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Dopamine beta-hydroxylase

Dopamine β-hydroxylase (DBH), also known as dopamine β-monooxygenase, is an enzyme (EC 1.14.17.1) that in humans is encoded by the DBH gene. Dopamine β-hydroxylase catalyzes the conversion of dopamine to norepinephrine.

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1.14.17.1
Aliases
DBH, DBM, Dopamine beta-monooxygenase, dopamine beta-hydroxylase, Dopamine β-hydroxylase, ORTHYP1
Available structures
Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes4ZEL
Band
9q34.2 · 2 A3|2 19.29 cM
Bgee
right lobe of liver · right adrenal gland · left adrenal gland · left adrenal cortex · sympathetic trunk
BioGPS
More reference expression data

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Overview

Mechanism of catalysis

Assays for DBH activity in human serum and cerebrospinal fluid

Clinical significance

Regulation and inhibition

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Dopamine beta-hydroxylase

Nodes50
Edges49
Triples119
Avg. degree1.96
Density0.04
Components1

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Dopamine beta-hydroxylase

Top relations

Gene ontology · 46
Dopamine beta-hydroxylase → associative learning, behavioral response to ethanol, blood vessel remodeling, catalytic activity, catecholamine biosynthetic process, chemical synaptic transmission, chromaffin granule lumen, chromaffin granule membrane, copper ion binding, cytokine production, cytoplasm, cytoplasmic vesicle, dopamine beta-monooxygenase activity, dopamine catabolic process, endoplasmic reticulum, extracellular region, extracellular space, fear response, glucose homeostasis, homoiothermy
Bgee · 20
Dopamine beta-hydroxylase → adrenal gland, body of pancreas, carotid body, external carotid artery, granulocyte, left adrenal cortex, left adrenal gland, lymph node, myocardium of ventricle, parasympathetic ganglion, parasympathetic nervous system, right adrenal cortex, right adrenal gland, right lobe of liver, secondary oocyte, submandibular gland, superior cervical ganglion, superior vestibular nucleus, sympathetic trunk, tunica adventitia of aorta
RNA expression pattern · 20
Dopamine beta-hydroxylase → adrenal gland, body of pancreas, carotid body, external carotid artery, granulocyte, left adrenal cortex, left adrenal gland, lymph node, myocardium of ventricle, parasympathetic ganglion, parasympathetic nervous system, right adrenal cortex, right adrenal gland, right lobe of liver, secondary oocyte, submandibular gland, superior cervical ganglion, superior vestibular nucleus, sympathetic trunk, tunica adventitia of aorta
related to External links · 6
Dopamine beta-hydroxylase → Dopamine Beta-Hydroxylase DeficiencyDopamine, GeneReviews/NIH/NCBI/UW, Hydroxylase, Medicine Medical Subject Headings, MeSH, National Library
Band · 2
Dopamine beta-hydroxylase → 2 A3|2 19.29 cM, 9q34.2
Chr. · 2
Dopamine beta-hydroxylase → Chromosome 2 (mouse), Chromosome 9 (human)
End · 2
Dopamine beta-hydroxylase → 133,659,329 bp, 27,073,212 bp
1.14.17.1 · 1
Dopamine beta-hydroxylase → ↗
Aliases · 1
Dopamine beta-hydroxylase → DBH, DBM, Dopamine beta-monooxygenase, dopamine beta-hydroxylase, Dopamine β-hydroxylase, ORTHYP1
Available structures · 1
Dopamine beta-hydroxylase → Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes4ZEL

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Important terminology

dbh dopamine enzyme human β-hydroxylase activity bp gene norepinephrine chr band ascorbate also known chromosome external location catalyzes expression regulation

Entity relationships Subject–Predicate–Object triples

SubjectPredicateObjectConfidenceSrc
Dopamine beta-hydroxylase1.14.17.11.00infobox
Dopamine beta-hydroxylaseAliasesDBH, DBM, Dopamine beta-monooxygenase, dopamine beta-hydroxylase, Dopamine β-hydroxylase, ORTHYP11.00infobox
Dopamine beta-hydroxylaseAvailable structuresAvailable structuresPDBOrtholog search: PDBe RCSB List of PDB id codes4ZEL1.00infobox
Dopamine beta-hydroxylaseBand9q34.21.00infobox
Dopamine beta-hydroxylaseBand2 A3|2 19.29 cM1.00infobox
Dopamine beta-hydroxylaseBgeeright lobe of liver1.00infobox
Dopamine beta-hydroxylaseBgeeright adrenal gland1.00infobox
Dopamine beta-hydroxylaseBgeeleft adrenal gland1.00infobox
Dopamine beta-hydroxylaseBgeeleft adrenal cortex1.00infobox
Dopamine beta-hydroxylaseBgeesympathetic trunk1.00infobox
Dopamine beta-hydroxylaseBgeesuperior vestibular nucleus1.00infobox
Dopamine beta-hydroxylaseBgeeright adrenal cortex1.00infobox
Dopamine beta-hydroxylaseBgeelymph node1.00infobox
Dopamine beta-hydroxylaseBgeebody of pancreas1.00infobox
Dopamine beta-hydroxylaseBgeegranulocyte1.00infobox
Dopamine beta-hydroxylaseBgeesuperior cervical ganglion1.00infobox
Dopamine beta-hydroxylaseBgeeadrenal gland1.00infobox
Dopamine beta-hydroxylaseBgeeexternal carotid artery1.00infobox
Dopamine beta-hydroxylaseBgeetunica adventitia of aorta1.00infobox
Dopamine beta-hydroxylaseBgeeparasympathetic nervous system1.00infobox
Dopamine beta-hydroxylaseBgeecarotid body1.00infobox
Dopamine beta-hydroxylaseBgeesubmandibular gland1.00infobox
Dopamine beta-hydroxylaseBgeeparasympathetic ganglion1.00infobox
Dopamine beta-hydroxylaseBgeemyocardium of ventricle1.00infobox
Dopamine beta-hydroxylaseBgeesecondary oocyte1.00infobox
Dopamine beta-hydroxylaseBioGPSMore reference expression data1.00infobox
Dopamine beta-hydroxylaseChr.Chromosome 9 (human)1.00infobox
Dopamine beta-hydroxylaseChr.Chromosome 2 (mouse)1.00infobox
Dopamine beta-hydroxylaseDatabasesNCBI: entry; OMA: entry1.00infobox
Dopamine beta-hydroxylaseEnd133,659,329 bp1.00infobox

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