FOXP2

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FOXP2 topic overview

The analysis highlights History, Art and Regions as prominent areas in the source structure around FOXP2.

Related topics: 107
Source areas: 7
Connected nodes: 114
Extracted relationships: 255
Concept neighborhoods: 23
Bridge connections: 114

What this topic covers Research coverage

Source areas are shown by the number of related topics found in each part of the analysis. Use smaller areas too: they can reveal specialized angles and content gaps.

In other animals · 33 topics

History · 18 topics

Evolution · 16 topics

Overview · 13 topics

Structure and function · 12 topics

Interactions · 11 topics

Clinical significance · 4 topics

Smaller areas are not necessarily less important. They contain fewer connections in this analysis and can be useful for finding specialized angles or coverage gaps.

Key facts & relationships

High-confidence facts extracted from structured source data. Use them as anchors for further research.

Aliases: FOXP2, CAGH44, SPCH1, TNRC10, forkhead box P2
Available structures: Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes2AS5, 2A07
Band: 7q31.1 · 6|6 A1
Bgee: buccal mucosa cell · tibialis anterior muscle · mucosa of paranasal sinus · bronchial epithelial cell · endothelial cell
BioGPS: More reference expression data
Chr.: Chromosome 7 (human) · Chromosome 6 (mouse)

Explore all related topics Closing gaps

Browse the complete topic structure, not only the most central items. Less prominent entities and concepts can reveal missing angles, specialized context and useful research gaps. Each item opens a new analysis centered on that subject.

Overview

Protein
Gene
Forkhead box
Transcription factors
Regulate gene expression Regulation of gene expression
Binding to DNA DNA-binding protein
Vertebrates
Birdsong
Echolocation Animal echolocation
Developmental verbal dyspraxia
Speech disorder
KE family
Evolutionary selection

Structure and function

FOX protein
Polyglutamine tract
Zinc finger
Leucine zipper
Knockout mice Knockout mouse
Purkinje layer
Basal ganglia
Frontal cortex
Broca's areas Broca's area
Post-transcriptional regulation
MicroRNA
3′ untranslated region Three prime untranslated region

Clinical significance

Evolution

Interactions

In other animals

Gene knockouts Gene knockout
Ultrasonic Ultrasound
Vocalisations Animal communication
Synaptic plasticity
Cerebellar
Cortico-basal ganglia Cortico-basal ganglia-thalamo-cortical loop
Homologous recombination
Medial geniculate nucleus
Type 1 dopamine receptors Dopamine receptor D1
Substantia nigra
Subthalamic nucleus
Ventral tegmental area
Long-term depression
EEG
Schizophrenia
Epilepsy
Autism
Bipolar disorder
Bat
Echolocating bats Microbat
Eutherian
Cetaceans
Toothed whales
Baleen cetaceans
Songbirds Songbird
Neuroplasticity
Gene knockdown
Adeno-associated virus
Gene expression
Zebrafish
Dorsal thalamus
Telencephalon
Diencephalon

History

Institute of Child Health of University College London UCL Institute of Child Health
Myrna Gopnik
McGill University
University of Oxford
Autosomal dominant
Autosome
Sex chromosome
Mendelian
Simon Fisher
Anthony Monaco
Faraneh Vargha-Khadem
Chromosome 7
Bacterial artificial chromosome
Translocation Chromosomal translocation
Bioinformatics
RNA
Heterozygous
Point mutation

Advanced semantic analysis

Deeper signals for content research, entity SEO and topical coverage. The plain-language headings explain what each technical view is useful for.

How FOXP2 connects Entity context

The extracted context around FOXP2 shows recurring relationship patterns in the source. For example, FOXP2 → anatomical structure morphogenesis, androgen receptor binding, camera-type eye development, caudate nucleus development, cell differentiation, cerebellum development, cerebral cortex development, DNA binding, DNA-binding transcription factor activity, DNA-binding transcription factor activity, RNA polymerase II-specific, DNA-binding transcription repressor activity, RNA polymerase II-specific, forebrain development, growth, identical protein binding, innate vocalization behavior, lung alveolus development, lung development, metal ion binding, negative regulation of transcription by RNA polymerase II, negative regulation of transcription, DNA-templated Another extracted example is FOXP2 → Anthony Monaco, Around, Cecilia, Child Health, CS, DNA, English, Faraneh Vargha-Khadem, Her, Human Genome Nomenclature, Hurst, In, Institute, Jane, KE, Lai, Linguistics, Mapping, McGill University, Mendelian. Use these groups to spot repeated connection types before inspecting the individual relationships.

Top relations

Gene ontology · 38

FOXP2 → anatomical structure morphogenesis, androgen receptor binding, camera-type eye development, caudate nucleus development, cell differentiation, cerebellum development, cerebral cortex development, DNA binding, DNA-binding transcription factor activity, DNA-binding transcription factor activity, RNA polymerase II-specific, DNA-binding transcription repressor activity, RNA polymerase II-specific, forebrain development, growth, identical protein binding, innate vocalization behavior, lung alveolus development, lung development, metal ion binding, negative regulation of transcription by RNA polymerase II, negative regulation of transcription, DNA-templated

related to history · 33

FOXP2 → Anthony Monaco, Around, Cecilia, Child Health, CS, DNA, English, Faraneh Vargha-Khadem, Her, Human Genome Nomenclature, Hurst, In, Institute, Jane, KE, Lai, Linguistics, Mapping, McGill University, Mendelian

Bgee · 20

FOXP2 → bronchial epithelial cell, buccal mucosa cell, deltoid muscle, endothelial cell, epithelium of colon, genital tubercle, habenula, inferior colliculi, left lung lobe, medial dorsal nucleus, medial geniculate nucleus, mucosa of paranasal sinus, multiform layer of neocortex, muscle layer of sigmoid colon, nucleus accumbens, olfactory tubercle, Rostral migratory stream, sperm, sural nerve, tibialis anterior muscle

RNA expression pattern · 20

related to Language disorder · 17

FOXP2 → Additionally, Broca's, CAS, Clinically, DNA-binding, DVD, DVD/CAS, General, It, KE, R328X, R553H, So, These, They, This, When

related to Clinical significance · 14

FOXP2 → Additionally, Although, Furthermore, In, It, Mutations, One, Other, P2, Specifically, The FOXP2, These, This, Transcription

related to Evolution · 14

FOXP2 → DNA, Homo, In, N325S, Neanderthal, Neanderthals, One, Other, Previous, Similar FOXP2, Some, T303N, The, The FOXP2

related to Birds · 12

FOXP2 → AAV1, Area, Directed, Gene, In, Levels, Overexpression, Similarly, Studies, This, Undirected, When

related to Structure and function · 10

FOXP2 → As, DNA, FOX, In, Knockout, Only, P2, Purkinje, The, The FOXP2

related to Mice · 9

FOXP2 → Humanized FOXP2, In, KE, Loss, Male, Mice, R552H, The, These

Important terminology

Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.

Important terminology

gene language human also speech mice mutations found development brain humans protein disorder one expression learning motor family expressed chromosome

FOXP2 relationships Subject–Predicate–Object triples

TTTA extracted 255 structured relationships around FOXP2. Examples in this analysis include FOXP2 → Aliases → FOXP2, CAGH44, SPCH1, TNRC10, forkhead box P2 and FOXP2 → Available structures → Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes2AS5, 2A07. The table shows each extracted connection, where it came from and its confidence.

Subject	Predicate	Object	Confidence	Src
FOXP2	Aliases	FOXP2, CAGH44, SPCH1, TNRC10, forkhead box P2	1.00	infobox
FOXP2	Available structures	Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes2AS5, 2A07	1.00	infobox
FOXP2	Band	7q31.1	1.00	infobox
FOXP2	Band	6\|6 A1	1.00	infobox
FOXP2	Bgee	buccal mucosa cell	1.00	infobox
FOXP2	Bgee	tibialis anterior muscle	1.00	infobox
FOXP2	Bgee	mucosa of paranasal sinus	1.00	infobox
FOXP2	Bgee	bronchial epithelial cell	1.00	infobox
FOXP2	Bgee	endothelial cell	1.00	infobox
FOXP2	Bgee	muscle layer of sigmoid colon	1.00	infobox
FOXP2	Bgee	epithelium of colon	1.00	infobox
FOXP2	Bgee	sperm	1.00	infobox
FOXP2	Bgee	deltoid muscle	1.00	infobox
FOXP2	Bgee	sural nerve	1.00	infobox
FOXP2	Bgee	olfactory tubercle	1.00	infobox
FOXP2	Bgee	Rostral migratory stream	1.00	infobox
FOXP2	Bgee	inferior colliculi	1.00	infobox
FOXP2	Bgee	multiform layer of neocortex	1.00	infobox
FOXP2	Bgee	medial dorsal nucleus	1.00	infobox
FOXP2	Bgee	medial geniculate nucleus	1.00	infobox
FOXP2	Bgee	nucleus accumbens	1.00	infobox
FOXP2	Bgee	habenula	1.00	infobox
FOXP2	Bgee	left lung lobe	1.00	infobox
FOXP2	Bgee	genital tubercle	1.00	infobox
FOXP2	BioGPS	More reference expression data	1.00	infobox
FOXP2	Chr.	Chromosome 7 (human)	1.00	infobox
FOXP2	Chr.	Chromosome 6 (mouse)	1.00	infobox
FOXP2	Databases	NCBI: entry; OMA: entry	1.00	infobox
FOXP2	End	114,693,772 bp	1.00	infobox
FOXP2	End	15,441,976 bp	1.00	infobox

Related concept clusters Concept neighborhoods

The concept neighborhoods around FOXP2 bring nearby vocabulary together. In this analysis, examples include Gene, Language and Development. Use the clusters to find adjacent concepts and terminology that may deserve separate research.

FOXP2
- Gene
- Language
- Development
- Speech
- Also
- Mice
- Human
- Mutations
- Brain
- Found
- Expression
- Humans
foxp2
- Gene
- Language
- Development
- Speech
- Also
- Mice
- Human
- Mutations
- Brain
- Found
- Expression
- Humans
gene
- Language
- Human
- Disorder
- Mice
- Speech
- Family
- Mutation
- Researchers
- Learning
- Protein
- Genetic
- Identified
regulate gene expression
- Language
- Protein
- Human
- Mouse
- Transcription
- Disorder
- Mice
- Birds
- Region
- Foxp2
- Speech
- Family
evolution of language in humans
- Speech
- Disorder
- Known
- Including
- Ke
- Language
- One
- Mutations
- Genetic
- Identified
- Researchers
- Amino
gene knockouts
- Language
- Human
- Disorder
- Mice
- Speech
- Family
- Mutation
- Researchers
- Learning
- Protein
- Genetic
- Identified
gene knockdown
- Language
- Human
- Disorder
- Mice
- Speech
- Family
- Mutation
- Researchers
- Learning
- Protein
- Genetic
- Identified
gene expression
- Language
- Protein
- Human
- Mouse
- Transcription
- Disorder
- Mice
- Birds
- Region
- Foxp2
- Speech
- Family

Connections between topic areas Semantic bridges

For FOXP2, one of the stronger structural bridges in this analysis connects FOXP2 with In other animals. Bridges highlight paths between different parts of the map and can reveal research angles that are easy to miss in a flat list.

Min side: 3

FOXP2 — In other animals · splits 81 ⟂ 34

FOXP2 — History · splits 96 ⟂ 19

FOXP2 — Evolution · splits 98 ⟂ 17

FOXP2 — Overview · splits 101 ⟂ 14

FOXP2 — Structure and function · splits 102 ⟂ 13

FOXP2 — Interactions · splits 103 ⟂ 12

FOXP2 — Clinical significance · splits 110 ⟂ 5

Map overview Semantic statistics

FOXP2

Nodes115

Edges114

Triples255

Avg. degree1.98

Density0.017391

Components1

Source & methodology

TTTA analyzes the structure around FOXP2 to surface related topics, entities, relationships, concept neighborhoods and bridge connections. Use the map to explore areas such as History, Art & Regions, including less central topics that may reveal useful research gaps. Automatically extracted connections are research leads rather than rewritten encyclopedia content.

Source: Wikipedia — FOXP2 · EN edition · Analysis: TopicsToTalkAbout