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CRYAB

Alpha-crystallin B chain is a protein that in humans is encoded by the CRYAB gene. It is part of the small heat shock protein family and functions as molecular chaperone that primarily binds misfolded proteins to prevent protein aggregation, as well as inhibit apoptosis and contribute to intracellular architecture. Post-translational modifications…

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Interactions

7 related topics

Structure

2 related topics

Clinical significance

2 related topics

Function

1 related topics

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Aliases
CRYAB, CMD1II, CRYA2, CTPP2, CTRCT16, HEL-S-101, HSPB5, MFM2, crystallin alpha B
Available structures
Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes2KLR, 2N0K, 2WJ7, 2Y1Y, 2Y1Z, 2Y22, 2YGD, 3L1G, 3SGM, 3SGN, 3SGO, 3SGP, 3SGR, 3SGS, 4M5S, 4M5T, 3J07
Band
11q23.1 · 9 A5.3|9 27.75 cM
Bgee
myocardium of left ventricle · middle frontal gyrus · right auricle of heart · C1 segment · olfactory bulb
BioGPS
More reference expression data
Chr.
Chromosome 11 (human) · Chromosome 9 (mouse)

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Overview

Structure

Function

Clinical significance

Interactions

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Map overview Semantic statistics

CRYAB

Nodes20
Edges19
Triples144
Avg. degree1.9
Density0.1
Components1

How this topic connects Entity context

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CRYAB

Top relations

Gene ontology · 61
CRYAB → actin filament bundle, ageing, amyloid-beta binding, apoptotic process involved in morphogenesis, axon, camera-type eye development, cardiac myofibril, cell surface, cellular response to gamma radiation, contractile fiber, cytoplasm, cytoskeletal protein binding, cytosol, dendritic spine, extracellular exosome, Golgi apparatus, I band, identical protein binding, lens development in camera-type eye, M band
Bgee · 20
CRYAB → apex of heart, C1 segment, ciliary body, epithelium of lens, gastrula, inferior ganglion of vagus nerve, intercostal muscle, iris, masseter muscle, middle frontal gyrus, muscle of thigh, myocardium of left ventricle, myocardium of ventricle, olfactory bulb, optic nerve, retinal pigment epithelium, right auricle of heart, right ventricle, sciatic nerve, soleus muscle
RNA expression pattern · 20
CRYAB → apex of heart, C1 segment, ciliary body, epithelium of lens, gastrula, inferior ganglion of vagus nerve, intercostal muscle, iris, masseter muscle, middle frontal gyrus, muscle of thigh, myocardium of left ventricle, myocardium of ventricle, olfactory bulb, optic nerve, retinal pigment epithelium, right auricle of heart, right ventricle, sciatic nerve, soleus muscle
related to Clinical significance · 10
CRYAB → Although, Alzheimer’s, ER, ER-anchored, HNSCC, Mutations, Parkinson’s, The, Though, Thus
related to Interactions · 5
CRYAB → CRYAA, CRYBB2, CRYGC, Hsp27, HSPB2
Band · 2
CRYAB → 11q23.1, 9 A5.3|9 27.75 cM
Chr. · 2
CRYAB → Chromosome 11 (human), Chromosome 9 (mouse)
End · 2
CRYAB → 111,923,722 bp, 50,667,936 bp
Aliases · 1
CRYAB → CRYAB, CMD1II, CRYA2, CTPP2, CTRCT16, HEL-S-101, HSPB5, MFM2, crystallin alpha B
Available structures · 1
CRYAB → Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes2KLR, 2N0K, 2WJ7, 2Y1Y, 2Y1Z, 2Y22, 2YGD, 3L1G, 3SGM, 3SGN, 3SGO, 3SGP, 3SGR, 3SGS, 4M5S, 4M5T, 3J07

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Important terminology

protein gene crystallins bp chr human band alpha lens αbc also chaperone chromosome 11 heat proteins disease expression molecular intracellular

Entity relationships Subject–Predicate–Object triples

SubjectPredicateObjectConfidenceSrc
CRYABAliasesCRYAB, CMD1II, CRYA2, CTPP2, CTRCT16, HEL-S-101, HSPB5, MFM2, crystallin alpha B1.00infobox
CRYABAvailable structuresAvailable structuresPDBOrtholog search: PDBe RCSB List of PDB id codes2KLR, 2N0K, 2WJ7, 2Y1Y, 2Y1Z, 2Y22, 2YGD, 3L1G, 3SGM, 3SGN, 3SGO, 3SGP, 3SGR, 3SGS, 4M5S, 4M5T, 3J071.00infobox
CRYABBand11q23.11.00infobox
CRYABBand9 A5.3|9 27.75 cM1.00infobox
CRYABBgeemyocardium of left ventricle1.00infobox
CRYABBgeemiddle frontal gyrus1.00infobox
CRYABBgeeright auricle of heart1.00infobox
CRYABBgeeC1 segment1.00infobox
CRYABBgeeolfactory bulb1.00infobox
CRYABBgeeapex of heart1.00infobox
CRYABBgeemuscle of thigh1.00infobox
CRYABBgeeoptic nerve1.00infobox
CRYABBgeeinferior ganglion of vagus nerve1.00infobox
CRYABBgeeright ventricle1.00infobox
CRYABBgeeepithelium of lens1.00infobox
CRYABBgeeciliary body1.00infobox
CRYABBgeeiris1.00infobox
CRYABBgeemyocardium of ventricle1.00infobox
CRYABBgeesoleus muscle1.00infobox
CRYABBgeesciatic nerve1.00infobox
CRYABBgeegastrula1.00infobox
CRYABBgeeintercostal muscle1.00infobox
CRYABBgeeretinal pigment epithelium1.00infobox
CRYABBgeemasseter muscle1.00infobox
CRYABBioGPSMore reference expression data1.00infobox
CRYABChr.Chromosome 11 (human)1.00infobox
CRYABChr.Chromosome 9 (mouse)1.00infobox
CRYABDatabasesNCBI: entry; OMA: entry1.00infobox
CRYABEnd111,923,722 bp1.00infobox
CRYABEnd50,667,936 bp1.00infobox

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