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Syndecan

Syndecans are single-pass membrane proteins that are thought to act as co-receptors, especially for G protein-coupled receptors. More specifically, these core proteins carry three to five heparan sulfate and chondroitin sulfate chains, i.e. they are proteoglycans, which allow for interaction with a large variety of ligands including fibroblast growth…

Members, Family members and Structure & Clinical significance

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Key facts & relationships

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AlphaFold
IPR001050 · PF01034
Available protein structures:
IPR001050 · PF01034
InterPro
IPR001050
Membranome
18
OPM protein
6ith
OPM superfamily
535

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Overview

Family members and Structure

Functions

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Clinical significance

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Map overview Semantic statistics

Syndecan

Nodes60
Edges59
Triples197
Avg. degree1.97
Density0.033333
Components1

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Syndecan

Top relations

related to References · 126
Syndecan → Abildgaard, An, Andtfolk, Anttonen, Bernfield, Biochemistry, Biological Chemistry, Bishop, BK, Blood, Breast Cancer Research, British Journal, Børset, Cancer, Cao, CD138, Cell, Cell Biology, Chang, Choi
related to Family members and Structure · 14
Syndecan → All, C-terminal, C1, C2, D-glucuronic, GAG, Glycosaminoglycan, In, N-acetylglucosaminyltransferase, N-terminal, Syndecans, The, This, Thr-Ser-Pro-rich
related to Functions · 13
Syndecan → Depending, EGF, FGF2, For, Functionality, Functions, Glycosaminoglycans, Growth, HGF, N-terminus, The, VEGF, Whereas
related to Expression · 5
Syndecan → For, In, It, Syndecans, These
related to Multiple Myeloma · 4
Syndecan → For, High, Many, Studies
AlphaFold · 2
Syndecan → IPR001050, PF01034
Available protein structures: · 2
Syndecan → IPR001050, PF01034
related to External links · 2
Syndecan → MBInfo, Syndecans
related to Osteoarthritis · 2
Syndecan → OA, Syndecan-4
InterPro · 1
Syndecan → IPR001050

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Important terminology

syndecans doi pmid syndecan-1 10 growth expression protein pmc expressed cell factors syndecan-4 cytoplasmic domain cells heparan family ectodomain transmembrane

Entity relationships Subject–Predicate–Object triples

SubjectPredicateObjectConfidenceSrc
SyndecanAlphaFoldIPR0010501.00infobox
SyndecanAlphaFoldPF010341.00infobox
SyndecanAvailable protein structures:IPR0010501.00infobox
SyndecanAvailable protein structures:PF010341.00infobox
SyndecanInterProIPR0010501.00infobox
SyndecanMembranome181.00infobox
SyndecanOPM protein6ith1.00infobox
SyndecanOPM superfamily5351.00infobox
SyndecanPDBIPR001050 PF01034 (ECOD; PDBsum)1.00infobox
SyndecanPfamPF010341.00infobox
SyndecanPROSITEPDOC007451.00infobox
SyndecanSCOP21ejp / SCOPe / SUPFAM1.00infobox
SyndecanSymbolSyndecan1.00infobox

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