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CCL21

Chemokine (C-C motif) ligand 21 (CCL21) is a small cytokine belonging to the CC chemokine family. This chemokine is also known as 6Ckine (because it has six conserved cysteine residues instead of the four cysteines typical to chemokines), exodus-2, and secondary lymphoid-tissue chemokine (SLC). CCL21 elicits its effects by binding to a cell surface…

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Aliases
CCL21, 6Ckine, CKb9, ECL, SCYA21, SLC, TCA4, C-C motif chemokine ligand 21
Available structures
Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes2L4N
Band
9p13.3 · 4 A5|4 22.81 cM
Bgee
lymph node · right lobe of thyroid gland · appendix · left lobe of thyroid gland · rectum
BioGPS
More reference expression data
Chr.
Chromosome 9 (human) · Chromosome 4 (mouse)

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Map overview Semantic statistics

CCL21

Nodes43
Edges42
Triples150
Avg. degree1.95
Density0.046512
Components1

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CCL21

Top relations

Gene ontology · 60
CCL21 → activation of GTPase activity, antimicrobial humoral immune response mediated by antimicrobial peptide, CCR chemokine receptor binding, CCR7 chemokine receptor binding, cell chemotaxis, cell maturation, cell-cell signaling, cellular response to chemokine, cellular response to interferon-gamma, cellular response to interleukin-1, cellular response to tumor necrosis factor, chemokine (C-C motif) ligand 21 signaling pathway, chemokine activity, chemokine receptor binding, chemokine-mediated signaling pathway, chemotaxis, cytokine activity, dendritic cell chemotaxis, dendritic cell dendrite assembly, establishment of T cell polarity
Bgee · 20
CCL21 → appendix, colon, esophagus, gallbladder, gastric mucosa, ileum, left lobe of thyroid gland, lip, lung, lymph node, mucosa of transverse colon, ovary, rectum, right lobe of thyroid gland, right uterine tube, spleen, thymus, upper lobe of left lung, urinary bladder, uterus
RNA expression pattern · 20
CCL21 → appendix, colon, esophagus, gallbladder, gastric mucosa, ileum, left lobe of thyroid gland, lip, lung, lymph node, mucosa of transverse colon, ovary, rectum, right lobe of thyroid gland, right uterine tube, spleen, thymus, upper lobe of left lung, urinary bladder, uterus
related to Migration to secondary lymphoid organs · 14
CCL21 → After, CCL21/CCR7, CCR7, CCR7-deficient, Dendritic, Full-length CCL21, In, Interactions, It, Naïve, Semi-mature, Then, They, When CCL21
related to Protein structure · 7
CCL21 → C-terminal, C-terminus, CCL19, CCR7, Chemokine CCL21, It, The
Band · 2
CCL21 → 4 A5|4 22.81 cM, 9p13.3
Chr. · 2
CCL21 → Chromosome 4 (mouse), Chromosome 9 (human)
End · 2
CCL21 → 34,710,136 bp, 42,773,993 bp
related to External links · 2
CCL21 → Human CCL21, UCSC Genome Browser
related to Gene · 2
CCL21 → However, The

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Important terminology

cells chemokine ccr7 lymph human cell bp gene secondary dendritic chr chromosome band migration lymphoid organs function nodes ligand thymus

Entity relationships Subject–Predicate–Object triples

SubjectPredicateObjectConfidenceSrc
CCL21AliasesCCL21, 6Ckine, CKb9, ECL, SCYA21, SLC, TCA4, C-C motif chemokine ligand 211.00infobox
CCL21Available structuresAvailable structuresPDBOrtholog search: PDBe RCSB List of PDB id codes2L4N1.00infobox
CCL21Band9p13.31.00infobox
CCL21Band4 A5|4 22.81 cM1.00infobox
CCL21Bgeelymph node1.00infobox
CCL21Bgeeright lobe of thyroid gland1.00infobox
CCL21Bgeeappendix1.00infobox
CCL21Bgeeleft lobe of thyroid gland1.00infobox
CCL21Bgeerectum1.00infobox
CCL21Bgeegallbladder1.00infobox
CCL21Bgeegastric mucosa1.00infobox
CCL21Bgeemucosa of transverse colon1.00infobox
CCL21Bgeeright uterine tube1.00infobox
CCL21Bgeeupper lobe of left lung1.00infobox
CCL21Bgeethymus1.00infobox
CCL21Bgeespleen1.00infobox
CCL21Bgeeurinary bladder1.00infobox
CCL21Bgeelip1.00infobox
CCL21Bgeeovary1.00infobox
CCL21Bgeelung1.00infobox
CCL21Bgeeesophagus1.00infobox
CCL21Bgeeuterus1.00infobox
CCL21Bgeecolon1.00infobox
CCL21Bgeeileum1.00infobox
CCL21BioGPSMore reference expression data1.00infobox
CCL21Chr.Chromosome 9 (human)1.00infobox
CCL21Chr.Chromosome 4 (mouse)1.00infobox
CCL21DatabasesNCBI: entry; OMA: entry1.00infobox
CCL21End34,710,136 bp1.00infobox
CCL21End42,773,993 bp1.00infobox

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