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Omeprazole

Omeprazole, sold under the brand names Prilosec and Losec among others, is a medication used in the treatment of gastroesophageal reflux disease (GERD), peptic ulcer disease, and Zollinger–Ellison syndrome. It is also used to prevent upper gastrointestinal bleeding in people who are at high risk. Omeprazole is a proton-pump inhibitor (PPI) and its…

History, Applications & Standards

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3D model (JSmol)
Interactive image
AHFS/Drugs.com
Monograph
ATC code
A02BC01 (WHO) A02BC51 (WHO)
Bioavailability
35–76%
CAS Number
73590-58-6 Y
ChEBI
CHEBI:7772 Y

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Overview

Medical uses

Adverse effects

Interactions

Pharmacology

Chemistry

History

Veterinary uses

Advanced semantic analysis

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Map overview Semantic statistics

Omeprazole

Nodes120
Edges119
Triples130
Avg. degree1.98
Density0.016667
Components1

How this topic connects Entity context

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Omeprazole

Top relations

related to history · 22
Omeprazole → Astra AB, AstraZeneca, Cable Guy, Drug Administration, FDA, Gamble, In, It, Larry, Lasix, Losec, PPI, Prilosec, Prilosec OTC, Procter, Prozac, Sweden, Swedish AB Hässle, The, United States
related to Further reading · 13
Omeprazole → Biotechnology Information, Bookshelf ID, CYP2C19 Genotype, Dean, In Pratt VM, McLeod HL, Medical Genetics Summaries, National Center, NBK100895, NCBI, Omeprazole Therapy, PMID, Rubinstein WS
related to Veterinary uses · 9
Omeprazole → April, Committee, European Medicines Agency, European Union, In February, Omeprazole TriviumVet, The, TriviumVet DAC, Veterinary Medicinal Products
related to Economics · 8
Omeprazole → Although, April, AstraZeneca, AstraZeneca's, Many, Nexium, The, When Prilosec's US
related to Interactions · 8
Omeprazole → Although, Clopidogrel, CYP2C19, CYP3A4, However, Important, Inhibition, This
related to Pharmacokinetics · 8
Omeprazole → About, CYP2C19, CYP3A4, Identified, It, L/kg, P450, The
Legal status · 5
Omeprazole → AU: S4 (Prescription only), CA: ℞-only, EU: Rx-only, UK: POM (Prescription only), US: OTC / Rx-only
is a · 4
Omeprazole → inhibitor of the enzymes CYP2C19 and CYP3A4, prodrug, proton-pump inhibitor, racemate
related to Mechanism of action · 4
Omeprazole → ATPase, Because, It, The
related to Peptic ulcers · 4
Omeprazole → Amoxicillin, Helicobacter, Infection, Peptic

Important terminology Word statistics

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Important terminology

cyp2c19 acid use prilosec inhibitor may also cyp3a4 drug stomach medication brand available effects losec names ppis risk pregnancy heartburn

Entity relationships Subject–Predicate–Object triples

SubjectPredicateObjectConfidenceSrc
Omeprazole3D model (JSmol)Interactive image1.00infobox
OmeprazoleAHFS/Drugs.comMonograph1.00infobox
OmeprazoleATC codeA02BC01 (WHO) A02BC51 (WHO)1.00infobox
OmeprazoleBioavailability35–76%1.00infobox
OmeprazoleCAS Number73590-58-6 Y1.00infobox
OmeprazoleChEBICHEBI:7772 Y1.00infobox
OmeprazoleChEMBLChEMBL1503 Y1.00infobox
OmeprazoleChemSpider4433 Y1.00infobox
OmeprazoleChiralityRacemic mixture1.00infobox
OmeprazoleCompTox Dashboard (EPA)DTXSID60210801.00infobox
OmeprazoleDensity1.4±0.1 g/cm31.00infobox
OmeprazoleDrug classProton-pump inhibitor1.00infobox
OmeprazoleDrugBankDB00338 Y1.00infobox
OmeprazoleECHA InfoCard100.122.9671.00infobox
OmeprazoleElimination half-life1–1.2 hours1.00infobox
OmeprazoleExcretion80% (urine) 20% (bile via feces)1.00infobox
OmeprazoleFormulaC17H19N3O3S1.00infobox
OmeprazoleIUPHAR/BPS42791.00infobox
OmeprazoleKEGGD00455 Y1.00infobox
OmeprazoleLegal statusAU: S4 (Prescription only)1.00infobox
OmeprazoleLegal statusCA: ℞-only1.00infobox
OmeprazoleLegal statusUK: POM (Prescription only)1.00infobox
OmeprazoleLegal statusUS: OTC / Rx-only1.00infobox
OmeprazoleLegal statusEU: Rx-only1.00infobox
OmeprazoleLicense dataUS DailyMed: Omeprazole1.00infobox
OmeprazoleMedlinePlusa6930501.00infobox
OmeprazoleMelting point156 °C (313 °F)1.00infobox
OmeprazoleMetabolismLiver (CYP2C19, CYP3A4)1.00infobox
OmeprazoleMolar mass345.42 g·mol−11.00infobox
OmeprazolePDB ligand1C6 (PDBe, RCSB PDB)1.00infobox

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