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YTHDC1

YTH domain-containing protein 1 is a protein that in humans is encoded by the YTHDC1 gene. YTHDC1 is a nuclear protein involved in splice site selection that localises to YT bodies; dynamic subnuclear compartments, which first appear at the beginning of S-phase in the cell cycle and disperse during mitosis.

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Aliases
YTHDC1, YT521, YT521-B, YTH domain containing 1
Available structures
Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes2YUD, 4R3H, 4R3I
Band
4q13.2 · 5|5 E1
Bgee
Achilles tendon · corpus callosum · sural nerve · left ovary · bone marrow
BioGPS
More reference expression data
Chr.
Chromosome 4 (human) · Chromosome 5 (mouse)

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Role in disease

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Map overview Semantic statistics

YTHDC1

Nodes16
Edges15
Triples90
Avg. degree1.88
Density0.125
Components1

How this topic connects Entity context

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YTHDC1

Top relations

Bgee · 20
YTHDC1 → Achilles tendon, bone marrow, ciliary body, conjunctival fornix, corpus callosum, cumulus cell, endometrium, left ovary, medullary collecting duct, Paneth cell, pineal gland, renal corpuscle, right lung, right ovary, Rostral migratory stream, sural nerve, ureter, vagina, ventricular zone, vestibular membrane of cochlear duct
RNA expression pattern · 20
YTHDC1 → Achilles tendon, bone marrow, ciliary body, conjunctival fornix, corpus callosum, cumulus cell, endometrium, left ovary, medullary collecting duct, Paneth cell, pineal gland, renal corpuscle, right lung, right ovary, Rostral migratory stream, sural nerve, ureter, vagina, ventricular zone, vestibular membrane of cochlear duct
Gene ontology · 14
YTHDC1 → dosage compensation by inactivation of X chromosome, mRNA export from nucleus, mRNA processing, mRNA splice site selection, N6-methyladenosine-containing RNA binding, nuclear speck, nucleoplasm, nucleus, plasma membrane, posttranscriptional regulation of gene expression, protein binding, regulation of mRNA splicing, via spliceosome, RNA binding, RNA splicing
related to Cancer · 7
YTHDC1 → BRCA1, CD44, DNA, In, MTDH, PGR, VEGF
related to Interactions · 4
YTHDC1 → Abl, C-src, Emerin, KHDRBS1
Band · 2
YTHDC1 → 4q13.2, 5|5 E1
Chr. · 2
YTHDC1 → Chromosome 4 (human), Chromosome 5 (mouse)
End · 2
YTHDC1 → 68,350,090 bp, 86,984,518 bp
Aliases · 1
YTHDC1 → YTHDC1, YT521, YT521-B, YTH domain containing 1
Available structures · 1
YTHDC1 → Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes2YUD, 4R3H, 4R3I

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Important terminology

bp gene chr human band protein chromosome cancer splice location mouse splicing yth nuclear site selection cell shown encoded search

Entity relationships Subject–Predicate–Object triples

SubjectPredicateObjectConfidenceSrc
YTHDC1AliasesYTHDC1, YT521, YT521-B, YTH domain containing 11.00infobox
YTHDC1Available structuresAvailable structuresPDBOrtholog search: PDBe RCSB List of PDB id codes2YUD, 4R3H, 4R3I1.00infobox
YTHDC1Band4q13.21.00infobox
YTHDC1Band5|5 E11.00infobox
YTHDC1BgeeAchilles tendon1.00infobox
YTHDC1Bgeecorpus callosum1.00infobox
YTHDC1Bgeesural nerve1.00infobox
YTHDC1Bgeeleft ovary1.00infobox
YTHDC1Bgeebone marrow1.00infobox
YTHDC1Bgeeendometrium1.00infobox
YTHDC1Bgeeventricular zone1.00infobox
YTHDC1Bgeeright ovary1.00infobox
YTHDC1Bgeeright lung1.00infobox
YTHDC1Bgeevagina1.00infobox
YTHDC1Bgeemedullary collecting duct1.00infobox
YTHDC1Bgeeconjunctival fornix1.00infobox
YTHDC1Bgeerenal corpuscle1.00infobox
YTHDC1Bgeecumulus cell1.00infobox
YTHDC1Bgeeureter1.00infobox
YTHDC1Bgeeciliary body1.00infobox
YTHDC1Bgeepineal gland1.00infobox
YTHDC1Bgeevestibular membrane of cochlear duct1.00infobox
YTHDC1BgeeRostral migratory stream1.00infobox
YTHDC1BgeePaneth cell1.00infobox
YTHDC1BioGPSMore reference expression data1.00infobox
YTHDC1Chr.Chromosome 4 (human)1.00infobox
YTHDC1Chr.Chromosome 5 (mouse)1.00infobox
YTHDC1DatabasesNCBI: entry; OMA: entry1.00infobox
YTHDC1End68,350,090 bp1.00infobox
YTHDC1End86,984,518 bp1.00infobox

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