Dedicator of cytokinesis protein 2

Use the mouse wheel or two fingers (on touchscreens) to zoom in and out of the map.

Export map as:

Research this topic

Explore the main themes, entities and connections around Dedicator of cytokinesis protein 2. Start with the topic map, then use the sections below for research and deeper semantic analysis.

Explore this topic

Start with a few of the strongest sections from the source topic. These are research directions, not a list of keywords you must use.

Signalling downstream of Dock2

Rac1 Rac2 Isoforms Neutrophil NADPH oxidase

29 related topics

Structure and function

Guanosine diphosphate Guanosine triphosphate DH PH DHR2 domain

15 related topics

Regulation of activity

Complex Adaptor proteins ELMO1 Lymphocyte Conformational changes

5 related topics

Discovery

4 related topics

Key facts & relationships

High-confidence facts extracted from structured source data. Use them as anchors for further research.

Aliases: DOCK2, IMD40, Dock2, dedicator of cytokinesis 2
Available structures: Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes2RQR, 2YIN, 3A98, 3B13
Band: 5q35.1 · 11|11 A4
Bgee: bone marrow cell · monocyte · granulocyte · blood · spleen
BioGPS: More reference expression data
Chr.: Chromosome 5 (human) · Chromosome 11 (mouse)

Topics to explore

Browse the full topic structure. Each item opens a new analysis centered on that subject.

Overview

Protein
Intracellular
Signalling networks Cell signalling
DOCK DOCK (protein)
Guanine nucleotide exchange factors
Small G-proteins Small G-protein
Rac Rac (GTPase)

Discovery

Structure and function

Regulation of activity

Complex Protein complex
Adaptor proteins Signal transducing adaptor protein
ELMO1
Lymphocyte
Conformational changes Conformational change

Signalling downstream of Dock2

Rac1
Rac2
Isoforms Isoform
Neutrophil
NADPH oxidase
Chemotaxis
Plasmacytoid dendritic cells Dendritic cell
Agonist
FMLP N-Formylmethionine leucyl-phenylalanine
G protein-coupled receptors G protein-coupled receptor
Chemokines
CXCL12/SDF-1 Stromal cell-derived factor-1
T lymphocytes
CXCL13/BLC CXCL13
B lymphocytes
CCL19/ELC CCL19
Thymocytes Thymocyte
Thymus
CCL21/SLC CCL21
Ex vivo
C5a Complement component 5a
CXCL8/IL-8 Interleukin 8
T cell receptor/TCR T cell receptor
EDG1
Sphingosine-1-phosphate (S1P) Sphingosine-1-phosphate
HIV-1
Nef Structure and genome of HIV
Immunological synapse
Immune response

Interactions

Interact Protein-protein interaction

Advanced semantic analysis

Deeper signals for content research, entity SEO and topical coverage. The plain-language headings explain what each technical view is useful for.

Map overview Semantic statistics

Nodes68

Edges67

Triples93

Avg. degree1.97

Density0.029412

Components1

How this topic connects Entity context

See the strongest relationship patterns around the current topic before diving into the raw triples.

Dedicator of cytokinesis protein 2

Top relations

Gene ontology · 32

Dedicator of cytokinesis protein 2 → actin cytoskeleton organization, alpha-beta T cell activation, alpha-beta T cell proliferation, chemotaxis, cytoplasm, cytoskeleton, cytoskeleton organization, cytosol, endomembrane system, establishment of T cell polarity, extracellular exosome, extracellular region, GTPase activator activity, guanyl-nucleotide exchange factor activity, immunological synapse formation, macropinocytosis, membrane, membrane raft polarization, mitigation of host defenses by virus, myeloid dendritic cell activation involved in immune response

Bgee · 16

Dedicator of cytokinesis protein 2 → ankle, appendix, blood, bone marrow cell, epithelium of colon, granulocyte, lymph node, mesenteric lymph nodes, monocyte, spleen, stroma of bone marrow, subcutaneous adipose tissue, thymus, tibiofemoral joint, trabecular bone, white adipose tissue

RNA expression pattern · 16

related to External links · 6

Dedicator of cytokinesis protein 2 → Dedicator, Overview, PDB, PDBe-KB, Q92608, UniProt

Band · 2

Dedicator of cytokinesis protein 2 → 11|11 A4, 5q35.1

Chr. · 2

Dedicator of cytokinesis protein 2 → Chromosome 11 (mouse), Chromosome 5 (human)

End · 2

Dedicator of cytokinesis protein 2 → 170,083,382 bp, 34,674,719 bp

Aliases · 1

Dedicator of cytokinesis protein 2 → DOCK2, IMD40, Dock2, dedicator of cytokinesis 2

Available structures · 1

Dedicator of cytokinesis protein 2 → Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes2RQR, 2YIN, 3A98, 3B13

BioGPS · 1

Dedicator of cytokinesis protein 2 → More reference expression data

Important terminology Word statistics

Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.

Important terminology

dock2 protein proteins rac human bp chr dock band chemotaxis binding activation exchange gene small chromosome dock180 activity function domain

Entity relationships Subject–Predicate–Object triples

Subject	Predicate	Object	Confidence	Src
Dedicator of cytokinesis protein 2	Aliases	DOCK2, IMD40, Dock2, dedicator of cytokinesis 2	1.00	infobox
Dedicator of cytokinesis protein 2	Available structures	Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes2RQR, 2YIN, 3A98, 3B13	1.00	infobox
Dedicator of cytokinesis protein 2	Band	5q35.1	1.00	infobox
Dedicator of cytokinesis protein 2	Band	11\|11 A4	1.00	infobox
Dedicator of cytokinesis protein 2	Bgee	bone marrow cell	1.00	infobox
Dedicator of cytokinesis protein 2	Bgee	monocyte	1.00	infobox
Dedicator of cytokinesis protein 2	Bgee	granulocyte	1.00	infobox
Dedicator of cytokinesis protein 2	Bgee	blood	1.00	infobox
Dedicator of cytokinesis protein 2	Bgee	spleen	1.00	infobox
Dedicator of cytokinesis protein 2	Bgee	lymph node	1.00	infobox
Dedicator of cytokinesis protein 2	Bgee	appendix	1.00	infobox
Dedicator of cytokinesis protein 2	Bgee	epithelium of colon	1.00	infobox
Dedicator of cytokinesis protein 2	Bgee	trabecular bone	1.00	infobox
Dedicator of cytokinesis protein 2	Bgee	thymus	1.00	infobox
Dedicator of cytokinesis protein 2	Bgee	mesenteric lymph nodes	1.00	infobox
Dedicator of cytokinesis protein 2	Bgee	stroma of bone marrow	1.00	infobox
Dedicator of cytokinesis protein 2	Bgee	tibiofemoral joint	1.00	infobox
Dedicator of cytokinesis protein 2	Bgee	subcutaneous adipose tissue	1.00	infobox
Dedicator of cytokinesis protein 2	Bgee	ankle	1.00	infobox
Dedicator of cytokinesis protein 2	Bgee	white adipose tissue	1.00	infobox
Dedicator of cytokinesis protein 2	BioGPS	More reference expression data	1.00	infobox
Dedicator of cytokinesis protein 2	Chr.	Chromosome 5 (human)	1.00	infobox
Dedicator of cytokinesis protein 2	Chr.	Chromosome 11 (mouse)	1.00	infobox
Dedicator of cytokinesis protein 2	Databases	NCBI: entry; OMA: entry	1.00	infobox
Dedicator of cytokinesis protein 2	End	170,083,382 bp	1.00	infobox
Dedicator of cytokinesis protein 2	End	34,674,719 bp	1.00	infobox
Dedicator of cytokinesis protein 2	Ensembl	ENSG00000134516	1.00	infobox
Dedicator of cytokinesis protein 2	Entrez	1794	1.00	infobox
Dedicator of cytokinesis protein 2	External IDs	OMIM: 603122; MGI: 2149010; GeneCards: DOCK2	1.00	infobox
Dedicator of cytokinesis protein 2	Gene location (Human)	Gene location (Human)Chr.Chromosome 5 (human)Band5q35.1Start169,637,268 bpEnd170,083,382 bp	1.00	infobox

Related concept clusters Concept neighborhoods

These clusters group vocabulary that occurs around closely connected concepts in the source material.

Connections between topic areas Semantic bridges

Bridges can reveal useful research angles that are easy to miss in a flat list of related terms.

Min side: 3