HSPA8

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HSPA8 topic overview

The analysis highlights Clinical significance, Interactions and Function as prominent areas in the source structure around HSPA8.

Related topics: 74
Source areas: 5
Connected nodes: 79
Extracted relationships: 188
Concept neighborhoods: 13
Bridge connections: 79

What this topic covers Research coverage

Source areas are shown by the number of related topics found in each part of the analysis. Use smaller areas too: they can reveal specialized angles and content gaps.

Clinical significance · 31 topics

Interactions · 16 topics

Function · 12 topics

Overview · 10 topics

Structure · 5 topics

Smaller areas are not necessarily less important. They contain fewer connections in this analysis and can be useful for finding specialized angles or coverage gaps.

Key facts & relationships

High-confidence facts extracted from structured source data. Use them as anchors for further research.

3.6.4.10: ↗
Aliases: HSPA8, HEL-33, HEL-S-72p, HSC54, HSC70, HSC71, HSP71, HSP73, HSPA10, LAP-1, LAP1, NIP71, heat shock protein family A (Hsp70) member 8
Available structures: Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes3AGY, 3AGZ, 3ESK, 3FZF, 3FZH, 3FZK, 3FZL, 3FZM, 4HWI, 3LDQ, 3M3Z, 4H5N, 4H5R, 4H5T, 4H5V, 4H5W, 4KBQ
Band: 11q24.1 · 9 A5.1|9 21.55 cM
Bgee: corpus callosum · superior frontal gyrus · right hemisphere of cerebellum · prefrontal cortex · right frontal lobe
BioGPS: More reference expression data

Explore all related topics Closing gaps

Browse the complete topic structure, not only the most central items. Less prominent entities and concepts can reveal missing angles, specialized context and useful research gaps. Each item opens a new analysis centered on that subject.

Clinical significance

Interactions

Hsp40
Hsp90
STUB1
HOP Hop (protein)
BAG1
Interact Protein-protein interaction
BAG2
BAG3
BAG4
CDC5L
CITED1
CCND1 Cyclin D1
DNAJA3
GJA1
HSPBP1
PARK2 Parkin (ligase)

Advanced semantic analysis

Deeper signals for content research, entity SEO and topical coverage. The plain-language headings explain what each technical view is useful for.

How HSPA8 connects Entity context

The extracted context around HSPA8 shows recurring relationship patterns in the source. For example, HSPA8 → ATP binding, ATP metabolic process, ATPase activity, autophagosome, axo-dendritic transport, axon, blood microparticle, C3HC4-type RING finger domain binding, cadherin binding, cellular response to heat, cellular response to starvation, chaperone binding, chaperone cofactor-dependent protein refolding, chaperone complex, chaperone-mediated autophagy, chaperone-mediated autophagy translocation complex disassembly, clathrin coat disassembly, clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane, clathrin-uncoating ATPase activity, cytokine-mediated signaling pathway Another extracted example is HSPA8 → AFP-expressing, Alternatively, Alzheimer's, Apoptosis, As, DNA, During, Elevated Hsp70, Hsc70, Hsp70, Hsp70s, Hsp72, Hsp72/AFP, Huntington's, In, It, Its, One, Parkinson's, The. Use these groups to spot repeated connection types before inspecting the individual relationships.

Top relations

Gene ontology · 94

HSPA8 → ATP binding, ATP metabolic process, ATPase activity, autophagosome, axo-dendritic transport, axon, blood microparticle, C3HC4-type RING finger domain binding, cadherin binding, cellular response to heat, cellular response to starvation, chaperone binding, chaperone cofactor-dependent protein refolding, chaperone complex, chaperone-mediated autophagy, chaperone-mediated autophagy translocation complex disassembly, clathrin coat disassembly, clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane, clathrin-uncoating ATPase activity, cytokine-mediated signaling pathway

related to Clinical significance · 24

HSPA8 → AFP-expressing, Alternatively, Alzheimer's, Apoptosis, As, DNA, During, Elevated Hsp70, Hsc70, Hsp70, Hsp70s, Hsp72, Hsp72/AFP, Huntington's, In, It, Its, One, Parkinson's, The

Bgee · 18

HSPA8 → corpus callosum, ganglionic eminence, genital tubercle, gonad, hippocampus proper, mesencephalon, neural tube, ovary, prefrontal cortex, primary visual cortex, proximal tubule, right frontal lobe, right hemisphere of cerebellum, right kidney, right testis, superior frontal gyrus, tail of embryo, ventricular zone

RNA expression pattern · 18

related to Interactions · 7

HSPA8 → BAG1, Bcl2-associated, HIP, HOP, Hsc70, Hsp40, Hsp90

Band · 2

HSPA8 → 11q24.1, 9 A5.1|9 21.55 cM

Chr. · 2

HSPA8 → Chromosome 11 (human), Chromosome 9 (mouse)

End · 2

HSPA8 → 123,063,230 bp, 40,721,383 bp

3.6.4.10 · 1

HSPA8 → ↗

Aliases · 1

HSPA8 → HSPA8, HEL-33, HEL-S-72p, HSC54, HSC70, HSC71, HSP71, HSP73, HSPA10, LAP-1, LAP1, NIP71, heat shock protein family A (Hsp70) member 8

Important terminology

Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.

Important terminology

protein hsc70 hsp70 cell heat shock proteins human bp chromosome 11 gene chr apoptosis band also processes 70 member folding

HSPA8 relationships Subject–Predicate–Object triples

TTTA extracted 188 structured relationships around HSPA8. Examples in this analysis include HSPA8 → 3.6.4.10 → ↗ and HSPA8 → Aliases → HSPA8, HEL-33, HEL-S-72p, HSC54, HSC70, HSC71, HSP71, HSP73, HSPA10, LAP-1, LAP1, NIP71, heat shock protein family A (Hsp70) member 8. The table shows each extracted connection, where it came from and its confidence.

Subject	Predicate	Object	Confidence	Src
HSPA8	3.6.4.10	↗	1.00	infobox
HSPA8	Aliases	HSPA8, HEL-33, HEL-S-72p, HSC54, HSC70, HSC71, HSP71, HSP73, HSPA10, LAP-1, LAP1, NIP71, heat shock protein family A (Hsp70) member 8	1.00	infobox
HSPA8	Available structures	Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes3AGY, 3AGZ, 3ESK, 3FZF, 3FZH, 3FZK, 3FZL, 3FZM, 4HWI, 3LDQ, 3M3Z, 4H5N, 4H5R, 4H5T, 4H5V, 4H5W, 4KBQ	1.00	infobox
HSPA8	Band	11q24.1	1.00	infobox
HSPA8	Band	9 A5.1\|9 21.55 cM	1.00	infobox
HSPA8	Bgee	corpus callosum	1.00	infobox
HSPA8	Bgee	superior frontal gyrus	1.00	infobox
HSPA8	Bgee	right hemisphere of cerebellum	1.00	infobox
HSPA8	Bgee	prefrontal cortex	1.00	infobox
HSPA8	Bgee	right frontal lobe	1.00	infobox
HSPA8	Bgee	ventricular zone	1.00	infobox
HSPA8	Bgee	gonad	1.00	infobox
HSPA8	Bgee	ganglionic eminence	1.00	infobox
HSPA8	Bgee	right testis	1.00	infobox
HSPA8	Bgee	primary visual cortex	1.00	infobox
HSPA8	Bgee	tail of embryo	1.00	infobox
HSPA8	Bgee	genital tubercle	1.00	infobox
HSPA8	Bgee	ovary	1.00	infobox
HSPA8	Bgee	mesencephalon	1.00	infobox
HSPA8	Bgee	neural tube	1.00	infobox
HSPA8	Bgee	right kidney	1.00	infobox
HSPA8	Bgee	hippocampus proper	1.00	infobox
HSPA8	Bgee	proximal tubule	1.00	infobox
HSPA8	BioGPS	More reference expression data	1.00	infobox
HSPA8	Chr.	Chromosome 11 (human)	1.00	infobox
HSPA8	Chr.	Chromosome 9 (mouse)	1.00	infobox
HSPA8	Databases	NCBI: entry; OMA: entry	1.00	infobox
HSPA8	End	123,063,230 bp	1.00	infobox
HSPA8	End	40,721,383 bp	1.00	infobox
HSPA8	Ensembl	ENSG00000109971	1.00	infobox

Related concept clusters Concept neighborhoods

The concept neighborhoods around HSPA8 bring nearby vocabulary together. In this analysis, examples include Location, Structure and Family. Use the clusters to find adjacent concepts and terminology that may deserve separate research.

HSPA8
- Location
- Structure
- Family
- Function
- Bp
- Chr
- Member
- Shock
- Human
- Hsp70
- Protein
- Autophagy
hspa8
- Location
- Structure
- Family
- Function
- Bp
- Chr
- Member
- Shock
- Human
- Hsp70
- Protein
- Autophagy
heat shock protein
- Shock
- Protein
- Chaperone
- Family
- Kda
- Structure
- Cognate
- Gene
- Chromosome
- Folding
- Hsc70
- Hspa8
gene
- Chromosome
- Location
- Bp
- Chr
- Hspa8
- Human
- Structure
- Band
- Family
- Function
- Member
- Heat
autophagy
- Pathway
- Membrane
- Location
- Proteins
- Structure
- Band
- Binding
- Cellular
- Chaperone
- Domain
- Family
- Function
cell growth
- Function
- Plasma
- Membrane
- Processes
- Senescence
- Hsp70
- Folding
- Hsc70
- Protein
- Role
- Heat
- Shock
protein folding
- Shock
- Binding
- Function
- Chaperone
- Family
- Folding
- Hsc70
- Member
- Protein
- Structure
- Hspa8
- Hsp70
chaperone-mediated autophagy
- Pathway
- Membrane
- Location
- Proteins
- Structure
- Band
- Binding
- Cellular
- Chaperone
- Domain
- Family
- Function

Connections between topic areas Semantic bridges

For HSPA8, one of the stronger structural bridges in this analysis connects HSPA8 with Clinical significance. Bridges highlight paths between different parts of the map and can reveal research angles that are easy to miss in a flat list.

Min side: 3

HSPA8 — Clinical significance · splits 48 ⟂ 32

HSPA8 — Interactions · splits 63 ⟂ 17

HSPA8 — Function · splits 67 ⟂ 13

HSPA8 — Overview · splits 69 ⟂ 11

HSPA8 — Structure · splits 74 ⟂ 6

Map overview Semantic statistics

HSPA8

Nodes80

Edges79

Triples188

Avg. degree1.98

Density0.025

Components1

Source & methodology

TTTA analyzes the structure around HSPA8 to surface related topics, entities, relationships, concept neighborhoods and bridge connections. Use the map to explore areas such as Clinical significance, Interactions & Function, including less central topics that may reveal useful research gaps. Automatically extracted connections are research leads rather than rewritten encyclopedia content.

Source: Wikipedia — HSPA8 · EN edition · Analysis: TopicsToTalkAbout