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CCL21: Function, Protein structure & Gene

Chemokine (C-C motif) ligand 21 (CCL21) is a small cytokine belonging to the CC chemokine family. This chemokine is also known as 6Ckine (because it has six conserved cysteine residues instead of the four cysteines typical to chemokines), exodus-2, and secondary lymphoid-tissue chemokine (SLC). CCL21 elicits its effects by binding to a cell surface…

Language: English [EN]
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CCL21 topic overview

The analysis highlights Function, Protein structure and Gene as prominent areas in the source structure around CCL21.

Related topics
38
Source areas
4
Connected nodes
42
Extracted relationships
150
Concept neighborhoods
25
Bridge connections
42

What this topic covers Research coverage

Source areas are shown by the number of related topics found in each part of the analysis. Use smaller areas too: they can reveal specialized angles and content gaps.

Function · 20 topics
Overview · 10 topics
Protein structure · 5 topics
Gene · 3 topics

Smaller areas are not necessarily less important. They contain fewer connections in this analysis and can be useful for finding specialized angles or coverage gaps.

Key facts & relationships

High-confidence facts extracted from structured source data. Use them as anchors for further research.

Aliases
CCL21, 6Ckine, CKb9, ECL, SCYA21, SLC, TCA4, C-C motif chemokine ligand 21
Available structures
Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes2L4N
Band
9p13.3 · 4 A5|4 22.81 cM
Bgee
lymph node · right lobe of thyroid gland · appendix · left lobe of thyroid gland · rectum
BioGPS
More reference expression data
Chr.
Chromosome 9 (human) · Chromosome 4 (mouse)

Explore all related topics Closing gaps

Browse the complete topic structure, not only the most central items. Less prominent entities and concepts can reveal missing angles, specialized context and useful research gaps. Each item opens a new analysis centered on that subject.

Overview

Gene

Protein structure

Function

Advanced semantic analysis

Deeper signals for content research, entity SEO and topical coverage. The plain-language headings explain what each technical view is useful for.

How CCL21 connects Entity context

The extracted context around CCL21 shows recurring relationship patterns in the source. For example, CCL21 → activation of GTPase activity, antimicrobial humoral immune response mediated by antimicrobial peptide, CCR chemokine receptor binding, CCR7 chemokine receptor binding, cell chemotaxis, cell maturation, cell-cell signaling, cellular response to chemokine, cellular response to interferon-gamma, cellular response to interleukin-1, cellular response to tumor necrosis factor, chemokine (C-C motif) ligand 21 signaling pathway, chemokine activity, chemokine receptor binding, chemokine-mediated signaling pathway, chemotaxis, cytokine activity, dendritic cell chemotaxis, dendritic cell dendrite assembly, establishment of T cell polarity Another extracted example is CCL21 → appendix, colon, esophagus, gallbladder, gastric mucosa, ileum, left lobe of thyroid gland, lip, lung, lymph node, mucosa of transverse colon, ovary, rectum, right lobe of thyroid gland, right uterine tube, spleen, thymus, upper lobe of left lung, urinary bladder, uterus. Use these groups to spot repeated connection types before inspecting the individual relationships.

CCL21

Top relations

Gene ontology · 60
CCL21 → activation of GTPase activity, antimicrobial humoral immune response mediated by antimicrobial peptide, CCR chemokine receptor binding, CCR7 chemokine receptor binding, cell chemotaxis, cell maturation, cell-cell signaling, cellular response to chemokine, cellular response to interferon-gamma, cellular response to interleukin-1, cellular response to tumor necrosis factor, chemokine (C-C motif) ligand 21 signaling pathway, chemokine activity, chemokine receptor binding, chemokine-mediated signaling pathway, chemotaxis, cytokine activity, dendritic cell chemotaxis, dendritic cell dendrite assembly, establishment of T cell polarity
Bgee · 20
CCL21 → appendix, colon, esophagus, gallbladder, gastric mucosa, ileum, left lobe of thyroid gland, lip, lung, lymph node, mucosa of transverse colon, ovary, rectum, right lobe of thyroid gland, right uterine tube, spleen, thymus, upper lobe of left lung, urinary bladder, uterus
RNA expression pattern · 20
CCL21 → appendix, colon, esophagus, gallbladder, gastric mucosa, ileum, left lobe of thyroid gland, lip, lung, lymph node, mucosa of transverse colon, ovary, rectum, right lobe of thyroid gland, right uterine tube, spleen, thymus, upper lobe of left lung, urinary bladder, uterus
related to Migration to secondary lymphoid organs · 14
CCL21 → After, CCL21/CCR7, CCR7, CCR7-deficient, Dendritic, Full-length CCL21, In, Interactions, It, Naïve, Semi-mature, Then, They, When CCL21
related to Protein structure · 7
CCL21 → C-terminal, C-terminus, CCL19, CCR7, Chemokine CCL21, It, The
Band · 2
CCL21 → 4 A5|4 22.81 cM, 9p13.3
Chr. · 2
CCL21 → Chromosome 4 (mouse), Chromosome 9 (human)
End · 2
CCL21 → 34,710,136 bp, 42,773,993 bp
related to External links · 2
CCL21 → Human CCL21, UCSC Genome Browser
related to Gene · 2
CCL21 → However, The

Important terminology

Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.

Important terminology

cells chemokine ccr7 lymph human cell bp gene secondary dendritic chr chromosome band migration lymphoid organs function nodes ligand thymus

CCL21 relationships Subject–Predicate–Object triples

TTTA extracted 150 structured relationships around CCL21. Examples in this analysis include CCL21 → Aliases → CCL21, 6Ckine, CKb9, ECL, SCYA21, SLC, TCA4, C-C motif chemokine ligand 21 and CCL21 → Available structures → Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes2L4N. The table shows each extracted connection, where it came from and its confidence.

SubjectPredicateObjectConfidenceSrc
CCL21AliasesCCL21, 6Ckine, CKb9, ECL, SCYA21, SLC, TCA4, C-C motif chemokine ligand 211.00infobox
CCL21Available structuresAvailable structuresPDBOrtholog search: PDBe RCSB List of PDB id codes2L4N1.00infobox
CCL21Band9p13.31.00infobox
CCL21Band4 A5|4 22.81 cM1.00infobox
CCL21Bgeelymph node1.00infobox
CCL21Bgeeright lobe of thyroid gland1.00infobox
CCL21Bgeeappendix1.00infobox
CCL21Bgeeleft lobe of thyroid gland1.00infobox
CCL21Bgeerectum1.00infobox
CCL21Bgeegallbladder1.00infobox
CCL21Bgeegastric mucosa1.00infobox
CCL21Bgeemucosa of transverse colon1.00infobox
CCL21Bgeeright uterine tube1.00infobox
CCL21Bgeeupper lobe of left lung1.00infobox
CCL21Bgeethymus1.00infobox
CCL21Bgeespleen1.00infobox
CCL21Bgeeurinary bladder1.00infobox
CCL21Bgeelip1.00infobox
CCL21Bgeeovary1.00infobox
CCL21Bgeelung1.00infobox
CCL21Bgeeesophagus1.00infobox
CCL21Bgeeuterus1.00infobox
CCL21Bgeecolon1.00infobox
CCL21Bgeeileum1.00infobox
CCL21BioGPSMore reference expression data1.00infobox
CCL21Chr.Chromosome 9 (human)1.00infobox
CCL21Chr.Chromosome 4 (mouse)1.00infobox
CCL21DatabasesNCBI: entry; OMA: entry1.00infobox
CCL21End34,710,136 bp1.00infobox
CCL21End42,773,993 bp1.00infobox

Related concept clusters Concept neighborhoods

The concept neighborhoods around CCL21 bring nearby vocabulary together. In this analysis, examples include Chemokine, Cell and Ccr7. Use the clusters to find adjacent concepts and terminology that may deserve separate research.

  • CCL21
    • Chemokine
    • Cell
    • Ccr7
    • Cells
    • Migration
    • Lymph
    • Nodes
    • Function
    • Ligand
    • Thymus
    • Lymphoid
    • Organs
  • ccl21
    • Chemokine
    • Cell
    • Ccr7
    • Cells
    • Migration
    • Lymph
    • Nodes
    • Function
    • Ligand
    • Thymus
    • Lymphoid
    • Organs
  • cytokine
    • Motif
    • Ligand
    • Binding
    • Mouse
    • Receptor
    • Adhesion
    • Antigen
    • Expression
    • Extracellular
    • Immune
    • Node
    • Response
  • chemokine
    • Ccl21
    • Ligand
    • Migration
    • Motif
    • Lymph
    • Secondary
    • Cell
    • 6ckine
    • Binding
    • Cytokine
    • Known
    • Receptor
  • chemokine receptor
    • Ccl21
    • Ligand
    • Migration
    • Motif
    • Lymph
    • Response
    • Secondary
    • Cell
    • Thymus
    • 6ckine
    • Binding
    • Cytokine
  • ccr7
    • Dendritic
    • Cell
    • Receptor
    • Cells
    • Expression
    • Function
    • Ligand
    • Thymus
    • Chemokine
    • Lymphoid
    • Organs
    • Migration
  • lymph nodes
    • Nodes
    • Node
    • Cells
    • Migration
    • Antigen
    • Immune
    • Response
    • Dendritic
    • Mouse
    • Organs
    • Receptor
    • Adhesion
  • gene
    • Location
    • Human
    • Chromosome
    • Bp
    • Chr
    • Mouse
    • Motif
    • Band
    • Ligand
    • Thymus
    • Migration
    • Receptor

Connections between topic areas Semantic bridges

For CCL21, one of the stronger structural bridges in this analysis connects CCL21 with Function. Bridges highlight paths between different parts of the map and can reveal research angles that are easy to miss in a flat list.

Min side: 3
CCL21Function · splits 22 ⟂ 21
CCL21Overview · splits 32 ⟂ 11
CCL21Protein structure · splits 37 ⟂ 6
CCL21Gene · splits 39 ⟂ 4

Map overview Semantic statistics

CCL21

Nodes43
Edges42
Triples150
Avg. degree1.95
Density0.046512
Components1

Source & methodology

TTTA analyzes the structure around CCL21 to surface related topics, entities, relationships, concept neighborhoods and bridge connections. Use the map to explore areas such as Function, Protein structure & Gene, including less central topics that may reveal useful research gaps. Automatically extracted connections are research leads rather than rewritten encyclopedia content.

Source: Wikipedia — CCL21 · EN edition · Analysis: TopicsToTalkAbout

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