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L-selectin

L-selectin, also known as CD62L, is a cell adhesion molecule found on the cell surface of leukocytes, and the blastocyst. It is coded for in humans by the SELL gene. L-selectin belongs to the selectin family of proteins, which recognize sialylated carbohydrate groups containing a Sialyl LewisX (sLeX) determinant. L-selectin plays an important role in…

Ligands, Clinical significance & Expression

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Aliases
SELL, CD62L, LAM1, LECAM1, LEU8, LNHR, LSEL, LYAM1, PLNHR, TQ1, selectin L
Available structures
Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes2LGF, 3CFW
Band
1q24.2 · 1 H2.2|1 71.37 cM
Bgee
blood · monocyte · granulocyte · bone marrow · appendix
BioGPS
More reference expression data
Chr.
Chromosome 1 (human) · Chromosome 1 (mouse)

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Ligands

Expression

Function

Clinical significance

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L-selectin

Nodes38
Edges37
Triples126
Avg. degree1.95
Density0.052632
Components1

How this topic connects Entity context

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L-selectin

Top relations

Gene ontology · 23
L-selectin → calcium ion binding, calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules, carbohydrate binding, cell adhesion, cell adhesion molecule binding, cell surface, external side of plasma membrane, glycosphingolipid binding, heparin binding, integral component of membrane, integral component of plasma membrane, leukocyte migration, leukocyte tethering or rolling, membrane, metal ion binding, neutrophil degranulation, oligosaccharide binding, plasma membrane, protease binding, protein binding
Bgee · 16
L-selectin → appendix, blood, bone marrow, bone marrow cell, granulocyte, lymph node, mesenteric lymph nodes, monocyte, periodontal fiber, right lung, right lung lobe, spleen, subcutaneous adipose tissue, thymus, tibiofemoral joint, trabecular bone
RNA expression pattern · 16
L-selectin → appendix, blood, bone marrow, bone marrow cell, granulocyte, lymph node, mesenteric lymph nodes, monocyte, periodontal fiber, right lung, right lung lobe, spleen, subcutaneous adipose tissue, thymus, tibiofemoral joint, trabecular bone
related to External links · 12
L-selectin → Immunology, MCG1/physrespOverview, Medicine, Medicine Medical Subject Headings, MeSH, National Library, P14151, PDB, PDBe-KB, This, UniProt, United States National Library
related to Lymphocytes · 8
L-selectin → Central, Effector, Here, High, Ligands, Naive T-lymphocytes, T-lymphocytes, The
related to Expression · 7
L-selectin → ADAM17, E-selectin, Ectodomain, FOXO, Human, Over, The
related to Neutrophils and monocytes · 6
L-selectin → Adhesion, AMC, MAPK, Prolonged, Similar, The
related to Human immunodeficiency virus (HIV) · 5
L-selectin → CD4, HIV, Infection, The, This
related to Embryo · 4
L-selectin → MUC-1, Removal, Similar, The
Band · 2
L-selectin → 1 H2.2|1 71.37 cM, 1q24.2

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Important terminology

cells human adhesion neutrophils cell expression ligands expressed monocytes lymphoid lymphocytes shedding also bp embryo gene found sell binding chr

Entity relationships Subject–Predicate–Object triples

SubjectPredicateObjectConfidenceSrc
L-selectinAliasesSELL, CD62L, LAM1, LECAM1, LEU8, LNHR, LSEL, LYAM1, PLNHR, TQ1, selectin L1.00infobox
L-selectinAvailable structuresAvailable structuresPDBOrtholog search: PDBe RCSB List of PDB id codes2LGF, 3CFW1.00infobox
L-selectinBand1q24.21.00infobox
L-selectinBand1 H2.2|1 71.37 cM1.00infobox
L-selectinBgeeblood1.00infobox
L-selectinBgeemonocyte1.00infobox
L-selectinBgeegranulocyte1.00infobox
L-selectinBgeebone marrow1.00infobox
L-selectinBgeeappendix1.00infobox
L-selectinBgeebone marrow cell1.00infobox
L-selectinBgeespleen1.00infobox
L-selectinBgeetrabecular bone1.00infobox
L-selectinBgeelymph node1.00infobox
L-selectinBgeeperiodontal fiber1.00infobox
L-selectinBgeemesenteric lymph nodes1.00infobox
L-selectinBgeetibiofemoral joint1.00infobox
L-selectinBgeethymus1.00infobox
L-selectinBgeesubcutaneous adipose tissue1.00infobox
L-selectinBgeeright lung1.00infobox
L-selectinBgeeright lung lobe1.00infobox
L-selectinBioGPSMore reference expression data1.00infobox
L-selectinChr.Chromosome 1 (human)1.00infobox
L-selectinChr.Chromosome 1 (mouse)1.00infobox
L-selectinDatabasesNCBI: entry; OMA: entry1.00infobox
L-selectinEnd169,711,702 bp1.00infobox
L-selectinEnd163,911,750 bp1.00infobox
L-selectinEnsemblENSG000001884041.00infobox
L-selectinEntrez64021.00infobox
L-selectinExternal IDsOMIM: 153240; MGI: 98279; GeneCards: SELL1.00infobox
L-selectinGene location (Human)Gene location (Human)Chr.Chromosome 1 (human)Band1q24.2Start169,690,665 bpEnd169,711,702 bp1.00infobox

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