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Dopamine

Dopamine (DA, a contraction of 3,4-dihydroxyphenethylamine) is a neuromodulatory molecule that plays several important roles in cells. It is an organic chemical of the catecholamine and phenethylamine families. It is an amine synthesized by removing a carboxyl group through decarboxylation from a molecule of its precursor chemical, L-DOPA, which is…

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3D model (JSmol)
Interactive image
Agonists
Direct: apomorphine, bromocriptine Indirect: cocaine, amphetamine, methylphenidate
Antagonists
Neuroleptics, metoclopramide, domperidone
Biosynthesis
DOPA decarboxylase
CAS Number
51-61-6 62-31-7 (hydrochloride)
ChemSpider
661

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Overview

Structure

Biochemistry

Functions

Medical uses

Disease, disorders, and pharmacology

Comparative biology and evolution

History and development

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Map overview Semantic statistics

Dopamine

Nodes446
Edges445
Triples299
Avg. degree2
Density0.004484
Components1

How this topic connects Entity context

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Dopamine

Top relations

related to history · 20
Dopamine → Arvid Carlsson, Barger-Ewens, Carlsson, Chemical Pharmacology, Dopamine's, England, George Barger, It, James Ewens, Katharine Montagu, L-DOPA, Laboratory, London, Medicine, National Heart Institute, Nils-Åke Hillarp, Nobel Prize, Physiology, Sweden, Wellcome Laboratories
related to Degradation · 14
Dopamine → ALDH, Both, COMT, Different, DOPAC, DOPAL, From, HVA, MAO, MAO-A, MAO-B, Methoxytyramine, O-methyl, The
related to Psychosis and antipsychotic drugs · 14
Dopamine → Antipsychotic, As, By, D2, Even, For, In, Later, Many, Psychiatrists, The, These, This, Thorazine
related to Drug addiction and psychostimulants · 13
Dopamine → Adderall, ADHD, An, Cocaine, Concerta, Drugs, However, Like, Methylphenidate, Ritalin, The, These, This
has effect · 12
Dopamine → All, Consequently, D1, D1-like, D2, D2-like, D3, D4, D5, For, In, These
related to Central nervous system · 12
Dopamine → A1, A14, A7, A8, Annica Dahlström, Dopaminergic, However, In, Inside, Kjell Fuxe, The, These
related to Medical uses · 12
Dopamine → At, Dopastat, Essential Medicines, Higher, Intropin, It, Its, Older, Revimine, Since, While, World Health Organization's List
related to Plants · 12
Dopamine → Another, Bauhinia, Brussels, Cassia, However, It, L-DOPA, Many, Mucuna, Potatoes, The, Vicia
related to Attention deficit hyperactivity disorder · 11
Dopamine → Adderall, ADHD, Altered, Concerta, D1, Dexedrine, Evekeo, Ritalin, Some, The, There
related to Parkinson's disease · 11
Dopamine → Awakenings, DOPA, In, It, L-DOPA, Most, MPTP, Parkinson's, The, These, When L-DOPA

Important terminology Word statistics

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Important terminology

brain also system receptors l-dopa drugs used reward levels cells neurons activity effects dopaminergic release form role synthesized pleasure norepinephrine

Entity relationships Subject–Predicate–Object triples

SubjectPredicateObjectConfidenceSrc
Dopamine3D model (JSmol)Interactive image1.00infobox
DopamineAgonistsDirect: apomorphine, bromocriptine Indirect: cocaine, amphetamine, methylphenidate1.00infobox
DopamineAntagonistsNeuroleptics, metoclopramide, domperidone1.00infobox
DopamineBiosynthesisDOPA decarboxylase1.00infobox
DopamineCAS Number51-61-6 62-31-7 (hydrochloride)1.00infobox
DopamineChemSpider6611.00infobox
DopamineCompTox Dashboard (EPA)DTXSID60224201.00infobox
DopamineDrugBankDB009881.00infobox
DopamineECHA InfoCard100.000.1011.00infobox
DopamineFormulaC8H11NO21.00infobox
DopamineIUPHAR/BPS9401.00infobox
DopamineKEGGC037581.00infobox
DopamineMetabolismMAO, COMT1.00infobox
DopamineMolar mass153.181 g·mol−11.00infobox
DopamineOther namesDA,1.00infobox
DopamineOther names2-(3,4-Dihydroxyphenyl)ethylamine,1.00infobox
DopamineOther names3,4-Dihydroxyphenethylamine,1.00infobox
DopamineOther names3-Hydroxytyramine,1.00infobox
DopamineOther namesOxytyramine,1.00infobox
DopamineOther namesIntropin,1.00infobox
DopamineOther namesRevivan1.00infobox
DopaminePrecursorPhenylalanine, tyrosine, and L-DOPA1.00infobox
DopaminePubChem CID6811.00infobox
DopamineReceptorsD1, D2, D3, D4, D5, TAAR11.00infobox
DopamineSource tissuesSubstantia nigra; ventral tegmental area; many others1.00infobox
DopamineTarget tissuesSystem-wide1.00infobox
DopamineUNIIVTD58H1Z2X1.00infobox
Dopamineis asimplest possible catecholamine0.90text
Dopamineis aorganic base0.90text
Dopamineis aprimary neuroendocrine inhibitor of the secretion of prolactin from the anterior pituitary gland0.90text

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