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Respiratory complex I

Respiratory complex I, EC 7.1.1.2 (also known as NADH:ubiquinone oxidoreductase, Type I NADH dehydrogenase and mitochondrial complex I) is the first large protein complex of the respiratory chains of many organisms from bacteria to humans. It catalyzes the transfer of electrons from NADH to coenzyme Q10 (CoQ10) and translocates protons across the inner…

Inhibitors, Genes & Function

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Membranome
255
OPM protein
6g72
OPM superfamily
246
Symbol
Respiratory complex I

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Overview

Function

Mechanism

Composition and structure

Inhibitors

Active/inactive transition

Production of superoxide

Pathology

In chloroplasts

Genes

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Respiratory complex I

Nodes152
Edges151
Triples9
Avg. degree1.99
Density0.013158
Components1

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Respiratory complex I

Top relations

Membranome · 1
Respiratory complex I → 255
OPM protein · 1
Respiratory complex I → 6g72
OPM superfamily · 1
Respiratory complex I → 246
Symbol · 1
Respiratory complex I → Respiratory complex I

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Important terminology

complex nadh electron ubiquinone enzyme transfer mitochondrial membrane subunits found dehydrogenase superoxide proton protons na two reduction electrons fmn iron-sulfur

Entity relationships Subject–Predicate–Object triples

SubjectPredicateObjectConfidenceSrc
Respiratory complex IMembranome2551.00infobox
Respiratory complex IOPM protein6g721.00infobox
Respiratory complex IOPM superfamily2461.00infobox
Respiratory complex ISymbolRespiratory complex I1.00infobox
ischemia/reperfusion damageinstance ofDefects in this enzyme are responsible for the development of several pathological processes0.80text
Schizosaccharomyces pombed Recent research has described NDUFA4 to be a subunit of complex IVinstance ofa Found in all species except fungib May or may not be present in any speciesc Found in fungal species0.80text
and not of complex I InhibitorsInhibition of complex I is the mode of action of the METI acaricidesinstance ofa Found in all species except fungib May or may not be present in any speciesc Found in fungal species0.80text
insecticidesinstance ofa Found in all species except fungib May or may not be present in any speciesc Found in fungal species0.80text
Antoniainstance ofRotenone and rotenoids are isoflavonoids occurring in several genera of tropical plants0.80text

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