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EPH receptor A4: Clinical significance, Structure & Function

EPH receptor A4 (ephrin type-A receptor 4) is a protein that in humans is encoded by the EPHA4 gene.

Language: English [EN]
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EPH receptor A4 topic overview

The analysis highlights Clinical significance, Structure and Function as prominent areas in the source structure around EPH receptor A4.

Related topics
22
Source areas
4
Connected nodes
26
Extracted relationships
153
Concept neighborhoods
16
Bridge connections
26

What this topic covers Research coverage

Source areas are shown by the number of related topics found in each part of the analysis. Use smaller areas too: they can reveal specialized angles and content gaps.

Clinical significance · 10 topics
Function · 5 topics
Structure · 5 topics
Overview · 2 topics

Smaller areas are not necessarily less important. They contain fewer connections in this analysis and can be useful for finding specialized angles or coverage gaps.

Key facts & relationships

High-confidence facts extracted from structured source data. Use them as anchors for further research.

2.7.10.1
Aliases
EPHA4, Epha4, 2900005C20Rik, AI385584, Cek8, Hek8, Sek, Sek1, Tyro1, rb, EPH receptor A4, HEK8, SEK, TYRO1, EK8
Available structures
Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes2LW8, 2WO1, 2WO2, 2WO3, 3CKH, 3GXU, 4BK4, 4BK5, 4BKA, 4BKF, 4M4P, 4M4R, 4W4Z, 4W50, 5JR2
Band
2q36.1 · 1 C4|1 39.55 cM
Bgee
Brodmann area 23 · frontal pole · middle temporal gyrus · lateral nuclear group of thalamus · endothelial cell
BioGPS
More reference expression data

Explore all related topics Closing gaps

Browse the complete topic structure, not only the most central items. Less prominent entities and concepts can reveal missing angles, specialized context and useful research gaps. Each item opens a new analysis centered on that subject.

Overview

Structure

Function

Clinical significance

Advanced semantic analysis

Deeper signals for content research, entity SEO and topical coverage. The plain-language headings explain what each technical view is useful for.

How EPH receptor A4 connects Entity context

The extracted context around EPH receptor A4 shows recurring relationship patterns in the source. For example, EPH receptor A4 → adult walking behavior, amyloid-beta binding, ATP binding, axon, axon guidance, axon terminus, axonal growth cone, cell adhesion, cell body, cell junction, cell projection, cell surface, cellular response to amyloid-beta, corticospinal tract morphogenesis, cytoplasm, dendrite, dendritic shaft, dendritic spine, DH domain binding, early endosome Another extracted example is EPH receptor A4 → Brodmann area 23, dentate gyrus of hippocampal formation granule cell, dorsal striatum, endothelial cell, frontal pole, genital tubercle, lateral geniculate nucleus, lateral nuclear group of thalamus, medial dorsal nucleus, medial ganglionic eminence, middle temporal gyrus, nucleus accumbens, palpebral conjunctiva, parietal lobe, postcentral gyrus, primary visual cortex, Rostral migratory stream, superior frontal gyrus, tail of embryo, ventricular zone. Use these groups to spot repeated connection types before inspecting the individual relationships.

EPH receptor A4

Top relations

Gene ontology · 87
EPH receptor A4 → adult walking behavior, amyloid-beta binding, ATP binding, axon, axon guidance, axon terminus, axonal growth cone, cell adhesion, cell body, cell junction, cell projection, cell surface, cellular response to amyloid-beta, corticospinal tract morphogenesis, cytoplasm, dendrite, dendritic shaft, dendritic spine, DH domain binding, early endosome
Bgee · 20
EPH receptor A4 → Brodmann area 23, dentate gyrus of hippocampal formation granule cell, dorsal striatum, endothelial cell, frontal pole, genital tubercle, lateral geniculate nucleus, lateral nuclear group of thalamus, medial dorsal nucleus, medial ganglionic eminence, middle temporal gyrus, nucleus accumbens, palpebral conjunctiva, parietal lobe, postcentral gyrus, primary visual cortex, Rostral migratory stream, superior frontal gyrus, tail of embryo, ventricular zone
RNA expression pattern · 20
EPH receptor A4 → Brodmann area 23, dentate gyrus of hippocampal formation granule cell, dorsal striatum, endothelial cell, frontal pole, genital tubercle, lateral geniculate nucleus, lateral nuclear group of thalamus, medial dorsal nucleus, medial ganglionic eminence, middle temporal gyrus, nucleus accumbens, palpebral conjunctiva, parietal lobe, postcentral gyrus, primary visual cortex, Rostral migratory stream, superior frontal gyrus, tail of embryo, ventricular zone
Band · 2
EPH receptor A4 → 1 C4|1 39.55 cM, 2q36.1
Chr. · 2
EPH receptor A4 → Chromosome 1 (mouse), Chromosome 2 (human)
End · 2
EPH receptor A4 → 221,574,202 bp, 77,491,725 bp
2.7.10.1 · 1
EPH receptor A4 → ↗
Aliases · 1
EPH receptor A4 → EPHA4, Epha4, 2900005C20Rik, AI385584, Cek8, Hek8, Sek, Sek1, Tyro1, rb, EPH receptor A4, HEK8, SEK, TYRO1, EK8
Available structures · 1
EPH receptor A4 → Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes2LW8, 2WO1, 2WO2, 2WO3, 3CKH, 3GXU, 4BK4, 4BK5, 4BKA, 4BKF, 4M4P, 4M4R, 4W4Z, 4W50, 5JR2
BioGPS · 1
EPH receptor A4 → More reference expression data

Important terminology

Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.

Important terminology

epha4 receptor bp gene chr human band kinase signaling synaptic eph ephrin chromosome axonal glial function activity motor nervous system

EPH receptor A4 relationships Subject–Predicate–Object triples

TTTA extracted 153 structured relationships around EPH receptor A4. Examples in this analysis include EPH receptor A4 → 2.7.10.1 → ↗ and EPH receptor A4 → Aliases → EPHA4, Epha4, 2900005C20Rik, AI385584, Cek8, Hek8, Sek, Sek1, Tyro1, rb, EPH receptor A4, HEK8, SEK, TYRO1, EK8. The table shows each extracted connection, where it came from and its confidence.

SubjectPredicateObjectConfidenceSrc
EPH receptor A42.7.10.11.00infobox
EPH receptor A4AliasesEPHA4, Epha4, 2900005C20Rik, AI385584, Cek8, Hek8, Sek, Sek1, Tyro1, rb, EPH receptor A4, HEK8, SEK, TYRO1, EK81.00infobox
EPH receptor A4Available structuresAvailable structuresPDBOrtholog search: PDBe RCSB List of PDB id codes2LW8, 2WO1, 2WO2, 2WO3, 3CKH, 3GXU, 4BK4, 4BK5, 4BKA, 4BKF, 4M4P, 4M4R, 4W4Z, 4W50, 5JR21.00infobox
EPH receptor A4Band2q36.11.00infobox
EPH receptor A4Band1 C4|1 39.55 cM1.00infobox
EPH receptor A4BgeeBrodmann area 231.00infobox
EPH receptor A4Bgeefrontal pole1.00infobox
EPH receptor A4Bgeemiddle temporal gyrus1.00infobox
EPH receptor A4Bgeelateral nuclear group of thalamus1.00infobox
EPH receptor A4Bgeeendothelial cell1.00infobox
EPH receptor A4Bgeeprimary visual cortex1.00infobox
EPH receptor A4Bgeesuperior frontal gyrus1.00infobox
EPH receptor A4Bgeeparietal lobe1.00infobox
EPH receptor A4Bgeepostcentral gyrus1.00infobox
EPH receptor A4Bgeepalpebral conjunctiva1.00infobox
EPH receptor A4BgeeRostral migratory stream1.00infobox
EPH receptor A4Bgeemedial ganglionic eminence1.00infobox
EPH receptor A4Bgeeventricular zone1.00infobox
EPH receptor A4Bgeedorsal striatum1.00infobox
EPH receptor A4Bgeegenital tubercle1.00infobox
EPH receptor A4Bgeedentate gyrus of hippocampal formation granule cell1.00infobox
EPH receptor A4Bgeemedial dorsal nucleus1.00infobox
EPH receptor A4Bgeelateral geniculate nucleus1.00infobox
EPH receptor A4Bgeenucleus accumbens1.00infobox
EPH receptor A4Bgeetail of embryo1.00infobox
EPH receptor A4BioGPSMore reference expression data1.00infobox
EPH receptor A4Chr.Chromosome 2 (human)1.00infobox
EPH receptor A4Chr.Chromosome 1 (mouse)1.00infobox
EPH receptor A4DatabasesNCBI: entry; OMA: entry1.00infobox
EPH receptor A4End221,574,202 bp1.00infobox

Related concept clusters Concept neighborhoods

The concept neighborhoods around EPH receptor A4 bring nearby vocabulary together. In this analysis, examples include A4, Eph and Receptor. Use the clusters to find adjacent concepts and terminology that may deserve separate research.

  • EPH receptor A4
    • A4
    • Eph
    • Receptor
    • Receptors
    • Signaling
    • Synaptic
    • Gene
    • Kinase
    • Nervous
    • System
    • Neuron
    • Motor
  • eph receptor a4
    • Activity
    • Gene
    • Tyrosine
    • A4
    • Eph
    • Kinase
    • Protein
    • Receptor
    • Receptors
    • Search
    • Structure
    • Signaling
  • protein
    • Gene
    • Mouse
    • Search
    • Structure
    • Receptor
    • Development
    • Domain
    • Formation
    • Location
    • Neuron
    • Regeneration
    • Tyrosine
  • gene
    • Location
    • Chromosome
    • Human
    • Bp
    • Chr
    • Mouse
    • Protein
    • Search
    • Structure
    • Receptor
    • Activity
    • Band
  • ephrin
    • Protein
    • Domain
    • Gene
    • Mouse
    • Receptor
    • Search
    • Structure
    • Development
    • Formation
    • Location
    • Neuron
    • Receptors
  • axonal guidance
    • Glial
    • Guidance
    • Development
    • Formation
    • Nervous
    • Regeneration
    • System
    • Signaling
    • Synaptic
    • Brain
    • Tyrosine
    • Kinase
  • function
    • Search
    • Structure
    • Location
    • Activity
    • Chromosome
    • Gene
    • Human
    • Motor
    • Bp
    • Chr
    • Signaling
    • Synaptic
  • protein-tyrosine kinase
    • Tyrosine
    • Signaling
    • Domain
    • Receptor
    • Glial
    • Guidance
    • Nervous
    • System
    • Synaptic
    • Mouse
    • Protein
    • Search

Connections between topic areas Semantic bridges

For EPH receptor A4, one of the stronger structural bridges in this analysis connects EPH receptor A4 with Clinical significance. Bridges highlight paths between different parts of the map and can reveal research angles that are easy to miss in a flat list.

Min side: 3
EPH receptor A4Clinical significance · splits 16 ⟂ 11
EPH receptor A4Structure · splits 21 ⟂ 6
EPH receptor A4Function · splits 21 ⟂ 6
EPH receptor A4Overview · splits 24 ⟂ 3

Map overview Semantic statistics

EPH receptor A4

Nodes27
Edges26
Triples153
Avg. degree1.93
Density0.074074
Components1

Source & methodology

TTTA analyzes the structure around EPH receptor A4 to surface related topics, entities, relationships, concept neighborhoods and bridge connections. Use the map to explore areas such as Clinical significance, Structure & Function, including less central topics that may reveal useful research gaps. Automatically extracted connections are research leads rather than rewritten encyclopedia content.

Source: Wikipedia — EPH receptor A4 · EN edition · Analysis: TopicsToTalkAbout

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