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Integrin alpha M: Measurement, Function & Therapeutic significance

Integrin alpha M (ITGAM) is one protein subunit that forms heterodimeric integrin alpha-M beta-2 (αMβ2) molecule, also known as macrophage-1 antigen (Mac-1) or complement receptor 3 (CR3). ITGAM is also known as CR3A and cluster of differentiation molecule 11B (CD11B). The second chain of αMβ2 is the common integrin β2 subunit known as CD18, and integrin…

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Integrin alpha M topic overview

The analysis highlights Measurement, Function and Therapeutic significance as prominent areas in the source structure around Integrin alpha M.

Related topics
65
Source areas
3
Connected nodes
68
Extracted relationships
110
Concept neighborhoods
27
Bridge connections
68

What this topic covers Research coverage

Source areas are shown by the number of related topics found in each part of the analysis. Use smaller areas too: they can reveal specialized angles and content gaps.

Function · 24 topics
Overview · 21 topics
Therapeutic significance · 20 topics

Smaller areas are not necessarily less important. They contain fewer connections in this analysis and can be useful for finding specialized angles or coverage gaps.

Key facts & relationships

High-confidence facts extracted from structured source data. Use them as anchors for further research.

Aliases
ITGAM, CD11B, CR3A, MAC-1, MAC1A, MO1A, SLEB6, integrin subunit alpha M
Available structures
Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1BHO, 1BHQ, 1IDN, 1IDO, 1JLM, 1M1U, 1MF7, 1N9Z, 1NA5, 2LKE, 2LKJ, 3Q3G, 3QA3, 4M76, 4XW2
Band
16p11.2 · 7|7 F3
Bgee
monocyte · granulocyte · trabecular bone · bone marrow · blood
BioGPS
More reference expression data
Chr.
Chromosome 16 (human) · Chromosome 7 (mouse)

Explore all related topics Closing gaps

Browse the complete topic structure, not only the most central items. Less prominent entities and concepts can reveal missing angles, specialized context and useful research gaps. Each item opens a new analysis centered on that subject.

Overview

Function

Therapeutic significance

Advanced semantic analysis

Deeper signals for content research, entity SEO and topical coverage. The plain-language headings explain what each technical view is useful for.

How Integrin alpha M connects Entity context

The extracted context around Integrin alpha M shows recurring relationship patterns in the source. For example, Integrin alpha M → amyloid-beta binding, amyloid-beta clearance, apoptotic signaling pathway, cargo receptor activity, cell adhesion, cell surface, cell surface receptor signaling pathway involved in cell-cell signaling, cell-cell adhesion via plasma-membrane adhesion molecules, complement component C3b binding, complement-mediated synapse pruning, cytokine-mediated signaling pathway, ectodermal cell differentiation, external side of plasma membrane, extracellular exosome, extracellular matrix organization, extracellular space, forebrain development, heat shock protein binding, immune system process, innate immune response Another extracted example is Integrin alpha M → appendix, blood, bone marrow, bone marrow cell, decidua, dentate gyrus of hippocampal formation granule cell, esophagus, granulocyte, hippocampus proper, ileum, jejunum, monocyte, spleen, striatum of neuraxis, trabecular bone, upper lobe of left lung, uterus. Use these groups to spot repeated connection types before inspecting the individual relationships.

Integrin alpha M

Top relations

Gene ontology · 49
Integrin alpha M → amyloid-beta binding, amyloid-beta clearance, apoptotic signaling pathway, cargo receptor activity, cell adhesion, cell surface, cell surface receptor signaling pathway involved in cell-cell signaling, cell-cell adhesion via plasma-membrane adhesion molecules, complement component C3b binding, complement-mediated synapse pruning, cytokine-mediated signaling pathway, ectodermal cell differentiation, external side of plasma membrane, extracellular exosome, extracellular matrix organization, extracellular space, forebrain development, heat shock protein binding, immune system process, innate immune response
Bgee · 17
Integrin alpha M → appendix, blood, bone marrow, bone marrow cell, decidua, dentate gyrus of hippocampal formation granule cell, esophagus, granulocyte, hippocampus proper, ileum, jejunum, monocyte, spleen, striatum of neuraxis, trabecular bone, upper lobe of left lung, uterus
RNA expression pattern · 17
Integrin alpha M → appendix, blood, bone marrow, bone marrow cell, decidua, dentate gyrus of hippocampal formation granule cell, esophagus, granulocyte, hippocampus proper, ileum, jejunum, monocyte, spleen, striatum of neuraxis, trabecular bone, upper lobe of left lung, uterus
Band · 2
Integrin alpha M → 16p11.2, 7|7 F3
Chr. · 2
Integrin alpha M → Chromosome 16 (human), Chromosome 7 (mouse)
End · 2
Integrin alpha M → 127,717,663 bp, 31,332,892 bp
Aliases · 1
Integrin alpha M → ITGAM, CD11B, CR3A, MAC-1, MAC1A, MO1A, SLEB6, integrin subunit alpha M
Available structures · 1
Integrin alpha M → Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1BHO, 1BHQ, 1IDN, 1IDO, 1JLM, 1M1U, 1MF7, 1N9Z, 1NA5, 2LKE, 2LKJ, 3Q3G, 3QA3, 4M76, 4XW2
BioGPS · 1
Integrin alpha M → More reference expression data
Databases · 1
Integrin alpha M → NCBI: entry; OMA: entry

Important terminology

Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.

Important terminology

cd11b itgam integrin also immune cytokines adhesion bp lupus migration involved human αmβ2 cell activation leukocyte leukocytes chr subunit complement

Integrin alpha M relationships Subject–Predicate–Object triples

TTTA extracted 110 structured relationships around Integrin alpha M. Examples in this analysis include Integrin alpha M → Aliases → ITGAM, CD11B, CR3A, MAC-1, MAC1A, MO1A, SLEB6, integrin subunit alpha M and Integrin alpha M → Available structures → Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1BHO, 1BHQ, 1IDN, 1IDO, 1JLM, 1M1U, 1MF7, 1N9Z, 1NA5, 2LKE, 2LKJ, 3Q3G, 3QA3, 4M76, 4XW2. The table shows each extracted connection, where it came from and its confidence.

SubjectPredicateObjectConfidenceSrc
Integrin alpha MAliasesITGAM, CD11B, CR3A, MAC-1, MAC1A, MO1A, SLEB6, integrin subunit alpha M1.00infobox
Integrin alpha MAvailable structuresAvailable structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1BHO, 1BHQ, 1IDN, 1IDO, 1JLM, 1M1U, 1MF7, 1N9Z, 1NA5, 2LKE, 2LKJ, 3Q3G, 3QA3, 4M76, 4XW21.00infobox
Integrin alpha MBand16p11.21.00infobox
Integrin alpha MBand7|7 F31.00infobox
Integrin alpha MBgeemonocyte1.00infobox
Integrin alpha MBgeegranulocyte1.00infobox
Integrin alpha MBgeetrabecular bone1.00infobox
Integrin alpha MBgeebone marrow1.00infobox
Integrin alpha MBgeeblood1.00infobox
Integrin alpha MBgeebone marrow cell1.00infobox
Integrin alpha MBgeespleen1.00infobox
Integrin alpha MBgeeappendix1.00infobox
Integrin alpha MBgeeupper lobe of left lung1.00infobox
Integrin alpha MBgeedecidua1.00infobox
Integrin alpha MBgeeileum1.00infobox
Integrin alpha MBgeejejunum1.00infobox
Integrin alpha MBgeedentate gyrus of hippocampal formation granule cell1.00infobox
Integrin alpha MBgeehippocampus proper1.00infobox
Integrin alpha MBgeeesophagus1.00infobox
Integrin alpha MBgeestriatum of neuraxis1.00infobox
Integrin alpha MBgeeuterus1.00infobox
Integrin alpha MBioGPSMore reference expression data1.00infobox
Integrin alpha MChr.Chromosome 16 (human)1.00infobox
Integrin alpha MChr.Chromosome 7 (mouse)1.00infobox
Integrin alpha MDatabasesNCBI: entry; OMA: entry1.00infobox
Integrin alpha MEnd31,332,892 bp1.00infobox
Integrin alpha MEnd127,717,663 bp1.00infobox
Integrin alpha MEnsemblENSG000001698961.00infobox
Integrin alpha MEntrez36841.00infobox
Integrin alpha MExternal IDsOMIM: 120980; MGI: 96607; GeneCards: ITGAM1.00infobox

Related concept clusters Concept neighborhoods

The concept neighborhoods around Integrin alpha M bring nearby vocabulary together. In this analysis, examples include Subunit, Integrin and Αmβ2. Use the clusters to find adjacent concepts and terminology that may deserve separate research.

  • Integrin alpha M
    • Subunit
    • Integrin
    • Αmβ2
    • Mac-1
    • Involved
    • Itgam
    • Cellular
    • Known
    • System
    • Chromosome
    • Complement
    • Expressed
  • integrin alpha m
    • Subunit
    • Αmβ2
    • Integrin
    • Mac-1
    • Involved
    • Itgam
    • Cellular
    • Known
    • System
    • Also
    • Chromosome
    • Complement
  • complement receptor
    • System
    • Phagocytosis
    • Involved
    • One
    • Integrin
    • Itgam
    • Cellular
    • Known
    • Αmβ2
    • Band
    • Chromosome
    • Expressed
  • integrin
    • Subunit
    • Αmβ2
    • Mac-1
    • Involved
    • Itgam
    • Cellular
    • Known
    • System
    • Chromosome
    • Complement
    • Expressed
    • Adhesion
  • innate immune system
    • Leukocyte
    • Cellular
    • System
    • Inflammation
    • Phagocytosis
    • Adhesion
    • Cells
    • Involved
    • Leukocytes
    • Macrophages
    • Migration
    • Regulation
  • adhesion
    • Migration
    • Cellular
    • Phagocytosis
    • Inflammation
    • Involved
    • Leukocyte
    • Activation
    • Cell
    • Immune
    • Integrin
    • Itgam
    • Alpha
  • complement system
    • System
    • Phagocytosis
    • Involved
    • One
    • Integrin
    • Cellular
    • Macrophages
    • Αmβ2
    • Itgam
    • Band
    • Chromosome
    • Known
  • complement component 3b
    • System
    • Phagocytosis
    • Involved
    • One
    • Integrin
    • Itgam
    • Cellular
    • Known
    • Αmβ2
    • Band
    • Chromosome
    • Expressed

Connections between topic areas Semantic bridges

For Integrin alpha M, one of the stronger structural bridges in this analysis connects Integrin alpha M with Function. Bridges highlight paths between different parts of the map and can reveal research angles that are easy to miss in a flat list.

Min side: 3
Integrin alpha MFunction · splits 44 ⟂ 25
Integrin alpha MOverview · splits 47 ⟂ 22
Integrin alpha MTherapeutic significance · splits 48 ⟂ 21

Map overview Semantic statistics

Integrin alpha M

Nodes69
Edges68
Triples110
Avg. degree1.97
Density0.028986
Components1

Source & methodology

TTTA analyzes the structure around Integrin alpha M to surface related topics, entities, relationships, concept neighborhoods and bridge connections. Use the map to explore areas such as Measurement, Function & Therapeutic significance, including less central topics that may reveal useful research gaps. Automatically extracted connections are research leads rather than rewritten encyclopedia content.

Source: Wikipedia — Integrin alpha M · EN edition · Analysis: TopicsToTalkAbout

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