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C-C chemokine receptor type 5, also known as CCR5 or CD195, is a protein on the surface of white blood cells that is involved in the immune system as it acts as a receptor for chemokines.
The analysis highlights Function, Clinical significance and Structure as prominent areas in the source structure around CCR5.
Source areas are shown by the number of related topics found in each part of the analysis. Use smaller areas too: they can reveal specialized angles and content gaps.
Smaller areas are not necessarily less important. They contain fewer connections in this analysis and can be useful for finding specialized angles or coverage gaps.
High-confidence facts extracted from structured source data. Use them as anchors for further research.
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The extracted context around CCR5 shows recurring relationship patterns in the source. For example, CCR5 → actin binding, C-C chemokine binding, C-C chemokine receptor activity, calcium ion transport, calcium-mediated signaling, cell chemotaxis, cell surface, cell surface receptor signaling pathway, cell-cell signaling, cellular defense response, cellular response to lipopolysaccharide, chemokine (C-C motif) ligand 5 binding, chemokine binding, chemokine receptor activity, chemokine-mediated signaling pathway, chemotaxis, coreceptor activity, cytokine-mediated signaling pathway, cytoplasm, defense response Another extracted example is CCR5 → Although, CCR5-using, CD4, CXCR4, During HIV-1, Following, Gp120, Gp120-Gp41, Gp160, Gp41, HIV, HIV-1, MIP-1α, MIP-1β, Moreover, N-linked, RANTES, The Gp120, The HIV-1, The V1-V2. Use these groups to spot repeated connection types before inspecting the individual relationships.
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chemokine protein co-receptor receptor gene hiv-1 cells immune hiv also human infection cell expressed gp120 bp cancer binding virus receptors
TTTA extracted 193 structured relationships around CCR5. Examples in this analysis include CCR5 → Aliases → CCR5, CC-CKR-5, CCCKR5, CCR-5, CD195, CKR-5, CKR5, CMKBR5, IDDM22, C-C motif chemokine receptor 5 (gene/pseudogene), C-C motif chemokine receptor 5 and CCR5 → Available structures → Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes2L87, 2RLL, 2RRS, 2MZX, 4MBS. The table shows each extracted connection, where it came from and its confidence.
| Subject | Predicate | Object | Confidence | Src |
|---|---|---|---|---|
| CCR5 | Aliases | CCR5, CC-CKR-5, CCCKR5, CCR-5, CD195, CKR-5, CKR5, CMKBR5, IDDM22, C-C motif chemokine receptor 5 (gene/pseudogene), C-C motif chemokine receptor 5 | 1.00 | infobox |
| CCR5 | Available structures | Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes2L87, 2RLL, 2RRS, 2MZX, 4MBS | 1.00 | infobox |
| CCR5 | Band | 3p21.31 | 1.00 | infobox |
| CCR5 | Band | 9 F4|9 75.05 cM | 1.00 | infobox |
| CCR5 | Bgee | epithelium of nasopharynx | 1.00 | infobox |
| CCR5 | Bgee | parietal pleura | 1.00 | infobox |
| CCR5 | Bgee | visceral pleura | 1.00 | infobox |
| CCR5 | Bgee | palpebral conjunctiva | 1.00 | infobox |
| CCR5 | Bgee | granulocyte | 1.00 | infobox |
| CCR5 | Bgee | germinal epithelium | 1.00 | infobox |
| CCR5 | Bgee | mucosa of urinary bladder | 1.00 | infobox |
| CCR5 | Bgee | appendix | 1.00 | infobox |
| CCR5 | Bgee | superficial temporal artery | 1.00 | infobox |
| CCR5 | Bgee | jejunal mucosa | 1.00 | infobox |
| CCR5 | Bgee | lumbar subsegment of spinal cord | 1.00 | infobox |
| CCR5 | Bgee | morula | 1.00 | infobox |
| CCR5 | Bgee | lumbar spinal ganglion | 1.00 | infobox |
| CCR5 | Bgee | blood | 1.00 | infobox |
| CCR5 | Bgee | embryo | 1.00 | infobox |
| CCR5 | Bgee | lymph node | 1.00 | infobox |
| CCR5 | Bgee | mesenteric lymph nodes | 1.00 | infobox |
| CCR5 | Bgee | submandibular gland | 1.00 | infobox |
| CCR5 | Bgee | blastocyst | 1.00 | infobox |
| CCR5 | BioGPS | n/a | 1.00 | infobox |
| CCR5 | Chr. | Chromosome 3 (human) | 1.00 | infobox |
| CCR5 | Chr. | Chromosome 9 (mouse) | 1.00 | infobox |
| CCR5 | Databases | NCBI: entry; OMA: entry | 1.00 | infobox |
| CCR5 | End | 46,376,206 bp | 1.00 | infobox |
| CCR5 | End | 123,947,736 bp | 1.00 | infobox |
| CCR5 | Ensembl | ENSG00000160791 | 1.00 | infobox |
The concept neighborhoods around CCR5 bring nearby vocabulary together. In this analysis, examples include Cells, Chemokine and Cancer. Use the clusters to find adjacent concepts and terminology that may deserve separate research.
For CCR5, one of the stronger structural bridges in this analysis connects CCR5 with Function. Bridges highlight paths between different parts of the map and can reveal research angles that are easy to miss in a flat list.
TTTA analyzes the structure around CCR5 to surface related topics, entities, relationships, concept neighborhoods and bridge connections. Use the map to explore areas such as Function, Clinical significance & Structure, including less central topics that may reveal useful research gaps. Automatically extracted connections are research leads rather than rewritten encyclopedia content.
Source: Wikipedia — CCR5 · EN edition · Analysis: TopicsToTalkAbout
