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STK4: Function, Interactions & Overview

Serine/threonine-protein kinase 4 is an enzyme that in humans is encoded by the STK4 gene.

Language: English [EN]
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STK4 topic overview

The analysis highlights Function, Interactions and Overview as prominent areas in the source structure around STK4.

Related topics
13
Source areas
3
Connected nodes
16
Extracted relationships
118
Related term clusters
9
Bridge connections
16

What this topic covers Research coverage

Source areas are shown by the number of related topics found in each part of the analysis. Use smaller areas too: they can reveal specialized angles and content gaps.

Function · 9 topics
Interactions · 2 topics
Overview · 2 topics

Smaller areas are not necessarily less important. They contain fewer connections in this analysis and can be useful for finding specialized angles or coverage gaps.

Key facts & relationships

High-confidence facts extracted from structured source data. Use them as anchors for further research.

2.7.11.1
↗
Aliases
STK4, KRS2, MST1, TIIAC, YSK3, serine/threonine kinase 4
Available structures
Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes3COM, 4NR2, 4OH8, 2JO8
Band
20q13.12 · 2|2 H3
Bgee
epithelium of colon · buccal mucosa cell · blood · monocyte · superficial temporal artery
BioGPS
More reference expression data

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Explore all related topics Closing gaps

Browse the complete topic structure, not only the most central items. Less prominent entities and concepts can reveal missing angles, specialized context and useful research gaps. Each item opens a new analysis centered on that subject.

Overview

Function

Interactions

For the semantics nerds

You can skip this section if you’re here for content ideas and keyword inspiration.

Advanced semantic analysis

How STK4 connects Entity context

The extracted context around STK4 shows recurring relationship patterns in the source. For example, STK4 → activation of protein kinase activity, apoptotic process, ATP binding, branching involved in blood vessel morphogenesis, cell differentiation involved in embryonic placenta development, cell morphogenesis, central nervous system development, cytoplasm, cytosol, endocardium development, hepatocyte apoptotic process, hippo signaling, identical protein binding, intracellular signal transduction, keratinocyte differentiation, kinase activity, magnesium ion binding, metal ion binding, negative regulation of canonical Wnt signaling pathway, negative regulation of cell population proliferation Another extracted example is STK4 → blood, buccal mucosa cell, condyle, epithelium of colon, fossa, Gonadal ridge, left lung lobe, lymph node, mesenteric lymph nodes, monocyte, pylorus, right lung lobe, saphenous vein, spleen, stroma of bone marrow, superficial temporal artery, thymus, tonsil, trabecular bone. Use these groups to spot repeated connection types before inspecting the individual relationships.

STK4

Top relations

Gene ontology · 53
STK4 → activation of protein kinase activity, apoptotic process, ATP binding, branching involved in blood vessel morphogenesis, cell differentiation involved in embryonic placenta development, cell morphogenesis, central nervous system development, cytoplasm, cytosol, endocardium development, hepatocyte apoptotic process, hippo signaling, identical protein binding, intracellular signal transduction, keratinocyte differentiation, kinase activity, magnesium ion binding, metal ion binding, negative regulation of canonical Wnt signaling pathway, negative regulation of cell population proliferation
Bgee · 19
STK4 → blood, buccal mucosa cell, condyle, epithelium of colon, fossa, Gonadal ridge, left lung lobe, lymph node, mesenteric lymph nodes, monocyte, pylorus, right lung lobe, saphenous vein, spleen, stroma of bone marrow, superficial temporal artery, thymus, tonsil, trabecular bone
RNA expression pattern · 19
STK4 → blood, buccal mucosa cell, condyle, epithelium of colon, fossa, Gonadal ridge, left lung lobe, lymph node, mesenteric lymph nodes, monocyte, pylorus, right lung lobe, saphenous vein, spleen, stroma of bone marrow, superficial temporal artery, thymus, tonsil, trabecular bone
Band · 2
STK4 → 20q13.12, 2|2 H3
Chr. · 2
STK4 → Chromosome 2 (mouse), Chromosome 20 (human)
End · 2
STK4 → 163,997,444 bp, 45,080,021 bp
related to Interactions · 2
STK4 → PRKRIR, Yap1
2.7.11.1 · 1
STK4 → ↗
Aliases · 1
STK4 → STK4, KRS2, MST1, TIIAC, YSK3, serine/threonine kinase 4
Available structures · 1
STK4 → Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes3COM, 4NR2, 4OH8, 2JO8

Important terminology

Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.

Important terminology

bp gene chr human band 20 kinase chromosome protein encoded serine location enzyme mouse function shown threonine search activity 080

STK4 relationships Subject–Predicate–Object triples

TTTA extracted 118 structured relationships around STK4. Examples in this analysis include STK4 → 2.7.11.1 → ↗ and STK4 → Aliases → STK4, KRS2, MST1, TIIAC, YSK3, serine/threonine kinase 4. The table shows each extracted connection, where it came from and its confidence.

SubjectPredicateObjectConfidenceSrc
STK42.7.11.1↗1.00infobox
STK4AliasesSTK4, KRS2, MST1, TIIAC, YSK3, serine/threonine kinase 41.00infobox
STK4Available structuresAvailable structuresPDBOrtholog search: PDBe RCSB List of PDB id codes3COM, 4NR2, 4OH8, 2JO81.00infobox
STK4Band20q13.121.00infobox
STK4Band2|2 H31.00infobox
STK4Bgeeepithelium of colon1.00infobox
STK4Bgeebuccal mucosa cell1.00infobox
STK4Bgeeblood1.00infobox
STK4Bgeemonocyte1.00infobox
STK4Bgeesuperficial temporal artery1.00infobox
STK4Bgeetrabecular bone1.00infobox
STK4Bgeepylorus1.00infobox
STK4Bgeetonsil1.00infobox
STK4Bgeelymph node1.00infobox
STK4Bgeesaphenous vein1.00infobox
STK4Bgeemesenteric lymph nodes1.00infobox
STK4Bgeeright lung lobe1.00infobox
STK4Bgeefossa1.00infobox
STK4Bgeespleen1.00infobox
STK4Bgeecondyle1.00infobox
STK4Bgeeleft lung lobe1.00infobox
STK4Bgeethymus1.00infobox
STK4Bgeestroma of bone marrow1.00infobox
STK4BgeeGonadal ridge1.00infobox
STK4BioGPSMore reference expression data1.00infobox
STK4Chr.Chromosome 20 (human)1.00infobox
STK4Chr.Chromosome 2 (mouse)1.00infobox
STK4DatabasesNCBI: entry; OMA: entry1.00infobox
STK4End45,080,021 bp1.00infobox
STK4End163,997,444 bp1.00infobox

Related concept clusters Related term clusters

The concept neighborhoods around STK4 bring nearby vocabulary together. In this analysis, examples include Activity, Cell and Function. Use the clusters to find adjacent concepts and terminology that may deserve separate research.

  • STK4
    • Activity
    • Cell
    • Function
    • Search
    • Threonine
    • Location
    • Shown
    • Chromosome
    • Human
    • Bp
    • Chr
    • Cascade
  • stk4
    • Activity
    • Cell
    • Function
    • Search
    • Threonine
    • Location
    • Shown
    • Chromosome
    • Human
    • Bp
    • Chr
    • Cascade
  • gene
    • Kinase
    • Location
    • Serine
    • Chromosome
    • Human
    • Activity
    • Bp
    • Chr
    • End
    • Function
    • Mouse
    • Search
  • mitogen-activated protein kinase
    • Serine
    • Gene
    • Activity
    • Enzyme
    • Function
    • Search
    • Threonine
    • Stk4
    • Location
    • Phosphorylation
    • Process
    • Chromosome
  • function
    • Activity
    • Search
    • Threonine
    • Kinase
    • Location
    • Serine
    • Cascade
    • Chromosome
    • Gene
    • Human
    • Interactions
    • Reading
  • autophosphorylation
    • Cascade
    • Encoded
    • Protein
    • Cell
    • End
    • Function
    • Mouse
    • Phosphorylation
    • Process
    • Search
    • Threonine
    • Kinase
  • enzyme
    • Kinase
    • Serine
    • Gene
    • Humans
    • Interactions
    • Reading
    • References
    • Threonine-protein
    • Stk4
    • Activity
    • Function
    • Search
  • interactions
    • Reading
    • References
    • Search
    • Threonine
    • Kinase
    • Location
    • Serine
    • Human
    • Stk4

Connections between topic areas Semantic bridges

For STK4, one of the stronger structural bridges in this analysis connects STK4 with Function. Bridges highlight paths between different parts of the map and can reveal research angles that are easy to miss in a flat list.

Min side: 3
STK4 — Function · splits 7 ⟂ 10
STK4 — Overview · splits 14 ⟂ 3
STK4 — Interactions · splits 14 ⟂ 3

Map overview Semantic statistics

STK4

Nodes17
Edges16
Triples118
Avg. degree1.88
Density0.117647
Components1

Source & methodology

TTTA analyzes the structure around STK4 to surface related topics, entities, relationships, concept neighborhoods and bridge connections. Use the map to explore areas such as Function, Interactions & Overview, including less central topics that may reveal useful research gaps. Automatically extracted connections are research leads rather than rewritten encyclopedia content.

Source: Wikipedia — STK4 · EN edition · Analysis: TopicsToTalkAbout

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