Research any topic before you write.

Find related topics. | Discover entities. | See connections. | Build a topical map.

ERCC4

ERCC4 is a protein designated as DNA repair endonuclease XPF that in humans is encoded by the ERCC4 gene. Together with ERCC1, ERCC4 forms the ERCC1-XPF enzyme complex that participates in DNA repair and DNA recombination.

Art, Clinical significance & Overview

Use the mouse wheel or two fingers (on touchscreens) to zoom in and out of the map.

Research this topic

Explore the main themes, entities and connections around ERCC4. Start with the topic map, then use the sections below for research and deeper semantic analysis.

Explore this topic

Start with a few of the strongest sections from the source topic. These are research directions, not a list of keywords you must use.

Clinical significance

12 related topics

Overview

14 related topics

Key facts & relationships

High-confidence facts extracted from structured source data. Use them as anchors for further research.

Aliases
ERCC4, ERCC11, FANCQ, RAD1, XPF, XFEPS, excision repair cross-complementation group 4, ERCC excision repair 4, endonuclease catalytic subunit, RAD1 checkpoint DNA exonuclease, c…
Available structures
Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1Z00, 2A1J, 2MUT, 2KN7, 2AQ0
Band
16p13.12 · 16|16 A1
Bgee
testicle · sperm · gonad · Achilles tendon · stromal cell of endometrium
BioGPS
More reference expression data
Chr.
Chromosome 16 (human) · Chromosome 16 (mouse)

Topics to explore

Browse the full topic structure. Each item opens a new analysis centered on that subject.

Overview

Clinical significance

Advanced semantic analysis

Deeper signals for content research, entity SEO and topical coverage. The plain-language headings explain what each technical view is useful for.

Map overview Semantic statistics

ERCC4

Nodes29
Edges28
Triples171
Avg. degree1.93
Density0.068966
Components1

How this topic connects Entity context

See the strongest relationship patterns around the current topic before diving into the raw triples.

ERCC4

Top relations

Gene ontology · 47
ERCC4 → 3' overhang single-stranded DNA endodeoxyribonuclease activity, cellular response to DNA damage stimulus, cellular response to UV, damaged DNA binding, DNA binding, DNA repair, double-strand break repair via homologous recombination, double-strand break repair via nonhomologous end joining, endodeoxyribonuclease activity, endonuclease activity, ERCC4-ERCC1 complex, global genome nucleotide-excision repair, hydrolase activity, identical protein binding, interstrand cross-link repair, negative regulation of double-stranded telomeric DNA binding, negative regulation of protection from non-homologous end joining at telomere, negative regulation of telomerase activity, negative regulation of telomere maintenance, negative regulation of telomere maintenance via telomere lengthening
Bgee · 19
ERCC4 → Achilles tendon, ganglionic eminence, gonad, lumbar subsegment of spinal cord, medullary collecting duct, proximal tubule, right kidney, right testis, secondary oocyte, seminiferous tubule, sperm, spermatid, spermatocyte, stromal cell of endometrium, superior frontal gyrus, sural nerve, testicle, thymus, ventricular zone
RNA expression pattern · 19
ERCC4 → Achilles tendon, ganglionic eminence, gonad, lumbar subsegment of spinal cord, medullary collecting duct, proximal tubule, right kidney, right testis, secondary oocyte, seminiferous tubule, sperm, spermatid, spermatocyte, stromal cell of endometrium, superior frontal gyrus, sural nerve, testicle, thymus, ventricular zone
related to ERCC4 (XPF) deficiency in the colon epithelium adjacent to and within cancers · 14
ERCC4 → Although, An, As, Deficiencies, DNA, Elledge, ERCC1, Harper, However, PMS2, The, These, When ERCC4, XPF
related to Protein · 11
ERCC4 → DNA, ERCC1, ERCC1-XPF, Figure, II, In, One ERCC1, The C-terminal, The ERCC4/XPF, The N-terminal, XPF
related to ERCC4 (XPF) in the normal colon · 10
ERCC4 → Cells, Crypts, DNA, ERCC1, If, PMS2, The, There, This, XPF
related to Gene · 9
ERCC4 → Chinese, CHO, DNA, Excision, Multiple, Reflecting, The, UV, XPF
related to Cockayne syndrome (CS) · 7
ERCC4 → Cockayne, CS, Most XP-F, Mutations, These, XF-E, XP
related to Xeroderma pigmentosum (XP) · 6
ERCC4 → Diagnostic, Some, These, UV, XP, XP-F
related to Fanconi anemia · 5
ERCC4 → DNA, FA, Fanconi, FANCQ, Several

Important terminology Word statistics

Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.

Important terminology

dna xpf repair ercc1 human gene nuclease protein ercc1-xpf colon cells mutations crypts bp normal activity two also syndrome chr

Entity relationships Subject–Predicate–Object triples

SubjectPredicateObjectConfidenceSrc
ERCC4AliasesERCC4, ERCC11, FANCQ, RAD1, XPF, XFEPS, excision repair cross-complementation group 4, ERCC excision repair 4, endonuclease catalytic subunit, RAD1 checkpoint DNA exonuclease, c…1.00infobox
ERCC4Available structuresAvailable structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1Z00, 2A1J, 2MUT, 2KN7, 2AQ01.00infobox
ERCC4Band16p13.121.00infobox
ERCC4Band16|16 A11.00infobox
ERCC4Bgeetesticle1.00infobox
ERCC4Bgeesperm1.00infobox
ERCC4Bgeegonad1.00infobox
ERCC4BgeeAchilles tendon1.00infobox
ERCC4Bgeestromal cell of endometrium1.00infobox
ERCC4Bgeeganglionic eminence1.00infobox
ERCC4Bgeesecondary oocyte1.00infobox
ERCC4Bgeeright testis1.00infobox
ERCC4Bgeeventricular zone1.00infobox
ERCC4Bgeesural nerve1.00infobox
ERCC4Bgeeseminiferous tubule1.00infobox
ERCC4Bgeespermatid1.00infobox
ERCC4Bgeespermatocyte1.00infobox
ERCC4Bgeeproximal tubule1.00infobox
ERCC4Bgeelumbar subsegment of spinal cord1.00infobox
ERCC4Bgeesuperior frontal gyrus1.00infobox
ERCC4Bgeeright kidney1.00infobox
ERCC4Bgeemedullary collecting duct1.00infobox
ERCC4Bgeethymus1.00infobox
ERCC4BioGPSMore reference expression data1.00infobox
ERCC4Chr.Chromosome 16 (human)1.00infobox
ERCC4Chr.Chromosome 16 (mouse)1.00infobox
ERCC4DatabasesNCBI: entry; OMA: entry1.00infobox
ERCC4End13,952,348 bp1.00infobox
ERCC4End12,968,481 bp1.00infobox
ERCC4EnsemblENSG000001755951.00infobox

Related concept clusters Concept neighborhoods

These clusters group vocabulary that occurs around closely connected concepts in the source material.

    Connections between topic areas Semantic bridges

    Bridges can reveal useful research angles that are easy to miss in a flat list of related terms.

    Min side: 3
    For writers, content strategists, SEOs, marketers and creators — from quick topic research to advanced semantic analysis.