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CDH8: Clinical significance & Overview

Cadherin-8 is a protein that in humans is encoded by the CDH8 gene.

Language: English [EN]
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CDH8 topic overview

The analysis highlights Clinical significance and Overview as prominent areas in the source structure around CDH8.

Related topics
3
Source areas
2
Connected nodes
5
Extracted relationships
98
Concept neighborhoods
4
Bridge connections
5

What this topic covers Research coverage

Source areas are shown by the number of related topics found in each part of the analysis. Use smaller areas too: they can reveal specialized angles and content gaps.

Overview · 2 topics
Clinical significance · 1 topics

Smaller areas are not necessarily less important. They contain fewer connections in this analysis and can be useful for finding specialized angles or coverage gaps.

Key facts & relationships

High-confidence facts extracted from structured source data. Use them as anchors for further research.

Aliases
CDH8, Nbla04261, cadherin 8
Available structures
Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1ZXK, 2A62
Band
16q21 · 8 D1|8 49.4 cM
Bgee
endothelial cell · Brodmann area 23 · prefrontal cortex · lateral nuclear group of thalamus · entorhinal cortex
BioGPS
More reference expression data
Chr.
Chromosome 16 (human) · Chromosome 8 (mouse)

Explore all related topics Closing gaps

Browse the complete topic structure, not only the most central items. Less prominent entities and concepts can reveal missing angles, specialized context and useful research gaps. Each item opens a new analysis centered on that subject.

Overview

Clinical significance

Advanced semantic analysis

Deeper signals for content research, entity SEO and topical coverage. The plain-language headings explain what each technical view is useful for.

How CDH8 connects Entity context

The extracted context around CDH8 shows recurring relationship patterns in the source. For example, CDH8 → adherens junction organization, axon terminus, cadherin binding, calcium ion binding, calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules, catenin complex, cell adhesion, cell morphogenesis, cell surface, cell-cell adhesion, cell-cell adhesion mediated by cadherin, cell-cell junction assembly, chemical synaptic transmission, cytoskeletal protein binding, glutamatergic synapse, homophilic cell adhesion via plasma membrane adhesion molecules, identical protein binding, integral component of membrane, membrane, metal ion binding Another extracted example is CDH8 → Brodmann area 23, Brodmann area 9, dentate gyrus of hippocampal formation granule cell, dorsal tegmental nucleus, dorsolateral prefrontal cortex, endothelial cell, entorhinal cortex, globus pallidus, gonad, habenula, lateral geniculate nucleus, lateral hypothalamus, lateral nuclear group of thalamus, lateral septal nucleus, medial dorsal nucleus, medial vestibular nucleus, middle temporal gyrus, prefrontal cortex, testicle, ventral tegmental area. Use these groups to spot repeated connection types before inspecting the individual relationships.

CDH8

Top relations

Gene ontology · 27
CDH8 → adherens junction organization, axon terminus, cadherin binding, calcium ion binding, calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules, catenin complex, cell adhesion, cell morphogenesis, cell surface, cell-cell adhesion, cell-cell adhesion mediated by cadherin, cell-cell junction assembly, chemical synaptic transmission, cytoskeletal protein binding, glutamatergic synapse, homophilic cell adhesion via plasma membrane adhesion molecules, identical protein binding, integral component of membrane, membrane, metal ion binding
Bgee · 20
CDH8 → Brodmann area 23, Brodmann area 9, dentate gyrus of hippocampal formation granule cell, dorsal tegmental nucleus, dorsolateral prefrontal cortex, endothelial cell, entorhinal cortex, globus pallidus, gonad, habenula, lateral geniculate nucleus, lateral hypothalamus, lateral nuclear group of thalamus, lateral septal nucleus, medial dorsal nucleus, medial vestibular nucleus, middle temporal gyrus, prefrontal cortex, testicle, ventral tegmental area
RNA expression pattern · 20
CDH8 → Brodmann area 23, Brodmann area 9, dentate gyrus of hippocampal formation granule cell, dorsal tegmental nucleus, dorsolateral prefrontal cortex, endothelial cell, entorhinal cortex, globus pallidus, gonad, habenula, lateral geniculate nucleus, lateral hypothalamus, lateral nuclear group of thalamus, lateral septal nucleus, medial dorsal nucleus, medial vestibular nucleus, middle temporal gyrus, prefrontal cortex, testicle, ventral tegmental area
related to External links · 7
CDH8 → Mouse Cadherin-8, Overview, P97291, PDB, PDBe-KB, UCSC Genome Browser, UniProt
Band · 2
CDH8 → 16q21, 8 D1|8 49.4 cM
Chr. · 2
CDH8 → Chromosome 16 (human), Chromosome 8 (mouse)
End · 2
CDH8 → 100,143,103 bp, 62,037,035 bp
Aliases · 1
CDH8 → CDH8, Nbla04261, cadherin 8
Available structures · 1
CDH8 → Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1ZXK, 2A62
BioGPS · 1
CDH8 → More reference expression data

Important terminology

Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.

Important terminology

gene human bp chr band cadherin chromosome 16 adhesion location mouse protein cell ucsc function external pdb uniprot p97291 cadherin-8

CDH8 relationships Subject–Predicate–Object triples

TTTA extracted 98 structured relationships around CDH8. Examples in this analysis include CDH8 → Aliases → CDH8, Nbla04261, cadherin 8 and CDH8 → Available structures → Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1ZXK, 2A62. The table shows each extracted connection, where it came from and its confidence.

SubjectPredicateObjectConfidenceSrc
CDH8AliasesCDH8, Nbla04261, cadherin 81.00infobox
CDH8Available structuresAvailable structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1ZXK, 2A621.00infobox
CDH8Band16q211.00infobox
CDH8Band8 D1|8 49.4 cM1.00infobox
CDH8Bgeeendothelial cell1.00infobox
CDH8BgeeBrodmann area 231.00infobox
CDH8Bgeeprefrontal cortex1.00infobox
CDH8Bgeelateral nuclear group of thalamus1.00infobox
CDH8Bgeeentorhinal cortex1.00infobox
CDH8Bgeegonad1.00infobox
CDH8Bgeemiddle temporal gyrus1.00infobox
CDH8Bgeetesticle1.00infobox
CDH8Bgeedorsolateral prefrontal cortex1.00infobox
CDH8BgeeBrodmann area 91.00infobox
CDH8Bgeehabenula1.00infobox
CDH8Bgeelateral septal nucleus1.00infobox
CDH8Bgeeglobus pallidus1.00infobox
CDH8Bgeedorsal tegmental nucleus1.00infobox
CDH8Bgeeventral tegmental area1.00infobox
CDH8Bgeemedial dorsal nucleus1.00infobox
CDH8Bgeelateral hypothalamus1.00infobox
CDH8Bgeedentate gyrus of hippocampal formation granule cell1.00infobox
CDH8Bgeemedial vestibular nucleus1.00infobox
CDH8Bgeelateral geniculate nucleus1.00infobox
CDH8BioGPSMore reference expression data1.00infobox
CDH8Chr.Chromosome 16 (human)1.00infobox
CDH8Chr.Chromosome 8 (mouse)1.00infobox
CDH8DatabasesNCBI: entry; OMA: entry1.00infobox
CDH8End62,037,035 bp1.00infobox
CDH8End100,143,103 bp1.00infobox

Related concept clusters Concept neighborhoods

The concept neighborhoods around CDH8 bring nearby vocabulary together. In this analysis, examples include Gene, Human and Ucsc. Use the clusters to find adjacent concepts and terminology that may deserve separate research.

  • CDH8
    • Gene
    • Human
    • Ucsc
    • Location
    • Function
    • Humans
    • Protein
    • Search
    • Chromosome
    • Bp
    • Cadherin
    • Chr
  • cdh8
    • Gene
    • Human
    • Ucsc
    • Location
    • Function
    • Humans
    • Protein
    • Search
    • Chromosome
    • Bp
    • Cadherin
    • Chr
  • gene
    • Human
    • Location
    • Ucsc
    • Chromosome
    • Bp
    • Chr
    • D1
    • End
    • Function
    • Protein
    • Search
    • Mouse
  • protein
    • P97291
    • Search
    • Synaptic
    • Uniprot
    • Ucsc

Connections between topic areas Semantic bridges

For CDH8, one of the stronger structural bridges in this analysis connects CDH8 with Overview. Bridges highlight paths between different parts of the map and can reveal research angles that are easy to miss in a flat list.

Min side: 3
CDH8Overview · splits 3 ⟂ 3

Map overview Semantic statistics

CDH8

Nodes6
Edges5
Triples98
Avg. degree1.67
Density0.333333
Components1

Source & methodology

TTTA analyzes the structure around CDH8 to surface related topics, entities, relationships, concept neighborhoods and bridge connections. Use the map to explore areas such as Clinical significance & Overview, including less central topics that may reveal useful research gaps. Automatically extracted connections are research leads rather than rewritten encyclopedia content.

Source: Wikipedia — CDH8 · EN edition · Analysis: TopicsToTalkAbout

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