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Caffeine

Caffeine is a stimulant of the methylxanthine class, and is the most commonly consumed psychoactive drug globally; it is nearly universally legal to produce and sell, usually in the form of caffeinated drinks. It is mainly used for its eugeroic (wakefulness promoting), ergogenic (physical performance-enhancing), or nootropic (cognitive-enhancing)…

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Key facts & relationships

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3D model (JSmol)
Interactive image
Addiction liability
None
AHFS/Drugs.com
Monograph
ATC code
N06BC01 (WHO) D11AX26 (WHO), V04CG30 (WHO)
Bioavailability
99%
CAS Number
58-08-2

Topics to explore

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Overview

Uses

Adverse effects

Overdose

Interactions

Pharmacology

Chemistry

Commercial sources

Natural occurrence

Products

History

Society and culture

Other organisms

Research

Advanced semantic analysis

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Map overview Semantic statistics

Caffeine

Nodes416
Edges415
Triples304
Avg. degree2
Density0.004808
Components1

How this topic connects Entity context

See the strongest relationship patterns around the current topic before diving into the raw triples.

Caffeine

Top relations

related to Chemical identification, isolation, and synthesis · 24
Caffeine → Berzelius, Berzelius's, Caffeebase, Caféine, French, Friedlieb Ferdinand Runge, Furthermore, German, However, In, It, Joseph Bienaimé Caventou, Jöns Jacob Berzelius, Kaffebase, Paris, Pelletier's, Pharmacy Society, Phytochemical Discoveries, Pierre Jean Robiquet, Pierre-Joseph Pelletier
related to Historic regulations · 24
Caffeine → Although, Because, Charles II, Chattanooga, Coca-Cola, Drug Act, England, For, Forty Barrels, Frederick II, In, Islamists, Mecca, Ottoman Empire, Prussia, Pure Food, Representatives, Supreme Court, Sweden, Tennessee
related to Natural occurrence · 13
Caffeine → Amazonian, Around, Coffea, Common, Firstly, High, In, Other, Secondly, South American, Temperate, Theobroma, This
related to Religions · 11
Caffeine → Church, Covenants, Doctrine, Gaudiya Vaishnavas, Jesus Christ, Latter-day Saints, Some, The Church, The Church's, The Seventh-day Adventist Church, To
related to Discovery and spread of use · 10
Caffeine → Also, BCE, Chocolate, Columbian Mesoamerica, It, Kola, Mayan, The, West African, Xocolatl
Legal status · 9
Caffeine → AU: Unscheduled, BR: Unscheduled, CA: Unscheduled, CN: OTC SE: Unscheduled[a], DE: Unscheduled, NZ: Unscheduled, UK: General sales list (GSL, OTC), UN: Unscheduled, US: Unscheduled
is a · 9
Caffeine → antagonist of all four adenosine receptor subtypes, bitter, bitter-tasting, coffee, example of convergent evolution among different species.Caffeine may be synthesized in the lab starting with 1, inositol trisphosphate receptor 1 antagonist and a voltage-independent activator of the ryanodine receptors, mild euphoriant, stimulant of the methylxanthine class, world's most widely consumed psychoactive drug
related to Combinations with other drugs · 9
Caffeine → Drug Administration, In, Painkillers, Some, Such, The, The ECA, United States Food, Ya
related to Pharmacokinetics · 9
Caffeine → AUC, Caffeine's, Cmax, However, In, It, Luvox, Peak, The
related to Alcohol · 8
Caffeine → According, Alcohol, Americans, DSST, For, However, The Dietary Guidelines, When

Important terminology Word statistics

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Important terminology

coffee effects also consumption may mg tea adenosine use drinks used per found intake receptor beverages receptors consumed two drug

Entity relationships Subject–Predicate–Object triples

SubjectPredicateObjectConfidenceSrc
Caffeine3D model (JSmol)Interactive image1.00infobox
CaffeineAddiction liabilityNone1.00infobox
CaffeineAHFS/Drugs.comMonograph1.00infobox
CaffeineATC codeN06BC01 (WHO) D11AX26 (WHO), V04CG30 (WHO)1.00infobox
CaffeineBioavailability99%1.00infobox
CaffeineCAS Number58-08-21.00infobox
CaffeineChEBICHEBI:277321.00infobox
CaffeineChEMBLChEMBL1131.00infobox
CaffeineChemSpider24241.00infobox
CaffeineCompTox Dashboard (EPA)DTXSID00202321.00infobox
CaffeineDensity1.23 g/cm31.00infobox
CaffeineDependence liabilityPhysical: Low–moderate (9–30%) Psychological: Low–moderate1.00infobox
CaffeineDrug classStimulant; Adenosinergic; Eugeroic; Nootropic; Anxiogenic; Analeptic; PDE inhibitor; Diuretic1.00infobox
CaffeineDrugBankDB002011.00infobox
CaffeineDuration of action3–4 hours1.00infobox
CaffeineECHA InfoCard100.000.3291.00infobox
CaffeineElimination half-lifeAdults: 3–7 hours Infants (full term): 8 hours Infants (premature): 100 hours1.00infobox
CaffeineExcretionUrine (100%)1.00infobox
CaffeineFormulaC8H10N4O21.00infobox
CaffeineIUPHAR/BPS4071.00infobox
CaffeineKEGGD005281.00infobox
CaffeineLegal statusAU: Unscheduled1.00infobox
CaffeineLegal statusBR: Unscheduled1.00infobox
CaffeineLegal statusCA: Unscheduled1.00infobox
CaffeineLegal statusDE: Unscheduled1.00infobox
CaffeineLegal statusNZ: Unscheduled1.00infobox
CaffeineLegal statusUK: General sales list (GSL, OTC)1.00infobox
CaffeineLegal statusUS: Unscheduled1.00infobox
CaffeineLegal statusUN: Unscheduled1.00infobox
CaffeineLegal statusCN: OTC SE: Unscheduled[a]1.00infobox

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