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CD74

HLA class II histocompatibility antigen gamma chain also known as HLA-DR antigens-associated invariant chain or CD74 (Cluster of Differentiation 74), is a protein that in humans is encoded by the CD74 gene. The invariant chain (Abbreviated Ii) is a polypeptide which plays a critical role in antigen presentation. It is involved in the formation and…

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Aliases
CD74, DHLAG, HLADG, II, Ia-GAMMA, CD74 molecule, p33, CLIP
Available structures
Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1A6A, 1ICF, 1IIE, 1L3H, 1MUJ, 3PDO, 3PGC, 3PGD, 3QXA, 3QXD, 4AEN, 4X5W
Band
5q33.1 · 18 E1|18 34.41 cM
Bgee
monocyte · appendix · granulocyte · spleen · lymph node
BioGPS
More reference expression data
Chr.
Chromosome 5 (human) · Chromosome 18 (mouse)

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Map overview Semantic statistics

CD74

Nodes40
Edges39
Triples171
Avg. degree1.95
Density0.05
Components1

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CD74

Top relations

Gene ontology · 85
CD74 → adaptive immune response, amyloid-beta binding, antigen processing and presentation, antigen processing and presentation of endogenous antigen, antigen processing and presentation of exogenous peptide antigen via MHC class II, CD4 receptor binding, cell population proliferation, cell surface, chaperone cofactor-dependent protein refolding, clathrin-coated endocytic vesicle membrane, cytokine binding, cytokine receptor activity, defense response, endocytic vesicle membrane, endoplasmic reticulum, endoplasmic reticulum membrane, endosome, ER to Golgi transport vesicle membrane, external side of plasma membrane, extracellular exosome
Bgee · 19
CD74 → adrenal gland, appendix, colon, gallbladder, granulocyte, ileum, jejunum, lip, lower lobe of lung, lymph node, monocyte, mucosa of ileum, right lung, spleen, thymus, upper lobe of left lung, uterus, white adipose tissue, zone of skin
RNA expression pattern · 19
CD74 → adrenal gland, appendix, colon, gallbladder, granulocyte, ileum, jejunum, lip, lower lobe of lung, lymph node, monocyte, mucosa of ileum, right lung, spleen, thymus, upper lobe of left lung, uterus, white adipose tissue, zone of skin
related to External links · 10
CD74 → ChainHuman CD74, Crystallography Archived, Davidson College, Medicine Medical Subject Headings, MeSH, National Library, Overview, School, UCSC Genome Browser, Wayback Machine The Invariant
related to Structure · 6
CD74 → II, Isoforms, MHC, N-terminal, RER, The
Band · 2
CD74 → 18 E1|18 34.41 cM, 5q33.1
Chr. · 2
CD74 → Chromosome 18 (mouse), Chromosome 5 (human)
End · 2
CD74 → 150,412,969 bp, 60,945,724 bp
related to Axial spondyloarthritis · 2
CD74 → Ankylosing, Autoantibodies
related to Interactions · 2
CD74 → Macrophage, MIF

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Important terminology

ii mhc class chain invariant cell human antigen bp gene surface chr band clip receptor chromosome protein also presentation peptide

Entity relationships Subject–Predicate–Object triples

SubjectPredicateObjectConfidenceSrc
CD74AliasesCD74, DHLAG, HLADG, II, Ia-GAMMA, CD74 molecule, p33, CLIP1.00infobox
CD74Available structuresAvailable structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1A6A, 1ICF, 1IIE, 1L3H, 1MUJ, 3PDO, 3PGC, 3PGD, 3QXA, 3QXD, 4AEN, 4X5W1.00infobox
CD74Band5q33.11.00infobox
CD74Band18 E1|18 34.41 cM1.00infobox
CD74Bgeemonocyte1.00infobox
CD74Bgeeappendix1.00infobox
CD74Bgeegranulocyte1.00infobox
CD74Bgeespleen1.00infobox
CD74Bgeelymph node1.00infobox
CD74Bgeeright lung1.00infobox
CD74Bgeegallbladder1.00infobox
CD74Bgeeupper lobe of left lung1.00infobox
CD74Bgeelower lobe of lung1.00infobox
CD74Bgeemucosa of ileum1.00infobox
CD74Bgeejejunum1.00infobox
CD74Bgeethymus1.00infobox
CD74Bgeeileum1.00infobox
CD74Bgeezone of skin1.00infobox
CD74Bgeecolon1.00infobox
CD74Bgeelip1.00infobox
CD74Bgeeuterus1.00infobox
CD74Bgeeadrenal gland1.00infobox
CD74Bgeewhite adipose tissue1.00infobox
CD74BioGPSMore reference expression data1.00infobox
CD74Chr.Chromosome 5 (human)1.00infobox
CD74Chr.Chromosome 18 (mouse)1.00infobox
CD74DatabasesNCBI: entry; OMA: entry1.00infobox
CD74End150,412,969 bp1.00infobox
CD74End60,945,724 bp1.00infobox
CD74EnsemblENSG000000195821.00infobox

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