Peroxisome proliferator-activated receptor alpha

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Explore the main themes, entities and connections around Peroxisome proliferator-activated receptor alpha. Start with the topic map, then use the sections below for research and deeper semantic analysis.

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Function

Free fatty acids Ketogenesis Mitochondrial Β-oxidation CPT1

14 related topics

Pharmacology

Triglycerides HDL Coronary heart disease Statins Non-alcoholic fatty liver disease

14 related topics

Interactions

Interact AIP EP300 HSP90AA1 NCOA1

11 related topics

Expression

Arachidonic acid Polyunsaturated fatty acids 15-hydroxyeicosatetraenoic acid 13-hydroxyoctadecadienoic acid Linoleic acid

10 related topics

Key facts & relationships

High-confidence facts extracted from structured source data. Use them as anchors for further research.

Aliases: PPARA, NR1C1, PPAR, PPARalpha, hPPAR, peroxisome proliferator activated receptor alpha, PPAR-alpha
Available structures: Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1I7G, 1K7L, 1KKQ, 2NPA, 2P54, 2REW, 2ZNN, 3ET1, 3FEI, 3G8I, 3KDT, 3KDU, 3SP6, 3VI8, 4BCR, 4CI4, 5AZT
Band: 22q13.31 · 15 E2|15 40.42 cM
Bgee: renal medulla · jejunal mucosa · biceps brachii · Skeletal muscle tissue of biceps brachii · right lobe of liver
BioGPS: More reference expression data
Chr.: Chromosome 22 (human) · Chromosome 15 (mouse)

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Tissue distribution

Fatty acids Fatty acid
MRNA Messenger RNA

Knockout studies

Pharmacology

Triglycerides Triglyceride
HDL High-density lipoprotein
Coronary heart disease Coronary disease
Statins Statin
Non-alcoholic fatty liver disease
Anticonvulsants Anticonvulsant
PubChem
National Center for Biotechnology Information
Docosanoid
FGF21
Amezalpat Amezalpat?action=edit&redlink=1
PPAR
Tempest Therapeutics Tempest Therapeutics?action=edit&redlink=1
FDA

Target genes

Interactions

Interact Protein-protein interaction
AIP AIP (gene)
EP300
HSP90AA1 Heat shock protein 90kDa alpha (cytosolic), member A1
NCOA1 Nuclear receptor coactivator 1
NCOR1 Nuclear receptor co-repressor 1
MECR
Palmitoylethanolamide
Oleoylethanolamide
Anandamide
PFAS

Advanced semantic analysis

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Map overview Semantic statistics

Peroxisome proliferator-activated receptor alpha

Nodes75

Edges74

Triples148

Avg. degree1.97

Density0.026667

Components1

How this topic connects Entity context

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Peroxisome proliferator-activated receptor alpha

Top relations

Gene ontology · 76

Peroxisome proliferator-activated receptor alpha → behavioral response to nicotine, cell differentiation, circadian regulation of gene expression, development of the heart, DNA binding, DNA-binding transcription activator activity, RNA polymerase II-specific, DNA-binding transcription factor activity, DNA-binding transcription factor activity, RNA polymerase II-specific, DNA-binding transcription repressor activity, RNA polymerase II-specific, enamel mineralization, epidermis development, fatty acid binding, fatty acid metabolic process, fatty acid transport, hormone-mediated signaling pathway, intracellular receptor signaling pathway, lipid binding, lipid metabolism, lipoprotein metabolic process, MDM2/MDM4 family protein binding

Bgee · 20

Peroxisome proliferator-activated receptor alpha → biceps brachii, body of tongue, brown adipose tissue, digastric muscle, human kidney, intercostal muscle, jejunal mucosa, left lobe of liver, mucosa of sigmoid colon, muscle of thigh, renal medulla, retinal pigment epithelium, right kidney, right lobe of liver, right ventricle, Skeletal muscle tissue of biceps brachii, soleus muscle, sternocleidomastoid muscle, thoracic diaphragm, transitional epithelium of urinary bladder

RNA expression pattern · 20

Band · 2

Peroxisome proliferator-activated receptor alpha → 15 E2|15 40.42 cM, 22q13.31

Chr. · 2

Peroxisome proliferator-activated receptor alpha → Chromosome 15 (mouse), Chromosome 22 (human)

End · 2

Peroxisome proliferator-activated receptor alpha → 46,243,755 bp, 85,687,020 bp

Aliases · 1

Peroxisome proliferator-activated receptor alpha → PPARA, NR1C1, PPAR, PPARalpha, hPPAR, peroxisome proliferator activated receptor alpha, PPAR-alpha

Available structures · 1

Peroxisome proliferator-activated receptor alpha → Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1I7G, 1K7L, 1KKQ, 2NPA, 2P54, 2REW, 2ZNN, 3ET1, 3FEI, 3G8I, 3KDT, 3KDU, 3SP6, 3VI8, 4BCR, 4CI4, 5AZT

BioGPS · 1

Peroxisome proliferator-activated receptor alpha → More reference expression data

Databases · 1

Peroxisome proliferator-activated receptor alpha → NCBI: entry; OMA: entry

Important terminology Word statistics

Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.

Important terminology

ppar-alpha ppar-α expression fatty receptor acid gene liver human bp peroxisome target genes chr band also ppar chromosome 22 mouse

Entity relationships Subject–Predicate–Object triples

Subject	Predicate	Object	Confidence	Src
Peroxisome proliferator-activated receptor alpha	Aliases	PPARA, NR1C1, PPAR, PPARalpha, hPPAR, peroxisome proliferator activated receptor alpha, PPAR-alpha	1.00	infobox
Peroxisome proliferator-activated receptor alpha	Available structures	Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1I7G, 1K7L, 1KKQ, 2NPA, 2P54, 2REW, 2ZNN, 3ET1, 3FEI, 3G8I, 3KDT, 3KDU, 3SP6, 3VI8, 4BCR, 4CI4, 5AZT	1.00	infobox
Peroxisome proliferator-activated receptor alpha	Band	22q13.31	1.00	infobox
Peroxisome proliferator-activated receptor alpha	Band	15 E2\|15 40.42 cM	1.00	infobox
Peroxisome proliferator-activated receptor alpha	Bgee	renal medulla	1.00	infobox
Peroxisome proliferator-activated receptor alpha	Bgee	jejunal mucosa	1.00	infobox
Peroxisome proliferator-activated receptor alpha	Bgee	biceps brachii	1.00	infobox
Peroxisome proliferator-activated receptor alpha	Bgee	Skeletal muscle tissue of biceps brachii	1.00	infobox
Peroxisome proliferator-activated receptor alpha	Bgee	right lobe of liver	1.00	infobox
Peroxisome proliferator-activated receptor alpha	Bgee	retinal pigment epithelium	1.00	infobox
Peroxisome proliferator-activated receptor alpha	Bgee	muscle of thigh	1.00	infobox
Peroxisome proliferator-activated receptor alpha	Bgee	right ventricle	1.00	infobox
Peroxisome proliferator-activated receptor alpha	Bgee	body of tongue	1.00	infobox
Peroxisome proliferator-activated receptor alpha	Bgee	mucosa of sigmoid colon	1.00	infobox
Peroxisome proliferator-activated receptor alpha	Bgee	left lobe of liver	1.00	infobox
Peroxisome proliferator-activated receptor alpha	Bgee	right kidney	1.00	infobox
Peroxisome proliferator-activated receptor alpha	Bgee	intercostal muscle	1.00	infobox
Peroxisome proliferator-activated receptor alpha	Bgee	brown adipose tissue	1.00	infobox
Peroxisome proliferator-activated receptor alpha	Bgee	digastric muscle	1.00	infobox
Peroxisome proliferator-activated receptor alpha	Bgee	human kidney	1.00	infobox
Peroxisome proliferator-activated receptor alpha	Bgee	sternocleidomastoid muscle	1.00	infobox
Peroxisome proliferator-activated receptor alpha	Bgee	thoracic diaphragm	1.00	infobox
Peroxisome proliferator-activated receptor alpha	Bgee	soleus muscle	1.00	infobox
Peroxisome proliferator-activated receptor alpha	Bgee	transitional epithelium of urinary bladder	1.00	infobox
Peroxisome proliferator-activated receptor alpha	BioGPS	More reference expression data	1.00	infobox
Peroxisome proliferator-activated receptor alpha	Chr.	Chromosome 22 (human)	1.00	infobox
Peroxisome proliferator-activated receptor alpha	Chr.	Chromosome 15 (mouse)	1.00	infobox
Peroxisome proliferator-activated receptor alpha	Databases	NCBI: entry; OMA: entry	1.00	infobox
Peroxisome proliferator-activated receptor alpha	End	46,243,755 bp	1.00	infobox
Peroxisome proliferator-activated receptor alpha	End	85,687,020 bp	1.00	infobox

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Function

Pharmacology

Interactions

Expression

Key facts & relationships

Topics to explore

Overview

Expression

Function

Tissue distribution

Knockout studies

Pharmacology

Target genes

Interactions

Advanced semantic analysis

Map overview Semantic statistics

Peroxisome proliferator-activated receptor alpha

How this topic connects Entity context

Peroxisome proliferator-activated receptor alpha

Top relations

Important terminology Word statistics

Important terminology

Entity relationships Subject–Predicate–Object triples

Related concept clusters Concept neighborhoods

Connections between topic areas Semantic bridges