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Carbidopa

Carbidopa, sold under the brand name Lodosyn, is a medication used primarily in the treatment of Parkinson's disease. It is a DOPA decarboxylase inhibitor — that is, it blocks the enzyme aromatic L-amino acid decarboxylase (DDC) in the peripheral nervous system, preventing the premature conversion of levodopa to dopamine outside the brain. Because…

Applications, Medical uses & Synthesis

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3D model (JSmol)
Interactive image
AHFS/Drugs.com
Monograph
CAS Number
28860-95-9 Y
ChEBI
CHEBI:39585 Y
ChEMBL
ChEMBL1201236 N
ChemSpider
31640 Y

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Overview

Medical uses

Pharmacology

Synthesis

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Map overview Semantic statistics

Carbidopa

Nodes24
Edges23
Triples62
Avg. degree1.92
Density0.083333
Components1

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Carbidopa

Top relations

related to Parkinson's disease · 12
Carbidopa → Atamet, By, Co-administration, COMT, DDC, However, Kinson, Parkinson's, Pharmacopa, Sinemet, Stalevo, The
related to Pharmacology · 9
Carbidopa → By, DDC, DOPA, However, L-amino, Levodopa, Parkinson's, This, When
related to Synthesis · 6
Carbidopa → HBr, HCl, More, Strecker, The, This
related to Serotonergic Enhancement · 5
Carbidopa → Because DDC, European, However, HTP, In
related to Chemistry · 4
Carbidopa → C10H14N2O4, H2O, It, N-amino-α-methyl-3-hydroxy-L-tyrosine
Legal status · 2
Carbidopa → UK: POM (Prescription only), US: ℞-only
License data · 2
Carbidopa → EU EMA: by INN, US FDA: Carbidopa
3D model (JSmol) · 1
Carbidopa → Interactive image
AHFS/Drugs.com · 1
Carbidopa → Monograph
CAS Number · 1
Carbidopa → 28860-95-9 Y

Important terminology Word statistics

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Important terminology

levodopa ddc peripheral acid dopamine nervous system brain parkinson's disease also inhibitor cross blood-brain barrier central lodosyn combination used conversion

Entity relationships Subject–Predicate–Object triples

SubjectPredicateObjectConfidenceSrc
Carbidopa3D model (JSmol)Interactive image1.00infobox
CarbidopaAHFS/Drugs.comMonograph1.00infobox
CarbidopaCAS Number28860-95-9 Y1.00infobox
CarbidopaChEBICHEBI:39585 Y1.00infobox
CarbidopaChEMBLChEMBL1201236 N1.00infobox
CarbidopaChemSpider31640 Y1.00infobox
CarbidopaCompTox Dashboard (EPA)DTXSID40227351.00infobox
CarbidopaDrugBankDB00190 Y1.00infobox
CarbidopaECHA InfoCard100.044.7781.00infobox
CarbidopaElimination half-life2 hours1.00infobox
CarbidopaFormulaC10H14N2O41.00infobox
CarbidopaIUPHAR/BPS51591.00infobox
CarbidopaKEGGD00558 Y1.00infobox
CarbidopaLegal statusUK: POM (Prescription only)1.00infobox
CarbidopaLegal statusUS: ℞-only1.00infobox
CarbidopaLicense dataEU EMA: by INN1.00infobox
CarbidopaLicense dataUS FDA: Carbidopa1.00infobox
CarbidopaMelting point203 to 205 °C (397 to 401 °F)1.00infobox
CarbidopaMetabolism7 metabolites known, not metabolized extensively1.00infobox
CarbidopaMolar mass226.232 g·mol−11.00infobox
CarbidopaProtein binding76%1.00infobox
CarbidopaPubChem CID343591.00infobox
CarbidopaTrade namesLodosyn1.00infobox
CarbidopaUNIIKR87B45RGH1.00infobox

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