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E-selectin: Art, Pathological relevance & Ligands

E-selectin, also known as CD62 antigen-like family member E (CD62E), endothelial-leukocyte adhesion molecule 1 (ELAM-1), or leukocyte-endothelial cell adhesion molecule 2 (LECAM2), is a selectin cell adhesion molecule expressed only on endothelial cells activated by cytokines. Like other selectins, it plays an important part in inflammation. In humans…

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E-selectin topic overview

The analysis highlights Art, Pathological relevance and Ligands as prominent areas in the source structure around E-selectin.

Related topics
79
Source areas
6
Connected nodes
85
Extracted relationships
185
Concept neighborhoods
20
Bridge connections
85

What this topic covers Research coverage

Source areas are shown by the number of related topics found in each part of the analysis. Use smaller areas too: they can reveal specialized angles and content gaps.

Pathological relevance · 24 topics
Ligands · 15 topics
Gene and regulation · 14 topics
Function · 13 topics
Structure · 7 topics
Overview · 6 topics

Smaller areas are not necessarily less important. They contain fewer connections in this analysis and can be useful for finding specialized angles or coverage gaps.

Key facts & relationships

High-confidence facts extracted from structured source data. Use them as anchors for further research.

Aliases
SELE, CD62E, ELAM, ELAM1, ESEL, LECAM2, selectin E, selectin-e
Available structures
Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1ESL, 1G1T, 4C16, 4CSY
Band
1q24.2 · 1 H2.2|1 71.35 cM
Bgee
vena cava · left uterine tube · testicle · seminal vesicula · olfactory zone of nasal mucosa
BioGPS
More reference expression data
Chr.
Chromosome 1 (human) · Chromosome 1 (mouse)

Explore all related topics Closing gaps

Browse the complete topic structure, not only the most central items. Less prominent entities and concepts can reveal missing angles, specialized context and useful research gaps. Each item opens a new analysis centered on that subject.

Overview

Structure

Gene and regulation

Ligands

Function

Pathological relevance

Advanced semantic analysis

Deeper signals for content research, entity SEO and topical coverage. The plain-language headings explain what each technical view is useful for.

How E-selectin connects Entity context

The extracted context around E-selectin shows recurring relationship patterns in the source. For example, E-selectin → actin filament-based process, activation of phospholipase C activity, calcium-mediated signaling, carbohydrate binding, caveola, cell adhesion, clathrin-coated pit, cortical cytoskeleton, extracellular space, heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules, inflammatory response, integral component of membrane, integral component of plasma membrane, leukocyte cell-cell adhesion, leukocyte migration, leukocyte migration involved in inflammatory response, leukocyte tethering or rolling, membrane, membrane raft, metal ion binding Another extracted example is E-selectin → atrioventricular valve, cartilage tissue, endothelial cell of lymphatic vessel, gallbladder, gastric mucosa, granulocyte, Ileal epithelium, intestinal villus, left uterine tube, lip, mucosa of urinary bladder, olfactory zone of nasal mucosa, semi-lunar valve, seminal vesicula, spermatid, spermatocyte, testicle, trachea, transitional epithelium of urinary bladder, vena cava. Use these groups to spot repeated connection types before inspecting the individual relationships.

E-selectin

Top relations

Gene ontology · 32
E-selectin → actin filament-based process, activation of phospholipase C activity, calcium-mediated signaling, carbohydrate binding, caveola, cell adhesion, clathrin-coated pit, cortical cytoskeleton, extracellular space, heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules, inflammatory response, integral component of membrane, integral component of plasma membrane, leukocyte cell-cell adhesion, leukocyte migration, leukocyte migration involved in inflammatory response, leukocyte tethering or rolling, membrane, membrane raft, metal ion binding
Bgee · 20
E-selectin → atrioventricular valve, cartilage tissue, endothelial cell of lymphatic vessel, gallbladder, gastric mucosa, granulocyte, Ileal epithelium, intestinal villus, left uterine tube, lip, mucosa of urinary bladder, olfactory zone of nasal mucosa, semi-lunar valve, seminal vesicula, spermatid, spermatocyte, testicle, trachea, transitional epithelium of urinary bladder, vena cava
RNA expression pattern · 20
E-selectin → atrioventricular valve, cartilage tissue, endothelial cell of lymphatic vessel, gallbladder, gastric mucosa, granulocyte, Ileal epithelium, intestinal villus, left uterine tube, lip, mucosa of urinary bladder, olfactory zone of nasal mucosa, semi-lunar valve, seminal vesicula, spermatid, spermatocyte, testicle, trachea, transitional epithelium of urinary bladder, vena cava
related to Gene and regulation · 16
E-selectin → Different, EGF-like, IL-1, In, It, Its C-type, L-selectin, LPS, Maximal, P-selectin, SCR, SELE, The, The E-selectin, TNFα, Weibel-Palade
related to Structure · 15
E-selectin → C-type, Ca2, EGF, Fucα1, GlcNAc, LewisX, N-terminal, NeuNAcα2, SCR, SLeX, Structure/function, Sushi, The, The E-selectin, TM
related to Role in cancer · 14
E-selectin → At, E-selectin-blocking, E-selectin-mediated, Esl1, Furthermore, Glg1, HL60, IL-1β, Other, Studies, The, This, TNFα, While
related to Pathogen attachment · 10
E-selectin → An, E-selecin-mediated, HUVECs, LewisX, OmpA-like, Pgm6/7, Porphyromonas, Study, These, TNF-α
related to Nicotine-mediated induction · 8
E-selectin → Arr1, E2F1, E2F1-mediated, In, Nicotine-stimulated, RRD-251, Smoking, Therefore
related to Role in inflammation · 6
E-selectin → As, During, IL-1, Leukocytes, The, TNF-α
related to Critical illness polyneuromyopathy · 5
E-selectin → CIPNM, In, The, This, Traditional Chinese

Important terminology

Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.

Important terminology

cells endothelial cancer human cell also gene tumor inflammation may bp ligands expression expressed inflammatory adhesion chr band surface found

E-selectin relationships Subject–Predicate–Object triples

TTTA extracted 185 structured relationships around E-selectin. Examples in this analysis include E-selectin → Aliases → SELE, CD62E, ELAM, ELAM1, ESEL, LECAM2, selectin E, selectin-e and E-selectin → Available structures → Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1ESL, 1G1T, 4C16, 4CSY. The table shows each extracted connection, where it came from and its confidence.

SubjectPredicateObjectConfidenceSrc
E-selectinAliasesSELE, CD62E, ELAM, ELAM1, ESEL, LECAM2, selectin E, selectin-e1.00infobox
E-selectinAvailable structuresAvailable structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1ESL, 1G1T, 4C16, 4CSY1.00infobox
E-selectinBand1q24.21.00infobox
E-selectinBand1 H2.2|1 71.35 cM1.00infobox
E-selectinBgeevena cava1.00infobox
E-selectinBgeeleft uterine tube1.00infobox
E-selectinBgeetesticle1.00infobox
E-selectinBgeeseminal vesicula1.00infobox
E-selectinBgeeolfactory zone of nasal mucosa1.00infobox
E-selectinBgeetrachea1.00infobox
E-selectinBgeegastric mucosa1.00infobox
E-selectinBgeecartilage tissue1.00infobox
E-selectinBgeemucosa of urinary bladder1.00infobox
E-selectinBgeegallbladder1.00infobox
E-selectinBgeetransitional epithelium of urinary bladder1.00infobox
E-selectinBgeespermatid1.00infobox
E-selectinBgeespermatocyte1.00infobox
E-selectinBgeegranulocyte1.00infobox
E-selectinBgeeendothelial cell of lymphatic vessel1.00infobox
E-selectinBgeeintestinal villus1.00infobox
E-selectinBgeesemi-lunar valve1.00infobox
E-selectinBgeeIleal epithelium1.00infobox
E-selectinBgeeatrioventricular valve1.00infobox
E-selectinBgeelip1.00infobox
E-selectinBioGPSMore reference expression data1.00infobox
E-selectinChr.Chromosome 1 (human)1.00infobox
E-selectinChr.Chromosome 1 (mouse)1.00infobox
E-selectinDatabasesNCBI: entry; OMA: entry1.00infobox
E-selectinEnd169,764,705 bp1.00infobox
E-selectinEnd163,885,246 bp1.00infobox

Related concept clusters Concept neighborhoods

The concept neighborhoods around E-selectin bring nearby vocabulary together. In this analysis, examples include Cells, Endothelial and Cancer. Use the clusters to find adjacent concepts and terminology that may deserve separate research.

  • E-selectin
    • Cells
    • Endothelial
    • Cancer
    • Expression
    • Found
    • Ligands
    • Tumor
    • Shown
    • Studies
    • Expressed
    • Inflammatory
    • Surface
  • e-selectin
    • Cells
    • Endothelial
    • Cancer
    • Expression
    • Found
    • Ligands
    • Tumor
    • Shown
    • Studies
    • Expressed
    • Inflammatory
    • Surface
  • cell adhesion molecule
    • Endothelial
    • Cell
    • Expressed
    • Found
    • Inflammatory
    • Surface
    • Binding
    • Gene
    • P-selectin
    • Cells
    • Function
    • Tumor
  • endothelial
    • Expressed
    • Inflammatory
    • Surface
    • Blood
    • Function
    • Binding
    • Gene
    • Inflammation
    • Found
    • Expression
    • Human
    • May
  • natural killer cells
    • E-selectin
    • Endothelial
    • Tumor
    • Sites
    • Cancer
    • Cytokines
    • Binding
    • Expressed
    • Inflammatory
    • Ligands
    • May
    • Activated
  • cancer metastasis
    • Metastasis
    • Bone
    • Ligands
    • Shown
    • Studies
    • Cells
    • Role
    • Tumor
    • E-selectin
    • Cytokines
    • Bind
    • Binding
  • circulating tumor cells
    • E-selectin
    • Binding
    • Endothelial
    • Studies
    • Cells
    • Tumor
    • Sites
    • Cancer
    • Activated
    • Bind
    • Cytokines
    • Endothelium
  • colorectal cancer
    • Metastasis
    • Ligands
    • Bone
    • Shown
    • Studies
    • Cells
    • Tumor
    • E-selectin
    • Cytokines
    • Bind
    • Binding
    • Role

Connections between topic areas Semantic bridges

For E-selectin, one of the stronger structural bridges in this analysis connects E-selectin with Pathological relevance. Bridges highlight paths between different parts of the map and can reveal research angles that are easy to miss in a flat list.

Min side: 3
E-selectin — Pathological relevance · splits 61 ⟂ 25
E-selectin — Ligands · splits 70 ⟂ 16
E-selectin — Gene and regulation · splits 71 ⟂ 15
E-selectin — Function · splits 72 ⟂ 14
E-selectin — Structure · splits 78 ⟂ 8
E-selectin — Overview · splits 79 ⟂ 7

Map overview Semantic statistics

E-selectin

Nodes86
Edges85
Triples185
Avg. degree1.98
Density0.023256
Components1

Source & methodology

TTTA analyzes the structure around E-selectin to surface related topics, entities, relationships, concept neighborhoods and bridge connections. Use the map to explore areas such as Art, Pathological relevance & Ligands, including less central topics that may reveal useful research gaps. Automatically extracted connections are research leads rather than rewritten encyclopedia content.

Source: Wikipedia — E-selectin · EN edition · Analysis: TopicsToTalkAbout

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