid → Baumann, Drug Administration, FDA, FDA's, Folinic, In September, Leuconostoc, Sauberlich, US Food

related to Biochemistry · 7

Folinic acid → According, AICARFT, MTHF, MTHFR, MTHFS, SHMT, THF

related to Cerebral folate deficiency · 7

Folinic acid → CFD, CSF, Drug Administration, FDA, Folinic, MTHF, US Food

related to Drug interactions · 5

Folinic acid → AIDS, Fluorouracil, Folinic, Pneumocystis, Sulfamethoxazole-trimethoprim

related to Mechanism of action · 5

Folinic acid → Although, DNA, Folinic, One, Since

related to Autism spectrum disorder · 4

Folinic acid → ASD, December, Folinic, In January

related to Names · 4

Folinic acid → B9, Folinic, INN, Levofolinic

has effect · 3

Folinic acid → Different, Folinic, Severe

is a · 2

Folinic acid → form of folic acid that does not require activation by dihydrofolate reductase to be useful to the body.Folinic acid was first made in 1945, vitamer of folic acid and has the full vitamin activity of this vitamin

3D model (JSmol) · 1

Folinic acid → Interactive image

Important terminology

Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.

Important terminology

acid folinic folate methotrexate used leucovorin also deficiency treatment may effects folic calcium dihydrofolate reductase known drug cerebral citrovorum factor

Folinic acid relationships Subject–Predicate–Object triples

TTTA extracted 78 structured relationships around Folinic acid. Examples in this analysis include Folinic acid → 3D model (JSmol) → Interactive image and Folinic acid → AHFS/Drugs.com → Monograph. The table shows each extracted connection, where it came from and its confidence.

Subject	Predicate	Object	Confidence	Src
Folinic acid	3D model (JSmol)	Interactive image	1.00	infobox
Folinic acid	AHFS/Drugs.com	Monograph	1.00	infobox
Folinic acid	ATC code	V03AF03 (WHO)	1.00	infobox
Folinic acid	Bioavailability	Dose dependent	1.00	infobox
Folinic acid	CAS Number	1492-18-8	1.00	infobox
Folinic acid	ChEMBL	ChEMBL1679	1.00	infobox
Folinic acid	ChemSpider	5784	1.00	infobox
Folinic acid	CompTox Dashboard (EPA)	DTXSID0048216	1.00	infobox
Folinic acid	DrugBank	DB00650	1.00	infobox
Folinic acid	ECHA InfoCard	100.000.328	1.00	infobox
Folinic acid	Elimination half-life	6.2 hours	1.00	infobox
Folinic acid	Excretion	Kidney	1.00	infobox
Folinic acid	Formula	C20H23N7O7	1.00	infobox
Folinic acid	IUPHAR/BPS	4816	1.00	infobox
Folinic acid	Legal status	US: ℞-only	1.00	infobox
Folinic acid	License data	US DailyMed: Leucovorin calcium	1.00	infobox
Folinic acid	MedlinePlus	a608038	1.00	infobox
Folinic acid	Melting point	245 °C (473 °F) decomp	1.00	infobox
Folinic acid	Molar mass	473.446 g·mol−1	1.00	infobox
Folinic acid	Other names	Leucovorin, citrovorum factor, 5-formyltetrahydrofolate	1.00	infobox
Folinic acid	Pregnancy category	AU: A	1.00	infobox
Folinic acid	Pronunciation	Leucovorin /ˌljuːkoʊˈvɔːrɪn/	1.00	infobox
Folinic acid	Protein binding	~15%	1.00	infobox
Folinic acid	PubChem CID	135403648	1.00	infobox
Folinic acid	Routes of administration	By mouth, intramuscular, intravenous	1.00	infobox
Folinic acid	Solubility in water	~0.3 mg/mL (20 °C)	1.00	infobox
Folinic acid	UNII	RPR1R4C0P4	1.00	infobox
Folinic acid	is a	form of folic acid that does not require activation by dihydrofolate reductase to be useful to the body.Folinic acid was first made in 1945	0.90	text
Folinic acid	is a	vitamer of folic acid and has the full vitamin activity of this vitamin	0.90	text

Related concept clusters Related term clusters

The concept neighborhoods around Folinic acid bring nearby vocabulary together. In this analysis, examples include Folinic, Methotrexate and Used. Use the clusters to find adjacent concepts and terminology that may deserve separate research.

Folinic acid
- Folinic
- Methotrexate
- Used
- Dihydrofolate
- Reductase
- Effects
- Treatment
- Patients
- Also
- Folic
- Factor
- Administered
folinic acid
- Folinic
- Methotrexate
- Used
- Folic
- Dihydrofolate
- Reductase
- Effects
- Treatment
- Patients
- Also
- Factor
- May
folate deficiency
- Cerebral
- Deficiency
- Folate
- Administration
- Tablets
- Calcium
- Drug
- Leucovorin
- Fda
- Clear
- Form
- Citrovorum
folate
- Deficiency
- Cerebral
- Administration
- Tablets
- Leucovorin
- Calcium
- Drug
- Clear
- Form
- Fda
- Citrovorum
- May
folic acid
- Folinic
- Vitamin
- Activity
- Methotrexate
- Used
- Dihydrofolate
- Reductase
- Folic
- Treatment
- Effects
- Also
- Form
cerebral folate deficiency
- Cerebral
- Deficiency
- Folate
- Tablets
- Drug
- Leucovorin
- Administration
- Calcium
- Fda
- Clear
- Form
- Treatment
tetrahydrofolic acid
- Folinic
- Methotrexate
- Used
- Folic
- Treatment
- Dihydrofolate
- Reductase
- Effects
- Also
- Patients
- Factor
- May
methotrexate
- Dihydrofolate
- Reductase
- Side
- Used
- Treatment
- Clear
- Function
- Mouth
- Pyrimethamine
- Administered
- Administration
- Vitamin

Connections between topic areas Semantic bridges

For Folinic acid, one of the stronger structural bridges in this analysis connects Folinic acid with Overview. Bridges highlight paths between different parts of the map and can reveal research angles that are easy to miss in a flat list.

Min side: 3

Folinic acid — Overview · splits 52 ⟂ 23

Folinic acid — Medical uses · splits 57 ⟂ 18

Folinic acid — Mechanism of action · splits 66 ⟂ 9

Folinic acid — Biochemistry · splits 68 ⟂ 7

Folinic acid — Drug interactions · splits 70 ⟂ 5

Folinic acid — Side effects · splits 71 ⟂ 4

Folinic acid — History · splits 71 ⟂ 4

Folinic acid — Society and culture · splits 71 ⟂ 4

Map overview Semantic statistics

Folinic acid

Nodes75

Edges74

Triples78

Avg. degree1.97

Density0.026667

Components1

Source & methodology

TTTA analyzes the structure around Folinic acid to surface related topics, entities, relationships, concept neighborhoods and bridge connections. Use the map to explore areas such as History, Community, Culture & Applications, including less central topics that may reveal useful research gaps. Automatically extracted connections are research leads rather than rewritten encyclopedia content.

Source: Wikipedia — Folinic acid · EN edition · Analysis: TopicsToTalkAbout

Folinic acid: History, Community, Culture & Applications

Folinic acid topic overview

What this topic covers Research coverage

Key facts & relationships

Start with your topic. Discover where to go next.

Questions to explore

Explore all related topics Closing gaps

Overview

Medical uses

Side effects

Drug interactions

Biochemistry

Mechanism of action

History

Society and culture

For the semantics nerds

Advanced semantic analysis

How Folinic acid connects Entity context

Folinic acid

Top relations

Important terminology

Important terminology

Folinic acid relationships Subject–Predicate–Object triples

Related concept clusters Related term clusters

Connections between topic areas Semantic bridges

Map overview Semantic statistics

Folinic acid

Source & methodology