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DUSP6

Dual specificity phosphatase 6 (DUSP6) is a phosphatase enzyme that is encoded by the DUSP6 gene in humans.

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Function

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3.1.3.16
3.1.3.48
Aliases
DUSP6, HH19, MKP3, PYST1, dual specificity phosphatase 6
Available structures
Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1HZM, 1MKP
Band
12q21.33 · 10|10 D1
Bgee
parotid gland · pericardium · monocyte · lactiferous duct · visceral pleura

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Overview

Function

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Map overview Semantic statistics

DUSP6

Nodes14
Edges13
Triples93
Avg. degree1.86
Density0.142857
Components1

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DUSP6

Top relations

Gene ontology · 26
DUSP6 → cell differentiation, cytoplasm, cytosol, dephosphorylation, dorsal/ventral pattern formation, hydrolase activity, MAP kinase tyrosine/serine/threonine phosphatase activity, MAPK cascade, negative regulation of ERK1 and ERK2 cascade, negative regulation of protein phosphorylation, nucleoplasm, peptidyl-tyrosine dephosphorylation, phosphatase activity, phosphoprotein phosphatase activity, positive regulation of apoptotic process, positive regulation of cell death, protein dephosphorylation, protein tyrosine phosphatase activity, protein tyrosine/serine/threonine phosphatase activity, regulation of endodermal cell fate specification
Bgee · 17
DUSP6 → atrioventricular valve, endocardial cushion, granulocyte, lactiferous duct, left lung lobe, lower lobe of lung, maxillary prominence, monocyte, parietal pleura, parotid gland, pericardium, retinal pigment epithelium, right lung lobe, stroma of bone marrow, tail of embryo, trachea, visceral pleura
RNA expression pattern · 17
DUSP6 → atrioventricular valve, endocardial cushion, granulocyte, lactiferous duct, left lung lobe, lower lobe of lung, maxillary prominence, monocyte, parietal pleura, parotid gland, pericardium, retinal pigment epithelium, right lung lobe, stroma of bone marrow, tail of embryo, trachea, visceral pleura
related to Function · 6
DUSP6 → ERK2, MAP, MAPK/ERK, SAPK/JNK, These, They
Band · 2
DUSP6 → 10|10 D1, 12q21.33
Chr. · 2
DUSP6 → Chromosome 10 (mouse), Chromosome 12 (human)
End · 2
DUSP6 → 89,352,501 bp, 99,103,351 bp
3.1.3.16 · 1
DUSP6 → ↗
3.1.3.48 · 1
DUSP6 → ↗
Aliases · 1
DUSP6 → DUSP6, HH19, MKP3, PYST1, dual specificity phosphatase 6

Important terminology Word statistics

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Important terminology

bp phosphatase gene chr human band chromosome 12 dual specificity protein location mouse enzyme function external pdb uniprot q16828 search

Entity relationships Subject–Predicate–Object triples

SubjectPredicateObjectConfidenceSrc
DUSP63.1.3.161.00infobox
DUSP63.1.3.481.00infobox
DUSP6AliasesDUSP6, HH19, MKP3, PYST1, dual specificity phosphatase 61.00infobox
DUSP6Available structuresAvailable structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1HZM, 1MKP1.00infobox
DUSP6Band12q21.331.00infobox
DUSP6Band10|10 D11.00infobox
DUSP6Bgeeparotid gland1.00infobox
DUSP6Bgeepericardium1.00infobox
DUSP6Bgeemonocyte1.00infobox
DUSP6Bgeelactiferous duct1.00infobox
DUSP6Bgeevisceral pleura1.00infobox
DUSP6Bgeelower lobe of lung1.00infobox
DUSP6Bgeeretinal pigment epithelium1.00infobox
DUSP6Bgeegranulocyte1.00infobox
DUSP6Bgeeparietal pleura1.00infobox
DUSP6Bgeetrachea1.00infobox
DUSP6Bgeeleft lung lobe1.00infobox
DUSP6Bgeestroma of bone marrow1.00infobox
DUSP6Bgeemaxillary prominence1.00infobox
DUSP6Bgeeendocardial cushion1.00infobox
DUSP6Bgeetail of embryo1.00infobox
DUSP6Bgeeatrioventricular valve1.00infobox
DUSP6Bgeeright lung lobe1.00infobox
DUSP6BioGPSMore reference expression data1.00infobox
DUSP6Chr.Chromosome 12 (human)1.00infobox
DUSP6Chr.Chromosome 10 (mouse)1.00infobox
DUSP6DatabasesNCBI: entry; OMA: entry1.00infobox
DUSP6End89,352,501 bp1.00infobox
DUSP6End99,103,351 bp1.00infobox
DUSP6EnsemblENSG000001393181.00infobox

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