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C-C chemokine receptor type 7: Function & Overview

C-C chemokine receptor type 7 is a protein that in humans is encoded by the CCR7 gene. Two ligands have been identified for this receptor: the chemokine (C-C motif) ligand 19 (CCL19/ELC) and (C-C motif) ligand 21 (CCL21). The ligands have similar affinity for the receptor, though CCL19 has been shown to induce internalisation of CCR7 and desensitisation…

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C-C chemokine receptor type 7 topic overview

The analysis highlights Function and Overview as prominent areas in the source structure around C-C chemokine receptor type 7.

Related topics
36
Source areas
2
Connected nodes
38
Extracted relationships
122
Related term clusters
19
Bridge connections
38

What this topic covers Research coverage

Source areas are shown by the number of related topics found in each part of the analysis. Use smaller areas too: they can reveal specialized angles and content gaps.

Function · 29 topics
Overview · 7 topics

Smaller areas are not necessarily less important. They contain fewer connections in this analysis and can be useful for finding specialized angles or coverage gaps.

Key facts & relationships

High-confidence facts extracted from structured source data. Use them as anchors for further research.

Aliases
CCR7, BLR2, CC-CKR-7, CCR-7, CD197, CDw197, CMKBR7, EBI1, C-C motif chemokine receptor 7
Band
17q21.2 · 11|11 D
Bgee
appendix · lymph node · blood · granulocyte · thymus
BioGPS
More reference expression data
Chr.
Chromosome 17 (human) · Chromosome 11 (mouse)
Databases
NCBI: entry; OMA: entry

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Explore all related topics Closing gaps

Browse the complete topic structure, not only the most central items. Less prominent entities and concepts can reveal missing angles, specialized context and useful research gaps. Each item opens a new analysis centered on that subject.

Overview

Function

For the semantics nerds

You can skip this section if you’re here for content ideas and keyword inspiration.

Advanced semantic analysis

How C-C chemokine receptor type 7 connects Entity context

The extracted context around C-C chemokine receptor type 7 shows recurring relationship patterns in the source. For example, C-C chemokine receptor type 7 → activation of GTPase activity, C-C chemokine binding, C-C chemokine receptor activity, C-C motif chemokine 19 receptor activity, C-C motif chemokine 21 receptor activity, calcium-mediated signaling, cell chemotaxis, cell surface, cellular response to cytokine stimulus, chemokine (C-C motif) ligand 19 binding, chemokine (C-C motif) ligand 19 signaling pathway, chemokine (C-C motif) ligand 21 binding, chemokine (C-C motif) ligand 21 signaling pathway, chemokine binding, chemokine receptor activity, chemokine-mediated signaling pathway, chemotaxis, dendritic cell chemotaxis, establishment of T cell polarity, external side of plasma membrane Another extracted example is C-C chemokine receptor type 7 → appendix, blood, bone marrow, embryo, granulocyte, lymph node, mesenteric lymph nodes, mucosa of ileum, right lung lobe, spleen, subcutaneous adipose tissue, superficial temporal artery, testicle, thymus. Use these groups to spot repeated connection types before inspecting the individual relationships.

C-C chemokine receptor type 7

Top relations

Gene ontology · 67
C-C chemokine receptor type 7 → activation of GTPase activity, C-C chemokine binding, C-C chemokine receptor activity, C-C motif chemokine 19 receptor activity, C-C motif chemokine 21 receptor activity, calcium-mediated signaling, cell chemotaxis, cell surface, cellular response to cytokine stimulus, chemokine (C-C motif) ligand 19 binding, chemokine (C-C motif) ligand 19 signaling pathway, chemokine (C-C motif) ligand 21 binding, chemokine (C-C motif) ligand 21 signaling pathway, chemokine binding, chemokine receptor activity, chemokine-mediated signaling pathway, chemotaxis, dendritic cell chemotaxis, establishment of T cell polarity, external side of plasma membrane
Bgee · 14
C-C chemokine receptor type 7 → appendix, blood, bone marrow, embryo, granulocyte, lymph node, mesenteric lymph nodes, mucosa of ileum, right lung lobe, spleen, subcutaneous adipose tissue, superficial temporal artery, testicle, thymus
RNA expression pattern · 14
C-C chemokine receptor type 7 → appendix, blood, bone marrow, embryo, granulocyte, lymph node, mesenteric lymph nodes, mucosa of ileum, right lung lobe, spleen, subcutaneous adipose tissue, superficial temporal artery, testicle, thymus
Band · 2
C-C chemokine receptor type 7 → 11|11 D, 17q21.2
Chr. · 2
C-C chemokine receptor type 7 → Chromosome 11 (mouse), Chromosome 17 (human)
End · 2
C-C chemokine receptor type 7 → 40,565,472 bp, 99,045,903 bp
Aliases · 1
C-C chemokine receptor type 7 → CCR7, BLR2, CC-CKR-7, CCR-7, CD197, CDw197, CMKBR7, EBI1, C-C motif chemokine receptor 7
BioGPS · 1
C-C chemokine receptor type 7 → More reference expression data
Databases · 1
C-C chemokine receptor type 7 → NCBI: entry; OMA: entry
Ensembl · 1
C-C chemokine receptor type 7 → ENSG00000126353

Important terminology

Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.

Important terminology

ccr7 receptor cells cell human dendritic gene also thymus bp expression lymph nodes chr band ccl19 ccl21 protein c-c chemokine

C-C chemokine receptor type 7 relationships Subject–Predicate–Object triples

TTTA extracted 122 structured relationships around C-C chemokine receptor type 7. Examples in this analysis include C-C chemokine receptor type 7 → Aliases → CCR7, BLR2, CC-CKR-7, CCR-7, CD197, CDw197, CMKBR7, EBI1, C-C motif chemokine receptor 7 and C-C chemokine receptor type 7 → Band → 17q21.2. The table shows each extracted connection, where it came from and its confidence.

SubjectPredicateObjectConfidenceSrc
C-C chemokine receptor type 7AliasesCCR7, BLR2, CC-CKR-7, CCR-7, CD197, CDw197, CMKBR7, EBI1, C-C motif chemokine receptor 71.00infobox
C-C chemokine receptor type 7Band17q21.21.00infobox
C-C chemokine receptor type 7Band11|11 D1.00infobox
C-C chemokine receptor type 7Bgeeappendix1.00infobox
C-C chemokine receptor type 7Bgeelymph node1.00infobox
C-C chemokine receptor type 7Bgeeblood1.00infobox
C-C chemokine receptor type 7Bgeegranulocyte1.00infobox
C-C chemokine receptor type 7Bgeethymus1.00infobox
C-C chemokine receptor type 7Bgeespleen1.00infobox
C-C chemokine receptor type 7Bgeesuperficial temporal artery1.00infobox
C-C chemokine receptor type 7Bgeemucosa of ileum1.00infobox
C-C chemokine receptor type 7Bgeetesticle1.00infobox
C-C chemokine receptor type 7Bgeebone marrow1.00infobox
C-C chemokine receptor type 7Bgeemesenteric lymph nodes1.00infobox
C-C chemokine receptor type 7Bgeeembryo1.00infobox
C-C chemokine receptor type 7Bgeesubcutaneous adipose tissue1.00infobox
C-C chemokine receptor type 7Bgeeright lung lobe1.00infobox
C-C chemokine receptor type 7BioGPSMore reference expression data1.00infobox
C-C chemokine receptor type 7Chr.Chromosome 17 (human)1.00infobox
C-C chemokine receptor type 7Chr.Chromosome 11 (mouse)1.00infobox
C-C chemokine receptor type 7DatabasesNCBI: entry; OMA: entry1.00infobox
C-C chemokine receptor type 7End40,565,472 bp1.00infobox
C-C chemokine receptor type 7End99,045,903 bp1.00infobox
C-C chemokine receptor type 7EnsemblENSG000001263531.00infobox
C-C chemokine receptor type 7Entrez12361.00infobox
C-C chemokine receptor type 7External IDsOMIM: 600242; MGI: 103011; GeneCards: CCR71.00infobox
C-C chemokine receptor type 7Gene location (Human)Gene location (Human)Chr.Chromosome 17 (human)Band17q21.2Start40,553,769 bpEnd40,565,472 bp1.00infobox
C-C chemokine receptor type 7Gene location (Mouse)Gene location (Mouse)Chr.Chromosome 11 (mouse)Band11|11 DStart99,035,022 bpEnd99,045,903 bp1.00infobox
C-C chemokine receptor type 7Gene ontologyC-C motif chemokine 19 receptor activity1.00infobox
C-C chemokine receptor type 7Gene ontologyC-C motif chemokine 21 receptor activity1.00infobox

Related concept clusters Related term clusters

The concept neighborhoods around C-C chemokine receptor type 7 bring nearby vocabulary together. In this analysis, examples include Chemokine, Motif and External. Use the clusters to find adjacent concepts and terminology that may deserve separate research.

  • C-C chemokine receptor type 7
    • Chemokine
    • Motif
    • External
    • Gene
    • Protein
    • Receptor
    • Chromosome
    • Function
    • Location
    • Cells
    • Nodes
    • Thymus
  • c-c chemokine receptor type 7
    • Chemokine
    • Motif
    • External
    • Gene
    • Protein
    • Immune
    • Receptor
    • Chromosome
    • Function
    • Location
    • Cells
    • Nodes
  • protein
    • Gene
    • External
    • Chemotaxis
    • Motif
    • Negative
    • Selection
    • Spleen
    • Actin
    • Band
    • Chromosome
    • Function
    • Immune
  • gene
    • Location
    • Human
    • Chromosome
    • Bp
    • Chr
    • External
    • Receptor
    • Motif
    • Protein
    • Band
    • Function
    • Mouse
  • c-c motif
    • Chemokine
    • Motif
    • External
    • Gene
    • Chromosome
    • Function
    • Location
    • Protein
    • Receptor
    • Bp
    • Chr
    • Human
  • g protein-coupled receptor
    • Immune
    • Cells
    • Nodes
    • Thymus
    • Lymph
    • Central
    • Dendritic
    • Function
    • Cell
    • Also
    • External
    • Spleen
  • lymph nodes
    • Nodes
    • Spleen
    • Thymus
    • Dendritic
    • Receptor
    • Also
    • Expression
    • External
    • Chemotaxis
    • Negative
    • Protein
    • Selection
  • actin
    • Chemotaxis
    • Pathway
    • Signalling
    • External
    • Dendritic
    • Motif
    • Negative
    • Protein
    • Selection
    • Spleen
    • Band
    • C-c

Connections between topic areas Semantic bridges

For C-C chemokine receptor type 7, one of the stronger structural bridges in this analysis connects C-C chemokine receptor type 7 with Function. Bridges highlight paths between different parts of the map and can reveal research angles that are easy to miss in a flat list.

Min side: 3
C-C chemokine receptor type 7 — Function · splits 9 ⟂ 30
C-C chemokine receptor type 7 — Overview · splits 31 ⟂ 8

Map overview Semantic statistics

C-C chemokine receptor type 7

Nodes39
Edges38
Triples122
Avg. degree1.95
Density0.051282
Components1

Source & methodology

TTTA analyzes the structure around C-C chemokine receptor type 7 to surface related topics, entities, relationships, concept neighborhoods and bridge connections. Use the map to explore areas such as Function & Overview, including less central topics that may reveal useful research gaps. Automatically extracted connections are research leads rather than rewritten encyclopedia content.

Source: Wikipedia — C-C chemokine receptor type 7 · EN edition · Analysis: TopicsToTalkAbout

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