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Chemokine (C-C motif) ligand 21 (CCL21) is a small cytokine belonging to the CC chemokine family. This chemokine is also known as 6Ckine (because it has six conserved cysteine residues instead of the four cysteines typical to chemokines), exodus-2, and secondary lymphoid-tissue chemokine (SLC). CCL21 elicits its effects by binding to a cell surface…
The analysis highlights Function, Protein structure and Gene as prominent areas in the source structure around CCL21.
Source areas are shown by the number of related topics found in each part of the analysis. Use smaller areas too: they can reveal specialized angles and content gaps.
Smaller areas are not necessarily less important. They contain fewer connections in this analysis and can be useful for finding specialized angles or coverage gaps.
High-confidence facts extracted from structured source data. Use them as anchors for further research.
Browse the complete topic structure, not only the most central items. Less prominent entities and concepts can reveal missing angles, specialized context and useful research gaps. Each item opens a new analysis centered on that subject.
Deeper signals for content research, entity SEO and topical coverage. The plain-language headings explain what each technical view is useful for.
The extracted context around CCL21 shows recurring relationship patterns in the source. For example, CCL21 → activation of GTPase activity, antimicrobial humoral immune response mediated by antimicrobial peptide, CCR chemokine receptor binding, CCR7 chemokine receptor binding, cell chemotaxis, cell maturation, cell-cell signaling, cellular response to chemokine, cellular response to interferon-gamma, cellular response to interleukin-1, cellular response to tumor necrosis factor, chemokine (C-C motif) ligand 21 signaling pathway, chemokine activity, chemokine receptor binding, chemokine-mediated signaling pathway, chemotaxis, cytokine activity, dendritic cell chemotaxis, dendritic cell dendrite assembly, establishment of T cell polarity Another extracted example is CCL21 → appendix, colon, esophagus, gallbladder, gastric mucosa, ileum, left lobe of thyroid gland, lip, lung, lymph node, mucosa of transverse colon, ovary, rectum, right lobe of thyroid gland, right uterine tube, spleen, thymus, upper lobe of left lung, urinary bladder, uterus. Use these groups to spot repeated connection types before inspecting the individual relationships.
Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.
cells chemokine ccr7 lymph human cell bp gene secondary dendritic chr chromosome band migration lymphoid organs function nodes ligand thymus
TTTA extracted 150 structured relationships around CCL21. Examples in this analysis include CCL21 → Aliases → CCL21, 6Ckine, CKb9, ECL, SCYA21, SLC, TCA4, C-C motif chemokine ligand 21 and CCL21 → Available structures → Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes2L4N. The table shows each extracted connection, where it came from and its confidence.
| Subject | Predicate | Object | Confidence | Src |
|---|---|---|---|---|
| CCL21 | Aliases | CCL21, 6Ckine, CKb9, ECL, SCYA21, SLC, TCA4, C-C motif chemokine ligand 21 | 1.00 | infobox |
| CCL21 | Available structures | Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes2L4N | 1.00 | infobox |
| CCL21 | Band | 9p13.3 | 1.00 | infobox |
| CCL21 | Band | 4 A5|4 22.81 cM | 1.00 | infobox |
| CCL21 | Bgee | lymph node | 1.00 | infobox |
| CCL21 | Bgee | right lobe of thyroid gland | 1.00 | infobox |
| CCL21 | Bgee | appendix | 1.00 | infobox |
| CCL21 | Bgee | left lobe of thyroid gland | 1.00 | infobox |
| CCL21 | Bgee | rectum | 1.00 | infobox |
| CCL21 | Bgee | gallbladder | 1.00 | infobox |
| CCL21 | Bgee | gastric mucosa | 1.00 | infobox |
| CCL21 | Bgee | mucosa of transverse colon | 1.00 | infobox |
| CCL21 | Bgee | right uterine tube | 1.00 | infobox |
| CCL21 | Bgee | upper lobe of left lung | 1.00 | infobox |
| CCL21 | Bgee | thymus | 1.00 | infobox |
| CCL21 | Bgee | spleen | 1.00 | infobox |
| CCL21 | Bgee | urinary bladder | 1.00 | infobox |
| CCL21 | Bgee | lip | 1.00 | infobox |
| CCL21 | Bgee | ovary | 1.00 | infobox |
| CCL21 | Bgee | lung | 1.00 | infobox |
| CCL21 | Bgee | esophagus | 1.00 | infobox |
| CCL21 | Bgee | uterus | 1.00 | infobox |
| CCL21 | Bgee | colon | 1.00 | infobox |
| CCL21 | Bgee | ileum | 1.00 | infobox |
| CCL21 | BioGPS | More reference expression data | 1.00 | infobox |
| CCL21 | Chr. | Chromosome 9 (human) | 1.00 | infobox |
| CCL21 | Chr. | Chromosome 4 (mouse) | 1.00 | infobox |
| CCL21 | Databases | NCBI: entry; OMA: entry | 1.00 | infobox |
| CCL21 | End | 34,710,136 bp | 1.00 | infobox |
| CCL21 | End | 42,773,993 bp | 1.00 | infobox |
The concept neighborhoods around CCL21 bring nearby vocabulary together. In this analysis, examples include Chemokine, Cell and Ccr7. Use the clusters to find adjacent concepts and terminology that may deserve separate research.
For CCL21, one of the stronger structural bridges in this analysis connects CCL21 with Function. Bridges highlight paths between different parts of the map and can reveal research angles that are easy to miss in a flat list.
TTTA analyzes the structure around CCL21 to surface related topics, entities, relationships, concept neighborhoods and bridge connections. Use the map to explore areas such as Function, Protein structure & Gene, including less central topics that may reveal useful research gaps. Automatically extracted connections are research leads rather than rewritten encyclopedia content.
Source: Wikipedia — CCL21 · EN edition · Analysis: TopicsToTalkAbout