ISL1

Use the mouse wheel or two fingers (on touchscreens) to zoom in and out of the map.

Export map as:

Research this topic

Explore the main themes, entities and connections around ISL1. Start with the topic map, then use the sections below for research and deeper semantic analysis.

Explore this topic

Start with a few of the strongest sections from the source topic. These are research directions, not a list of keywords you must use.

Function

Transcription factor N-terminal LIM domains C-terminal Homeodomain

7 related topics

Role in cardiac development

Secondary heart field Cardiomyocytes Smooth muscle Endothelial Neural crest

5 related topics

Interactions

Interact Estrogen receptor alpha

2 related topics

Overview

Protein Gene

2 related topics

Key facts & relationships

High-confidence facts extracted from structured source data. Use them as anchors for further research.

Aliases: ISL1, ISLET1, Isl-1, ISL LIM homeobox 1
Available structures: Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes2RGT, 4JCJ
Band: 5q11.1 · 13|13 D2.2
Bgee: secondary oocyte · islet of Langerhans · human penis · urethra · pylorus
BioGPS: More reference expression data
Chr.: Chromosome 5 (human) · Chromosome 13 (mouse)

Topics to explore

Browse the full topic structure. Each item opens a new analysis centered on that subject.

Overview

Function

Interactions

Interact Protein-protein interaction
Estrogen receptor alpha

Role in cardiac development

Secondary heart field Secondary heart field?action=edit&redlink=1
Cardiomyocytes
Smooth muscle
Endothelial
Neural crest

Advanced semantic analysis

Deeper signals for content research, entity SEO and topical coverage. The plain-language headings explain what each technical view is useful for.

Map overview Semantic statistics

Nodes21

Edges20

Triples159

Avg. degree1.9

Density0.095238

Components1

How this topic connects Entity context

See the strongest relationship patterns around the current topic before diving into the raw triples.

ISL1

Top relations

Gene ontology · 82

ISL1 → atrial septum morphogenesis, axon regeneration, axonogenesis, bHLH transcription factor binding, cardiac cell fate determination, cardiac muscle cell myoblast differentiation, cardiac right ventricle morphogenesis, cell differentiation, cellular response to glucocorticoid stimulus, chromatin binding, cis-regulatory region sequence-specific DNA binding, cytoplasm, development of the heart, DNA binding, DNA-binding transcription activator activity, RNA polymerase II-specific, DNA-binding transcription factor activity, RNA polymerase II-specific, endocardial cushion morphogenesis, estrogen receptor binding, heart morphogenesis, innervation

Bgee · 19

ISL1 → buccal mucosa cell, cardia, facial motor nucleus, gastric mucosa, genital tubercle, human penis, islet of Langerhans, lumbar spinal ganglion, medial ganglionic eminence, median eminence, neural layer of retina, pancreatic ductal cell, pylorus, secondary oocyte, sperm, superior cervical ganglion, trigeminal ganglion, urethra, vestibular sensory epithelium

RNA expression pattern · 19

related to Role in cardiac development · 9

ISL1 → Furthermore, ISL1-positive, More, Research, SHF, The, This, Vilquin, While

related to External links · 6

ISL1 → Medicine, Medicine Medical Subject Headings, MeSH, National Library, This, United States National Library

Band · 2

ISL1 → 13|13 D2.2, 5q11.1

Chr. · 2

ISL1 → Chromosome 13 (mouse), Chromosome 5 (human)

End · 2

ISL1 → 116,446,225 bp, 51,394,730 bp

Aliases · 1

ISL1 → ISL1, ISLET1, Isl-1, ISL LIM homeobox 1

Available structures · 1

ISL1 → Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes2RGT, 4JCJ

Important terminology Word statistics

Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.

Important terminology

cardiac bp gene human chr band chromosome protein cell heart mouse neural location function cells differentiation field crest insulin isl-1

Entity relationships Subject–Predicate–Object triples

Subject	Predicate	Object	Confidence	Src
ISL1	Aliases	ISL1, ISLET1, Isl-1, ISL LIM homeobox 1	1.00	infobox
ISL1	Available structures	Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes2RGT, 4JCJ	1.00	infobox
ISL1	Band	5q11.1	1.00	infobox
ISL1	Band	13\|13 D2.2	1.00	infobox
ISL1	Bgee	secondary oocyte	1.00	infobox
ISL1	Bgee	islet of Langerhans	1.00	infobox
ISL1	Bgee	human penis	1.00	infobox
ISL1	Bgee	urethra	1.00	infobox
ISL1	Bgee	pylorus	1.00	infobox
ISL1	Bgee	cardia	1.00	infobox
ISL1	Bgee	sperm	1.00	infobox
ISL1	Bgee	buccal mucosa cell	1.00	infobox
ISL1	Bgee	pancreatic ductal cell	1.00	infobox
ISL1	Bgee	gastric mucosa	1.00	infobox
ISL1	Bgee	superior cervical ganglion	1.00	infobox
ISL1	Bgee	genital tubercle	1.00	infobox
ISL1	Bgee	trigeminal ganglion	1.00	infobox
ISL1	Bgee	lumbar spinal ganglion	1.00	infobox
ISL1	Bgee	medial ganglionic eminence	1.00	infobox
ISL1	Bgee	neural layer of retina	1.00	infobox
ISL1	Bgee	facial motor nucleus	1.00	infobox
ISL1	Bgee	vestibular sensory epithelium	1.00	infobox
ISL1	Bgee	median eminence	1.00	infobox
ISL1	BioGPS	More reference expression data	1.00	infobox
ISL1	Chr.	Chromosome 5 (human)	1.00	infobox
ISL1	Chr.	Chromosome 13 (mouse)	1.00	infobox
ISL1	Databases	NCBI: entry; OMA: entry	1.00	infobox
ISL1	End	51,394,730 bp	1.00	infobox
ISL1	End	116,446,225 bp	1.00	infobox
ISL1	Ensembl	ENSG00000016082	1.00	infobox

Related concept clusters Concept neighborhoods

These clusters group vocabulary that occurs around closely connected concepts in the source material.

Connections between topic areas Semantic bridges

Bridges can reveal useful research angles that are easy to miss in a flat list of related terms.

Min side: 3