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ERCC4 is a protein designated as DNA repair endonuclease XPF that in humans is encoded by the ERCC4 gene. Together with ERCC1, ERCC4 forms the ERCC1-XPF enzyme complex that participates in DNA repair and DNA recombination.
The analysis highlights Art, Clinical significance and Overview as prominent areas in the source structure around ERCC4.
Source areas are shown by the number of related topics found in each part of the analysis. Use smaller areas too: they can reveal specialized angles and content gaps.
Smaller areas are not necessarily less important. They contain fewer connections in this analysis and can be useful for finding specialized angles or coverage gaps.
High-confidence facts extracted from structured source data. Use them as anchors for further research.
Browse the complete topic structure, not only the most central items. Less prominent entities and concepts can reveal missing angles, specialized context and useful research gaps. Each item opens a new analysis centered on that subject.
Deeper signals for content research, entity SEO and topical coverage. The plain-language headings explain what each technical view is useful for.
The extracted context around ERCC4 shows recurring relationship patterns in the source. For example, ERCC4 → 3' overhang single-stranded DNA endodeoxyribonuclease activity, cellular response to DNA damage stimulus, cellular response to UV, damaged DNA binding, DNA binding, DNA repair, double-strand break repair via homologous recombination, double-strand break repair via nonhomologous end joining, endodeoxyribonuclease activity, endonuclease activity, ERCC4-ERCC1 complex, global genome nucleotide-excision repair, hydrolase activity, identical protein binding, interstrand cross-link repair, negative regulation of double-stranded telomeric DNA binding, negative regulation of protection from non-homologous end joining at telomere, negative regulation of telomerase activity, negative regulation of telomere maintenance, negative regulation of telomere maintenance via telomere lengthening Another extracted example is ERCC4 → Achilles tendon, ganglionic eminence, gonad, lumbar subsegment of spinal cord, medullary collecting duct, proximal tubule, right kidney, right testis, secondary oocyte, seminiferous tubule, sperm, spermatid, spermatocyte, stromal cell of endometrium, superior frontal gyrus, sural nerve, testicle, thymus, ventricular zone. Use these groups to spot repeated connection types before inspecting the individual relationships.
Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.
dna xpf repair ercc1 human gene nuclease protein ercc1-xpf colon cells mutations crypts bp normal activity two also syndrome chr
TTTA extracted 171 structured relationships around ERCC4. Examples in this analysis include ERCC4 → Aliases → ERCC4, ERCC11, FANCQ, RAD1, XPF, XFEPS, excision repair cross-complementation group 4, ERCC excision repair 4, endonuclease catalytic subunit, RAD1 checkpoint DNA exonuclease, c… and ERCC4 → Available structures → Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1Z00, 2A1J, 2MUT, 2KN7, 2AQ0. The table shows each extracted connection, where it came from and its confidence.
| Subject | Predicate | Object | Confidence | Src |
|---|---|---|---|---|
| ERCC4 | Aliases | ERCC4, ERCC11, FANCQ, RAD1, XPF, XFEPS, excision repair cross-complementation group 4, ERCC excision repair 4, endonuclease catalytic subunit, RAD1 checkpoint DNA exonuclease, c… | 1.00 | infobox |
| ERCC4 | Available structures | Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1Z00, 2A1J, 2MUT, 2KN7, 2AQ0 | 1.00 | infobox |
| ERCC4 | Band | 16p13.12 | 1.00 | infobox |
| ERCC4 | Band | 16|16 A1 | 1.00 | infobox |
| ERCC4 | Bgee | testicle | 1.00 | infobox |
| ERCC4 | Bgee | sperm | 1.00 | infobox |
| ERCC4 | Bgee | gonad | 1.00 | infobox |
| ERCC4 | Bgee | Achilles tendon | 1.00 | infobox |
| ERCC4 | Bgee | stromal cell of endometrium | 1.00 | infobox |
| ERCC4 | Bgee | ganglionic eminence | 1.00 | infobox |
| ERCC4 | Bgee | secondary oocyte | 1.00 | infobox |
| ERCC4 | Bgee | right testis | 1.00 | infobox |
| ERCC4 | Bgee | ventricular zone | 1.00 | infobox |
| ERCC4 | Bgee | sural nerve | 1.00 | infobox |
| ERCC4 | Bgee | seminiferous tubule | 1.00 | infobox |
| ERCC4 | Bgee | spermatid | 1.00 | infobox |
| ERCC4 | Bgee | spermatocyte | 1.00 | infobox |
| ERCC4 | Bgee | proximal tubule | 1.00 | infobox |
| ERCC4 | Bgee | lumbar subsegment of spinal cord | 1.00 | infobox |
| ERCC4 | Bgee | superior frontal gyrus | 1.00 | infobox |
| ERCC4 | Bgee | right kidney | 1.00 | infobox |
| ERCC4 | Bgee | medullary collecting duct | 1.00 | infobox |
| ERCC4 | Bgee | thymus | 1.00 | infobox |
| ERCC4 | BioGPS | More reference expression data | 1.00 | infobox |
| ERCC4 | Chr. | Chromosome 16 (human) | 1.00 | infobox |
| ERCC4 | Chr. | Chromosome 16 (mouse) | 1.00 | infobox |
| ERCC4 | Databases | NCBI: entry; OMA: entry | 1.00 | infobox |
| ERCC4 | End | 13,952,348 bp | 1.00 | infobox |
| ERCC4 | End | 12,968,481 bp | 1.00 | infobox |
| ERCC4 | Ensembl | ENSG00000175595 | 1.00 | infobox |
The concept neighborhoods around ERCC4 bring nearby vocabulary together. In this analysis, examples include Xpf, Mutations and Repair. Use the clusters to find adjacent concepts and terminology that may deserve separate research.
For ERCC4, one of the stronger structural bridges in this analysis connects ERCC4 with Overview. Bridges highlight paths between different parts of the map and can reveal research angles that are easy to miss in a flat list.
TTTA analyzes the structure around ERCC4 to surface related topics, entities, relationships, concept neighborhoods and bridge connections. Use the map to explore areas such as Art, Clinical significance & Overview, including less central topics that may reveal useful research gaps. Automatically extracted connections are research leads rather than rewritten encyclopedia content.
Source: Wikipedia — ERCC4 · EN edition · Analysis: TopicsToTalkAbout