Research any topic before you write.

Find related topics. | Discover entities. | See connections. | Build a topical map.

Clomifene: History, Applications & Research

Clomifene, also known as clomiphene, is a medication used to treat infertility in women who do not ovulate, including those with polyendocrine metabolic ovarian syndrome. It is taken by mouth.

Language: English [EN]
Use the mouse wheel or two fingers (on touchscreens) to zoom in and out of the map.
100%
More settings
100% 100% 100% 100% 100%

Clomifene topic overview

The analysis highlights History, Applications and Research as prominent areas in the source structure around Clomifene.

Related topics
134
Source areas
9
Connected nodes
143
Extracted relationships
155
Concept neighborhoods
38
Bridge connections
143

What this topic covers Research coverage

Source areas are shown by the number of related topics found in each part of the analysis. Use smaller areas too: they can reveal specialized angles and content gaps.

Overview · 88 topics
History · 13 topics
Side effects · 13 topics
Pharmacology · 10 topics
Research · 4 topics
Medical uses · 2 topics
Prohibited use in sports · 2 topics
Chemistry · 1 topics
Contraindications · 1 topics

Smaller areas are not necessarily less important. They contain fewer connections in this analysis and can be useful for finding specialized angles or coverage gaps.

Key facts & relationships

High-confidence facts extracted from structured source data. Use them as anchors for further research.

3D model (JSmol)
Interactive image
AHFS/Drugs.com
Monograph
ATC code
G03GB02 (WHO)
Bioavailability
High (>90%)
CAS Number
911-45-5 Y
ChEBI
CHEBI:3752 Y

Explore all related topics Closing gaps

Browse the complete topic structure, not only the most central items. Less prominent entities and concepts can reveal missing angles, specialized context and useful research gaps. Each item opens a new analysis centered on that subject.

Overview

Medical uses

Prohibited use in sports

Contraindications

Side effects

Pharmacology

Chemistry

History

Research

Advanced semantic analysis

Deeper signals for content research, entity SEO and topical coverage. The plain-language headings explain what each technical view is useful for.

How Clomifene connects Entity context

The extracted context around Clomifene shows recurring relationship patterns in the source. For example, Clomifene → Beclom, Bemot, Biogen, Blesifen, Chloramiphene, Clofert, Clomene, ClomHEXAL, Clomi, Clomid, Clomidac, Clomifen, Clomifencitrat, Clomifeni, Clomifeno, Clomifert, Clomifène, Clomihexal, Clomiphen, Clomiphene Another extracted example is Clomifene → Clinical, Clomid, Cosmetic Act, Drug, Federal Food, Frank Palopoli, IND, Investigational New Drug Application, It, Kefauver Harris Amendment, Merrell, Merrell Chemical Company, November, Scientists, Short-term, William. Use these groups to spot repeated connection types before inspecting the individual relationships.

Clomifene

Top relations

related to Brand names · 76
Clomifene → Beclom, Bemot, Biogen, Blesifen, Chloramiphene, Clofert, Clomene, ClomHEXAL, Clomi, Clomid, Clomidac, Clomifen, Clomifencitrat, Clomifeni, Clomifeno, Clomifert, Clomifène, Clomihexal, Clomiphen, Clomiphene
related to history · 16
Clomifene → Clinical, Clomid, Cosmetic Act, Drug, Federal Food, Frank Palopoli, IND, Investigational New Drug Application, It, Kefauver Harris Amendment, Merrell, Merrell Chemical Company, November, Scientists, Short-term, William
related to Pharmacokinetics · 7
Clomifene → CYP2D6, In, Individuals, N-desethylclomiphene, N-desethylclomiphenewas, N-oxide, Primarily
related to Prohibited use in sports · 6
Clomifene → Because, It, Like, S4, The World Anti-Doping Agency, WADA
related to Cancer risk · 4
Clomifene → Some, Subsequent, This, Thyroid
related to Chemistry · 4
Clomifene → It, The, The United States Pharmacopeia, These
Legal status · 3
Clomifene → AU: S4 (Prescription only), UK: POM (Prescription only), US: ℞-only
is a · 3
Clomifene → long-acting ER ligand, prodrug being activated via similar metabolic pathways as the related triphenylethylene SERMs tamoxifen and toremifene, prodrug most importantly of 4-hydroxyclomifene and 4-hydroxy-N-desethylclomiphene
related to Reproductive medicine · 3
Clomifene → Evidence, In, The
has effect · 2
Clomifene → Less, The

Important terminology

Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.

Important terminology

testosterone levels use cancer effects treatment found used estrogen liver enclomifene zuclomifene 4-hydroxyclomifene ovarian days receptor increase men include ovulation

Clomifene relationships Subject–Predicate–Object triples

TTTA extracted 155 structured relationships around Clomifene. Examples in this analysis include Clomifene → 3D model (JSmol) → Interactive image and Clomifene → AHFS/Drugs.com → Monograph. The table shows each extracted connection, where it came from and its confidence.

SubjectPredicateObjectConfidenceSrc
Clomifene3D model (JSmol)Interactive image1.00infobox
ClomifeneAHFS/Drugs.comMonograph1.00infobox
ClomifeneATC codeG03GB02 (WHO)1.00infobox
ClomifeneBioavailabilityHigh (>90%)1.00infobox
ClomifeneCAS Number911-45-5 Y1.00infobox
ClomifeneChEBICHEBI:3752 Y1.00infobox
ClomifeneChEMBLChEMBL2355051 Y1.00infobox
ClomifeneChemSpider2698 Y1.00infobox
ClomifeneCompTox Dashboard (EPA)DTXSID10228431.00infobox
ClomifeneDrug classSelective estrogen receptor modulator; Progonadotropin1.00infobox
ClomifeneDrugBankDB00882 Y1.00infobox
ClomifeneECHA InfoCard100.011.8261.00infobox
ClomifeneElimination half-life4–7 days active metabolites: 4-OH-CLO : 13–34 hrs 4-OH-DE-CLO : 15–37 hrs1.00infobox
ClomifeneExcretionMainly feces, some in urine1.00infobox
ClomifeneFormulaC26H28ClNO1.00infobox
ClomifeneIUPHAR/BPS41591.00infobox
ClomifeneKEGGD07726 Y1.00infobox
ClomifeneLegal statusAU: S4 (Prescription only)1.00infobox
ClomifeneLegal statusUK: POM (Prescription only)1.00infobox
ClomifeneLegal statusUS: ℞-only1.00infobox
ClomifeneLicense dataUS DailyMed: Clomiphene1.00infobox
ClomifeneMedlinePlusa6827041.00infobox
ClomifeneMetabolismLiver CYP2D6 (with enterohepatic circulation)1.00infobox
ClomifeneMetabolites4-Hydroxyclomiphene (4-OH-CLO), 4-Hydroxy-N-desethylclomiphene (4-OH-DE-CLO)1.00infobox
ClomifeneMolar mass405.97 g·mol−11.00infobox
ClomifeneOther namesClomiphene; Chloramifene; Chloramiphene; MRL-41; MRL/41; NSC-357701.00infobox
ClomifenePregnancy categoryAU: B31.00infobox
ClomifenePubChem CID28001.00infobox
ClomifeneRoutes of administrationBy mouth1.00infobox
ClomifeneTrade namesClomid, Serophene, others1.00infobox

Related concept clusters Concept neighborhoods

The concept neighborhoods around Clomifene bring nearby vocabulary together. In this analysis, examples include Use, Levels and Days. Use the clusters to find adjacent concepts and terminology that may deserve separate research.

  • Clomifene
    • Use
    • Levels
    • Days
    • Increase
    • Cancer
    • Found
    • Testosterone
    • Used
    • Treatment
    • Due
    • Men
    • 4-hydroxyclomifene
  • clomifene
    • Use
    • Levels
    • Days
    • Increase
    • Cancer
    • Found
    • Testosterone
    • Used
    • Treatment
    • Due
    • Men
    • 4-hydroxyclomifene
  • ovarian cancer
    • Risk
    • Include
    • Side
    • Use
    • Due
    • High
    • Pregnancy
    • Effects
    • Liver
    • Treatment
    • Increase
    • Drug
  • selective estrogen receptor modulator
    • Selective
    • Receptor
    • Modulator
    • High
    • Medical
    • Pregnancy
    • Ovulation
    • Due
    • Days
    • Reproductive
    • Side
    • Gynecomastia
  • gynecomastia
    • Half-life
    • Medical
    • Treatment
    • Due
    • Zuclomifene
    • Days
    • Modulator
    • Selective
    • Reproductive
    • Side
    • High
    • Metabolites
  • estrogen receptor
    • Receptor
    • Modulator
    • Selective
    • High
    • Medical
    • Pregnancy
    • Ovulation
    • Due
    • Days
    • Reproductive
    • Side
    • Levels
  • estrogen
    • Receptor
    • Modulator
    • Selective
    • High
    • Medical
    • Pregnancy
    • Ovulation
    • Due
    • Days
    • Levels
    • Reproductive
    • Side
  • breast cancer
    • Risk
    • Side
    • Use
    • Due
    • Effects
    • Treatment
    • Drug
    • Tamoxifen
    • Ovarian
    • Increase
    • Clomifene
    • Modulator

Connections between topic areas Semantic bridges

For Clomifene, one of the stronger structural bridges in this analysis connects Clomifene with Overview. Bridges highlight paths between different parts of the map and can reveal research angles that are easy to miss in a flat list.

Min side: 3
ClomifeneOverview · splits 55 ⟂ 89
ClomifeneSide effects · splits 130 ⟂ 14
ClomifeneHistory · splits 130 ⟂ 14
ClomifenePharmacology · splits 133 ⟂ 11
ClomifeneResearch · splits 139 ⟂ 5
ClomifeneMedical uses · splits 141 ⟂ 3
ClomifeneProhibited use in sports · splits 141 ⟂ 3

Map overview Semantic statistics

Clomifene

Nodes144
Edges143
Triples155
Avg. degree1.99
Density0.013889
Components1

Source & methodology

TTTA analyzes the structure around Clomifene to surface related topics, entities, relationships, concept neighborhoods and bridge connections. Use the map to explore areas such as History, Applications & Research, including less central topics that may reveal useful research gaps. Automatically extracted connections are research leads rather than rewritten encyclopedia content.

Source: Wikipedia — Clomifene · EN edition · Analysis: TopicsToTalkAbout

For writers, content strategists, SEOs, marketers and creators — from quick topic research to advanced semantic analysis.