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E-selectin

E-selectin, also known as CD62 antigen-like family member E (CD62E), endothelial-leukocyte adhesion molecule 1 (ELAM-1), or leukocyte-endothelial cell adhesion molecule 2 (LECAM2), is a selectin cell adhesion molecule expressed only on endothelial cells activated by cytokines. Like other selectins, it plays an important part in inflammation. In humans…

Art, Pathological relevance & Ligands

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Aliases
SELE, CD62E, ELAM, ELAM1, ESEL, LECAM2, selectin E, selectin-e
Available structures
Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1ESL, 1G1T, 4C16, 4CSY
Band
1q24.2 · 1 H2.2|1 71.35 cM
Bgee
vena cava · left uterine tube · testicle · seminal vesicula · olfactory zone of nasal mucosa
BioGPS
More reference expression data
Chr.
Chromosome 1 (human) · Chromosome 1 (mouse)

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Overview

Structure

Gene and regulation

Ligands

Function

Pathological relevance

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Map overview Semantic statistics

E-selectin

Nodes86
Edges85
Triples185
Avg. degree1.98
Density0.023256
Components1

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E-selectin

Top relations

Gene ontology · 32
E-selectin → actin filament-based process, activation of phospholipase C activity, calcium-mediated signaling, carbohydrate binding, caveola, cell adhesion, clathrin-coated pit, cortical cytoskeleton, extracellular space, heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules, inflammatory response, integral component of membrane, integral component of plasma membrane, leukocyte cell-cell adhesion, leukocyte migration, leukocyte migration involved in inflammatory response, leukocyte tethering or rolling, membrane, membrane raft, metal ion binding
Bgee · 20
E-selectin → atrioventricular valve, cartilage tissue, endothelial cell of lymphatic vessel, gallbladder, gastric mucosa, granulocyte, Ileal epithelium, intestinal villus, left uterine tube, lip, mucosa of urinary bladder, olfactory zone of nasal mucosa, semi-lunar valve, seminal vesicula, spermatid, spermatocyte, testicle, trachea, transitional epithelium of urinary bladder, vena cava
RNA expression pattern · 20
E-selectin → atrioventricular valve, cartilage tissue, endothelial cell of lymphatic vessel, gallbladder, gastric mucosa, granulocyte, Ileal epithelium, intestinal villus, left uterine tube, lip, mucosa of urinary bladder, olfactory zone of nasal mucosa, semi-lunar valve, seminal vesicula, spermatid, spermatocyte, testicle, trachea, transitional epithelium of urinary bladder, vena cava
related to Gene and regulation · 16
E-selectin → Different, EGF-like, IL-1, In, It, Its C-type, L-selectin, LPS, Maximal, P-selectin, SCR, SELE, The, The E-selectin, TNFα, Weibel-Palade
related to Structure · 15
E-selectin → C-type, Ca2, EGF, Fucα1, GlcNAc, LewisX, N-terminal, NeuNAcα2, SCR, SLeX, Structure/function, Sushi, The, The E-selectin, TM
related to Role in cancer · 14
E-selectin → At, E-selectin-blocking, E-selectin-mediated, Esl1, Furthermore, Glg1, HL60, IL-1β, Other, Studies, The, This, TNFα, While
related to Pathogen attachment · 10
E-selectin → An, E-selecin-mediated, HUVECs, LewisX, OmpA-like, Pgm6/7, Porphyromonas, Study, These, TNF-α
related to Nicotine-mediated induction · 8
E-selectin → Arr1, E2F1, E2F1-mediated, In, Nicotine-stimulated, RRD-251, Smoking, Therefore
related to Role in inflammation · 6
E-selectin → As, During, IL-1, Leukocytes, The, TNF-α
related to Critical illness polyneuromyopathy · 5
E-selectin → CIPNM, In, The, This, Traditional Chinese

Important terminology Word statistics

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Important terminology

cells endothelial cancer human cell also gene tumor inflammation may bp ligands expression expressed inflammatory adhesion chr band surface found

Entity relationships Subject–Predicate–Object triples

SubjectPredicateObjectConfidenceSrc
E-selectinAliasesSELE, CD62E, ELAM, ELAM1, ESEL, LECAM2, selectin E, selectin-e1.00infobox
E-selectinAvailable structuresAvailable structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1ESL, 1G1T, 4C16, 4CSY1.00infobox
E-selectinBand1q24.21.00infobox
E-selectinBand1 H2.2|1 71.35 cM1.00infobox
E-selectinBgeevena cava1.00infobox
E-selectinBgeeleft uterine tube1.00infobox
E-selectinBgeetesticle1.00infobox
E-selectinBgeeseminal vesicula1.00infobox
E-selectinBgeeolfactory zone of nasal mucosa1.00infobox
E-selectinBgeetrachea1.00infobox
E-selectinBgeegastric mucosa1.00infobox
E-selectinBgeecartilage tissue1.00infobox
E-selectinBgeemucosa of urinary bladder1.00infobox
E-selectinBgeegallbladder1.00infobox
E-selectinBgeetransitional epithelium of urinary bladder1.00infobox
E-selectinBgeespermatid1.00infobox
E-selectinBgeespermatocyte1.00infobox
E-selectinBgeegranulocyte1.00infobox
E-selectinBgeeendothelial cell of lymphatic vessel1.00infobox
E-selectinBgeeintestinal villus1.00infobox
E-selectinBgeesemi-lunar valve1.00infobox
E-selectinBgeeIleal epithelium1.00infobox
E-selectinBgeeatrioventricular valve1.00infobox
E-selectinBgeelip1.00infobox
E-selectinBioGPSMore reference expression data1.00infobox
E-selectinChr.Chromosome 1 (human)1.00infobox
E-selectinChr.Chromosome 1 (mouse)1.00infobox
E-selectinDatabasesNCBI: entry; OMA: entry1.00infobox
E-selectinEnd169,764,705 bp1.00infobox
E-selectinEnd163,885,246 bp1.00infobox

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