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FOXP2

Forkhead box protein P2 (FOXP2) is a protein that, in humans, is encoded by the FOXP2 gene. FOXP2 is a member of the forkhead box family of transcription factors, proteins that regulate gene expression by binding to DNA. It is expressed in the brain, heart, lungs and digestive system.

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Aliases
FOXP2, CAGH44, SPCH1, TNRC10, forkhead box P2
Available structures
Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes2AS5, 2A07
Band
7q31.1 · 6|6 A1
Bgee
buccal mucosa cell · tibialis anterior muscle · mucosa of paranasal sinus · bronchial epithelial cell · endothelial cell
BioGPS
More reference expression data
Chr.
Chromosome 7 (human) · Chromosome 6 (mouse)

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Overview

Structure and function

Clinical significance

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In other animals

History

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Map overview Semantic statistics

FOXP2

Nodes115
Edges114
Triples255
Avg. degree1.98
Density0.017391
Components1

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FOXP2

Top relations

Gene ontology · 38
FOXP2 → anatomical structure morphogenesis, androgen receptor binding, camera-type eye development, caudate nucleus development, cell differentiation, cerebellum development, cerebral cortex development, DNA binding, DNA-binding transcription factor activity, DNA-binding transcription factor activity, RNA polymerase II-specific, DNA-binding transcription repressor activity, RNA polymerase II-specific, forebrain development, growth, identical protein binding, innate vocalization behavior, lung alveolus development, lung development, metal ion binding, negative regulation of transcription by RNA polymerase II, negative regulation of transcription, DNA-templated
related to history · 33
FOXP2 → Anthony Monaco, Around, Cecilia, Child Health, CS, DNA, English, Faraneh Vargha-Khadem, Her, Human Genome Nomenclature, Hurst, In, Institute, Jane, KE, Lai, Linguistics, Mapping, McGill University, Mendelian
Bgee · 20
FOXP2 → bronchial epithelial cell, buccal mucosa cell, deltoid muscle, endothelial cell, epithelium of colon, genital tubercle, habenula, inferior colliculi, left lung lobe, medial dorsal nucleus, medial geniculate nucleus, mucosa of paranasal sinus, multiform layer of neocortex, muscle layer of sigmoid colon, nucleus accumbens, olfactory tubercle, Rostral migratory stream, sperm, sural nerve, tibialis anterior muscle
RNA expression pattern · 20
FOXP2 → bronchial epithelial cell, buccal mucosa cell, deltoid muscle, endothelial cell, epithelium of colon, genital tubercle, habenula, inferior colliculi, left lung lobe, medial dorsal nucleus, medial geniculate nucleus, mucosa of paranasal sinus, multiform layer of neocortex, muscle layer of sigmoid colon, nucleus accumbens, olfactory tubercle, Rostral migratory stream, sperm, sural nerve, tibialis anterior muscle
related to Language disorder · 17
FOXP2 → Additionally, Broca's, CAS, Clinically, DNA-binding, DVD, DVD/CAS, General, It, KE, R328X, R553H, So, These, They, This, When
related to Clinical significance · 14
FOXP2 → Additionally, Although, Furthermore, In, It, Mutations, One, Other, P2, Specifically, The FOXP2, These, This, Transcription
related to Evolution · 14
FOXP2 → DNA, Homo, In, N325S, Neanderthal, Neanderthals, One, Other, Previous, Similar FOXP2, Some, T303N, The, The FOXP2
related to Birds · 12
FOXP2 → AAV1, Area, Directed, Gene, In, Levels, Overexpression, Similarly, Studies, This, Undirected, When
related to Structure and function · 10
FOXP2 → As, DNA, FOX, In, Knockout, Only, P2, Purkinje, The, The FOXP2
related to Mice · 9
FOXP2 → Humanized FOXP2, In, KE, Loss, Male, Mice, R552H, The, These

Important terminology Word statistics

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Important terminology

gene language human also speech mice mutations found development brain humans protein disorder one expression learning motor family expressed chromosome

Entity relationships Subject–Predicate–Object triples

SubjectPredicateObjectConfidenceSrc
FOXP2AliasesFOXP2, CAGH44, SPCH1, TNRC10, forkhead box P21.00infobox
FOXP2Available structuresAvailable structuresPDBOrtholog search: PDBe RCSB List of PDB id codes2AS5, 2A071.00infobox
FOXP2Band7q31.11.00infobox
FOXP2Band6|6 A11.00infobox
FOXP2Bgeebuccal mucosa cell1.00infobox
FOXP2Bgeetibialis anterior muscle1.00infobox
FOXP2Bgeemucosa of paranasal sinus1.00infobox
FOXP2Bgeebronchial epithelial cell1.00infobox
FOXP2Bgeeendothelial cell1.00infobox
FOXP2Bgeemuscle layer of sigmoid colon1.00infobox
FOXP2Bgeeepithelium of colon1.00infobox
FOXP2Bgeesperm1.00infobox
FOXP2Bgeedeltoid muscle1.00infobox
FOXP2Bgeesural nerve1.00infobox
FOXP2Bgeeolfactory tubercle1.00infobox
FOXP2BgeeRostral migratory stream1.00infobox
FOXP2Bgeeinferior colliculi1.00infobox
FOXP2Bgeemultiform layer of neocortex1.00infobox
FOXP2Bgeemedial dorsal nucleus1.00infobox
FOXP2Bgeemedial geniculate nucleus1.00infobox
FOXP2Bgeenucleus accumbens1.00infobox
FOXP2Bgeehabenula1.00infobox
FOXP2Bgeeleft lung lobe1.00infobox
FOXP2Bgeegenital tubercle1.00infobox
FOXP2BioGPSMore reference expression data1.00infobox
FOXP2Chr.Chromosome 7 (human)1.00infobox
FOXP2Chr.Chromosome 6 (mouse)1.00infobox
FOXP2DatabasesNCBI: entry; OMA: entry1.00infobox
FOXP2End114,693,772 bp1.00infobox
FOXP2End15,441,976 bp1.00infobox

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