Research any topic before you write.

Find related topics. | Discover entities. | See connections. | Build a topical map.

ICAM-1

ICAM-1 (intercellular adhesion molecule 1) also known as CD54 (Cluster of Differentiation 54) is a protein that in humans is encoded by the ICAM1 gene. This gene encodes a cell surface glycoprotein which is typically expressed on endothelial cells and cells of the immune system. It binds to integrins of type CD11a / CD18, or CD11b / CD18 and is also…

Function, Clinical significance & Structure

Use the mouse wheel or two fingers (on touchscreens) to zoom in and out of the map.

Research this topic

Explore the main themes, entities and connections around ICAM-1. Start with the topic map, then use the sections below for research and deeper semantic analysis.

Explore this topic

Start with a few of the strongest sections from the source topic. These are research directions, not a list of keywords you must use.

Key facts & relationships

High-confidence facts extracted from structured source data. Use them as anchors for further research.

Aliases
ICAM1, BB2, CD54, P3.58, intercellular adhesion molecule 1
Available structures
Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1D3E, 1D3I, 1D3L, 1IAM, 1IC1, 1MQ8, 1P53, 1Z7Z, 2OZ4, 3TCX
Band
19p13.2 · 9 A3|9 7.69 cM
Bgee
vena cava · upper lobe of left lung · cartilage tissue · right lung · beta cell
BioGPS
More reference expression data
Chr.
Chromosome 19 (human) · Chromosome 9 (mouse)

Topics to explore

Browse the full topic structure. Each item opens a new analysis centered on that subject.

Overview

Structure

Function

Clinical significance

Interactions

Advanced semantic analysis

Deeper signals for content research, entity SEO and topical coverage. The plain-language headings explain what each technical view is useful for.

Map overview Semantic statistics

ICAM-1

Nodes62
Edges61
Triples183
Avg. degree1.97
Density0.032258
Components1

How this topic connects Entity context

See the strongest relationship patterns around the current topic before diving into the raw triples.

ICAM-1

Top relations

Gene ontology · 81
ICAM-1 → acute inflammatory response to antigenic stimulus, cell adhesion, cell adhesion mediated by integrin, cell surface, cell-cell adhesion, cellular response to alkaloid, cellular response to amyloid-beta, cellular response to dexamethasone stimulus, cellular response to glucose stimulus, cellular response to hypoxia, cellular response to interferon-gamma, cellular response to interleukin-1, cellular response to interleukin-6, cellular response to leukemia inhibitory factor, cellular response to lipopolysaccharide, cellular response to nutrient levels, cellular response to organic substance, cellular response to tumor necrosis factor, collagen-containing extracellular matrix, cytokine-mediated signaling pathway
Bgee · 19
ICAM-1 → ankle joint, aortic valve, beta cell, cartilage tissue, decidua, gallbladder, gastrula, left lung, left lung lobe, lower lobe of lung, lymph node, mesenteric lymph nodes, monocyte, right lung, right lung lobe, spleen, thymus, upper lobe of left lung, vena cava
RNA expression pattern · 19
ICAM-1 → ankle joint, aortic valve, beta cell, cartilage tissue, decidua, gallbladder, gastrula, left lung, left lung lobe, lower lobe of lung, lymph node, mesenteric lymph nodes, monocyte, right lung, right lung lobe, spleen, thymus, upper lobe of left lung, vena cava
related to Other functions · 8
ICAM-1 → As, ITGAM, ITGB2, LFA-1, Mac-1, Notably, The, These
related to Function · 7
ICAM-1 → ICAM-1/LFA-1, IL-1, LFA-1, The, TNF, Upon, When
is a · 3
ICAM-1 → ligand for LFA-1, primary entry receptor for Coxsackievirus A21, transmembrane protein possessing an amino-terminus extracellular domain
related to Clinical significance · 3
ICAM-1 → Levels, SAH, While ICAM-1
related to Interactions · 3
ICAM-1 → CD11a, CD18, EZR
Band · 2
ICAM-1 → 19p13.2, 9 A3|9 7.69 cM
Chr. · 2
ICAM-1 → Chromosome 19 (human), Chromosome 9 (mouse)

Important terminology Word statistics

Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.

Important terminology

adhesion protein endothelial human signaling gene cells also bp molecule entry receptor role expressed chr band leukocyte binding inflammatory intercellular

Entity relationships Subject–Predicate–Object triples

SubjectPredicateObjectConfidenceSrc
ICAM-1AliasesICAM1, BB2, CD54, P3.58, intercellular adhesion molecule 11.00infobox
ICAM-1Available structuresAvailable structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1D3E, 1D3I, 1D3L, 1IAM, 1IC1, 1MQ8, 1P53, 1Z7Z, 2OZ4, 3TCX1.00infobox
ICAM-1Band19p13.21.00infobox
ICAM-1Band9 A3|9 7.69 cM1.00infobox
ICAM-1Bgeevena cava1.00infobox
ICAM-1Bgeeupper lobe of left lung1.00infobox
ICAM-1Bgeecartilage tissue1.00infobox
ICAM-1Bgeeright lung1.00infobox
ICAM-1Bgeebeta cell1.00infobox
ICAM-1Bgeegallbladder1.00infobox
ICAM-1Bgeelower lobe of lung1.00infobox
ICAM-1Bgeespleen1.00infobox
ICAM-1Bgeemonocyte1.00infobox
ICAM-1Bgeelymph node1.00infobox
ICAM-1Bgeeright lung lobe1.00infobox
ICAM-1Bgeeleft lung1.00infobox
ICAM-1Bgeeleft lung lobe1.00infobox
ICAM-1Bgeemesenteric lymph nodes1.00infobox
ICAM-1Bgeedecidua1.00infobox
ICAM-1Bgeeankle joint1.00infobox
ICAM-1Bgeegastrula1.00infobox
ICAM-1Bgeethymus1.00infobox
ICAM-1Bgeeaortic valve1.00infobox
ICAM-1BioGPSMore reference expression data1.00infobox
ICAM-1Chr.Chromosome 19 (human)1.00infobox
ICAM-1Chr.Chromosome 9 (mouse)1.00infobox
ICAM-1DatabasesNCBI: entry; OMA: entry1.00infobox
ICAM-1End10,286,615 bp1.00infobox
ICAM-1End20,940,113 bp1.00infobox
ICAM-1EnsemblENSG000000903391.00infobox

Related concept clusters Concept neighborhoods

These clusters group vocabulary that occurs around closely connected concepts in the source material.

    Connections between topic areas Semantic bridges

    Bridges can reveal useful research angles that are easy to miss in a flat list of related terms.

    Min side: 3
    For writers, content strategists, SEOs, marketers and creators — from quick topic research to advanced semantic analysis.