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Methyl-CpG-binding domain protein 1 is a protein that in humans is encoded by the MBD1 gene. The protein encoded by MBD1 binds to methylated sequences in DNA, and thereby influences transcription. It binds to a variety of methylated sequences, and appears to mediate repression of gene expression. It has been shown to play a role in chromatin modification…
The analysis highlights Interactions and Overview as prominent areas in the source structure around MBD1.
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Smaller areas are not necessarily less important. They contain fewer connections in this analysis and can be useful for finding specialized angles or coverage gaps.
High-confidence facts extracted from structured source data. Use them as anchors for further research.
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The extracted context around MBD1 shows recurring relationship patterns in the source. For example, MBD1 → anterior pituitary, lacrimal gland, left colon, left lobe of liver, left ovary, left testis, lobe of prostate, lumbar subsegment of spinal cord, middle temporal gyrus, neural layer of retina, parotid gland, pituitary gland, right lobe of thyroid gland, right ovary, right testis, skin of leg, thymus, tibiofemoral joint, vestibular membrane of cochlear duct Another extracted example is MBD1 → chromosome, DNA binding, DNA methylation-dependent heterochromatin assembly, DNA-binding transcription factor activity, RNA polymerase II-specific, double-stranded methylated DNA binding, metal ion binding, methyl-CpG binding, negative regulation of transcription by RNA polymerase II, negative regulation of transcription, DNA-templated, nuclear matrix, nuclear speck, nucleoplasm, nucleus, protein binding, regulation of transcription by RNA polymerase II, regulation of transcription, DNA-templated, transcription by RNA polymerase II, transcription, DNA-templated, zinc ion binding. Use these groups to spot repeated connection types before inspecting the individual relationships.
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gene methylated bp protein human chromosome chr band 18 dna transcription domain binding modification location methyl-cpg encoded binds sequences mouse
TTTA extracted 95 structured relationships around MBD1. Examples in this analysis include MBD1 → Aliases → MBD1, CXXC3, PCM1, RFT, methyl-CpG binding domain protein 1 and MBD1 → Available structures → Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1IG4, 1D9N, 4D4W. The table shows each extracted connection, where it came from and its confidence.
| Subject | Predicate | Object | Confidence | Src |
|---|---|---|---|---|
| MBD1 | Aliases | MBD1, CXXC3, PCM1, RFT, methyl-CpG binding domain protein 1 | 1.00 | infobox |
| MBD1 | Available structures | Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1IG4, 1D9N, 4D4W | 1.00 | infobox |
| MBD1 | Band | 18q21.1 | 1.00 | infobox |
| MBD1 | Band | 18 E2|18 50.7 cM | 1.00 | infobox |
| MBD1 | Bgee | left testis | 1.00 | infobox |
| MBD1 | Bgee | right testis | 1.00 | infobox |
| MBD1 | Bgee | parotid gland | 1.00 | infobox |
| MBD1 | Bgee | pituitary gland | 1.00 | infobox |
| MBD1 | Bgee | anterior pituitary | 1.00 | infobox |
| MBD1 | Bgee | skin of leg | 1.00 | infobox |
| MBD1 | Bgee | middle temporal gyrus | 1.00 | infobox |
| MBD1 | Bgee | left ovary | 1.00 | infobox |
| MBD1 | Bgee | right lobe of thyroid gland | 1.00 | infobox |
| MBD1 | Bgee | right ovary | 1.00 | infobox |
| MBD1 | Bgee | lacrimal gland | 1.00 | infobox |
| MBD1 | Bgee | lobe of prostate | 1.00 | infobox |
| MBD1 | Bgee | left lobe of liver | 1.00 | infobox |
| MBD1 | Bgee | left colon | 1.00 | infobox |
| MBD1 | Bgee | neural layer of retina | 1.00 | infobox |
| MBD1 | Bgee | vestibular membrane of cochlear duct | 1.00 | infobox |
| MBD1 | Bgee | lumbar subsegment of spinal cord | 1.00 | infobox |
| MBD1 | Bgee | tibiofemoral joint | 1.00 | infobox |
| MBD1 | Bgee | thymus | 1.00 | infobox |
| MBD1 | BioGPS | More reference expression data | 1.00 | infobox |
| MBD1 | Chr. | Chromosome 18 (human) | 1.00 | infobox |
| MBD1 | Chr. | Chromosome 18 (mouse) | 1.00 | infobox |
| MBD1 | Databases | NCBI: entry; OMA: entry | 1.00 | infobox |
| MBD1 | End | 50,281,774 bp | 1.00 | infobox |
| MBD1 | End | 74,415,803 bp | 1.00 | infobox |
| MBD1 | Ensembl | ENSG00000141644 | 1.00 | infobox |
The concept neighborhoods around MBD1 bring nearby vocabulary together. In this analysis, examples include Protein, Gene and Mbd2. Use the clusters to find adjacent concepts and terminology that may deserve separate research.
For MBD1, one of the stronger structural bridges in this analysis connects MBD1 with Overview. Bridges highlight paths between different parts of the map and can reveal research angles that are easy to miss in a flat list.
TTTA analyzes the structure around MBD1 to surface related topics, entities, relationships, concept neighborhoods and bridge connections. Use the map to explore areas such as Interactions & Overview, including less central topics that may reveal useful research gaps. Automatically extracted connections are research leads rather than rewritten encyclopedia content.
Source: Wikipedia — MBD1 · EN edition · Analysis: TopicsToTalkAbout